Keywords
Last Name
Institution

Thomas Weber

TitleASSISTANT PROFESSOR
InstitutionMount Sinai
DepartmentCardiology
Address
    Other Positions
    TitleASSISTANT PROFESSOR
    InstitutionMount Sinai
    DepartmentDevelopmental and Regenerative Biology

    TitleASSISTANT PROFESSOR
    InstitutionMount Sinai
    DepartmentMicrobiology


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego C, Lee A, Karakikes I, Xie C, Akar F, Shimada Y, Gwathmey JK, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ. Cardiac I-1c Over-expression with Reengineered AAV Improves Cardiac Function in Swine Ischemic Heart Failure. Mol Ther. 2014 Jul 15.
      View in: PubMed
    2. O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J. Gene therapy: charting a future course-summary of a national institutes of health workshop, april 12, 2013. Hum Gene Ther. 2014 Jun; 25(6):488-97.
      View in: PubMed
    3. Chaanine AH, Nonnenmacher M, Kohlbrenner E, Jin D, Kovacic JC, Akar FG, Hajjar RJ, Weber T. Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure. Gene Ther. 2014 Apr; 21(4):379-86.
      View in: PubMed
    4. Louis Jeune V, Joergensen JA, Hajjar RJ, Weber T. Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy. Hum Gene Ther Methods. 2013 Apr; 24(2):59-67.
      View in: PubMed
    5. Weber T. Response to 'Run for your life ... at a comfortable speed and not too far'. Heart. 2013 Apr; 99(8):588.
      View in: PubMed
    6. Kohlbrenner E, Henckaerts E, Rapti K, Gordon RE, Linden RM, Hajjar RJ, Weber T. Quantification of AAV particle titers by infrared fluorescence scanning of coomassie-stained sodium dodecyl sulfate-polyacrylamide gels. Hum Gene Ther Methods. 2012 Jun; 23(3):198-203.
      View in: PubMed
    7. Tilemann L, Ishikawa K, Weber T, Hajjar RJ. Gene therapy for heart failure. Circ Res. 2012 Mar 2; 110(5):777-93.
      View in: PubMed
    8. Nonnenmacher M, Weber T. Intracellular transport of recombinant adeno-associated virus vectors. Gene Ther. 2012 Jun; 19(6):649-58.
      View in: PubMed
    9. Karakikes I, Hadri L, Rapti K, Ladage D, Ishikawa K, Tilemann L, Yi GH, Morel C, Gwathmey JK, Zsebo K, Weber T, Kawase Y, Hajjar RJ. Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer in porcine hearts. Mol Ther. 2012 Mar; 20(3):565-71.
      View in: PubMed
    10. Nonnenmacher M, Weber T. Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway. Cell Host Microbe. 2011 Dec 15; 10(6):563-76.
      View in: PubMed
    11. Rapti K, Louis-Jeune V, Kohlbrenner E, Ishikawa K, Ladage D, Zolotukhin S, Hajjar RJ, Weber T. Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models. Mol Ther. 2012 Jan; 20(1):73-83.
      View in: PubMed
    12. Zeltner N, Kohlbrenner E, Clément N, Weber T, Linden RM. Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors. Gene Ther. 2010 Jul; 17(7):872-9.
      View in: PubMed
    13. Hirosue S, Senn K, Clément N, Nonnenmacher M, Gigout L, Linden RM, Weber T. Effect of inhibition of dynein function and microtubule-altering drugs on AAV2 transduction. Virology. 2007 Oct 10; 367(1):10-8.
      View in: PubMed
    14. Hirosue S, Weber T. pH-Dependent lytic peptides discovered by phage display. Biochemistry. 2006 May 23; 45(20):6476-87.
      View in: PubMed
    15. Gigout L, Rebollo P, Clement N, Warrington KH, Muzyczka N, Linden RM, Weber T. Altering AAV tropism with mosaic viral capsids. Mol Ther. 2005 Jun; 11(6):856-65.
      View in: PubMed
    16. Tucker WC, Weber T, Chapman ER. Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs. Science. 2004 Apr 16; 304(5669):435-8.
      View in: PubMed
    17. Murrell M, Porotto M, Weber T, Greengard O, Moscona A. Mutations in human parainfluenza virus type 3 hemagglutinin-neuraminidase causing increased receptor binding activity and resistance to the transition state sialic acid analog 4-GU-DANA (Zanamivir). J Virol. 2003 Jan; 77(1):309-17.
      View in: PubMed
    18. Scott BL, Van Komen JS, Liu S, Weber T, Melia TJ, McNew JA. Liposome fusion assay to monitor intracellular membrane fusion machines. Methods Enzymol. 2003; 372:274-300.
      View in: PubMed
    19. Chan AM, Weber T. A putative link between exocytosis and tumor development. Cancer Cell. 2002 Dec; 2(6):427-8.
      View in: PubMed
    20. Melia TJ, Weber T, McNew JA, Fisher LE, Johnston RJ, Parlati F, Mahal LK, Sollner TH, Rothman JE. Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. J Cell Biol. 2002 Sep 2; 158(5):929-40.
      View in: PubMed
    21. Cheetham JJ, Hilfiker S, Benfenati F, Weber T, Greengard P, Czernik AJ. Identification of synapsin I peptides that insert into lipid membranes. Biochem J. 2001 Feb 15; 354(Pt 1):57-66.
      View in: PubMed
    22. Fukuda R, McNew JA, Weber T, Parlati F, Engel T, Nickel W, Rothman JE, Söllner TH. Functional architecture of an intracellular membrane t-SNARE. Nature. 2000 Sep 14; 407(6801):198-202.
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    23. McNew JA, Weber T, Parlati F, Johnston RJ, Melia TJ, Söllner TH, Rothman JE. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J Cell Biol. 2000 Jul 10; 150(1):105-17.
      View in: PubMed
    24. Weber T, Parlati F, McNew JA, Johnston RJ, Westermann B, Söllner TH, Rothman JE. SNAREpins are functionally resistant to disruption by NSF and alphaSNAP. J Cell Biol. 2000 May 29; 149(5):1063-72.
      View in: PubMed
    25. Brügger B, Nickel W, Weber T, Parlati F, McNew JA, Rothman JE, Söllner T. Putative fusogenic activity of NSF is restricted to a lipid mixture whose coalescence is also triggered by other factors. EMBO J. 2000 Mar 15; 19(6):1272-8.
      View in: PubMed
    26. Schütze S, Wickel M, Heinrich M, Winoto-Morbach S, Weber T, Brunner J, Krönke M. Use of affinity chromatography and TID-ceramide photoaffinity labeling for detection of ceramide-binding proteins. Methods Enzymol. 2000; 312:429-38.
      View in: PubMed
    27. Heinrich M, Wickel M, Winoto-Morbach S, Schneider-Brachert W, Weber T, Brunner J, Saftig P, Peters C, Krönke M, Schütze S. Ceramide as an activator lipid of cathepsin D. Adv Exp Med Biol. 2000; 477:305-15.
      View in: PubMed
    28. Parlati F, Weber T, McNew JA, Westermann B, Söllner TH, Rothman JE. Rapid and efficient fusion of phospholipid vesicles by the alpha-helical core of a SNARE complex in the absence of an N-terminal regulatory domain. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12565-70.
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    29. Nickel W, Weber T, McNew JA, Parlati F, Söllner TH, Rothman JE. Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12571-6.
      View in: PubMed
    30. Heinrich M, Wickel M, Schneider-Brachert W, Sandberg C, Gahr J, Schwandner R, Weber T, Saftig P, Peters C, Brunner J, Krönke M, Schütze S. Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J. 1999 Oct 1; 18(19):5252-63.
      View in: PubMed
    31. McNew JA, Weber T, Engelman DM, Söllner TH, Rothman JE. The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion. Mol Cell. 1999 Sep; 4(3):415-21.
      View in: PubMed
    32. Wickel M, Heinrich M, Weber T, Brunner J, Krönke M, Schütze S. Identification of intracellular ceramide target proteins by affinity chromatography and TID-ceramide photoaffinity labelling. Biochem Soc Trans. 1999 Aug; 27(4):393-9.
      View in: PubMed
    33. Weber T, Zemelman BV, McNew JA, Westermann B, Gmachl M, Parlati F, Söllner TH, Rothman JE. SNAREpins: minimal machinery for membrane fusion. Cell. 1998 Mar 20; 92(6):759-72.
      View in: PubMed
    34. Vergères G, Manenti S, Weber T, Stürzinger C. The myristoyl moiety of myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein is embedded in the membrane. J Biol Chem. 1995 Aug 25; 270(34):19879-87.
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    35. Weber, T Brunner, J. 2-(Tributylstannyl)-4-[3-(trifluoromethyl)-3Hdiazirin-3-yl]benzyl Alcohol: A Building Block for Photolabeling and Crosslinking Reagents of Very High Specific Radioactivity. J. Am. Chem. Soc. 1995; (117):3084.
    36. Tempel M, Goldmann WH, Dietrich C, Niggli V, Weber T, Sackmann E, Isenberg G. Insertion of filamin into lipid membranes examined by calorimetry, the film balance technique, and lipid photolabeling. Biochemistry. 1994 Oct 25; 33(42):12565-72.
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    37. Niggli V, Kaufmann S, Goldmann WH, Weber T, Isenberg G. Identification of functional domains in the cytoskeletal protein talin. Eur J Biochem. 1994 Sep 15; 224(3):951-7.
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    38. Weber T, Paesold G, Galli C, Mischler R, Semenza G, Brunner J. Evidence for H(+)-induced insertion of influenza hemagglutinin HA2 N-terminal segment into viral membrane. J Biol Chem. 1994 Jul 15; 269(28):18353-8.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067