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Matthew J. O'Connell

TitlePROFESSOR
InstitutionMount Sinai
DepartmentOncological Sciences
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Caparelli ML, O'Connell MJ. Regulatory motifs in Chk1. Cell Cycle. 2013 Mar 15; 12(6):916-22.
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    2. Kuntz K, O'Connell MJ. Initiation of DNA damage responses through XPG-related nucleases. EMBO J. 2013 Jan 23; 32(2):290-302.
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    3. Bass KL, Murray JM, O'Connell MJ. Brc1-dependent recovery from replication stress. J Cell Sci. 2012 Jun 1; 125(Pt 11):2753-64.
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    4. Wang Y, Kallgren SP, Reddy BD, Kuntz K, López-Maury L, Thompson J, Watt S, Ma C, Hou H, Shi Y, Yates JR, Bähler J, O'Connell MJ, Jia S. Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast. J Biol Chem. 2012 Feb 3; 287(6):4386-93.
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    5. Tapia-Alveal C, O'Connell MJ. Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes. Mol Biol Cell. 2011 Dec; 22(23):4669-82.
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    6. Tapia-Alveal C, O'Connell MJ. Methods for studying the G2 DNA damage checkpoint in mammalian cells. Methods Mol Biol. 2011; 782:23-31.
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    7. Tapia-Alveal C, O'Connell MJ. Methods for studying checkpoint kinases - Chk1. Methods Mol Biol. 2011; 782:171-9.
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    8. Tapia-Alveal C, Outwin EA, Trempolec N, Dziadkowiec D, Murray JM, O'Connell MJ. SMC complexes and topoisomerase II work together so that sister chromatids can work apart. Cell Cycle. 2010 Jun 1; 9(11):2065-70.
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    9. Calonge TM, Eshaghi M, Liu J, Ronai Z, O'Connell MJ. Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1. Genetics. 2010 May; 185(1):81-93.
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    10. Rego RL, Foster NR, Smyrk TC, Le M, O'Connell MJ, Sargent DJ, Windschitl H, Sinicrope FA. Prognostic effect of activated EGFR expression in human colon carcinomas: comparison with EGFR status. Br J Cancer. 2010 Jan 5; 102(1):165-72.
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    11. Kuntz K, O'Connell MJ. The G(2) DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer? Cancer Biol Ther. 2009 Aug; 8(15):1433-9.
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    12. Outwin EA, Irmisch A, Murray JM, O'Connell MJ. Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes. Mol Cell Biol. 2009 Aug; 29(16):4363-75.
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    13. Tapia-Alveal C, Calonge TM, O'Connell MJ. Regulation of chk1. Cell Div. 2009; 4:8.
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    14. Irmisch A, Ampatzidou E, Mizuno K, O'Connell MJ, Murray JM. Smc5/6 maintains stalled replication forks in a recombination-competent conformation. EMBO J. 2009 Jan 21; 28(2):144-55.
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    15. Kosoy A, O'Connell MJ. Regulation of Chk1 by its C-terminal domain. Mol Biol Cell. 2008 Nov; 19(11):4546-53.
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    16. Bhoumik A, Singha N, O'Connell MJ, Ronai ZA. Regulation of TIP60 by ATF2 modulates ATM activation. J Biol Chem. 2008 Jun 20; 283(25):17605-14.
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    17. Calonge TM, O'Connell MJ. Turning off the G2 DNA damage checkpoint. DNA Repair (Amst). 2008 Feb 1; 7(2):136-40.
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    18. Umanskaya K, Radke S, Chander H, Monardo R, Xu X, Pan ZQ, O'Connell MJ, Germain D. Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor. Mol Cell Biol. 2007 Nov; 27(21):7615-22.
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    19. Kosoy A, Calonge TM, Outwin EA, O'Connell MJ. Fission yeast Rnf4 homologs are required for DNA repair. J Biol Chem. 2007 Jul 13; 282(28):20388-94.
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    20. Lee KM, Nizza S, Hayes T, Bass KL, Irmisch A, Murray JM, O'Connell MJ. Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function. Genetics. 2007 Apr; 175(4):1585-95.
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    21. Ampatzidou E, Irmisch A, O'Connell MJ, Murray JM. Smc5/6 is required for repair at collapsed replication forks. Mol Cell Biol. 2006 Dec; 26(24):9387-401.
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    22. Ishii Y, Pirkmaier A, Alvarez JV, Frank DA, Keselman I, Logothetis D, Mandeli J, O'Connell MJ, Waxman S, Germain D. Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. J Natl Cancer Inst. 2006 Sep 6; 98(17):1238-47.
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    23. Calonge TM, O'Connell MJ. Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1. Genetics. 2006 Sep; 174(1):113-23.
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    24. Macip S, Kosoy A, Lee SW, O'Connell MJ, Aaronson SA. Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint. Oncogene. 2006 Oct 5; 25(45):6037-47.
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    25. Lee KM, O'Connell MJ. A new SUMO ligase in the DNA damage response. DNA Repair (Amst). 2006 Jan 5; 5(1):138-41.
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    26. Sheedy DM, Dimitrova D, Rankin JK, Bass KL, Lee KM, Tapia-Alveal C, Harvey SH, Murray JM, O'Connell MJ. Brc1-mediated DNA repair and damage tolerance. Genetics. 2005 Oct; 171(2):457-68.
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    27. Bimbó A, Jia Y, Poh SL, Karuturi RK, den Elzen N, Peng X, Zheng L, O'Connell M, Liu ET, Balasubramanian MK, Liu J. Systematic deletion analysis of fission yeast protein kinases. Eukaryot Cell. 2005 Apr; 4(4):799-813.
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    28. O'Connell MJ, Cimprich KA. G2 damage checkpoints: what is the turn-on? J Cell Sci. 2005 Jan 1; 118(Pt 1):1-6.
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    29. Zheng LX, O'Connell MJ, Doorn SK, Liao XZ, Zhao YH, Akhadov EA, Hoffbauer MA, Roop BJ, Jia QX, Dye RC, Peterson DE, Huang SM, Liu J, Zhu YT. Ultralong single-wall carbon nanotubes. Nat Mater. 2004 Oct; 3(10):673-6.
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    30. Latif C, den Elzen NR, O'Connell MJ. DNA damage checkpoint maintenance through sustained Chk1 activity. J Cell Sci. 2004 Jul 15; 117(Pt 16):3489-98.
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    31. den Elzen N, Kosoy A, Christopoulos H, O'Connell MJ. Resisting arrest: recovery from checkpoint arrest through dephosphorylation of Chk1 by PP1. Cell Cycle. 2004 May; 3(5):529-33.
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    32. den Elzen NR, O'Connell MJ. Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J. 2004 Feb 25; 23(4):908-18.
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    33. Mochida S, Esashi F, Aono N, Tamai K, O'Connell MJ, Yanagida M. Regulation of checkpoint kinases through dynamic interaction with Crb2. EMBO J. 2004 Jan 28; 23(2):418-28.
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    34. Harvey SH, Sheedy DM, Cuddihy AR, O'Connell MJ. Coordination of DNA damage responses via the Smc5/Smc6 complex. Mol Cell Biol. 2004 Jan; 24(2):662-74.
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    35. O'Connell MJ, Krien MJ, Hunter T. Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol. 2003 May; 13(5):221-8.
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    36. Pirkmaier A, Yuen K, Hendley J, O'Connell MJ, Germain D. Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide. Clin Cancer Res. 2003 May; 9(5):1877-84.
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    37. Cuddihy AR, O'Connell MJ. Cell-cycle responses to DNA damage in G2. Int Rev Cytol. 2003; 222:99-140.
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    38. Frew IJ, Dickins RA, Cuddihy AR, Del Rosario M, Reinhard C, O'Connell MJ, Bowtell DD. Normal p53 function in primary cells deficient for Siah genes. Mol Cell Biol. 2002 Dec; 22(23):8155-64.
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    39. Capasso H, Palermo C, Wan S, Rao H, John UP, O'Connell MJ, Walworth NC. Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest. J Cell Sci. 2002 Dec 1; 115(Pt 23):4555-64.
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    40. Krien MJ, West RR, John UP, Koniaras K, McIntosh JR, O'Connell MJ. The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity. EMBO J. 2002 Apr 2; 21(7):1713-22.
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    41. Harvey SH, Krien MJ, O'Connell MJ. Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases. Genome Biol. 2002; 3(2):REVIEWS3003.
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    42. Latif C, Harvey SH, O'Connell MJ. Ensuring the stability of the genome: DNA damage checkpoints. ScientificWorldJournal. 2001 Nov 20; 1:684-702.
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    43. Koniaras K, Cuddihy AR, Christopoulos H, Hogg A, O'Connell MJ. Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene. 2001 Nov 8; 20(51):7453-63.
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    44. Huang HK, Forsburg SL, John UP, O'Connell MJ, Hunter T. Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe. J Cell Sci. 2001 Oct; 114(Pt 20):3779-88.
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    45. Verkade HM, Teli T, Laursen LV, Murray JM, O'Connell MJ. A homologue of the Rad18 postreplication repair gene is required for DNA damage responses throughout the fission yeast cell cycle. Mol Genet Genomics. 2001 Aug; 265(6):993-1003.
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    46. O'Connell MJ, Walworth NC, Carr AM. The G2-phase DNA-damage checkpoint. Trends Cell Biol. 2000 Jul; 10(7):296-303.
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    47. Sargent DJ, Goldberg RM, Mahoney MR, Hillman DW, McKeough T, Hamilton SF, Darcy JM, Anderson VL, Krook JE, O'Connell MJ. Rapid reporting and review of an increased incidence of a known adverse event. J Natl Cancer Inst. 2000 Jun 21; 92(12):1011-3.
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    48. Raleigh JM, O'Connell MJ. The G(2) DNA damage checkpoint targets both Wee1 and Cdc25. J Cell Sci. 2000 May; 113 ( Pt 10):1727-36.
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    49. Hymowitz SG, Christinger HW, Fuh G, Ultsch M, O'Connell M, Kelley RF, Ashkenazi A, de Vos AM. Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol Cell. 1999 Oct; 4(4):563-71.
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    50. Verkade HM, Bugg SJ, Lindsay HD, Carr AM, O'Connell MJ. Rad18 is required for DNA repair and checkpoint responses in fission yeast. Mol Biol Cell. 1999 Sep; 10(9):2905-18.
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    51. Uren AG, Beilharz T, O'Connell MJ, Bugg SJ, van Driel R, Vaux DL, Lithgow T. Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10170-5.
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    52. Halling KC, French AJ, McDonnell SK, Burgart LJ, Schaid DJ, Peterson BJ, Moon-Tasson L, Mahoney MR, Sargent DJ, O'Connell MJ, Witzig TE, Farr GH, Goldberg RM, Thibodeau SN. Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst. 1999 Aug 4; 91(15):1295-303.
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    53. Ha SB, Smith AP, Howden R, Dietrich WM, Bugg S, O'Connell MJ, Goldsbrough PB, Cobbett CS. Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe. Plant Cell. 1999 Jun; 11(6):1153-64.
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    54. Wagner JL, Alberts SR, Sloan JA, Cha S, Killian J, O'Connell MJ, Van Grevenhof P, Lindman J, Chute CG. Incremental costs of enrolling cancer patients in clinical trials: a population-based study. J Natl Cancer Inst. 1999 May 19; 91(10):847-53.
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    55. Chen P, Gatei M, O'Connell MJ, Khanna KK, Bugg SJ, Hogg A, Scott SP, Hobson K, Lavin MF. Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells. Oncogene. 1999 Jan 7; 18(1):249-56.
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    56. Verkade HM, O'Connell MJ. Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast. Mol Gen Genet. 1998 Dec; 260(5):426-33.
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    57. Lies CM, Cheng J, James SW, Morris NR, O'Connell MJ, Mirabito PM. BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function. J Cell Sci. 1998 May; 111 ( Pt 10):1453-65.
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    58. Thibodeau SN, French AJ, Cunningham JM, Tester D, Burgart LJ, Roche PC, McDonnell SK, Schaid DJ, Vockley CW, Michels VV, Farr GH, O'Connell MJ. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res. 1998 Apr 15; 58(8):1713-8.
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    59. Krien MJ, Bugg SJ, Palatsides M, Asouline G, Morimyo M, O'Connell MJ. A NIMA homologue promotes chromatin condensation in fission yeast. J Cell Sci. 1998 Apr; 111 ( Pt 7):967-76.
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    60. Durand-Zaleski I, Roche B, Buyse M, Carlson R, O'Connell MJ, Rougier P, Chang AE, Sondak VK, Kemeny MM, Allen-Mersh TG, Fagniez PL, Le Bourgeois JP, Piedbois P. Economic implications of hepatic arterial infusion chemotherapy in treatment of nonresectable colorectal liver metastases. Meta-Analysis Group in Cancer. J Natl Cancer Inst. 1997 Jun 4; 89(11):790-5.
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    61. O'Connell MJ, Raleigh JM, Verkade HM, Nurse P. Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J. 1997 Feb 3; 16(3):545-54.
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    62. O'Connell MJ, Chua R, Hoyos B, Buck J, Chen Y, Derguini F, Hämmerling U. Retro-retinoids in regulated cell growth and death. J Exp Med. 1996 Aug 1; 184(2):549-55.
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    63. Law TM, Motzer RJ, Mazumdar M, Sell KW, Walther PJ, O'Connell M, Khan A, Vlamis V, Vogelzang NJ, Bajorin DF. Phase III randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma. Cancer. 1995 Sep 1; 76(5):824-32.
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    64. O'Connell MJ, Nurse P. How cells know they are in G1 or G2. Curr Opin Cell Biol. 1994 Dec; 6(6):867-71.
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    65. O'Connell MJ, Norbury C, Nurse P. Premature chromatin condensation upon accumulation of NIMA. EMBO J. 1994 Oct 17; 13(20):4926-37.
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    66. Fitzsimons A, Hols P, Jore J, Leer RJ, O'Connell M, Delcour J. Development of an amylolytic Lactobacillus plantarum silage strain expressing the Lactobacillus amylovorus alpha-amylase gene. Appl Environ Microbiol. 1994 Oct; 60(10):3529-35.
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    67. Marschke RF, Wieand HS, O'Connell MJ, Rubin J, Schutt AJ, Burch PA, Kovach JS. Advanced colorectal adenocarcinoma: treatment with amonafide. J Natl Cancer Inst. 1994 Jun 15; 86(12):944-5.
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    68. Osmani AH, van Peij N, Mischke M, O'Connell MJ, Osmani SA. A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans. J Cell Sci. 1994 Jun; 107 ( Pt 6):1519-28.
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    69. Jacobson L, O'Connell M, O'Brien CN, Weissman GK. A century of progress: nursing quality improvement at the Mount Sinai Medical Center. Mt Sinai J Med. 1993 Oct; 60(5):363-7.
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    70. Sun W, O'Connell M, Speck NA. Characterization of a protein that binds multiple sequences in mammalian type C retrovirus enhancers. J Virol. 1993 Apr; 67(4):1976-86.
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    71. Manley NR, O'Connell M, Sun W, Speck NA, Hopkins N. Two factors that bind to highly conserved sequences in mammalian type C retroviral enhancers. J Virol. 1993 Apr; 67(4):1967-75.
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    72. O'Connell MJ, Meluh PB, Rose MD, Morris NR. Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans. J Cell Biol. 1993 Jan; 120(1):153-62.
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    73. O'Connell MJ, Osmani AH, Morris NR, Osmani SA. An extra copy of nimEcyclinB elevates pre-MPF levels and partially suppresses mutation of nimTcdc25 in Aspergillus nidulans. EMBO J. 1992 Jun; 11(6):2139-49.
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    74. Morris NR, James SW, O'Connell MJ. Mitotic regulation in Aspergillus nidulans. Ciba Found Symp. 1992; 170:115-23; discussion 123-9.
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    75. Enos AP, O'Connell M, Morris NR. Kinesin-like proteins of Aspergillus nidulans. Cold Spring Harb Symp Quant Biol. 1991; 56:643-8.
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    76. O'Connell MJ, Kelly JM. Physical characterization of the aldehyde-dehydrogenase-encoding gene of Aspergillus niger. Gene. 1989 Dec 7; 84(1):173-80.
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    77. Mayer RJ, O'Connell MJ, Tepper JE, Wolmark N. Status of adjuvant therapy for colorectal cancer. J Natl Cancer Inst. 1989 Sep 20; 81(18):1359-64.
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    78. O'Connell MJ, Kelly JM. Differences in the regulation of aldehyde dehydrogenase genes in Aspergillus niger and Aspergillus nidulans. Curr Genet. 1988 Aug; 14(2):95-103.
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    79. Hodgson D, Shaw P, O'Connell M, Henry S, Shapiro L. Caulobacter crescentus fatty acid-dependent cell cycle mutant. J Bacteriol. 1984 Apr; 158(1):156-62.
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    80. Duffy MJ, O'Connell M, McDonnell L. Peroxidase activity as a marker for estrogen action in rat uteri and human mammary carcinomas. Recent Results Cancer Res. 1984; 91:283-8.
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    81. Hutchinson AP, O'Connell M, Richards BB, Thompson JL, Wheeler RA. Proposed standards for professional health sciences library services in hospitals of New York State. Bull Med Libr Assoc. 1981 Jul; 69(3):287-93.
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