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Calogera M. Simonaro

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentGenetics and Genomic Sciences
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA. Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med. 2013 Jun; 5(6):827-42.
      View in: PubMed
    2. Simonaro CM, Sachot S, Ge Y, He X, Deangelis VA, Eliyahu E, Leong DJ, Sun HB, Mason JB, Haskins ME, Richardson DW, Schuchman EH. Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells. PLoS One. 2013; 8(4):e62715.
      View in: PubMed
    3. Schuchman EH, Ge Y, Lai A, Borisov Y, Faillace M, Eliyahu E, He X, Iatridis J, Vlassara H, Striker G, Simonaro CM. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses. PLoS One. 2013; 8(1):e54459.
      View in: PubMed
    4. Schuchman EH, Simonaro CM. The genetics of sphingolipid hydrolases and sphingolipid storage diseases. Handb Exp Pharmacol. 2013; (215):3-32.
      View in: PubMed
    5. Lai A, Simonaro CM, Schuchman EH, Ge Y, Laudier DM, Iatridis JC. Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome). J Orthop Res. 2013 Apr; 31(4):621-31.
      View in: PubMed
    6. Gucev Z, Tasic V, Pop-Jordanova N, Jancevska A, Simonaro CM, Schuchmann EH. Two siblings with Niemann-Pick disease (NPD) type B: clinical findings and novel mutations of the acid sphingomyelinase gene. Indian J Pediatr. 2013 Feb; 80(2):163-4.
      View in: PubMed
    7. Eliyahu E, Wolfson T, Ge Y, Jepsen KJ, Schuchman EH, Simonaro CM. Anti-TNF-alpha therapy enhances the effects of enzyme replacement therapy in rats with mucopolysaccharidosis type VI. PLoS One. 2011; 6(8):e22447.
      View in: PubMed
    8. Desnick JP, Kim J, He X, Wasserstein MP, Simonaro CM, Schuchman EH. Identification and characterization of eight novel SMPD1 mutations causing types A and B Niemann-Pick disease. Mol Med. 2010 Jul-Aug; 16(7-8):316-21.
      View in: PubMed
    9. Simonaro CM. Cartilage and chondrocyte pathology in the mucopolysaccharidoses: The role of glycosaminoglycan-mediated inflammation. J Pediatr Rehabil Med. 2010; 3(2):85-8.
      View in: PubMed
    10. Simonaro CM, Ge Y, Eliyahu E, He X, Jepsen KJ, Schuchman EH. Involvement of the Toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses. Proc Natl Acad Sci U S A. 2010 Jan 5; 107(1):222-7.
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    11. Simonaro CM, D'Angelo M, He X, Eliyahu E, Shtraizent N, Haskins ME, Schuchman EH. Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases. Am J Pathol. 2008 Jan; 172(1):112-22.
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    12. Fotoulaki M, Schuchman EH, Simonaro CM, Augoustides-Savvopoulou P, Michelakakis H, Panagopoulou P, Varlamis G, Nousia-Arvanitakis S. Acid sphingomyelinase-deficient Niemann-Pick disease: novel findings in a Greek child. J Inherit Metab Dis. 2007 Nov; 30(6):986.
      View in: PubMed
    13. Wasserstein MP, Aron A, Brodie SE, Simonaro C, Desnick RJ, McGovern MM. Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease. J Pediatr. 2006 Oct; 149(4):554-9.
      View in: PubMed
    14. Simonaro CM, Park JH, Eliyahu E, Shtraizent N, McGovern MM, Schuchman EH. Imprinting at the SMPD1 locus: implications for acid sphingomyelinase-deficient Niemann-Pick disease. Am J Hum Genet. 2006 May; 78(5):865-70.
      View in: PubMed
    15. Simonaro CM, D'Angelo M, Haskins ME, Schuchman EH. Joint and bone disease in mucopolysaccharidoses VI and VII: identification of new therapeutic targets and biomarkers using animal models. Pediatr Res. 2005 May; 57(5 Pt 1):701-7.
      View in: PubMed
    16. Simonaro CM, Desnick RJ, McGovern MM, Wasserstein MP, Schuchman EH. The demographics and distribution of type B Niemann-Pick disease: novel mutations lead to new genotype/phenotype correlations. Am J Hum Genet. 2002 Dec; 71(6):1413-9.
      View in: PubMed
    17. Li CM, Park JH, Simonaro CM, He X, Gordon RE, Friedman AH, Ehleiter D, Paris F, Manova K, Hepbildikler S, Fuks Z, Sandhoff K, Kolesnick R, Schuchman EH, Hepbiloikler S. Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics. 2002 Feb; 79(2):218-24.
      View in: PubMed
    18. Simonaro CM, Haskins ME, Schuchman EH. Articular chondrocytes from animals with a dermatan sulfate storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidoses. Lab Invest. 2001 Sep; 81(9):1319-28.
      View in: PubMed
    19. Miranda SR, He X, Simonaro CM, Gatt S, Dagan A, Desnick RJ, Schuchman EH. Infusion of recombinant human acid sphingomyelinase into niemann-pick disease mice leads to visceral, but not neurological, correction of the pathophysiology. FASEB J. 2000 Oct; 14(13):1988-95.
      View in: PubMed
    20. He X, Li CM, Simonaro CM, Wan Q, Haskins ME, Desnick RJ, Schuchman EH. Identification and characterization of the molecular lesion causing mucopolysaccharidosis type I in cats. Mol Genet Metab. 1999 Jun; 67(2):106-12.
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    21. Simonaro CM, Haskins ME, Abkowitz JL, Brooks DA, Hopwood JJ, Zhang J, Schuchman EH. Autologous transplantation of retrovirally transduced bone marrow or neonatal blood cells into cats can lead to long-term engraftment in the absence of myeloablation. Gene Ther. 1999 Jan; 6(1):107-13.
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    22. Simonaro CM, Haskins ME, Kunieda T, Evans SM, Visser JW, Schuchman EH. Bone marrow transplantation in newborn rats with mucopolysaccharidosis type VI: biochemical, pathological, and clinical findings. Transplantation. 1997 May 27; 63(10):1386-93.
      View in: PubMed
    23. Fillat C, Simonaro CM, Yeyati PL, Abkowitz JL, Haskins ME, Schuchman EH. Arylsulfatase B activities and glycosaminoglycan levels in retrovirally transduced mucopolysaccharidosis type VI cells. Prospects for gene therapy. J Clin Invest. 1996 Jul 15; 98(2):497-502.
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    24. Palmeri MA, Chianchiano N, Simonaro C, Perino A. [The role of heparin sulfate in the treatment of pregnant women with circulatory deficiency syndrome]. Minerva Ginecol. 1996 Mar; 48(3):119-23.
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    25. Simonaro CM, Schuchman EH. N-acetylgalactosamine-4-sulfatase: identification of four new mutations within the conserved sulfatase region causing mucopolysaccharidosis type VI. Biochim Biophys Acta. 1995 Dec 12; 1272(3):129-32.
      View in: PubMed
    26. Kunieda T, Simonaro CM, Yoshida M, Ikadai H, Levan G, Desnick RJ, Schuchman EH. Mucopolysaccharidosis type VI in rats: isolation of cDNAs encoding arylsulfatase B, chromosomal localization of the gene, and identification of the mutation. Genomics. 1995 Oct 10; 29(3):582-7.
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    27. Perino A, Chianchiano N, Simonaro C, Cittadini E. Endoscopic management of a case of 'complete septate uterus with unilateral haematometra'. Hum Reprod. 1995 Aug; 10(8):2171-3.
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    28. Palermo R, Simonaro C, Albano C. Endocrine causes of recurrent spontaneous abortion (RSA). Acta Eur Fertil. 1994 May-Jun; 25(3):177-86.
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    29. Palermo R, Benigno MA, Napoli P, Perino A, Simonaro C. Immunological recurrent spontaneous abortion. Acta Eur Fertil. 1994 Mar-Apr; 25(2):111-8.
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    30. Palermo R, Simonaro C, Carlino L, Ubaldi F, Albano C. Operative laparoscopy in assisted reproduction. Acta Eur Fertil. 1992 Jul-Aug; 23(4):187-9.
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    31. Chianchiano N, Rossi C, Bertolino G, Simonaro C, Perino A, Cittadini E. Uteroplacental blood flow in pregnant women with hypertension and recurrent spontaneous abortion. Acta Eur Fertil. 1991 May-Jun; 22(3):151-2.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067