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Mihaly Mezei

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentStructural and Chemical Biology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jin YJ, Cai CY, Mezei M, Ohlmeyer M, Sanchez R, Burakoff SJ. Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation. AIDS Res Hum Retroviruses. 2013 Apr; 29(4):725-31.
      View in: PubMed
    2. Beveridge DL, Cheatham TE, Mezei M. The ABCs of molecular dynamics simulations on B-DNA, circa 2012. J Biosci. 2012 Jul; 37(3):379-97.
      View in: PubMed
    3. Dixit SB, Mezei M, Beveridge DL. Studies of base pair sequence effects on DNA solvation based on all-atom molecular dynamics simulations. J Biosci. 2012 Jul; 37(3):399-421.
      View in: PubMed
    4. Meng XY, Xu Y, Zhang HX, Mezei M, Cui M. Predicting protein interactions by Brownian dynamics simulations. J Biomed Biotechnol. 2012; 2012:121034.
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    5. Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 2011; 6(9):e23679.
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    6. Meng XY, Zhang HX, Mezei M, Cui M. Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput Aided Drug Des. 2011 Jun; 7(2):146-57.
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    7. Mezei M. Discriminatory power of stoichiometry-driven protein folding? J Biomol Struct Dyn. 2011 Feb; 28(4):625-6; discussion 669-674.
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    8. Mezei M. Simulaid: a simulation facilitator and analysis program. J Comput Chem. 2010 Nov 15; 31(14):2658-68.
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    9. Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL. Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15151-6.
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    10. Eichenbaum KD, Rodríguez Y, Mezei M, Osman R. The energetics of the acetylation switch in p53-mediated transcriptional activation. Proteins. 2010 Feb 1; 78(2):447-56.
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    11. Lupyan D, Mezei M, Logothetis DE, Osman R. A molecular dynamics investigation of lipid bilayer perturbation by PIP2. Biophys J. 2010 Jan 20; 98(2):240-7.
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    12. Mezei M, Zhou MM. Dockres: a computer program that analyzes the output of virtual screening of small molecules. Source Code Biol Med. 2010; 5:2.
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    13. Chaurasia P, Mezei M, Zhou MM, Ossowski L. Computer aided identification of small molecules disrupting uPAR/alpha5beta1--integrin interaction: a new paradigm for metastasis prevention. PLoS One. 2009; 4(2):e4617.
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    14. Rodríguez Y, Mezei M, Osman R. The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study. Biochemistry. 2008 Dec 16; 47(50):13267-78.
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    15. Cui M, Mezei M, Osman R. Prediction of protein loop structures using a local move Monte Carlo approach and a grid-based force field. Protein Eng Des Sel. 2008 Dec; 21(12):729-35.
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    16. Buku A, Keselman I, Lupyan D, Mezei M, Price JA. Effective mast cell degranulating peptide inhibitors of the IgE/Fc epsilonRI receptor interaction. Chem Biol Drug Des. 2008 Aug; 72(2):133-9.
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    17. Gagnidze K. Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem. 2008 Jun 26; 51(12):3378-87.
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    18. Cunha L, Kuti M, Bishop DF, Mezei M, Zeng L, Zhou MM, Desnick RJ. Human uroporphyrinogen III synthase: NMR-based mapping of the active site. Proteins. 2008 May 1; 71(2):855-73.
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    19. Cui M, Mezei M, Osman R. Modeling dimerizations of transmembrane proteins using Brownian dynamics simulations. J Comput Aided Mol Des. 2008 Aug; 22(8):553-61.
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    20. Mezei M, Zhou MM. Pspace: a program that assesses protein space. Source Code Biol Med. 2007; 2:6.
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    21. Kentsis A, Gindin T, Mezei M, Osman R. Calculation of the free energy and cooperativity of protein folding. PLoS One. 2007; 2(5):e446.
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    22. Pan C, Mezei M, Mujtaba S, Muller M, Zeng L, Li J, Wang Z, Zhou MM. Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor. J Med Chem. 2007 May 17; 50(10):2285-8.
      View in: PubMed
    23. Rodríguez Y, Mezei M, Osman R. Association free energy of dipalmitoylphosphatidylserines in a mixed dipalmitoylphosphatidylcholine membrane. Biophys J. 2007 May 1; 92(9):3071-80.
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    24. Mezei M, Jedlovszky P. Statistical thermodynamics through computer simulation to characterize phospholipid interactions in membranes. Methods Mol Biol. 2007; 400:127-44.
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    25. Mezei M, Filizola M. TRAJELIX: a computational tool for the geometric characterization of protein helices during molecular dynamics simulations. J Comput Aided Mol Des. 2006 Feb; 20(2):97-107.
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    26. Kentsis A, Mezei M, Osman R. Origin of the sequence-dependent polyproline II structure in unfolded peptides. Proteins. 2005 Dec 1; 61(4):769-76.
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    27. Buku A, Condie BA, Price JA, Mezei M. [Ala12]MCD peptide: a lead peptide to inhibitors of immunoglobulin E binding to mast cell receptors. J Pept Res. 2005 Sep; 66(3):132-7.
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    28. Alinchenko MG, Voloshin VP, Medvedev NN, Mezei M, Pártay L, Jedlovszky P. Effect of cholesterol on the properties of phospholipid membranes. 4. Interatomic voids. J Phys Chem B. 2005 Sep 1; 109(34):16490-502.
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    29. Fuxreiter M, Mezei M, Simon I, Osman R. Interfacial water as a "hydration fingerprint" in the noncognate complex of BamHI. Biophys J. 2005 Aug; 89(2):903-11.
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    30. Fleming PJ, Fitzkee NC, Mezei M, Srinivasan R, Rose GD. A novel method reveals that solvent water favors polyproline II over beta-strand conformation in peptides and unfolded proteins: conditional hydrophobic accessible surface area (CHASA). Protein Sci. 2005 Jan; 14(1):111-8.
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    31. Kentsis A, Mezei M, Gindin T, Osman R. Unfolded state of polyalanine is a segmented polyproline II helix. Proteins. 2004 May 15; 55(3):493-501.
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    32. Mezei M, Fleming PJ, Srinivasan R, Rose GD. Polyproline II helix is the preferred conformation for unfolded polyalanine in water. Proteins. 2004 May 15; 55(3):502-7.
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    33. Mezei M. A novel fingerprint for the characterization of protein folds. Protein Eng. 2003 Oct; 16(10):713-5.
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    34. Mezei M. A new method for mapping macromolecular topography. J Mol Graph Model. 2003 Mar; 21(5):463-72.
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    35. Kentsis A, Mezei M, Osman R. MC-PHS: a Monte Carlo implementation of the primary hydration shell for protein folding and design. Biophys J. 2003 Feb; 84(2 Pt 1):805-15.
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    36. Mezei M, Guarnieri F. Computer simulation studies of the fully solvated wild-type and mutated GnRH in extended and beta-turn conformations. J Biomol Struct Dyn. 1998 Dec; 16(3):723-32.
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    37. Mezei M. Chameleon sequences in the PDB. Protein Eng. 1998 Jun; 11(6):411-4.
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    38. Resat H, Maye PV, Mezei M. The sensitivity of conformational free energies of the alanine dipeptide to atomic site charges. Biopolymers. 1997 Jan; 41(1):73-81.
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    39. Resat H, Mezei M. Grand canonical ensemble Monte Carlo simulation of the dCpG/proflavine crystal hydrate. Biophys J. 1996 Sep; 71(3):1179-90.
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    40. Mezei M. A heuristic procedure for the detection of locally similar substructures of two equivalent structures. Protein Eng. 1994 Mar; 7(3):331-3.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067