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Last Name
Institution

Natalia Nieto

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentLiver Diseases
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Leung TM, Wang X, Kitamura N, Fiel MI, Nieto N. Osteopontin delays resolution of liver fibrosis. Lab Invest. 2013 Oct; 93(10):1082-9.
      View in: PubMed
    2. Smalling RL, Delker DA, Zhang Y, Nieto N, McGuiness MS, Liu S, Friedman SL, Hagedorn CH, Wang L. Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease. Am J Physiol Gastrointest Liver Physiol. 2013 Sep 1; 305(5):G364-74.
      View in: PubMed
    3. Ge X, Lu Y, Leung TM, Sørensen ES, Nieto N. Milk osteopontin, a nutritional approach to prevent alcohol-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2013 May 15; 304(10):G929-39.
      View in: PubMed
    4. Hernández-Gea V, Hilscher M, Rozenfeld R, Lim MP, Nieto N, Werner S, Devi LA, Friedman SL. Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J Hepatol. 2013 Jul; 59(1):98-104.
      View in: PubMed
    5. Arriazu E, Ruiz de Galarreta M, López-Zabalza MJ, Leung TM, Nieto N, Iraburu MJ. GCN2 kinase is a key regulator of fibrogenesis and acute and chronic liver injury induced by carbon tetrachloride in mice. Lab Invest. 2013 Mar; 93(3):303-10.
      View in: PubMed
    6. Leung TM, Nieto N. CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. J Hepatol. 2013 Feb; 58(2):395-8.
      View in: PubMed
    7. Leung TM, Lu Y, Yan W, Morón-Concepción JA, Ward SC, Ge X, Conde de la Rosa L, Nieto N. Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice. Hepatology. 2012 May; 55(5):1596-609.
      View in: PubMed
    8. Cubero FJ, Nieto N. Arachidonic acid stimulates TNFa production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15; 303(2):G228-39.
      View in: PubMed
    9. Urtasun R, Cubero FJ, Nieto N. Oxidative stress modulates KLF6Full and its splice variants. Alcohol Clin Exp Res. 2012 Nov; 36(11):1851-62.
      View in: PubMed
    10. Rivas-Estilla AM, Bryan-Marrugo OL, Trujillo-Murillo K, Pérez-Ibave D, Charles-Niño C, Pedroza-Roldan C, Ríos-Ibarra C, Ramírez-Valles E, Ortiz-López R, Islas-Carbajal MC, Nieto N, Rincón-Sánchez AR. Cu/Zn superoxide dismutase (SOD1) induction is implicated in the antioxidative and antiviral activity of acetylsalicylic acid in HCV-expressing cells. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1; 302(11):G1264-73.
      View in: PubMed
    11. Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N. Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin a(V)ß(3) engagement and PI3K/pAkt/NF?B signaling. Hepatology. 2012 Feb; 55(2):594-608.
      View in: PubMed
    12. Mormone E, Lu Y, Ge X, Fiel MI, Nieto N. Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice. Gastroenterology. 2012 Mar; 142(3):612-621.e5.
      View in: PubMed
    13. Lu Y, Leung TM, Ward SC, Nieto N. Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress. Am J Physiol Gastrointest Liver Physiol. 2012 Feb 1; 302(3):G287-95.
      View in: PubMed
    14. Howarth DL, Vacaru AM, Tsedensodnom O, Mormone E, Nieto N, Costantini LM, Snapp EL, Sadler KC. Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes. Alcohol Clin Exp Res. 2012 Jan; 36(1):14-23.
      View in: PubMed
    15. Mormone E, George J, Nieto N. Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches. Chem Biol Interact. 2011 Sep 30; 193(3):225-31.
      View in: PubMed
    16. Nieto N. A systems biology approach for understanding the collagen regulatory network in alcoholic liver disease. Liver Int. 2012 Feb; 32(2):189-98.
      View in: PubMed
    17. Nieto N, Lutolf MP. Extracellular matrix bioengineering and systems biology approaches in liver disease. Syst Synth Biol. 2011 Jun; 5(1-2):11-20.
      View in: PubMed
    18. Kastanis GJ, Hernandez-Nazara Z, Nieto N, Rincón-Sanchez AR, Popratiloff A, Dominguez-Rosales JA, Lechuga CG, Rojkind M. The role of dystroglycan in PDGF-BB-dependent migration of activated hepatic stellate cells/myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 301(3):G464-74.
      View in: PubMed
    19. Rozenfeld R, Gupta A, Gagnidze K, Lim MP, Gomes I, Lee-Ramos D, Nieto N, Devi LA. AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J. 2011 Jun 15; 30(12):2350-63.
      View in: PubMed
    20. Cubero FJ, Urtasun R, Nieto N. Alcohol and liver fibrosis. Semin Liver Dis. 2009 May; 29(2):211-21.
      View in: PubMed
    21. Urtasun R, Cubero FJ, Vera M, Nieto N. Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology. 2009 Apr; 136(4):1410-22, e1-4.
      View in: PubMed
    22. Cubero FJ, Nieto N. Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms. Hepatology. 2008 Dec; 48(6):2027-39.
      View in: PubMed
    23. Urtasun R, Conde de la Rosa L, Nieto N. Oxidative and nitrosative stress and fibrogenic response. Clin Liver Dis. 2008 Nov; 12(4):769-90, viii.
      View in: PubMed
    24. Nieto N, Munslow IJ, Barr J, Benet-Buchholz J, Vidal-Ferran A. Dioxirane mediated asymmetric epoxidations: stereochemical studies via isotopic labeling. Org Biomol Chem. 2008 Jul 7; 6(13):2276-81.
      View in: PubMed
    25. Friedman SL, Nieto N. Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors. Cell Metab. 2008 Mar; 7(3):187-8.
      View in: PubMed
    26. Conde de la Rosa L, Moshage H, Nieto N. [Hepatocyte oxidant stress and alcoholic liver disease]. Rev Esp Enferm Dig. 2008 Mar; 100(3):156-63.
      View in: PubMed
    27. Nieto N. Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathway. Hepatology. 2007 Jun; 45(6):1433-45.
      View in: PubMed
    28. Urtasun R, Nieto N. [Hepatic stellate cells and oxidative stress]. Rev Esp Enferm Dig. 2007 Apr; 99(4):223-30.
      View in: PubMed
    29. Nieto N, Mesa MD, López-Pedrosa JM, Torres MI, Ríos A, Suárez MD, Gil A. Contribution of polyunsaturated fatty acids to intestinal repair in protein-energy malnutrition. Dig Dis Sci. 2007 Jun; 52(6):1485-96.
      View in: PubMed
    30. Nieto N. Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells. Hepatology. 2006 Dec; 44(6):1487-501.
      View in: PubMed
    31. Nieto N, Rojkind M. Repeated whiskey binges promote liver injury in rats fed a choline-deficient diet. J Hepatol. 2007 Feb; 46(2):330-9.
      View in: PubMed
    32. Vera M, Nieto N. Hepatic stellate cells and alcoholic liver disease. Rev Esp Enferm Dig. 2006 Sep; 98(9):674-84.
      View in: PubMed
    33. Cubero FJ, Nieto N. Kupffer cells and alcoholic liver disease. Rev Esp Enferm Dig. 2006 Jun; 98(6):460-72.
      View in: PubMed
    34. Nieto N, Cederbaum AI. S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. J Biol Chem. 2005 Sep 2; 280(35):30963-74.
      View in: PubMed
    35. Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J. 2005 Jan; 19(1):136-8.
      View in: PubMed
    36. Gong P, Cederbaum AI, Nieto N. Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. Free Radic Biol Med. 2004 Feb 1; 36(3):307-18.
      View in: PubMed
    37. Gong P, Cederbaum AI, Nieto N. The liver-selective nitric oxide donor O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. Mol Pharmacol. 2004 Jan; 65(1):130-8.
      View in: PubMed
    38. Carmiel-Haggai M, Cederbaum AI, Nieto N. Binge ethanol exposure increases liver injury in obese rats. Gastroenterology. 2003 Dec; 125(6):1818-33.
      View in: PubMed
    39. Gong P, Cederbaum AI, Nieto N. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. J Biol Chem. 2003 Aug 8; 278(32):29693-700.
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    40. Nieto N, Cederbaum AI. Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1. J Biol Chem. 2003 Apr 25; 278(17):15360-72.
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    41. Nieto N, Marí M, Cederbaum AI. Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit. Hepatology. 2003 Jan; 37(1):96-106.
      View in: PubMed
    42. Nieto N, Friedman SL, Cederbaum AI. Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem. 2002 Mar 22; 277(12):9853-64.
      View in: PubMed
    43. Nieto N, Torres MI, Ríos A, Gil A. Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis. J Nutr. 2002 Jan; 132(1):11-9.
      View in: PubMed
    44. Nieto N, Friedman SL, Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology. 2002 Jan; 35(1):62-73.
      View in: PubMed
    45. Marí M, Wu D, Nieto N, Cederbaum AI. CYP2E1-dependent toxicity and up-regulation of antioxidant genes. J Biomed Sci. 2001 Jan-Feb; 8(1):52-8.
      View in: PubMed
    46. Nieto N, Greenwel P, Friedman SL, Zhang F, Dannenberg AJ, Cederbaum AI. Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2. J Biol Chem. 2000 Jun 30; 275(26):20136-45.
      View in: PubMed
    47. Nieto N, Friedman SL, Greenwel P, Cederbaum AI. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology. 1999 Oct; 30(4):987-96.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067