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Last Name
Institution

Ana Fernandez-Sesma

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentMicrobiology
Address
    Other Positions
    TitleASSISTANT PROFESSOR
    InstitutionMount Sinai
    DepartmentInfectious Diseases


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Suthar MS, Aguirre S, Fernandez-Sesma A. Innate immune sensing of flaviviruses. PLoS Pathog. 2013 Sep; 9(9):e1003541.
      View in: PubMed
    2. Ramos I, Krammer F, Hai R, Aguilera D, Bernal-Rubio D, Steel J, García-Sastre A, Fernandez-Sesma A. H7N9 influenza viruses interact preferentially with a2,3-linked sialic acids and bind weakly to a2,6-linked sialic acids. J Gen Virol. 2013 Nov; 94(Pt 11):2417-23.
      View in: PubMed
    3. Morrison J, Laurent-Rolle M, Maestre AM, Rajsbaum R, Pisanelli G, Simon V, Mulder LC, Fernandez-Sesma A, García-Sastre A. Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling. PLoS Pathog. 2013 Mar; 9(3):e1003265.
      View in: PubMed
    4. Versteeg GA, Rajsbaum R, Sánchez-Aparicio MT, Maestre AM, Valdiviezo J, Shi M, Inn KS, Fernandez-Sesma A, Jung J, García-Sastre A. The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors. Immunity. 2013 Feb 21; 38(2):384-98.
      View in: PubMed
    5. Ramos I, Carnero E, Bernal-Rubio D, Seibert CW, Westera L, García-Sastre A, Fernandez-Sesma A. Contribution of double-stranded RNA and CPSF30 binding domains of influenza virus NS1 to the inhibition of type I interferon production and activation of human dendritic cells. J Virol. 2013 Mar; 87(5):2430-40.
      View in: PubMed
    6. Pagni S, Fernandez-Sesma A. Evasion of the human innate immune system by dengue virus. Immunol Res. 2012 Dec; 54(1-3):152-9.
      View in: PubMed
    7. Melandri V, Guimarães AÉ, Komar N, Nogueira ML, Mondini A, Fernandez-Sesma A, Alencar J, Bosch I. Serological detection of West Nile virus in horses and chicken from Pantanal, Brazil. Mem Inst Oswaldo Cruz. 2012 Dec; 107(8):1073-5.
      View in: PubMed
    8. Ramos I, Fernandez-Sesma A. Innate immunity to H5N1 influenza viruses in humans. Viruses. 2012 Dec; 4(12):3363-88.
      View in: PubMed
    9. Stefanidou M, Ramos I, Mas Casullo V, Trépanier JB, Rosenbaum S, Fernandez-Sesma A, Herold BC. Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy. J Virol. 2013 Feb; 87(3):1443-53.
      View in: PubMed
    10. Aguirre S, Maestre AM, Pagni S, Patel JR, Savage T, Gutman D, Maringer K, Bernal-Rubio D, Shabman RS, Simon V, Rodriguez-Madoz JR, Mulder LC, Barber GN, Fernandez-Sesma A. DENV inhibits type I IFN production in infected cells by cleaving human STING. PLoS Pathog. 2012; 8(10):e1002934.
      View in: PubMed
    11. Ramos I, Fernandez-Sesma A. Cell receptors for influenza a viruses and the innate immune response. Front Microbiol. 2012; 3:117.
      View in: PubMed
    12. Krause JC, Tsibane T, Tumpey TM, Huffman CJ, Albrecht R, Blum DL, Ramos I, Fernandez-Sesma A, Edwards KM, García-Sastre A, Basler CF, Crowe JE. Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses. J Virol. 2012 Jun; 86(11):6334-40.
      View in: PubMed
    13. Chiang CY, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, Barton GM, Chanda SK. Cofactors required for TLR7- and TLR9-dependent innate immune responses. Cell Host Microbe. 2012 Mar 15; 11(3):306-18.
      View in: PubMed
    14. Morrison J, Aguirre S, Fernandez-Sesma A. Innate immunity evasion by Dengue virus. Viruses. 2012 Mar; 4(3):397-413.
      View in: PubMed
    15. Belicha-Villanueva A, Rodriguez-Madoz JR, Maamary J, Baum A, Bernal-Rubio D, Minguito de la Escalera M, Fernandez-Sesma A, García-Sastre A. Recombinant influenza A viruses with enhanced levels of PB1 and PA viral protein expression. J Virol. 2012 May; 86(10):5926-30.
      View in: PubMed
    16. Berger A, Sommer AF, Zwarg J, Hamdorf M, Welzel K, Esly N, Panitz S, Reuter A, Ramos I, Jatiani A, Mulder LC, Fernandez-Sesma A, Rutsch F, Simon V, König R, Flory E. SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection. PLoS Pathog. 2011 Dec; 7(12):e1002425.
      View in: PubMed
    17. Pica N, Iyer A, Ramos I, Bouvier NM, Fernandez-Sesma A, García-Sastre A, Lowen AC, Palese P, Steel J. The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses. J Virol. 2011 Dec; 85(23):12825-9.
      View in: PubMed
    18. Long CB, Ramos I, Rastogi D, Manwani D, Janow G, Del Rio M, Mayers M, Herold BC, Fernandez-Sesma A, Madan RP. Humoral and cell-mediated immune responses to monovalent 2009 influenza A/H1N1 and seasonal trivalent influenza vaccines in high-risk children. J Pediatr. 2012 Jan; 160(1):74-81.
      View in: PubMed
    19. Varga ZT, Ramos I, Hai R, Schmolke M, García-Sastre A, Fernandez-Sesma A, Palese P. The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein. PLoS Pathog. 2011 Jun; 7(6):e1002067.
      View in: PubMed
    20. Ramos I, Bernal-Rubio D, Durham N, Belicha-Villanueva A, Lowen AC, Steel J, Fernandez-Sesma A. Effects of receptor binding specificity of avian influenza virus on the human innate immune response. J Virol. 2011 May; 85(9):4421-31.
      View in: PubMed
    21. Ashour J, Morrison J, Laurent-Rolle M, Belicha-Villanueva A, Plumlee CR, Bernal-Rubio D, Williams KL, Harris E, Fernandez-Sesma A, Schindler C, García-Sastre A. Mouse STAT2 restricts early dengue virus replication. Cell Host Microbe. 2010 Nov 18; 8(5):410-21.
      View in: PubMed
    22. Rodriguez-Madoz JR, Belicha-Villanueva A, Bernal-Rubio D, Ashour J, Ayllon J, Fernandez-Sesma A. Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex. J Virol. 2010 Oct; 84(19):9760-74.
      View in: PubMed
    23. Rodriguez-Madoz JR, Bernal-Rubio D, Kaminski D, Boyd K, Fernandez-Sesma A. Dengue virus inhibits the production of type I interferon in primary human dendritic cells. J Virol. 2010 May; 84(9):4845-50.
      View in: PubMed
    24. Haye K, Burmakina S, Moran T, García-Sastre A, Fernandez-Sesma A. The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells. J Virol. 2009 Jul; 83(13):6849-62.
      View in: PubMed
    25. Bordería AV, Hartmann BM, Fernandez-Sesma A, Moran TM, Sealfon SC. Antiviral-activated dendritic cells: a paracrine-induced response state. J Immunol. 2008 Nov 15; 181(10):6872-81.
      View in: PubMed
    26. Phipps-Yonas H, Seto J, Sealfon SC, Moran TM, Fernandez-Sesma A. Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. PLoS Pathog. 2008 Oct; 4(10):e1000193.
      View in: PubMed
    27. Escribese MM, Kraus T, Rhee E, Fernandez-Sesma A, López CB, Moran TM. Estrogen inhibits dendritic cell maturation to RNA viruses. Blood. 2008 Dec 1; 112(12):4574-84.
      View in: PubMed
    28. Madan RP, Tan M, Fernandez-Sesma A, Moran TM, Emre S, Campbell A, Herold BC. A prospective, comparative study of the immune response to inactivated influenza vaccine in pediatric liver transplant recipients and their healthy siblings. Clin Infect Dis. 2008 Mar 1; 46(5):712-8.
      View in: PubMed
    29. Fernandez-Sesma A. The influenza virus NS1 protein: inhibitor of innate and adaptive immunity. Infect Disord Drug Targets. 2007 Dec; 7(4):336-43.
      View in: PubMed
    30. Hu J, Sealfon SC, Hayot F, Jayaprakash C, Kumar M, Pendleton AC, Ganee A, Fernandez-Sesma A, Moran TM, Wetmur JG. Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells. Nucleic Acids Res. 2007; 35(15):5232-41.
      View in: PubMed
    31. Fernandez-Sesma A, Marukian S, Ebersole BJ, Kaminski D, Park MS, Yuen T, Sealfon SC, García-Sastre A, Moran TM. Influenza virus evades innate and adaptive immunity via the NS1 protein. J Virol. 2006 Jul; 80(13):6295-304.
      View in: PubMed
    32. Martinez-Sobrido L, Gitiban N, Fernandez-Sesma A, Cros J, Mertz SE, Jewell NA, Hammond S, Flano E, Durbin RK, García-Sastre A, Durbin JE. Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector. J Virol. 2006 Feb; 80(3):1130-9.
      View in: PubMed
    33. Falcón AM, Fernandez-Sesma A, Nakaya Y, Moran TM, Ortín J, García-Sastre A. Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins. J Gen Virol. 2005 Oct; 86(Pt 10):2817-21.
      View in: PubMed
    34. Vecino WH, Quanquin NM, Martinez-Sobrido L, Fernandez-Sesma A, García-Sastre A, Jacobs WR, Fennelly GJ. Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge. Virology. 2004 Aug 1; 325(2):192-9.
      View in: PubMed
    35. López CB, Moran TM, Schulman JL, Fernandez-Sesma A. Antiviral immunity and the role of dendritic cells. Int Rev Immunol. 2002 Jul-Oct; 21(4-5):339-53.
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    36. López CB, Fernandez-Sesma A, Schulman JL, Moran TM. Myeloid dendritic cells stimulate both Th1 and Th2 immune responses depending on the nature of the antigen. J Interferon Cytokine Res. 2001 Sep; 21(9):763-73.
      View in: PubMed
    37. López CB, Fernandez-Sesma A, Czelusniak SM, Schulman JL, Moran TM. A mouse model for immunization with ex vivo virus-infected dendritic cells. Cell Immunol. 2000 Dec 15; 206(2):107-15.
      View in: PubMed
    38. Durbin JE, Fernandez-Sesma A, Lee CK, Rao TD, Frey AB, Moran TM, Vukmanovic S, García-Sastre A, Levy DE. Type I IFN modulates innate and specific antiviral immunity. J Immunol. 2000 Apr 15; 164(8):4220-8.
      View in: PubMed
    39. Moran TM, Park H, Fernandez-Sesma A, Schulman JL. Th2 responses to inactivated influenza virus can Be converted to Th1 responses and facilitate recovery from heterosubtypic virus infection. J Infect Dis. 1999 Sep; 180(3):579-85.
      View in: PubMed
    40. Fernandez-Sesma A, Peluso RW, Bai X, Schulman JL, Levy DE, Moran TM. Superantigen-activated T cells redirected by a bispecific antibody inhibit vesicular stomatitis virus replication in vitro and in vivo. J Immunol. 1998 Feb 15; 160(4):1841-9.
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    41. Moran TM, Isobe H, Fernandez-Sesma A, Schulman JL. Interleukin-4 causes delayed virus clearance in influenza virus-infected mice. J Virol. 1996 Aug; 70(8):5230-5.
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    42. Fernandez-Sesma A, Schulman JL, Moran TM. A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro. J Virol. 1996 Jul; 70(7):4800-4.
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    43. Piccone ME, Fernandez-Sesma A, Palese P. Mutational analysis of the influenza virus vRNA promoter. Virus Res. 1993 May; 28(2):99-112.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067