Keywords
Last Name
Institution

Lei Zeng

TitleASSISTANT PROFESSOR
InstitutionMount Sinai
DepartmentStructural and Chemical Biology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang G, Plotnikov AN, Rusinova E, Shen T, Morohashi K, Joshua J, Zeng L, Mujtaba S, Ohlmeyer M, Zhou MM. Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains. J Med Chem. 2013 Nov 27; 56(22):9251-64.
      View in: PubMed
    2. Li MJ, Yang YH, Chen XJ, Wang FQ, Lin WX, Yi YJ, Zeng L, Yang SY, Zhang ZY. Transcriptome/degradome-wide identification of R. glutinosa miRNAs and their targets: the role of miRNA activity in the replanting disease. PLoS One. 2013; 8(7):e68531.
      View in: PubMed
    3. Zhang G, Liu R, Zhong Y, Plotnikov AN, Zhang W, Zeng L, Rusinova E, Gerona-Nevarro G, Moshkina N, Joshua J, Chuang PY, Ohlmeyer M, He JC, Zhou MM. Down-regulation of NF-?B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17; 287(34):28840-51.
      View in: PubMed
    4. Liu J, Zeng L, Kennedy RM, Gruenig NM, Childs SJ. ßPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin avß8. Dev Biol. 2012 Mar 1; 363(1):95-105.
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    5. Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem. 2012 Jan 6; 287(2):1090-9.
      View in: PubMed
    6. Borah JC, Mujtaba S, Karakikes I, Zeng L, Muller M, Patel J, Moshkina N, Morohashi K, Zhang W, Gerona-Navarro G, Hajjar RJ, Zhou MM. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22; 18(4):531-41.
      View in: PubMed
    7. Zeng L, Zhang Q, Yan K, Zhou MM. Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain. Proteins. 2011 Jun; 79(6):2004-9.
      View in: PubMed
    8. Gerona-Navarro G. Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors. J Am Chem Soc. 2011 Feb 23; 133(7):2040-3.
      View in: PubMed
    9. Zeng L, Zhang Q, Li S, Plotnikov AN, Walsh MJ, Zhou MM. Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature. 2010 Jul 8; 466(7303):258-62.
      View in: PubMed
    10. Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, Gil J, Walsh MJ, Zhou MM. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell. 2010 Jun 11; 38(5):662-74.
      View in: PubMed
    11. Wang C, Li J, Liu L, Zeng L, Xue L. [Characterization of the functional domain of STT3a of oligosaccharyltransferase from Dunaliella salina]. Sheng Wu Gong Cheng Xue Bao. 2010 Jun; 26(6):760-6.
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    12. Charlop-Powers Z, Zeng L, Zhang Q, Zhou MM. Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res. 2010 May; 20(5):529-38.
      View in: PubMed
    13. Zhang Q, Chakravarty S, Ghersi D, Zeng L, Plotnikov AN, Sanchez R, Zhou MM. Biochemical profiling of histone binding selectivity of the yeast bromodomain family. PLoS One. 2010; 5(1):e8903.
      View in: PubMed
    14. Zeng L, Carter AD, Childs SJ. miR-145 directs intestinal maturation in zebrafish. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17793-8.
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    15. Chakravarty S, Zeng L, Zhou MM. Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator. Structure. 2009 May 13; 17(5):670-9.
      View in: PubMed
    16. Qian C, Li S, Jakoncic J, Zeng L, Walsh MJ, Zhou MM. Structure and hemimethylated CpG binding of the SRA domain from human UHRF1. J Biol Chem. 2008 Dec 12; 283(50):34490-4.
      View in: PubMed
    17. Zhang J, Ma H, Feng J, Zeng L, Wang Z, Chen S. Grape berry plasma membrane proteome analysis and its differential expression during ripening. J Exp Bot. 2008; 59(11):2979-90.
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    18. Zeng L, Yap KL, Ivanov AV, Wang X, Mujtaba S, Plotnikova O, Rauscher FJ, Zhou MM. Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing. Nat Struct Mol Biol. 2008 Jun; 15(6):626-33.
      View in: PubMed
    19. Cunha L, Kuti M, Bishop DF, Mezei M, Zeng L, Zhou MM, Desnick RJ. Human uroporphyrinogen III synthase: NMR-based mapping of the active site. Proteins. 2008 May 1; 71(2):855-73.
      View in: PubMed
    20. Zeng L, Zhang Q, Gerona-Navarro G, Moshkina N, Zhou MM. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure. 2008 Apr; 16(4):643-52.
      View in: PubMed
    21. Mujtaba S, Zeng L, Zhou MM. Structure and acetyl-lysine recognition of the bromodomain. Oncogene. 2007 Aug 13; 26(37):5521-7.
      View in: PubMed
    22. Pan C, Mezei M, Mujtaba S, Muller M, Zeng L, Li J, Wang Z, Zhou MM. Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor. J Med Chem. 2007 May 17; 50(10):2285-8.
      View in: PubMed
    23. Mujtaba S, Zeng L, Zhou MM. Modulating molecular functions of p53 with small molecules. Cell Cycle. 2006 Nov; 5(22):2575-8.
      View in: PubMed
    24. Qian C, Wang X, Manzur K. Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase. J Mol Biol. 2006 May 26; 359(1):86-96.
      View in: PubMed
    25. Zeng L, Cao J. [Construction of prokaryotic expression vectors of HAI-1 with different domains and expression of the fusion proteins]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006 Mar; 22(2):174-7.
      View in: PubMed
    26. Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol. 2006 Jan; 13(1):81-90.
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    27. Edwards TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer AG, Aggarwal AK. Solution structure of the Vts1 SAM domain in the presence of RNA. J Mol Biol. 2006 Mar 10; 356(5):1065-72.
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    28. Qian C, Zhang Q, Li S, Zeng L, Walsh MJ, Zhou MM. Structure and chromosomal DNA binding of the SWIRM domain. Nat Struct Mol Biol. 2005 Dec; 12(12):1078-85.
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    29. Zhang Q, Muller M, Chen CH, Zeng L, Farooq A, Zhou MM. New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. J Mol Biol. 2005 Dec 9; 354(4):777-88.
      View in: PubMed
    30. Zeng L, Li J, Muller M, Yan S, Mujtaba S, Pan C, Wang Z, Zhou MM. Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc. 2005 Mar 2; 127(8):2376-7.
      View in: PubMed
    31. Qian C, Zhang Q, Wang X, Zeng L, Farooq A, Zhou MM. Structure of the adaptor protein p14 reveals a profilin-like fold with distinct function. J Mol Biol. 2005 Mar 25; 347(2):309-21.
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    32. Qian C, Zeng L, Farooq A, Zhou MM. Resonance assignments for the endosomal adaptor protein p14. J Biomol NMR. 2004 Nov; 30(3):367-8.
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    33. Koch AW, Farooq A, Shan W, Zeng L, Colman DR, Zhou MM. Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics. Structure. 2004 May; 12(5):793-805.
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    34. Mujtaba S, He Y, Zeng L, Yan S, Plotnikova O. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell. 2004 Jan 30; 13(2):251-63.
      View in: PubMed
    35. Koch AW, Farooq A, Zeng L, Colman DR, Zhou MM. 1H, 13C and 15N resonance assignments for the N-cadherin prodomain. J Biomol NMR. 2004 Jan; 28(1):87-8.
      View in: PubMed
    36. Zeng L, Chen K, Muller M, Zhou MM. Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci. 2004; 24(1):81-4.
      View in: PubMed
    37. Yan KS, Yan S, Farooq A, Han A, Zeng L, Zhou MM. Structure and conserved RNA binding of the PAZ domain. Nature. 2003 Nov 27; 426(6965):468-74.
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    38. Farooq A, Zeng L, Yan KS, Ravichandran KS, Zhou MM. Coupling of folding and binding in the PTB domain of the signaling protein Shc. Structure. 2003 Aug; 11(8):905-13.
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    39. Manzur K, Farooq A, Zeng L, Zhou MM. 1H, 13C and 15N resonance assignments of a viral SET domain histone lysine methyltransferase. J Biomol NMR. 2003 Jul; 26(3):279-80.
      View in: PubMed
    40. Farooq A, Zeng L, Zhou MM. 1H, 15N and 13C resonance assignments for the PTB domain of the signaling protein Shc. J Biomol NMR. 2003 Mar; 25(3):255-6.
      View in: PubMed
    41. Manzur KL, Farooq A, Zeng L, Plotnikova O, Koch AW. A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3. Nat Struct Biol. 2003 Mar; 10(3):187-96.
      View in: PubMed
    42. Farooq A, Plotnikova O, Chaturvedi G, Yan S, Zeng L, Zhang Q, Zhou MM. Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. Structure. 2003 Feb; 11(2):155-64.
      View in: PubMed
    43. Zeng L, Chen CH, Muller M, Zhou MM. Structure-based rational design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci. 2003; 20(3):345-8.
      View in: PubMed
    44. Chaturvedi G, Farooq A, Zeng L, Zhou MM. 1H, 13C and 15N resonance assignments of the catalytic domain of human MAPK phosphatase, PAC-1. J Biomol NMR. 2003 Jan; 25(1):79-80.
      View in: PubMed
    45. Sun AQ, Salkar R. A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter. J Biol Chem. 2003 Feb 7; 278(6):4000-9.
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    46. Zeng L, Lu L, Muller M, Gouaux E, Zhou MM. Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):113-6.
      View in: PubMed
    47. Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell. 2002 Mar; 9(3):575-86.
      View in: PubMed
    48. Zeng L, Zhou MM. Bromodomain: an acetyl-lysine binding domain. FEBS Lett. 2002 Feb 20; 513(1):124-8.
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    49. Farooq A, Chaturvedi G, Mujtaba S, Plotnikova O, Zeng L, Dhalluin C, Ashton R, Zhou MM. Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2. Mol Cell. 2001 Feb; 7(2):387-99.
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    50. Sun AQ, Arrese MA, Zeng L, Swaby I, Zhou MM, Suchy FJ. The rat liver Na(+)/bile acid cotransporter. Importance of the cytoplasmic tail to function and plasma membrane targeting. J Biol Chem. 2001 Mar 2; 276(9):6825-33.
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    51. Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, Welsh J, Wang LH. Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. Mol Cell Biol. 2000 Dec; 20(24):9212-24.
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    52. Dhalluin C, Yan KS, Plotnikova O, Lee KW, Zeng L, Kuti M, Mujtaba S, Goldfarb MP, Zhou MM. Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors. Mol Cell. 2000 Oct; 6(4):921-9.
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    53. Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM. Structure and ligand of a histone acetyltransferase bromodomain. Nature. 1999 Jun 3; 399(6735):491-6.
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    54. Farooq A, Plotnikova O, Zeng L, Zhou MM. Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner. J Biol Chem. 1999 Mar 5; 274(10):6114-21.
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    55. Zong CS, Zeng L, Jiang Y, Sadowski HB, Wang LH. Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth. J Biol Chem. 1998 Oct 23; 273(43):28065-72.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067