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Marta Filizola

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentStructural and Chemical Biology
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Scarabelli G, Provasi D, Negri A, Filizola M. Bioactive conformations of two seminal delta opioid receptor penta-peptides inferred from free-energy profiles. Biopolymers. 2014 Jan; 101(1):21-7.
      View in: PubMed
    2. Johnston JM, Filizola M. Beyond standard molecular dynamics: investigating the molecular mechanisms of g protein-coupled receptors with enhanced molecular dynamics methods. Adv Exp Med Biol. 2014; 796:95-125.
      View in: PubMed
    3. Mondal S, Johnston JM, Wang H, Khelashvili G, Filizola M, Weinstein H. Membrane driven spatial organization of GPCRs. Sci Rep. 2013; 3:2909.
      View in: PubMed
    4. Gomes I, Fujita W, Gupta A, Saldanha AS, Negri A, Pinello CE, Roberts E, Filizola M, Hodder P, Devi LA. Identification of a µ-d opioid receptor heteromer-biased agonist with antinociceptive activity. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12072-7.
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    5. Coudray N, Valvo S, Hu M, Lasala R, Kim C, Vink M, Zhou M, Provasi D, Filizola M, Tao J, Fang J, Penczek PA, Ubarretxena-Belandia I, Stokes DL. Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2140-5.
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    6. Filizola M, Devi LA. Grand opening of structure-guided design for novel opioids. Trends Pharmacol Sci. 2013 Jan; 34(1):6-12.
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    7. Johnston JM, Wang H, Provasi D, Filizola M. Assessing the relative stability of dimer interfaces in g protein-coupled receptors. PLoS Comput Biol. 2012; 8(8):e1002649.
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    8. Negri A, Li J, Naini S, Coller BS, Filizola M. Structure-based virtual screening of small-molecule antagonists of platelet integrin aIIbß3 that do not prime the receptor to bind ligand. J Comput Aided Mol Des. 2012 Sep; 26(9):1005-15.
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    9. Filizola M, Devi LA. Structural biology: How opioid drugs bind to receptors. Nature. 2012 May 17; 485(7398):314-7.
      View in: PubMed
    10. Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS. Structure-guided design of a high-affinity platelet integrin aIIbß3 receptor antagonist that disrupts Mg²? binding to the MIDAS. Sci Transl Med. 2012 Mar 14; 4(125):125ra32.
      View in: PubMed
    11. Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell. 2011 Nov 23; 147(5):1011-23.
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    12. Provasi D, Artacho MC, Negri A, Mobarec JC, Filizola M. Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques. PLoS Comput Biol. 2011 Oct; 7(10):e1002193.
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    13. Johnston JM, Filizola M. Showcasing modern molecular dynamics simulations of membrane proteins through G protein-coupled receptors. Curr Opin Struct Biol. 2011 Aug; 21(4):552-8.
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    14. Wang H, Barreyro L, Provasi D, Djemil I, Torres-Arancivia C, Filizola M, Ubarretxena-Belandia I. Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease. J Mol Biol. 2011 May 20; 408(5):879-95.
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    15. Golebiewska U, Johnston JM, Devi L, Filizola M, Scarlata S. Differential response to morphine of the oligomeric state of µ-opioid in the presence of d-opioid receptors. Biochemistry. 2011 Apr 12; 50(14):2829-37.
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    16. Johnston JM, Aburi M, Provasi D, Bortolato A, Urizar E, Lambert NA, Javitch JA, Filizola M. Making structural sense of dimerization interfaces of delta opioid receptor homodimers. Biochemistry. 2011 Mar 15; 50(10):1682-90.
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    17. Provasi D, Johnston JM, Filizola M. Lessons from free energy simulations of delta-opioid receptor homodimers involving the fourth transmembrane helix. Biochemistry. 2010 Aug 10; 49(31):6771-6.
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    18. Zhu J, Zhu J, Negri A, Provasi D, Filizola M, Coller BS, Springer TA. Closed headpiece of integrin aIIbß3 and its complex with an aIIbß3-specific antagonist that does not induce opening. Blood. 2010 Dec 2; 116(23):5050-9.
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    19. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15; 26(14):1804-5.
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    20. Provasi D, Filizola M. Putative active states of a prototypic g-protein-coupled receptor from biased molecular dynamics. Biophys J. 2010 May 19; 98(10):2347-55.
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    21. Blue R, Li J, Steinberger J, Murcia M, Filizola M, Coller BS. Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3. J Biol Chem. 2010 Jun 4; 285(23):17604-13.
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    22. Provasi D, Murcia M, Coller BS, Filizola M. Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins. Proteins. 2009 Nov 1; 77(2):477-89.
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    23. Provasi D, Bortolato A, Filizola M. Exploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics. Biochemistry. 2009 Oct 27; 48(42):10020-9.
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    24. Mobarec JC, Sanchez R, Filizola M. Modern homology modeling of G-protein coupled receptors: which structural template to use? J Med Chem. 2009 Aug 27; 52(16):5207-16.
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    25. Filizola M. Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery? Life Sci. 2010 Apr 10; 86(15-16):590-7.
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    26. Blue R, Kowalska MA, Hirsch J, Murcia M, Janczak CA, Harrington A, Jirouskova M, Li J, Fuentes R, Thornton MA, Filizola M, Poncz M, Coller BS. Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood. 2009 Jul 2; 114(1):195-201.
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    27. Bortolato A, Mobarec JC, Provasi D, Filizola M. Progress in elucidating the structural and dynamic character of G Protein-Coupled Receptor oligomers for use in drug discovery. Curr Pharm Des. 2009; 15(35):4017-25.
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    28. Guo W, Urizar E, Kralikova M, Mobarec JC, Shi L, Filizola M, Javitch JA. Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J. 2008 Sep 3; 27(17):2293-304.
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    29. Murcia M, Jirouskova M, Li J, Coller BS, Filizola M. Functional and computational studies of the ligand-associated metal binding site of beta3 integrins. Proteins. 2008 Jun; 71(4):1779-91.
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    30. Niv MY, Filizola M. Influence of oligomerization on the dynamics of G-protein coupled receptors as assessed by normal mode analysis. Proteins. 2008 May 1; 71(2):575-86.
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    31. González-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, López-Giménez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008 Mar 6; 452(7183):93-7.
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    32. Taylor MS, Fung HK, Rajgaria R, Filizola M, Weinstein H, Floudas CA. Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework. Biophys J. 2008 Apr 1; 94(7):2470-81.
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    33. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007; 8:177.
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    34. Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev. 2007 Mar; 59(1):5-13.
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    35. Niv MY, Skrabanek L, Filizola M, Weinstein H. Modeling activated states of GPCRs: the rhodopsin template. J Comput Aided Mol Des. 2006 Jul-Aug; 20(7-8):437-48.
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    36. Filizola M, Wang SX, Weinstein H. Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer. J Comput Aided Mol Des. 2006 Jul-Aug; 20(7-8):405-16.
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    37. Mezei M, Filizola M. TRAJELIX: a computational tool for the geometric characterization of protein helices during molecular dynamics simulations. J Comput Aided Mol Des. 2006 Feb; 20(2):97-107.
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    38. Guo W, Shi L, Filizola M, Weinstein H, Javitch JA. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17495-500.
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    39. Filizola M, Weinstein H. The structure and dynamics of GPCR oligomers: a new focus in models of cell-signaling mechanisms and drug design. Curr Opin Drug Discov Devel. 2005 Sep; 8(5):577-84.
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    40. Filizola M, Weinstein H. The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics. FEBS J. 2005 Jun; 272(12):2926-38.
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    41. Filizola M, Hassan SA, Artoni A, Coller BS, Weinstein H. Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3. J Biol Chem. 2004 Jun 4; 279(23):24624-30.
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    42. Filizola M, Olmea O, Weinstein H. Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein Eng. 2002 Nov; 15(11):881-5.
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    43. Filizola M, Weinstein H. Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers. 2002; 66(5):317-25.
      View in: PubMed
    44. Filizola M, Villar HO, Loew GH. Differentiation of delta, mu, and kappa opioid receptor agonists based on pharmacophore development and computed physicochemical properties. J Comput Aided Mol Des. 2001 Apr; 15(4):297-307.
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    45. Filizola M, Villar HO, Loew GH. Molecular determinants of non-specific recognition of delta, mu, and kappa opioid receptors. Bioorg Med Chem. 2001 Jan; 9(1):69-76.
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    46. Filizola M, Harris DL, Loew GH. Development of a 3D pharmacophore for nonspecific ligand recognition of alpha1, alpha2, alpha3, alpha5, and alpha6 containing GABA(A)/benzodiazepine receptors. Bioorg Med Chem. 2000 Jul; 8(7):1799-807.
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    47. Filizola M, Harris DL, Loew GH. Benzodiazepine-induced hyperphagia: development and assessment of a 3D pharmacophore by computational methods. J Biomol Struct Dyn. 2000 Apr; 17(5):769-78.
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    48. Perez JJ, Filizola M, Corcho F. Docking of peptide-T onto the D1 domain of the CD4 receptor. J Biomol Struct Dyn. 2000 Feb; 17(4):725-33.
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    49. Filizola M, Laakkonen L, Loew GH. 3D modeling, ligand binding and activation studies of the cloned mouse delta, mu; and kappa opioid receptors. Protein Eng. 1999 Nov; 12(11):927-42.
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    50. Filizola M, Carteni-Farina M, Perez JJ. Molecular modeling study of the differential ligand-receptor interaction at the mu, delta and kappa opioid receptors. J Comput Aided Mol Des. 1999 Jul; 13(4):397-407.
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    51. Corcho FJ, Filizola M, Perez JJ. Assessment of the bioactive conformation of the farnesyltransferase protein binding recognition motif by computational methods. J Biomol Struct Dyn. 1999 Apr; 16(5):1043-52.
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    52. Filizola M, Llorens O, Cartení-Farina M, Perez JJ. New insights into the conformational requirements of B2 bradykinin antagonism. Bioorg Med Chem. 1998 Sep; 6(9):1491-500.
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    53. Llorens O, Filizola M, Spisani S, Marastoni M, Herranz C, Perez JJ. Amygdalin binds to the CD4 receptor as suggested from molecular modeling studies. Bioorg Med Chem Lett. 1998 Apr 7; 8(7):781-6.
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    54. Filizola M, Perez JJ, Cartenì-Farina M. BUNDLE: a program for building the transmembrane domains of G-protein-coupled receptors. J Comput Aided Mol Des. 1998 Mar; 12(2):111-8.
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    55. Filizola M, Centeno NB, Cartení-Farina M, Perez JJ. Conformational analysis of the highly potent bradykinin antagonist Hoe-140 by means of two different computational methods. J Biomol Struct Dyn. 1998 Feb; 15(4):639-52.
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    56. Filizola M, Perez JJ, Palomer A, Mauleón D. Comparative molecular modeling study of the three-dimensional structures of prostaglandin endoperoxide H2 synthase 1 and 2 (COX-1 and COX-2). J Mol Graph Model. 1997 Oct; 15(5):290-300.
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    57. Filizola M, Cartenì-Farina M, Perez JJ. Conformational study of vasoactive intestinal peptide by computational methods. J Pept Res. 1997 Jul; 50(1):55-64.
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    58. Filizola M, Centeno NB, Perez JJ. Computational study of the conformational domains of peptide T. J Pept Sci. 1997 Mar-Apr; 3(2):85-92.
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    59. Saviano M, Rossi F, Filizola M, Isernia C, Di Blasio B, Benedetti E, Pedone C, Siemion IZ, Pedyczak A. Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide A. Biopolymers. 1995 Oct; 36(4):453-60.
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    60. Saviano M, Rossi F, Filizola M, Di Blasio B, Pedone C. [Aib5,6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture. Acta Crystallogr C. 1995 Apr 15; 51 ( Pt 4):663-6.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067