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Last Name
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Miguel A. Gama Sosa

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentPsychiatry
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sosa MA, De Gasperi R, Paulino AJ, Pricop PE, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Janssen WG, Yuk FJ, Dorr NP, Dickstein DL, McCarron RM, Chavko M, Hof PR, Ahlers ST, Elder GA. Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury. Acta Neuropathol Commun. 2013; 1(1):51.
      View in: PubMed
    2. De Gasperi R, Gama Sosa MA, Elder GA. Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells. BMC Biochem. 2012; 13:28.
      View in: PubMed
    3. De Gasperi R, Gama Sosa MA, Kim SH, Steele JW, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Dekosky ST, McCarron RM, Nambiar MP, Gandy S, Ahlers ST, Elder GA. Acute blast injury reduces brain abeta in two rodent species. Front Neurol. 2012; 3:177.
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    4. Elder GA, Dorr NP, De Gasperi R, Gama Sosa MA, Shaughness MC, Maudlin-Jeronimo E, Hall AA, McCarron RM, Ahlers ST. Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild traumatic brain injury. J Neurotrauma. 2012 Nov 1; 29(16):2564-75.
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    5. Gama Sosa MA, De Gasperi R, Elder GA. Modeling human neurodegenerative diseases in transgenic systems. Hum Genet. 2012 Apr; 131(4):535-63.
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    6. Elder GA, Gama Sosa MA, De Gasperi R. Transgenic mouse models of Alzheimer's disease. Mt Sinai J Med. 2010 Jan-Feb; 77(1):69-81.
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    7. Sakurai T, Ramoz N, Barreto M, Gazdoiu M, Takahashi N, Gertner M, Dorr N, Gama Sosa MA, De Gasperi R, Perez G, Schmeidler J, Mitropoulou V, Le HC, Lupu M, Hof PR, Elder GA, Buxbaum JD. Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders. Biol Psychiatry. 2010 May 1; 67(9):887-94.
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    8. Gama Sosa MA, Gasperi RD, Rocher AB, Wang AC, Janssen WG, Flores T, Perez GM, Schmeidler J, Dickstein DL, Hof PR, Elder GA. Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations. Am J Pathol. 2010 Jan; 176(1):353-68.
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    9. Gama Sosa MA, De Gasperi R, Elder GA. Animal transgenesis: an overview. Brain Struct Funct. 2010 Mar; 214(2-3):91-109.
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    10. Elder GA, Gama Sosa MA, De Gasperi R, Dickstein DL, Hof PR. Presenilin transgenic mice as models of Alzheimer's disease. Brain Struct Funct. 2010 Mar; 214(2-3):127-43.
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    11. Franciosi S, Gama Sosa MA, English DF, Oler E, Oung T, Janssen WG, De Gasperi R, Schmeidler J, Dickstein DL, Schmitz C, Gandy S, Hof PR, Buxbaum JD, Elder GA. Novel cerebrovascular pathology in mice fed a high cholesterol diet. Mol Neurodegener. 2009; 4:42.
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    12. De Gasperi R, Gama Sosa MA, Wen PH, Li J, Perez GM, Curran T, Elder GA. Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling. Dev Dyn. 2008 Sep; 237(9):2405-14.
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    13. Gama Sosa MA, De Gasperi R, Rocher AB, Perez GM, Simons K, Cruz DE, Hof PR, Elder GA. Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact. Cell Res. 2007 Jul; 17(7):619-26.
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    14. Elder GA, De Gasperi R, Gama Sosa MA. Research update: neurogenesis in adult brain and neuropsychiatric disorders. Mt Sinai J Med. 2006 Nov; 73(7):931-40.
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    15. Wen PH, De Gasperi R, Gama Sosa MA, Elder GA. Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice. Neurosci Lett. 2004 Nov 23; 371(2-3):249-54.
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    16. Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol. 2004 Aug; 188(2):224-37.
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    17. De Gasperi R, Friedrich VL, Perez GM, Senturk E, Wen PH, Kelley K, Elder GA, Gama Sosa MA. Transgenic rescue of Krabbe disease in the twitcher mouse. Gene Ther. 2004 Aug; 11(15):1188-94.
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    18. Gama Sosa MA, Wen PH, De Gasperi R, Perez GM, Senturk E, Friedrich VL, Elder GA. Entorhinal cortex lesioning promotes neurogenesis in the hippocampus of adult mice. Neuroscience. 2004; 127(4):881-91.
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    19. Gama Sosa MA, Friedrich VL, DeGasperi R, Kelley K, Wen PH, Senturk E, Lazzarini RA, Elder GA. Human midsized neurofilament subunit induces motor neuron disease in transgenic mice. Exp Neurol. 2003 Nov; 184(1):408-19.
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    20. Gama SM, De Gasperi R, Wen PH, Gonzalez EA, Kelley K, Lazzarini RA, Elder GA. BAC and PAC DNA for the generation of transgenic animals. Biotechniques. 2002 Jul; 33(1):51-3.
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    21. De Gasperi R, Gama Sosa MA, Sartorato E, Battistini S, Raghavan S, Kolodny EH. Molecular basis of late-life globoid cell leukodystrophy. Hum Mutat. 1999; 14(3):256-62.
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    22. Wang ZH, Samuels S, Gama Sosa MA, Kolodny EH. 5-Fluorocytosine-mediated apoptosis and DNA damage in glioma cells engineered to express cytosine deaminase and their enhancement with interferon. J Neurooncol. 1998 Feb; 36(3):219-29.
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    23. Wang ZH, Ma J, Zeng BJ, Catanese VM, Samuels S, Gama Sosa MA, Kolodny EH. Correlation of glioma cell regression with inhibition of insulin-like growth factor 1 and insulin-like growth factor-binding protein-2 expression. Neuroendocrinology. 1997 Sep; 66(3):203-11.
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    24. Gama Sosa MA, De Gasperi R, Patarca R, Fletcher MA, Kolodny EH. Antisulfatide IgG antibodies recognize HIV proteins. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 May 1; 15(1):83-4.
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    25. Bernardini GL, Herrera DG, Carson D, DeGasperi R, Gama Sosa MA, Kolodny EH, Trifiletti R. Adult-onset Krabbe's disease in siblings with novel mutations in the galactocerebrosidase gene. Ann Neurol. 1997 Jan; 41(1):111-4.
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    26. De Gasperi R, Gama Sosa MA, Sartorato EL, Battistini S, MacFarlane H, Gusella JF, Krivit W, Kolodny EH. Molecular heterogeneity of late-onset forms of globoid-cell leukodystrophy. Am J Hum Genet. 1996 Dec; 59(6):1233-42.
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    27. De Gasperi R, Gama Sosa MA, Battistini S, Yeretsian J, Raghavan S, Zelnik N, Leshinsky E, Kolodny EH. Late-onset GM2 gangliosidosis: Ashkenazi Jewish family with an exon 5 mutation (Tyr180-->His) in the Hex A alpha-chain gene. Neurology. 1996 Aug; 47(2):547-52.
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    28. Gama Sosa MA, de Gasperi R, Undevia S, Yeretsian J, Rouse SC, Lyerla TA, Kolodny EH. Correction of the galactocerebrosidase deficiency in globoid cell leukodystrophy-cultured cells by SL3-3 retroviral-mediated gene transfer. Biochem Biophys Res Commun. 1996 Jan 26; 218(3):766-71.
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    29. De Gasperi R, Gama Sosa MA, Grebner EE, Mansfield D, Battistini S, Sartorato EL, Raghavan SS, Davis JG, Kolodny EH. Substitution of alanine543 with a threonine residue at the carboxy terminal end of the beta-chain is associated with thermolabile hexosaminidase B in a Jewish family of Oriental ancestry. Biochem Mol Med. 1995 Oct; 56(1):31-6.
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    30. Gama Sosa MA, Rosas DH, DeGasperi R, Morita E, Hutchison MR, Ruprecht RM. Negative regulation of the 5' long terminal repeat (LTR) by the 3' LTR in the murine proviral genome. J Virol. 1994 Apr; 68(4):2662-70.
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    31. Gama Sosa MA, DeGasperi R, Kim YS, Fazely F, Sharma P, Ruprecht RM. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. AIDS Res Hum Retroviruses. 1991 Nov; 7(11):859-60.
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    32. Ruprecht RM, Bernard LD, Bronson R, Gama Sosa MA, Mullaney S. Castanospermine vs. its 6-O-butanoyl analog: a comparison of toxicity and antiviral activity in vitro and in vivo. J Acquir Immune Defic Syndr. 1991; 4(1):48-55.
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    33. Ruprecht RM, Bernard LD, Gama Sosa MA, Sosa MA, Fazely F, Koch J, Sharma PL, Mullaney S. Murine models for evaluating antiretroviral therapy. Cancer Res. 1990 Sep 1; 50(17 Suppl):5618S-5627S.
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    34. Ruprecht RM, Mullaney S, Bernard LD, Gama Sosa MA, Hom RC, Finberg RW. Vaccination with a live retrovirus: the nature of the protective immune response. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5558-62.
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    35. Gama Sosa MA, Hall JC, Schneider KE, Lukaszewicz GC, Ruprecht RM. Unusual DNA structures at the integration site of an HIV provirus. Biochem Biophys Res Commun. 1989 May 30; 161(1):134-42.
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    36. Gama Sosa MA, Hall JC, Ruprecht RM. Slipped DNA structures within the enhancer region of the Moloney murine leukemia virus. Biochem Biophys Res Commun. 1988 Oct 14; 156(1):417-23.
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