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Last Name
Institution

Pullanipally Shashidharan

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentNeurology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Armata IA, Diplas AI, Ozelius LJ, Shashidharan P. Allelic Imbalance in TOR1A mRNA Expression in Manifesting and Non-Manifesting Carriers of the GAG-Deletion. J Nucleic Acids. 2012; 2012:985260.
      View in: PubMed
    2. Nambu A, Chiken S, Shashidharan P, Nishibayashi H, Ogura M, Kakishita K, Tanaka S, Tachibana Y, Kita H, Itakura T. Reduced pallidal output causes dystonia. Front Syst Neurosci. 2011; 5:89.
      View in: PubMed
    3. Giannakopoulou D, Armata I, Mitsacos A, Shashidharan P, Giompres P. Modulation of the basal ganglia dopaminergic system in a transgenic mouse exhibiting dystonia-like features. J Neural Transm. 2010 Dec; 117(12):1401-9.
      View in: PubMed
    4. Lange N, Hamann M, Shashidharan P, Richter A. Behavioural and pharmacological examinations in a transgenic mouse model of early-onset torsion dystonia. Pharmacol Biochem Behav. 2011 Feb; 97(4):647-55.
      View in: PubMed
    5. Bao L, Patel JC, Walker RH, Shashidharan P, Rice ME. Dysregulation of striatal dopamine release in a mouse model of dystonia. J Neurochem. 2010 Sep; 114(6):1781-91.
      View in: PubMed
    6. Chiken S, Shashidharan P, Nambu A. Cortically evoked long-lasting inhibition of pallidal neurons in a transgenic mouse model of dystonia. J Neurosci. 2008 Dec 17; 28(51):13967-77.
      View in: PubMed
    7. Armata IA, Ananthanarayanan M, Balasubramaniyan N, Shashidharan P. Regulation of DYT1 gene expression by the Ets family of transcription factors. J Neurochem. 2008 Aug; 106(3):1052-65.
      View in: PubMed
    8. Holton JL, Schneider SA, Ganesharajah T, Gandhi S, Strand C, Shashidharan P, Barreto J, Wood NW, Lees AJ, Bhatia KP, Revesz T. Neuropathology of primary adult-onset dystonia. Neurology. 2008 Feb 26; 70(9):695-9.
      View in: PubMed
    9. Shashidharan P, Sandu D, Potla U, Armata IA, Walker RH, McNaught KS, Weisz D, Sreenath T, Brin MF, Olanow CW. Transgenic mouse model of early-onset DYT1 dystonia. Hum Mol Genet. 2005 Jan 1; 14(1):125-33.
      View in: PubMed
    10. Torres GE, Sweeney AL, Beaulieu JM, Shashidharan P, Caron MG. Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant. Proc Natl Acad Sci U S A. 2004 Nov 2; 101(44):15650-5.
      View in: PubMed
    11. McNaught KS, Kapustin A, Jackson T, Jengelley TA, Jnobaptiste R, Shashidharan P, Perl DP, Pasik P, Olanow CW. Brainstem pathology in DYT1 primary torsion dystonia. Ann Neurol. 2004 Oct; 56(4):540-7.
      View in: PubMed
    12. Mytilineou C, McNaught KS, Shashidharan P, Yabut J, Baptiste RJ, Parnandi A, Olanow CW. Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stress. J Neural Transm. 2004 Oct; 111(10-11):1237-51.
      View in: PubMed
    13. Shashidharan P, Paris N, Sandu D, Karthikeyan L, McNaught KS, Walker RH, Olanow CW. Overexpression of torsinA in PC12 cells protects against toxicity. J Neurochem. 2004 Feb; 88(4):1019-25.
      View in: PubMed
    14. Walker RH, Shashidharan P. Developments in the molecular biology of DYT1 dystonia. Mov Disord. 2003 Oct; 18(10):1102-7.
      View in: PubMed
    15. Walker RH, Good PF, Shashidharan P. TorsinA immunoreactivity in inclusion bodies in trinucleotide repeat diseases. Mov Disord. 2003 Sep; 18(9):1041-4.
      View in: PubMed
    16. McNaught KS, Shashidharan P, Perl DP, Jenner P, Olanow CW. Aggresome-related biogenesis of Lewy bodies. Eur J Neurosci. 2002 Dec; 16(11):2136-48.
      View in: PubMed
    17. Walker RH, Morgello S, Davidoff-Feldman B, Melnick A, Walsh MJ, Shashidharan P, Brin MF. Autosomal dominant chorea-acanthocytosis with polyglutamine-containing neuronal inclusions. Neurology. 2002 Apr 9; 58(7):1031-7.
      View in: PubMed
    18. McNaught KS, Mytilineou C, Jnobaptiste R, Yabut J, Shashidharan P, Jennert P, Olanow CW. Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures. J Neurochem. 2002 Apr; 81(2):301-6.
      View in: PubMed
    19. Walker RH, Brin MF, Sandu D, Good PF, Shashidharan P. TorsinA immunoreactivity in brains of patients with DYT1 and non-DYT1 dystonia. Neurology. 2002 Jan 8; 58(1):120-4.
      View in: PubMed
    20. Walker RH, Brin MF, Sandu D, Gujjari P, Hof PR, Warren Olanow C, Shashidharan P. Distribution and immunohistochemical characterization of torsinA immunoreactivity in rat brain. Brain Res. 2001 May 11; 900(2):348-54.
      View in: PubMed
    21. Plaitakis A, Metaxari M, Shashidharan P. Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function. J Neurochem. 2000 Nov; 75(5):1862-9.
      View in: PubMed
    22. Shashidharan P, Good PF, Hsu A, Perl DP, Brin MF, Olanow CW. TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease. Brain Res. 2000 Sep 22; 877(2):379-81.
      View in: PubMed
    23. Plaitakis A, Shashidharan P. Glutamate transport and metabolism in dopaminergic neurons of substantia nigra: implications for the pathogenesis of Parkinson's disease. J Neurol. 2000 Apr; 247 Suppl 2:II25-35.
      View in: PubMed
    24. Shashidharan P, Kramer BC, Walker RH, Olanow CW, Brin MF. Immunohistochemical localization and distribution of torsinA in normal human and rat brain. Brain Res. 2000 Jan 24; 853(2):197-206.
      View in: PubMed
    25. Shashidharan P, Chalmers-Redman RM, Carlile GW, Rodic V, Gurvich N, Yuen T, Tatton WG, Sealfon SC. Nuclear translocation of GAPDH-GFP fusion protein during apoptosis. Neuroreport. 1999 Apr 6; 10(5):1149-53.
      View in: PubMed
    26. Shashidharan P, Huntley GW, Murray JM, Buku A, Moran T, Walsh MJ, Morrison JH, Plaitakis A. Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody. Brain Res. 1997 Oct 31; 773(1-2):139-48.
      View in: PubMed
    27. Shashidharan P, Clarke DD, Ahmed N, Moschonas N, Plaitakis A. Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP. J Neurochem. 1997 May; 68(5):1804-11.
      View in: PubMed
    28. Tzagournissakis M, Fesdjian CO, Shashidharan P, Plaitakis A. Stability of the Huntington disease (CAG)n repeat in a late onset form occuring on the Island of Crete. Hum Mol Genet. 1995 Dec; 4(12):2239-43.
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    29. Shashidharan P, Huntley GW, Meyer T, Morrison JH, Plaitakis A. Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain. Brain Res. 1994 Oct 31; 662(1-2):245-50.
      View in: PubMed
    30. Shashidharan P, Michaelidis TM, Robakis NK, Kresovali A, Papamatheakis J, Plaitakis A. Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. J Biol Chem. 1994 Jun 17; 269(24):16971-6.
      View in: PubMed
    31. Shashidharan P, Wittenberg I, Plaitakis A. Molecular cloning of human brain glutamate/aspartate transporter II. Biochim Biophys Acta. 1994 May 11; 1191(2):393-6.
      View in: PubMed
    32. Shashidharan P, Plaitakis A. Cloning and characterization of a glutamate transporter cDNA from human cerebellum. Biochim Biophys Acta. 1993 Oct 19; 1216(1):161-4.
      View in: PubMed
    33. Plaitakis A, Flessas P, Natsiou AB, Shashidharan P. Glutamate dehydrogenase deficiency in cerebellar degenerations: clinical, biochemical and molecular genetic aspects. Can J Neurol Sci. 1993 May; 20 Suppl 3:S109-16.
      View in: PubMed
    34. Shashidharan P, Ramachandran LK. Stabilisation of bacterial protoplasts by cardiotoxin II. Indian J Biochem Biophys. 1984 Oct; 21(5):304-8.
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    35. Shashidharan P, Ramachandran LK. Inhibitory activity of cardiotoxin II of the Indian cobra & certain antibiotics on lysis of bacteria promoted by lysozyme. Indian J Biochem Biophys. 1983 Jun; 20(3):132-5.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067