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Yongkui Jing

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentHematology and Medical Oncology
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhao XW, Liu D, Luan SL, Hu GD, Lv JL, Jing YK, Zhao LX. Synthesis and biological evaluation of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3-triazines as inhibitors of vascular endothelial growth factor receptor-2. Bioorg Med Chem. 2013 Dec 15; 21(24):7807-15.
      View in: PubMed
    2. Jiang C, Li ZL, Gong P, Kang SL, Liu MS, Pei YH, Jing YK, Hua HM. Five novel naphthylisoquinoline alkaloids with growth inhibitory activities against human leukemia cells HL-60, K562 and U937 from stems and leaves of Ancistrocladus tectorius. Fitoterapia. 2013 Dec; 91:305-12.
      View in: PubMed
    3. Liu G, Wang R, Wang Y, Li P, Zhao G, Zhao L, Jing Y. Ethacrynic acid oxadiazole analogs induce apoptosis in malignant hematologic cells through downregulation of Mcl-1 and c-FLIP, which was attenuated by GSTP1-1. Mol Cancer Ther. 2013 Sep; 12(9):1837-47.
      View in: PubMed
    4. Gong YX, Hua HM, Xu YN, Liu JY, Yu ZG, Ma J, Zhang H, Jing YK. Triterpene saponins from Clematis mandshurica and their antiproliferative activity. Planta Med. 2013 Jul; 79(11):987-94.
      View in: PubMed
    5. Li F, Zhao D, Ren J, Hao F, Liu G, Jin S, Jing Y, Cheng M. 2-(2-Methylfuran-3-carboxamido)-3-phenylpropanoic acid, a potential CYP26A1 inhibitor to enhance all-trans retinoic acid-induced leukemia cell differentiation based on virtual screening and biological evaluation. Bioorg Med Chem. 2013 Jun 1; 21(11):3256-61.
      View in: PubMed
    6. Leal AS, Wang R, Salvador JA, Jing Y. Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells. Org Biomol Chem. 2013 Feb 13; 11(10):1726-38.
      View in: PubMed
    7. Wang R, Liu C, Xia L, Zhao G, Gabrilove J, Waxman S, Jing Y. Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15; 18(24):6690-701.
      View in: PubMed
    8. Wang N, Li ZL, Song DD, Li W, Pei YH, Jing YK, Hua HM. Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea. Planta Med. 2012 Oct; 78(15):1661-6.
      View in: PubMed
    9. Qian H, Xia L, Ling P, Waxman S, Jing Y. CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts. Cancer Biol Ther. 2012 Nov; 13(13):1276-83.
      View in: PubMed
    10. Leal AS, Wang R, Salvador JA, Jing Y. Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells. Bioorg Med Chem. 2012 Oct 1; 20(19):5774-86.
      View in: PubMed
    11. Leal AS, Wang R, Salvador JA, Jing Y. Semisynthetic ursolic acid fluorolactone derivatives inhibit growth with induction of p21(waf1) and induce apoptosis with upregulation of NOXA and downregulation of c-FLIP in cancer cells. ChemMedChem. 2012 Sep; 7(9):1635-46.
      View in: PubMed
    12. Li T, Liu G, Li H, Yang X, Jing Y, Zhao G. The synthesis of ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors. Bioorg Med Chem. 2012 Apr 1; 20(7):2316-22.
      View in: PubMed
    13. Niu SL, Li ZL, Ji F, Liu GY, Zhao N, Liu XQ, Jing YK, Hua HM. Xanthones from the stem bark of Garcinia bracteata with growth inhibitory effects against HL-60 cells. Phytochemistry. 2012 May; 77:280-6.
      View in: PubMed
    14. Wang Y, Li ZL, Bai J, Zhang LM, Wu X, Zhang L, Pei YH, Jing YK, Hua HM. 2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7. Chem Biodivers. 2012 Feb; 9(2):385-93.
      View in: PubMed
    15. Guo J, Li ZL, Wang AL, Liu XQ, Wang J, Guo X, Jing YK, Hua HM. Three new phenolic compounds from the lichen Thamnolia vermicularis and their antiproliferative effects in prostate cancer cells. Planta Med. 2011 Dec; 77(18):2042-6.
      View in: PubMed
    16. Yin S, Wang R, Zhou F, Zhang H, Jing Y. Bcl-xL is a dominant antiapoptotic protein that inhibits homoharringtonine-induced apoptosis in leukemia cells. Mol Pharmacol. 2011 Jun; 79(6):1072-83.
      View in: PubMed
    17. Wang F, Li ZL, Cui HH, Hua HM, Jing YK, Liang SW. Two new triterpenoids from the resin of Boswellia carterii. J Asian Nat Prod Res. 2011 Mar; 13(3):193-7.
      View in: PubMed
    18. Yu Z, Wang R, Xu L, Xie S, Dong J, Jing Y. ß-Elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-FLIP and generation of ROS. PLoS One. 2011; 6(1):e15843.
      View in: PubMed
    19. Gao Y, Guo X, Li X, Liu D, Song D, Xu Y, Sun M, Jing Y, Zhao L. The synthesis of glycyrrhetinic acid derivatives containing a nitrogen heterocycle and their antiproliferative effects in human leukemia cells. Molecules. 2010 Jun; 15(6):4439-49.
      View in: PubMed
    20. Li Y, Wang R, Ma E, Deng Y, Wang X, Xiao J, Jing Y. The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells. Anticancer Drugs. 2010 Apr; 21(4):389-400.
      View in: PubMed
    21. Li YZ, Li ZL, Yin SL, Shi G, Liu MS, Jing YK, Hua HM. Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells. Fitoterapia. 2010 Sep; 81(6):586-9.
      View in: PubMed
    22. Yang X, Liu G, Li H, Zhang Y, Song D, Li C, Wang R, Liu B, Liang W, Jing Y, Zhao G. Novel oxadiazole analogues derived from ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation. J Med Chem. 2010 Feb 11; 53(3):1015-22.
      View in: PubMed
    23. Song D, Gao Y, Wang R, Liu D, Zhao L, Jing Y. Downregulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhetinic acid derivatives in leukemia cells. Cancer Biol Ther. 2010 Jan; 9(2):96-108.
      View in: PubMed
    24. Chang S, Yin SL, Wang J, Jing YK, Dong JH. Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells. Molecules. 2009; 14(10):4166-79.
      View in: PubMed
    25. Yang X, Wang W, Tan J, Song D, Li M, Liu D, Jing Y, Zhao L. Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells. Bioorg Med Chem Lett. 2009 Aug 1; 19(15):4385-8.
      View in: PubMed
    26. Scher W, Jing Y, Lu M, Bishop DF, Scher BM. Sequences of polycythemia-type Friend spleen focus-forming virus in clone-745-derived mouse erythroleukemia cells. Arch Virol. 2009; 154(5):895-8.
      View in: PubMed
    27. Wang J, Wang S, Song D, Zhao D, Sha Y, Jiang Y, Jing Y, Cheng M. Chalcone derivatives inhibit glutathione S-transferase P1-1 activity: insights into the interaction mode of alpha, beta-unsaturated carbonyl compounds. Chem Biol Drug Des. 2009 May; 73(5):511-4.
      View in: PubMed
    28. Wang LL, Li ZL, Song DD, Sun L, Pei YH, Jing YK, Hua HM. Two novel triterpenoids with antiproliferative and apoptotic activities in human leukemia cells isolated from the resin of Garcinia hanburyi. Planta Med. 2008 Nov; 74(14):1735-40.
      View in: PubMed
    29. Guo G, Li G, Liu D, Yang QJ, Liu Y, Jing YK, Zhao LX. Synthesis and antiproliferative activities of 5-azacytidine analogues in human leukemia cells. Molecules. 2008; 13(7):1487-500.
      View in: PubMed
    30. Lv JL, Wang R, Liu D, Guo G, Jing YK, Zhao LX. Design, synthesis, and antitumor activities of some novel substituted 1,2,3-benzotriazines. Molecules. 2008; 13(6):1427-40.
      View in: PubMed
    31. Yu Z, Wang R, Xu L, Dong J, Jing Y. N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway. Cancer Lett. 2008 Sep 28; 269(1):165-73.
      View in: PubMed
    32. Wang N, Li Z, Song D, Li W, Fu H, Koike K, Pei Y, Jing Y, Hua H. Lanostane-type triterpenoids from the roots of Kadsura coccinea. J Nat Prod. 2008 Jun; 71(6):990-4.
      View in: PubMed
    33. Chen L, Zhu H, Wang R, Zhou K, Jing Y, Qiu F. ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata. J Nat Prod. 2008 May; 71(5):852-5.
      View in: PubMed
    34. Lu M, Xia L, Hua H, Jing Y. Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells. Cancer Res. 2008 Feb 15; 68(4):1180-6.
      View in: PubMed
    35. Wang R, Li C, Song D, Zhao G, Zhao L, Jing Y. Ethacrynic acid butyl-ester induces apoptosis in leukemia cells through a hydrogen peroxide mediated pathway independent of glutathione S-transferase P1-1 inhibition. Cancer Res. 2007 Aug 15; 67(16):7856-64.
      View in: PubMed
    36. Gao LL, Yin SL, Li ZL, Sha Y, Pei YH, Shi G, Jing YK, Hua HM. Three novel sterols isolated from Selaginella tamariscina with antiproliferative activity in leukemia cells. Planta Med. 2007 Aug; 73(10):1112-5.
      View in: PubMed
    37. Liu D, Song D, Guo G, Wang R, Lv J, Jing Y, Zhao L. The synthesis of 18beta-glycyrrhetinic acid derivatives which have increased antiproliferative and apoptotic effects in leukemia cells. Bioorg Med Chem. 2007 Aug 15; 15(16):5432-9.
      View in: PubMed
    38. Zhao G, Liu C, Wang R, Song D, Wang X, Lou H, Jing Y. The synthesis of alpha,beta-unsaturated carbonyl derivatives with the ability to inhibit both glutathione S-transferase P1-1 activity and the proliferation of leukemia cells. Bioorg Med Chem. 2007 Apr 1; 15(7):2701-7.
      View in: PubMed
    39. Chen D, Chan R, Waxman S, Jing Y. Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors. Cancer Res. 2006 Dec 1; 66(23):11416-23.
      View in: PubMed
    40. Chen J, Lu M, Jing Y, Dong J. The synthesis of L-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells. Bioorg Med Chem. 2006 Oct 1; 14(19):6539-47.
      View in: PubMed
    41. Wang F, Hua H, Pei Y, Chen D, Jing Y. Triterpenoids from the resin of Styrax tonkinensis and their antiproliferative and differentiation effects in human leukemia HL-60 cells. J Nat Prod. 2006 May; 69(5):807-10.
      View in: PubMed
    42. Xu L, Tao S, Wang X, Yu Z, Wang M, Chen D, Jing Y, Dong J. The synthesis and anti-proliferative effects of beta-elemene derivatives with mTOR inhibition activity. Bioorg Med Chem. 2006 Aug 1; 14(15):5351-6.
      View in: PubMed
    43. Wang F, Hua HM, Bian X, Pei YH, Jing YK. Two new aromatic compounds from the resin of Styrax tonkinensis (Pier.) Craib. J Asian Nat Prod Res. 2006 Jan-Mar; 8(1-2):137-41.
      View in: PubMed
    44. Jing Y, Hellinger N, Xia L, Monks A, Sausville EA, Zelent A, Waxman S. Benzodithiophenes induce differentiation and apoptosis in human leukemia cells. Cancer Res. 2005 Sep 1; 65(17):7847-55.
      View in: PubMed
    45. Xu K, Guidez F, Glasow A, Chung D, Petrie K, Stegmaier K, Wang KK, Zhang J, Jing Y, Zelent A, Waxman S. Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1; 65(17):7856-65.
      View in: PubMed
    46. Lu M, Mira-y-Lopez R, Nakajo S, Nakaya K, Jing Y. Expression of estrogen receptor alpha, retinoic acid receptor alpha and cellular retinoic acid binding protein II genes is coordinately regulated in human breast cancer cells. Oncogene. 2005 Jun 23; 24(27):4362-9.
      View in: PubMed
    47. Zhao G, Yu T, Wang R, Wang X, Jing Y. Synthesis and structure-activity relationship of ethacrynic acid analogues on glutathione-s-transferase P1-1 activity inhibition. Bioorg Med Chem. 2005 Jun 2; 13(12):4056-62.
      View in: PubMed
    48. Xia L, Chen D, Han R, Fang Q, Waxman S, Jing Y. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Mol Cancer Ther. 2005 Mar; 4(3):381-8.
      View in: PubMed
    49. Wang J, Zhao L, Wang R, Lu M, Chen D, Jing Y. Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl-methylenecyclopentanone hydrochlorides and related compounds. Bioorg Med Chem. 2005 Feb 15; 13(4):1285-91.
      View in: PubMed
    50. Zhou L, Jing Y, Styblo M, Chen Z, Waxman S. Glutathione-S-transferase pi inhibits As2O3-induced apoptosis in lymphoma cells: involvement of hydrogen peroxide catabolism. Blood. 2005 Feb 1; 105(3):1198-203.
      View in: PubMed
    51. Lu M, Xia L, Luo D, Waxman S, Jing Y. Dual effects of glutathione-S-transferase pi on As2O3 action in prostate cancer cells: enhancement of growth inhibition and inhibition of apoptosis. Oncogene. 2004 May 13; 23(22):3945-52.
      View in: PubMed
    52. Jing Y. The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia. Leuk Lymphoma. 2004 Apr; 45(4):639-48.
      View in: PubMed
    53. Mann KK, Rephaeli A, Colosimo AL, Diaz Z, Nudelman A, Levovich I, Jing Y, Waxman S, Miller WH. A retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis. Mol Cancer Res. 2003 Oct; 1(12):903-12.
      View in: PubMed
    54. Jing Y, Xia L, Lu M, Waxman S. The cleavage product deltaPML-RARalpha contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells. Oncogene. 2003 Jun 26; 22(26):4083-91.
      View in: PubMed
    55. Chen GQ, Zhou L, Styblo M, Walton F, Jing Y, Weinberg R, Chen Z, Waxman S. Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells. Cancer Res. 2003 Apr 15; 63(8):1853-9.
      View in: PubMed
    56. Jing Y, Xia L, Waxman S. Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia. Blood. 2002 Aug 1; 100(3):1008-13.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067