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James J. Manfredi

TitlePROFESSOR
InstitutionMount Sinai
DepartmentOncological Sciences
Address
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentDevelopmental and Regenerative Biology


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hamard PJ, Barthelery N, Hogstad B, Mungamuri SK, Tonnessen CA, Carvajal LA, Senturk E, Gillespie V, Aaronson SA, Merad M, Manfredi JJ. The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev. 2013 Sep 1; 27(17):1868-85.
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    2. Carvajal LA, Manfredi JJ. Another fork in the road--life or death decisions by the tumour suppressor p53. EMBO Rep. 2013 May; 14(5):414-21.
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    3. Senturk E, Manfredi JJ. Determine the effect of p53 on chemosensitivity. Methods Mol Biol. 2013; 962:113-25.
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    4. Senturk E, Manfredi JJ. p53 and cell cycle effects after DNA damage. Methods Mol Biol. 2013; 962:49-61.
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    5. Carvajal LA, Hamard PJ, Tonnessen C, Manfredi JJ. E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression. Genes Dev. 2012 Jul 15; 26(14):1533-45.
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    6. Hamard PJ, Lukin DJ, Manfredi JJ. p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes. J Biol Chem. 2012 Jun 22; 287(26):22397-407.
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    7. Manfredi JJ. Monographs editor. Genes Cancer. 2012 Mar; 3(3-4):191.
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    8. Senturk E, Manfredi JJ. Mdm2 and tumorigenesis: evolving theories and unsolved mysteries. Genes Cancer. 2012 Mar; 3(3-4):192-8.
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    9. Livesey KM, Kang R, Vernon P, Buchser W, Loughran P, Watkins SC, Zhang L, Manfredi JJ, Zeh HJ, Li L, Lotze MT, Tang D. p53/HMGB1 complexes regulate autophagy and apoptosis. Cancer Res. 2012 Apr 15; 72(8):1996-2005.
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    10. Hamard PJ, Manfredi JJ. Mdm2's dilemma: to degrade or to translate p53? Cancer Cell. 2012 Jan 17; 21(1):3-5.
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    11. Chander H, Halpern M, Resnick-Silverman L, Manfredi JJ, Germain D. Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4. PLoS One. 2011; 6(8):e22456.
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    12. Resnick-Silverman L, Manfredi JJ. Analyzing p53 regulated DNA damage checkpoints by flow cytometry. Methods Mol Biol. 2011; 782:193-203.
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    13. Manfredi JJ. An identity crisis for a cancer gene: subcellular location determines ASPP1 function. Cancer Cell. 2010 Nov 16; 18(5):409-10.
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    14. Manfredi JJ. The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev. 2010 Aug 1; 24(15):1580-9.
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    15. Chander H, Halpern M, Resnick-Silverman L, Manfredi JJ, Germain D. Skp2B attenuates p53 function by inhibiting prohibitin. EMBO Rep. 2010 Mar; 11(3):220-5.
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    16. Manfredi JJ. Insights from a novel p53 isoform in zebrafish want to reel us in, but will we take the bait? Genes Dev. 2009 Feb 1; 23(3):261-4.
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    17. Varmeh S, Manfredi JJ. Inappropriate activation of cyclin-dependent kinases by the phosphatase Cdc25b results in premature mitotic entry and triggers a p53-dependent checkpoint. J Biol Chem. 2009 Apr 3; 284(14):9475-88.
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    18. Zhao B, Benson EK, Qiao R, Wang X, Kim S, Manfredi JJ, Lee SW, Aaronson SA. Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice. EMBO Rep. 2009 Jan; 10(1):71-8.
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    19. Varmeh S, Manfredi JJ. Overexpression of the dual specificity phosphatase, Cdc25C, confers sensitivity on tumor cells to doxorubicin-induced cell death. Mol Cancer Ther. 2008 Dec; 7(12):3789-99.
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    20. Torti FM, Altieri D, Broach J, Fan H, Lotze M, Manfredi J, Matrisian L, Yu D, Giaccia A. Ph.D. Training in cancer biology. Cancer Res. 2008 Nov 15; 68(22):9122-4.
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    21. Giono LE, Manfredi JJ. Mdm2 plays a positive role as an effector of p53-dependent responses. Cell Cycle. 2007 Sep 1; 6(17):2143-7.
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    22. Varmeh-Ziaie S, Manfredi JJ. The dual specificity phosphatase Cdc25B, but not the closely related Cdc25C, is capable of inhibiting cellular proliferation in a manner dependent upon its catalytic activity. J Biol Chem. 2007 Aug 24; 282(34):24633-41.
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    23. Giono LE, Manfredi JJ. Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest. Mol Cell Biol. 2007 Jun; 27(11):4166-78.
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    24. Resnick-Silverman L, Manfredi JJ. Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy. J Cell Biochem. 2006 Oct 15; 99(3):679-89.
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    25. Giono LE, Manfredi JJ. The p53 tumor suppressor participates in multiple cell cycle checkpoints. J Cell Physiol. 2006 Oct; 209(1):13-20.
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    26. St Clair S, Manfredi JJ. The dual specificity phosphatase Cdc25C is a direct target for transcriptional repression by the tumor suppressor p53. Cell Cycle. 2006 Apr; 5(7):709-13.
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    27. Zhang XH, Zhao C, Seleznev K, Song K, Manfredi JJ, Ma ZA. Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase. J Cell Sci. 2006 Mar 15; 119(Pt 6):1005-15.
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    28. Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol. 2006 Jan; 13(1):81-90.
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    29. Prives C, Manfredi JJ. The continuing saga of p53--more sleepless nights ahead. Mol Cell. 2005 Sep 16; 19(6):719-21.
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    30. Manfredi JJ, Dong J, Liu WJ, Resnick-Silverman L, Qiao R, Chahinian P, Saric M, Gibbs AR, Phillips JI, Murray J, Axten CW, Nolan RP, Aaronson SA. Evidence against a role for SV40 in human mesothelioma. Cancer Res. 2005 Apr 1; 65(7):2602-9.
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    31. St Clair S, Giono L, Varmeh-Ziaie S, Resnick-Silverman L, Liu WJ, Padi A, Dastidar J, DaCosta A, Mattia M, Manfredi JJ. DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter. Mol Cell. 2004 Dec 3; 16(5):725-36.
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    32. Manfredi JJ. p53 and apoptosis: it's not just in the nucleus anymore. Mol Cell. 2003 Mar; 11(3):552-4.
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    33. Thornborrow EC, Maurer M, Manfredi JJ. Electrophoretic mobility shift analysis of the DNA binding of tumor suppressor gene products. Methods Mol Biol. 2003; 223:87-100.
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    34. Thornborrow EC, Patel S, Mastropietro AE, Schwartzfarb EM, Manfredi JJ. A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes. Oncogene. 2002 Feb 7; 21(7):990-9.
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    35. Bargonetti J, Manfredi JJ. Multiple roles of the tumor suppressor p53. Curr Opin Oncol. 2002 Jan; 14(1):86-91.
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    36. Thornborrow EC, Manfredi JJ. The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter. J Biol Chem. 2001 May 11; 276(19):15598-608.
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    37. Buschmann T, Lin Y, Aithmitti N, Fuchs SY, Lu H, Resnick-Silverman L, Manfredi JJ, Ronai Z, Wu X. Stabilization and activation of p53 by the coactivator protein TAFII31. J Biol Chem. 2001 Apr 27; 276(17):13852-7.
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    38. Houvras Y, Benezra M, Zhang H, Manfredi JJ, Weber BL, Licht JD. BRCA1 physically and functionally interacts with ATF1. J Biol Chem. 2000 Nov 17; 275(46):36230-7.
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    39. Thornborrow EC, Manfredi JJ. One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element. J Biol Chem. 1999 Nov 19; 274(47):33747-56.
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    40. Tang HY, Zhao K, Pizzolato JF, Fonarev M, Langer JC, Manfredi JJ. Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53. J Biol Chem. 1998 Oct 30; 273(44):29156-63.
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    41. Resnick-Silverman L, St Clair S, Maurer M, Zhao K, Manfredi JJ. Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev. 1998 Jul 15; 12(14):2102-7.
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    42. Manfredi JJ, Prives C. The transforming activity of simian virus 40 large tumor antigen. Biochim Biophys Acta. 1994 May 27; 1198(1):65-83.
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    43. Bargonetti J, Manfredi JJ, Chen X, Marshak DR, Prives C. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev. 1993 Dec; 7(12B):2565-74.
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    44. Manfredi JJ, Prives C. Primary rat cells expressing a hybrid polyomavirus-simian virus 40 large T antigen have altered growth properties. J Virol. 1993 Aug; 67(8):4750-9.
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    45. Prives C, Manfredi JJ. The p53 tumor suppressor protein: meeting review. Genes Dev. 1993 Apr; 7(4):529-34.
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    46. Prives C, Bargonetti J, Friedman PN, Manfredi JJ, Wang EH. Functional consequences of the interactions of the p53 tumor suppressor protein and SV40 large tumor antigen. Cold Spring Harb Symp Quant Biol. 1991; 56:227-35.
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    47. Manfredi JJ, Prives C. Binding of p53 and p105-RB is not sufficient for oncogenic transformation by a hybrid polyomavirus-simian virus 40 large T antigen. J Virol. 1990 Nov; 64(11):5250-9.
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    48. Erickson-Viitanen S, Manfredi J, Viitanen P, Tribe DE, Tritch R, Hutchison CA, Loeb DD, Swanstrom R. Cleavage of HIV-1 gag polyprotein synthesized in vitro: sequential cleavage by the viral protease. AIDS Res Hum Retroviruses. 1989 Dec; 5(6):577-91.
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    49. Manfredi JJ, Bazari WL. Purification and characterization of two distinct complexes of assembly polypeptides from calf brain coated vesicles that differ in their polypeptide composition and kinase activities. J Biol Chem. 1987 Sep 5; 262(25):12182-8.
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    50. Manfredi JJ, Horwitz SB. Vinblastine paracrystals from cultured cells are calcium-stable. Exp Cell Res. 1984 Jan; 150(1):205-12.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067