Keywords
Last Name
Institution

Isabelle M. Germano

TitlePROFESSOR
InstitutionMount Sinai
DepartmentNeurosurgery
Address120 New York Avenue
Huntington NY 11743
Phone631-351-3815
Fax212-831-3324
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentNeurology

    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentOncological Sciences


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mccormick PJ, Osborn IP, Germano IM, Green S, Deiner SG. Scalp nerve blockade reduces pain after headframe placement in radiosurgery: a double blind, randomized clinical trial. Middle East J Anesthesiol. 2013 Feb; 22(1):79-85.
      View in: PubMed
    2. Caixas U, Ferreira J, Marinho AT, Faustino I, Grilo NM, Lampreia F, Germano I, Monteiro EC, Pereira SA. Long-term maraviroc use as salvage therapy in HIV-2 infection. J Antimicrob Chemother. 2012 Oct; 67(10):2538-9.
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    3. Patel SH, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano I, Ghafoori P, Henderson MA, Lutz ST, McDermott MW, Patchell RA, Robins HI, Vassil AD, Wippold FJ, Videtic GM. ACR Appropriateness Criteria® follow-up and retreatment of brain metastases. Am J Clin Oncol. 2012 Jun; 35(3):302-6.
      View in: PubMed
    4. Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surg Neurol Int. 2012; 3(Suppl 2):S118-26.
      View in: PubMed
    5. Binello E, Qadeer ZA, Kothari HP, Emdad L, Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro. J Cancer. 2012; 3:166-74.
      View in: PubMed
    6. Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol. 2012 Mar; 14(3):256-65.
      View in: PubMed
    7. Binello E, Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci. 2011 Nov; 102(11):1958-66.
      View in: PubMed
    8. Emdad L, D'Souza SL, Kothari HP, Qadeer ZA, Germano IM. Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes. Stem Cells Dev. 2012 Feb 10; 21(3):404-10.
      View in: PubMed
    9. Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas? Neuro Oncol. 2011 Jul; 13(7):725-35.
      View in: PubMed
    10. Lehrer S, Labombardi V, Green S, Pessin-Minsley MS, Germano IM, Rosenzweig KE. No circulating cytomegalovirus in five patients with glioblastoma multiforme. Anticancer Res. 2011 Mar; 31(3):959-60.
      View in: PubMed
    11. Germano IM, Emdad L, Qadeer ZA, Binello E, Uzzaman M. Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Ther. 2010 Sep; 17(9):664-74.
      View in: PubMed
    12. Roberts CC, Daffner RH, Weissman BN, Bancroft L, Bennett DL, Blebea JS, Bruno MA, Fries IB, Germano IM, Holly L, Jacobson JA, Luchs JS, Morrison WB, Olson JJ, Payne WK, Resnik CS, Schweitzer ME, Seeger LL, Taljanovic M, Wise JN, Lutz ST. ACR appropriateness criteria on metastatic bone disease. J Am Coll Radiol. 2010 Jun; 7(6):400-9.
      View in: PubMed
    13. Suh JH, Videtic GM, Aref AM, Germano I, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Wolfson AH, Wippold FJ, Gaspar LE. ACR Appropriateness Criteria: single brain metastasis. Curr Probl Cancer. 2010 May-Jun; 34(3):162-74.
      View in: PubMed
    14. Germano I, Swiss V, Casaccia P. Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link? Neuropharmacology. 2010 May; 58(6):903-10.
      View in: PubMed
    15. Pereira SA, Batuca JR, Caixas U, Branco T, Delgado-Alves J, Germano I, Lampreia F, Monteiro EC. Effect of efavirenz on high-density lipoprotein antioxidant properties in HIV-infected patients. Br J Clin Pharmacol. 2009 Dec; 68(6):891-7.
      View in: PubMed
    16. American College of Radiology appropriateness criteria on multiple brain metastases. Int J Radiat Oncol Biol Phys. 2009 Nov 15; 75(4):961-5.
      View in: PubMed
    17. Germano IM, Binello E. Gene therapy as an adjuvant treatment for malignant gliomas: from bench to bedside. J Neurooncol. 2009 May; 93(1):79-87.
      View in: PubMed
    18. Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neurooncol. 2009 Aug; 94(1):145-8.
      View in: PubMed
    19. Gonzalez-Duarte A, Sullivan S, Sips GJ, Naidich T, Kleinman G, Murray J, Morgello S, Germano I, Mullen M, Simpson D. Inflammatory pseudotumor associated with HIV, JCV, and immune reconstitution syndrome. Neurology. 2009 Jan 20; 72(3):289-90.
      View in: PubMed
    20. Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? Cancer Biol Ther. 2008 Sep; 7(9):1341-7.
      View in: PubMed
    21. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurg. 2008 Sep; 109(3):378-86.
      View in: PubMed
    22. Uzzaman M, Keller G, Germano IM. In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas. Neuro Oncol. 2009 Apr; 11(2):102-8.
      View in: PubMed
    23. Pereira SA, Caixas U, Branco T, Germano I, Lampreia F, Papoila AL, Monteiro EC. Efavirenz concentrations in HIV-infected patients with and without viral hepatitis. Br J Clin Pharmacol. 2008 Oct; 66(4):551-5.
      View in: PubMed
    24. Pereira SA, Branco T, Caixas U, Côrte-Real RM, Germano I, Lampreia F, Monteiro EC. Intra-individual variability in efavirenz plasma concentrations supports therapeutic drug monitoring based on quarterly sampling in the first year of therapy. Ther Drug Monit. 2008 Feb; 30(1):60-6.
      View in: PubMed
    25. Uzzaman M, Keller G, Germano IM. Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells. J Neurosurg. 2007 Apr; 106(4):646-51.
      View in: PubMed
    26. Germano IM, Uzzaman M, Benveniste RJ, Zaurova M, Keller G. Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand. J Neurosurg. 2006 Jul; 105(1):88-95.
      View in: PubMed
    27. Pereira SA, Branco T, Côrte-Real RM, Germano I, Lampreia F, Caixas U, Monteiro EC. Long-term and concentration-dependent beneficial effect of efavirenz on HDL-cholesterol in HIV-infected patients. Br J Clin Pharmacol. 2006 May; 61(5):601-4.
      View in: PubMed
    28. Uzzaman M, Benveniste RJ, Keller G, Germano IM. Embryonic stem cell-derived astrocytes: a novel gene therapy vector for brain tumors. Neurosurg Focus. 2005 Sep 15; 19(3):E6.
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    29. Benveniste RJ, Keller G, Germano I. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: differentiation and transplantion into the mouse brain. J Neurosurg. 2005 Jul; 103(1):115-23.
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    30. Benveniste RJ, Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol. 2005 Jun; 63(6):542-8; discussion 548-9.
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    31. Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene. 2005 Feb 3; 24(6):980-91.
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    32. Germano IM, Gracies JM, Weisz DJ, Tse W, Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson disease: a double-blind 12-month evaluation study. J Neurosurg. 2004 Jul; 101(1):36-42.
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    33. Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 2004 Apr; 11(4):448-57.
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    34. Morrison CE, Borod JC, Perrine K, Beric A, Brin MF, Rezai A, Kelly P, Sterio D, Germano I, Weisz D, Olanow CW. Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson's disease. Arch Clin Neuropsychol. 2004 Mar; 19(2):165-81.
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    35. Kanzawa T, Bedwell J, Kondo Y, Kondo S, Germano IM. Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide. J Neurosurg. 2003 Dec; 99(6):1047-52.
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    36. Kanzawa T, Komata T, Kyo S, Germano IM, Kondo Y, Kondo S. Down-regulation of telomerase activity in malignant glioma cells by p27KIP1. Int J Oncol. 2003 Dec; 23(6):1703-8.
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    37. Germano IM, Fable J, Gultekin SH, Silvers A. Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: preliminary results of a phase I trial in patients with recurrent malignant gliomas. J Neurooncol. 2003 Dec; 65(3):279-89.
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    38. Kanzawa T, Germano IM, Kondo Y, Ito H, Kyo S, Kondo S. Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide. Br J Cancer. 2003 Sep 1; 89(5):922-9.
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    39. Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res. 2003 May 1; 63(9):2103-8.
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    40. Komata T, Kanzawa T, Takeuchi H, Germano IM, Schreiber M, Kondo Y, Kondo S. Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells. Br J Cancer. 2003 Apr 22; 88(8):1277-80.
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    41. Benveniste R, Germano IM. Evaluation of factors predicting accurate resection of high-grade gliomas by using frameless image-guided stereotactic guidance. Neurosurg Focus. 2003 Feb 15; 14(2):e5.
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    42. Yao KC, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM. Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg. 2003 Feb; 98(2):378-84.
      View in: PubMed
    43. Komata T, Kondo Y, Kanzawa T, Ito H, Hirohata S, Koga S, Sumiyoshi H, Takakura M, Inoue M, Barna BP, Germano IM, Kyo S, Kondo S. Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells. Hum Gene Ther. 2002 Jun 10; 13(9):1015-25.
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    44. Komata T, Koga S, Hirohata S, Takakura M, Germano IM, Inoue M, Kyo S, Kondo S, Kondo Y. A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter. Int J Oncol. 2001 Nov; 19(5):1015-20.
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    45. Komata T, Kondo Y, Kanzawa T, Hirohata S, Koga S, Sumiyoshi H, Srinivasula SM, Barna BP, Germano IM, Takakura M, Inoue M, Alnemri ES, Shay JW, Kyo S, Kondo S. Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter. Cancer Res. 2001 Aug 1; 61(15):5796-802.
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    46. Walker RH, Danisi FO, Swope DM, Goodman RR, Germano IM, Brin MF. Intrathecal baclofen for dystonia: benefits and complications during six years of experience. Mov Disord. 2000 Nov; 15(6):1242-7.
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    47. Morrison CE, Borod JC, Brin MF, Raskin SA, Germano IM, Weisz DJ, Olanow CW. A program for neuropsychological investigation of deep brain stimulation (PNIDBS) in movement disorder patients: development, feasibility, and preliminary data. Neuropsychiatry Neuropsychol Behav Neurol. 2000 Jul; 13(3):204-19.
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    48. Germano IM, Villalobos H, Silvers A, Post KD. Clinical use of the optical digitizer for intracranial neuronavigation. Neurosurgery. 1999 Aug; 45(2):261-9; discussion 269-70.
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    49. Sperber EF, Velísková J, Germano IM, Friedman LK, Moshé SL. Age-dependent vulnerability to seizures. Adv Neurol. 1999; 79:161-9.
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    50. Villalobos H, Germano IM. Clinical evaluation of multimodality registration in frameless stereotaxy. Comput Aided Surg. 1999; 4(1):45-9.
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    51. Germano IM, Sperber EF, Ahuja S, Moshé SL. Evidence of enhanced kindling and hippocampal neuronal injury in immature rats with neuronal migration disorders. Epilepsia. 1998 Dec; 39(12):1253-60.
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    52. Germano IM, Sperber EF. Transplacentally induced neuronal migration disorders: an animal model for the study of the epilepsies. J Neurosci Res. 1998 Feb 15; 51(4):473-88.
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    53. Germano IM, Queenan JV. Clinical experience with intracranial brain needle biopsy using frameless surgical navigation. Comput Aided Surg. 1998; 3(1):33-9.
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    54. Germano IM, Sperber EF. Increased seizure susceptibility in adult rats with neuronal migration disorders. Brain Res. 1997 Nov 28; 777(1-2):219-22.
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    55. Segal DH, Germano IM, Bederson JB. Effects of basic fibroblast growth factor on in vivo cerebral tumorigenesis in rats. Neurosurgery. 1997 May; 40(5):1027-33.
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    56. Lorberboym M, Mandell LR, Mosesson RE, Germano I, Lou W, DaCosta M, Linzer DG, Machac J. The role of thallium-201 uptake and retention in intracranial tumors after radiotherapy. J Nucl Med. 1997 Feb; 38(2):223-6.
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    57. Brisman MH, Bederson JB, Sen CN, Germano IM, Moore F, Post KD. Intracerebral hemorrhage occurring remote from the craniotomy site. Neurosurgery. 1996 Dec; 39(6):1114-21; discussion 1121-2.
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    58. Germano IM. Transsulcal approach to mesiotemporal lesions. Anatomy, technique, and report of three cases. Neurosurg Focus. 1996 Nov 15; 1(5):e4.
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    59. Germano IM, Zhang YF, Sperber EF, Moshé SL. Neuronal migration disorders increase susceptibility to hyperthermia-induced seizures in developing rats. Epilepsia. 1996 Sep; 37(9):902-10.
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    60. Lorberboym M, Estok L, Machac J, Germano I, Sacher M, Feldman R, Wallach F, Dorfman D. Rapid differential diagnosis of cerebral toxoplasmosis and primary central nervous system lymphoma by thallium-201 SPECT. J Nucl Med. 1996 Jul; 37(7):1150-4.
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    61. Marcão I, Teixeira H, Germano I, Bandeira Costa J, Gonçalves C, Magalhães M, Farrajota F. [Cerebellar hematomas in a patient with atrial myxoma]. Acta Med Port. 1995 Dec; 8(12):695-9.
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    62. Bederson JB, Germano IM, Guarino L. Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat. Stroke. 1995 Jun; 26(6):1086-91; discussion 1091-2.
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    63. Olivier A, Germano IM, Cukiert A, Peters T. Frameless stereotaxy for surgery of the epilepsies: preliminary experience. Technical note. J Neurosurg. 1994 Oct; 81(4):629-33.
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    64. Germano IM, Poulin N, Olivier A. Reoperation for recurrent temporal lobe epilepsy. J Neurosurg. 1994 Jul; 81(1):31-6.
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    65. Germano IM, Edwards MS, Davis RL, Schiffer D. Intracranial meningiomas of the first two decades of life. J Neurosurg. 1994 Mar; 80(3):447-53.
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    66. de los Reyes RA, Bederson JB, Germano IM. Direct endarterectomy of the middle cerebral artery for treatment of symptomatic stenosis: case report. Neurosurgery. 1993 Mar; 32(3):464-7; discussion 467.
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    67. Germano IM, Davis RL, Wilson CB, Hieshima GB. Histopathological follow-up study of 66 cerebral arteriovenous malformations after therapeutic embolization with polyvinyl alcohol. J Neurosurg. 1992 Apr; 76(4):607-14.
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    68. Cohen Y, Chang LH, Litt L, Kim F, Severinghaus JW, Weinstein PR, Davis RL, Germano I, James TL. Stability of brain intracellular lactate and 31P-metabolite levels at reduced intracellular pH during prolonged hypercapnia in rats. J Cereb Blood Flow Metab. 1990 Mar; 10(2):277-84.
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    69. Germano IM, Ito M, Cho KG, Hoshino T, Davis RL, Wilson CB. Correlation of histopathological features and proliferative potential of gliomas. J Neurosurg. 1989 May; 70(5):701-6.
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    70. Germano IM, Pitts LH, Berry I, Moseley M. Magnetic resonance imaging and 31P magnetic resonance spectroscopy for evaluating focal cerebral ischemia. J Neurosurg. 1989 Apr; 70(4):612-8.
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    71. Germano IM, Pitts LH, Berry I, De Armond SJ. High energy phosphate metabolism in experimental permanent focal cerebral ischemia: an in vivo 31P magnetic resonance spectroscopy study. J Cereb Blood Flow Metab. 1988 Feb; 8(1):24-31.
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    72. Germano IM, Pitts LH, Meldrum BS, Bartkowski HM, Simon RP. Kynurenate inhibition of cell excitation decreases stroke size and deficits. Ann Neurol. 1987 Dec; 22(6):730-4.
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    73. Germano IM, Bartkowski HM, Cassel ME, Pitts LH. The therapeutic value of nimodipine in experimental focal cerebral ischemia. Neurological outcome and histopathological findings. J Neurosurg. 1987 Jul; 67(1):81-7.
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    74. Schiffer D, Giordana MT, Germano I, Mauro A. Anaplasia and heterogeneity of GFAP expression in gliomas. Tumori. 1986 Apr 30; 72(2):163-70.
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    75. Schiffer D, Giordana MT, Mauro A, Migheli A, Germano I, Giaccone G. Immunohistochemical demonstration of vimentin in human cerebral tumors. Acta Neuropathol. 1986; 70(3-4):209-19.
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    76. Berry I, Moseley M, Germano IM, Ishige N, Nishimura MC, Bartkowski HM, Pitts LH, Brant-Zawadzki M. Combined magnetic resonance imaging and spectroscopy in experimental regional injury of the brain. Ischemia and impact trauma. Acta Radiol Suppl. 1986; 369:338-49.
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    77. Germano IM, Bartkowski HM, Berry I, Moseley M, Brant-Zawadzki M, Pitts LH. Magnetic resonance imaging in the evaluation of nimodipine-treated acute experimental focal cerebral ischemia. Acta Radiol Suppl. 1986; 369:49-52.
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    78. Mauro A, Germano I, Giaccone G, Giordana MT, Schiffer D. 1-Naphthol basic dye (1-NBD). An alternative to diaminobenzidine (DAB) in immunoperoxidase techniques. Histochemistry. 1985; 83(2):97-102.
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    79. Giordana MT, Germano I, Giaccone G, Mauro A, Migheli A, Schiffer D. The distribution of laminin in human brain tumors: an immunohistochemical study. Acta Neuropathol. 1985; 67(1-2):51-7.
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    80. Mauro A, Bertolotto A, Germano I, Giaccone G, Giordana MT, Migheli A, Schiffer D. Collagenase in the immunohistochemical demonstration of laminin, fibronectin and factor VIII/RAg in nervous tissue after fixation. Histochemistry. 1984; 80(2):157-63.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067