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Last Name
Institution

Gregory A. Elder

TitleRESEARCH PROFESSOR
InstitutionMount Sinai
DepartmentPsychiatry
Address
    Other Positions
    TitleRESEARCH PROFESSOR (PENDING)
    InstitutionMount Sinai
    DepartmentNeurology


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sosa MA, De Gasperi R, Paulino AJ, Pricop PE, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Janssen WG, Yuk FJ, Dorr NP, Dickstein DL, McCarron RM, Chavko M, Hof PR, Ahlers ST, Elder GA. Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury. Acta Neuropathol Commun. 2013; 1(1):51.
      View in: PubMed
    2. De Gasperi R, Gama Sosa MA, Kim SH, Steele JW, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Dekosky ST, McCarron RM, Nambiar MP, Gandy S, Ahlers ST, Elder GA. Acute blast injury reduces brain abeta in two rodent species. Front Neurol. 2012; 3:177.
      View in: PubMed
    3. De Gasperi R, Gama Sosa MA, Elder GA. Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells. BMC Biochem. 2012; 13:28.
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    4. Elder GA, Dorr NP, De Gasperi R, Gama Sosa MA, Shaughness MC, Maudlin-Jeronimo E, Hall AA, McCarron RM, Ahlers ST. Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild traumatic brain injury. J Neurotrauma. 2012 Nov 1; 29(16):2564-75.
      View in: PubMed
    5. Buxbaum JD, Betancur C, Bozdagi O, Dorr NP, Elder GA, Hof PR. Optimizing the phenotyping of rodent ASD models: enrichment analysis of mouse and human neurobiological phenotypes associated with high-risk autism genes identifies morphological, electrophysiological, neurological, and behavioral features. Mol Autism. 2012; 3(1):1.
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    6. Gama Sosa MA, De Gasperi R, Elder GA. Modeling human neurodegenerative diseases in transgenic systems. Hum Genet. 2012 Apr; 131(4):535-63.
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    7. Takahashi N, Sakurai T, Bozdagi-Gunal O, Dorr NP, Moy J, Krug L, Gama-Sosa M, Elder GA, Koch RJ, Walker RH, Hof PR, Davis KL, Buxbaum JD. Increased expression of receptor phosphotyrosine phosphatase-ß/? is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes. Transl Psychiatry. 2011; 1:e8.
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    8. Sakurai T, Dorr NP, Takahashi N, McInnes LA, Elder GA, Buxbaum JD. Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions. Autism Res. 2011 Feb; 4(1):28-39.
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    9. Elder GA, Mitsis EM, Ahlers ST, Cristian A. Blast-induced mild traumatic brain injury. Psychiatr Clin North Am. 2010 Dec; 33(4):757-81.
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    10. De Gasperi R, Sosa MA, Dracheva S, Elder GA. Presenilin-1 regulates induction of hypoxia inducible factor-1a: altered activation by a mutation associated with familial Alzheimer's disease. Mol Neurodegener. 2010; 5:38.
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    11. Hof PR, Elder GA. Introduction to the special issue of brain structure and function on transgenic modeling of neurodegenerative disorders. Brain Struct Funct. 2010 Mar; 214(2-3):89-90.
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    12. Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z. Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J Neurosci. 2010 Feb 3; 30(5):1788-97.
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    13. Elder GA, Gama Sosa MA, De Gasperi R. Transgenic mouse models of Alzheimer's disease. Mt Sinai J Med. 2010 Jan-Feb; 77(1):69-81.
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    14. Sakurai T, Ramoz N, Barreto M, Gazdoiu M, Takahashi N, Gertner M, Dorr N, Gama Sosa MA, De Gasperi R, Perez G, Schmeidler J, Mitropoulou V, Le HC, Lupu M, Hof PR, Elder GA, Buxbaum JD. Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders. Biol Psychiatry. 2010 May 1; 67(9):887-94.
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    15. Gama Sosa MA, Gasperi RD, Rocher AB, Wang AC, Janssen WG, Flores T, Perez GM, Schmeidler J, Dickstein DL, Hof PR, Elder GA. Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations. Am J Pathol. 2010 Jan; 176(1):353-68.
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    16. Gama Sosa MA, De Gasperi R, Elder GA. Animal transgenesis: an overview. Brain Struct Funct. 2010 Mar; 214(2-3):91-109.
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    17. Elder GA, Gama Sosa MA, De Gasperi R, Dickstein DL, Hof PR. Presenilin transgenic mice as models of Alzheimer's disease. Brain Struct Funct. 2010 Mar; 214(2-3):127-43.
      View in: PubMed
    18. Franciosi S, Gama Sosa MA, English DF, Oler E, Oung T, Janssen WG, De Gasperi R, Schmeidler J, Dickstein DL, Schmitz C, Gandy S, Hof PR, Buxbaum JD, Elder GA. Novel cerebrovascular pathology in mice fed a high cholesterol diet. Mol Neurodegener. 2009; 4:42.
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    19. Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Gill H, Raoof S, De Gasperi R, Elder G, Kessaris N, Richardson WD, Malas S. SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch. Biochem Biophys Res Commun. 2009 Dec 25; 390(4):1114-20.
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    20. Eder-Colli L, Abad-Estarlich N, Pannetier C, Vallet PG, Walzer C, Elder GA, Robakis NK, Bouras C, Savioz A. The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells. Brain Res Bull. 2009 Oct 28; 80(4-5):296-301.
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    21. Elder GA, Cristian A. Blast-related mild traumatic brain injury: mechanisms of injury and impact on clinical care. Mt Sinai J Med. 2009 Apr; 76(2):111-8.
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    22. Silverman JM, Beeri MS, Schmeidler J, Rosendorff C, Angelo G, Mavris RS, Grossman HT, Elder GA, Carrion-Baralt J, West R. C-reactive protein and memory function suggest antagonistic pleiotropy in very old nondemented subjects. Age Ageing. 2009 Mar; 38(2):237-41.
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    23. De Gasperi R, Gama Sosa MA, Wen PH, Li J, Perez GM, Curran T, Elder GA. Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling. Dev Dyn. 2008 Sep; 237(9):2405-14.
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    24. De Gasperi R, Rocher AB, Sosa MA, Wearne SL, Perez GM, Friedrich VL, Hof PR, Elder GA. The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ. Genesis. 2008 Jun; 46(6):308-17.
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    25. Elder GA, Ragnauth A, Dorr N, Franciosi S, Schmeidler J, Haroutunian V, Buxbaum JD. Increased locomotor activity in mice lacking the low-density lipoprotein receptor. Behav Brain Res. 2008 Aug 22; 191(2):256-65.
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    26. Gama Sosa MA, De Gasperi R, Rocher AB, Perez GM, Simons K, Cruz DE, Hof PR, Elder GA. Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact. Cell Res. 2007 Jul; 17(7):619-26.
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    27. Elder GA, Cho JY, English DF, Franciosi S, Schmeidler J, Sosa MA, Gasperi RD, Fisher EA, Mathews PM, Haroutunian V, Buxbaum JD. Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor. J Neurochem. 2007 Aug; 102(4):1220-31.
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    28. Franciosi S, De Gasperi R, Dickstein DL, English DF, Rocher AB, Janssen WG, Christoffel D, Sosa MA, Hof PR, Buxbaum JD, Elder GA. Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brain. J Neurosci Methods. 2007 Jun 15; 163(1):76-82.
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    29. Elder GA, De Gasperi R, Gama Sosa MA. Research update: neurogenesis in adult brain and neuropsychiatric disorders. Mt Sinai J Med. 2006 Nov; 73(7):931-40.
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    30. Wen PH, De Gasperi R, Sosa MA, Rocher AB, Friedrich VL, Hof PR, Elder GA. Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice. Development. 2005 Sep; 132(17):3873-83.
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    31. Shu W, Cho JY, Jiang Y, Zhang M, Weisz D, Elder GA, Schmeidler J, De Gasperi R, Sosa MA, Rabidou D, Santucci AC, Perl D, Morrisey E, Buxbaum JD. Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proc Natl Acad Sci U S A. 2005 Jul 5; 102(27):9643-8.
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    32. Wen PH, De Gasperi R, Gama Sosa MA, Elder GA. Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice. Neurosci Lett. 2004 Nov 23; 371(2-3):249-54.
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    33. De Gasperi R, Friedrich VL, Perez GM, Senturk E, Wen PH, Kelley K, Elder GA, Gama Sosa MA. Transgenic rescue of Krabbe disease in the twitcher mouse. Gene Ther. 2004 Aug; 11(15):1188-94.
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    34. Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol. 2004 Aug; 188(2):224-37.
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    35. Gama Sosa MA, Wen PH, De Gasperi R, Perez GM, Senturk E, Friedrich VL, Elder GA. Entorhinal cortex lesioning promotes neurogenesis in the hippocampus of adult mice. Neuroscience. 2004; 127(4):881-91.
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    36. Gama Sosa MA, Friedrich VL, DeGasperi R, Kelley K, Wen PH, Senturk E, Lazzarini RA, Elder GA. Human midsized neurofilament subunit induces motor neuron disease in transgenic mice. Exp Neurol. 2003 Nov; 184(1):408-19.
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    37. Gama SM, De Gasperi R, Wen PH, Gonzalez EA, Kelley K, Lazzarini RA, Elder GA. BAC and PAC DNA for the generation of transgenic animals. Biotechniques. 2002 Jul; 33(1):51-3.
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    38. Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiol Dis. 2002 Jun; 10(1):8-19.
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    39. Wen PH, Friedrich VL, Shioi J, Robakis NK, Elder GA. Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice. Neurosci Lett. 2002 Jan 25; 318(2):53-6.
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    40. Elder GA, Friedrich VL, Lazzarini RA. Schwann cells and oligodendrocytes read distinct signals in establishing myelin sheath thickness. J Neurosci Res. 2001 Sep 15; 65(6):493-9.
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    41. Elder GA, Friedrich VL, Chu K, Lazzarini RA. Presence of unmyelinated axons in the lumbar ventral roots of the 129 mouse strain. Neurosci Lett. 2000 Jun 23; 287(2):101-4.
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    42. Elder GA, Friedrich VL, Margita A, Lazzarini RA. Age-related atrophy of motor axons in mice deficient in the mid-sized neurofilament subunit. J Cell Biol. 1999 Jul 12; 146(1):181-92.
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    43. Elder GA, Friedrich VL, Pereira D, Tu PH, Zhang B, Lee VM, Lazzarini RA. Mice with disrupted midsized and heavy neurofilament genes lack axonal neurofilaments but have unaltered numbers of axonal microtubules. J Neurosci Res. 1999 Jul 1; 57(1):23-32.
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    44. Elder GA, Friedrich VL, Kang C, Bosco P, Gourov A, Tu PH, Zhang B, Lee VM, Lazzarini RA. Requirement of heavy neurofilament subunit in the development of axons with large calibers. J Cell Biol. 1998 Oct 5; 143(1):195-205.
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    45. Elder GA, Friedrich VL, Bosco P, Kang C, Gourov A, Tu PH, Lee VM, Lazzarini RA. Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content. J Cell Biol. 1998 May 4; 141(3):727-39.
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    46. Carter J, Gragerov A, Konvicka K, Elder G, Weinstein H, Lazzarini RA. Neurofilament (NF) assembly; divergent characteristics of human and rodent NF-L subunits. J Biol Chem. 1998 Feb 27; 273(9):5101-8.
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    47. Haroutunian V, Zhou Y, Elder G, Li C, Lazzarini RA. Age-dependent spatial memory deficits in transgenic mice expressing the human mid-sized neurofilament gene: I. Brain Res Mol Brain Res. 1996 Nov; 42(1):62-70.
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    48. Elder GA, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, Johnston JM, Efthimiopoulos S, Friedrich VL, Robakis NK. Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. J Neurosci Res. 1996 Aug 1; 45(3):308-20.
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    49. Tu PH, Elder G, Lazzarini RA, Nelson D, Trojanowski JQ, Lee VM. Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits. J Cell Biol. 1995 Jun; 129(6):1629-40.
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    50. Elder GA, Friedrich VL, Liang Z, Li X, Lazzarini RA. Enhancer trapping by a human mid-sized neurofilament transgene reveals unexpected patterns of neuronal enhancer activity. Brain Res Mol Brain Res. 1994 Oct; 26(1-2):177-88.
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    51. Vickers JC, Morrison JH, Friedrich VL, Elder GA, Perl DP, Katz RN, Lazzarini RA. Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit. J Neurosci. 1994 Sep; 14(9):5603-12.
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    52. Elder GA, Liang Z, Li C, Lazzarini RA. Targeting of Sp1 to a non-Sp1 site in the human neurofilament (H) promoter via an intermediary DNA-binding protein. Nucleic Acids Res. 1992 Dec 11; 20(23):6281-5.
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    53. Elder GA, Liang Z, Lee N, Friedrich VL, Lazzarini RA. Novel DNA binding proteins participate in the regulation of human neurofilament H gene expression. Brain Res Mol Brain Res. 1992 Sep; 15(1-2):85-98.
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    54. Lee VM, Elder GA, Chen LC, Liang Z, Snyder SE, Friedrich VL, Lazzarini RA. Expression of human mid-sized neurofilament subunit in transgenic mice. Brain Res Mol Brain Res. 1992 Sep; 15(1-2):76-84.
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    55. Elder GA, Liang Z, Snyder SE, Lazzarini RA. Multiple nuclear factors interact with the promoter of the human neurofilament M gene. Brain Res Mol Brain Res. 1992 Sep; 15(1-2):99-107.
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    56. Major EO, Amemiya K, Elder G, Houff SA. Glial cells of the human developing brain and B cells of the immune system share a common DNA binding factor for recognition of the regulatory sequences of the human polyomavirus, JCV. J Neurosci Res. 1990 Dec; 27(4):461-71.
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    57. Elder GA, Major EO. Early appearance of type II astrocytes in developing human fetal brain. Brain Res. 1988 Jul 1; 470(1):146-50.
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    58. de Verneuil H, Hansen J, Picat C, Grandchamp B, Kushner J, Roberts A, Elder G, Nordmann Y. Prevalence of the 281 (Gly----Glu) mutation in hepatoerythropoietic porphyria and porphyria cutanea tarda. Hum Genet. 1988 Jan; 78(1):101-2.
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    59. Elder GA, Sever JL. AIDS and neurological disorders: an overview. Ann Neurol. 1988; 23 Suppl:S4-6.
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    60. Elder GA, Potts BJ, Sawyer M. Characterization of glial subpopulations in cultures of the ovine central nervous system. Glia. 1988; 1(5):317-27.
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    61. Elder GA, Potts BJ. Multiple neural cell types are infected in vitro by border disease virus. J Neuropathol Exp Neurol. 1987 Nov; 46(6):653-67.
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    62. Stuart A, McComas AJ, Goldspink G, Elder G. Electrophysiologic features of muscle regeneration. Exp Neurol. 1981 Oct; 74(1):148-59.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067