Keywords
Last Name
Institution

Roman Osman

TitlePROFESSOR
InstitutionMount Sinai
DepartmentStructural and Chemical Biology
Address
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentPharmacology and Systems Therapeutics


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Joseph TT, Osman R. Convergent transmission of RNAi guide-target mismatch information across Argonaute internal allosteric network. PLoS Comput Biol. 2012; 8(9):e1002693.
      View in: PubMed
    2. Joseph TT, Osman R. Thermodynamic basis of selectivity in guide-target-mismatched RNA interference. Proteins. 2012 May; 80(5):1283-98.
      View in: PubMed
    3. Gerona-Navarro G. Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors. J Am Chem Soc. 2011 Feb 23; 133(7):2040-3.
      View in: PubMed
    4. Menconi F, Osman R, Monti MC, Greenberg DA, Concepcion ES, Tomer Y. Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):16899-903.
      View in: PubMed
    5. Menconi F, Huber A, Osman R, Concepcion E, Jacobson EM, Stefan M, David CS, Tomer Y. Tg.2098 is a major human thyroglobulin T-cell epitope. J Autoimmun. 2010 Aug; 35(1):45-51.
      View in: PubMed
    6. Eichenbaum KD, Rodríguez Y, Mezei M, Osman R. The energetics of the acetylation switch in p53-mediated transcriptional activation. Proteins. 2010 Feb 1; 78(2):447-56.
      View in: PubMed
    7. Lupyan D, Mezei M, Logothetis DE, Osman R. A molecular dynamics investigation of lipid bilayer perturbation by PIP2. Biophys J. 2010 Jan 20; 98(2):240-7.
      View in: PubMed
    8. Lavery R, Zakrzewska K, Beveridge D, Bishop TC, Case DA, Cheatham T, Dixit S, Jayaram B, Lankas F, Laughton C, Maddocks JH, Michon A, Osman R, Orozco M, Perez A, Singh T, Spackova N, Sponer J. A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA. Nucleic Acids Res. 2010 Jan; 38(1):299-313.
      View in: PubMed
    9. Jacobson EM, Yang H, Menconi F, Wang R, Osman R, Skrabanek L, Li CW, Fadlalla M, Gandhi A, Chaturvedi V, Smith EP, Schwemberger S, Osterburg A, Babcock GF, Tomer Y. Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective. J Biol Chem. 2009 Dec 4; 284(49):34231-43.
      View in: PubMed
    10. Rodríguez Y, Mezei M, Osman R. The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study. Biochemistry. 2008 Dec 16; 47(50):13267-78.
      View in: PubMed
    11. Cui M, Mezei M, Osman R. Prediction of protein loop structures using a local move Monte Carlo approach and a grid-based force field. Protein Eng Des Sel. 2008 Dec; 21(12):729-35.
      View in: PubMed
    12. Menconi F, Monti MC, Greenberg DA, Oashi T, Osman R, Davies TF, Ban Y, Jacobson EM, Concepcion ES, Li CW, Tomer Y. Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14034-9.
      View in: PubMed
    13. Yamoah K, Oashi T, Sarikas A, Gazdoiu S, Osman R, Pan ZQ. Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12230-5.
      View in: PubMed
    14. Cui M, Mezei M, Osman R. Modeling dimerizations of transmembrane proteins using Brownian dynamics simulations. J Comput Aided Mol Des. 2008 Aug; 22(8):553-61.
      View in: PubMed
    15. Kentsis A, Gindin T, Mezei M, Osman R. Calculation of the free energy and cooperativity of protein folding. PLoS One. 2007; 2(5):e446.
      View in: PubMed
    16. Rodríguez Y, Mezei M, Osman R. Association free energy of dipalmitoylphosphatidylserines in a mixed dipalmitoylphosphatidylcholine membrane. Biophys J. 2007 May 1; 92(9):3071-80.
      View in: PubMed
    17. Cui M, Jiang P, Maillet E, Max M, Margolskee RF, Osman R. The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Curr Pharm Des. 2006; 12(35):4591-600.
      View in: PubMed
    18. Kentsis A, Mezei M, Osman R. Origin of the sequence-dependent polyproline II structure in unfolded peptides. Proteins. 2005 Dec 1; 61(4):769-76.
      View in: PubMed
    19. Dixit SB, Beveridge DL, Case DA, Cheatham TE, Giudice E, Lankas F, Lavery R, Maddocks JH, Osman R, Sklenar H, Thayer KM, Varnai P. Molecular dynamics simulations of the 136 unique tetranucleotide sequences of DNA oligonucleotides. II: sequence context effects on the dynamical structures of the 10 unique dinucleotide steps. Biophys J. 2005 Dec; 89(6):3721-40.
      View in: PubMed
    20. Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF. Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem. 2005 Oct 7; 280(40):34296-305.
      View in: PubMed
    21. Fuxreiter M, Mezei M, Simon I, Osman R. Interfacial water as a "hydration fingerprint" in the noncognate complex of BamHI. Biophys J. 2005 Aug; 89(2):903-11.
      View in: PubMed
    22. Huang W, Osman R, Gershengorn MC. Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches. Biochemistry. 2005 Feb 22; 44(7):2419-31.
      View in: PubMed
    23. Jiang P, Cui M, Zhao B, Liu Z, Snyder LA, Benard LM, Osman R, Margolskee RF, Max M. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem. 2005 Apr 15; 280(15):15238-46.
      View in: PubMed
    24. Jiang P, Cui M, Ji Q, Snyder L, Liu Z, Benard L, Margolskee RF, Osman R, Max M. Molecular mechanisms of sweet receptor function. Chem Senses. 2005 Jan; 30 Suppl 1:i17-8.
      View in: PubMed
    25. Miller F, Kentsis A, Osman R, Pan ZQ. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. J Biol Chem. 2005 Mar 4; 280(9):7985-96.
      View in: PubMed
    26. Beveridge DL, Barreiro G, Byun KS, Case DA, Cheatham TE, Dixit SB, Giudice E, Lankas F, Lavery R, Maddocks JH, Osman R, Seibert E, Sklenar H, Stoll G, Thayer KM, Varnai P, Young MA. Molecular dynamics simulations of the 136 unique tetranucleotide sequences of DNA oligonucleotides. I. Research design and results on d(CpG) steps. Biophys J. 2004 Dec; 87(6):3799-813.
      View in: PubMed
    27. Lu X, Huang W, Worthington S, Drabik P, Osman R, Gershengorn MC. A model of inverse agonist action at thyrotropin-releasing hormone receptor type 1: role of a conserved tryptophan in helix 6. Mol Pharmacol. 2004 Nov; 66(5):1192-200.
      View in: PubMed
    28. Kentsis A, Mezei M, Gindin T, Osman R. Unfolded state of polyalanine is a segmented polyproline II helix. Proteins. 2004 May 15; 55(3):493-501.
      View in: PubMed
    29. Ban Y, Davies TF, Greenberg DA, Concepcion ES, Osman R, Oashi T, Tomer Y. Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease. Genes Immun. 2004 May; 5(3):203-8.
      View in: PubMed
    30. Seibert E, Ross JB, Osman R. Contribution of opening and bending dynamics to specific recognition of DNA damage. J Mol Biol. 2003 Jul 18; 330(4):687-703.
      View in: PubMed
    31. Kentsis A, Mezei M, Osman R. MC-PHS: a Monte Carlo implementation of the primary hydration shell for protein folding and design. Biophys J. 2003 Feb; 84(2 Pt 1):805-15.
      View in: PubMed
    32. Fuxreiter M, Luo N, Jedlovszky P, Simon I, Osman R. Role of base flipping in specific recognition of damaged DNA by repair enzymes. J Mol Biol. 2002 Nov 8; 323(5):823-34.
      View in: PubMed
    33. Seibert E, Ross JB, Osman R. Role of DNA flexibility in sequence-dependent activity of uracil DNA glycosylase. Biochemistry. 2002 Sep 10; 41(36):10976-84.
      View in: PubMed
    34. Fuxreiter M, Osman R. Probing the general base catalysis in the first step of BamHI action by computer simulations. Biochemistry. 2001 Dec 11; 40(49):15017-23.
      View in: PubMed
    35. Rachofsky EL, Ross JB, Osman R. Conformation and dynamics of normal and damaged DNA. Comb Chem High Throughput Screen. 2001 Dec; 4(8):675-706.
      View in: PubMed
    36. Rachofsky EL, Seibert E, Stivers JT, Osman R, Ross JB. Conformation and dynamics of abasic sites in DNA investigated by time-resolved fluorescence of 2-aminopurine. Biochemistry. 2001 Jan 30; 40(4):957-67.
      View in: PubMed
    37. Rachofsky EL, Osman R, Ross JB. Probing structure and dynamics of DNA with 2-aminopurine: effects of local environment on fluorescence. Biochemistry. 2001 Jan 30; 40(4):946-56.
      View in: PubMed
    38. Rosenhouse-Dantsker A, Osman R. Application of the primary hydration shell approach to locally enhanced sampling simulated annealing: computer simulation of thyrotropin-releasing hormone in water. Biophys J. 2000 Jul; 79(1):66-79.
      View in: PubMed
    39. Osman R, Fuxreiter M, Luo N. Specificity of damage recognition and catalysis of DNA repair. Comput Chem. 2000 May; 24(3-4):331-9.
      View in: PubMed
    40. Fuxreiter M, Warshel A, Osman R. Role of active site residues in the glycosylase step of T4 endonuclease V. Computer simulation studies on ionization states. Biochemistry. 1999 Jul 27; 38(30):9577-89.
      View in: PubMed
    41. Luo N, Mehler E, Osman R. Specificity and catalysis of uracil DNA glycosylase. A molecular dynamics study of reactant and product complexes with DNA. Biochemistry. 1999 Jul 20; 38(29):9209-20.
      View in: PubMed
    42. Colson AO, Perlman JH, Jinsi-Parimoo A, Nussenzveig DR, Osman R, Gershengorn MC. A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation. Mol Pharmacol. 1998 Dec; 54(6):968-78.
      View in: PubMed
    43. Colson AO, Perlman JH, Smolyar A, Gershengorn MC, Osman R. Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor. Biophys J. 1998 Mar; 74(3):1087-100.
      View in: PubMed
    44. Laakkonen LJ, Guarnieri F, Perlman JH, Gershengorn MC, Osman R. A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Novel mixed mode Monte Carlo/stochastic dynamics simulations of the complex between TRH and TRH receptor. Biochemistry. 1996 Jun 18; 35(24):7651-63.
      View in: PubMed
    45. Laakkonen L, Li W, Perlman JH, Guarnieri F, Osman R, Moeller KD, Gershengorn MC. Restricted analogues provide evidence of a biologically active conformation of thyrotropin-releasing hormone. Mol Pharmacol. 1996 Jun; 49(6):1092-6.
      View in: PubMed
    46. Miaskiewicz K, Miller J, Osman R. Energetic basis for structural preferences in 5/6-hydroxy-5,6-dihydropyrimidines: products of ionizing and ultraviolet radiation action on DNA bases. Biochim Biophys Acta. 1994 Aug 2; 1218(3):283-91.
      View in: PubMed
    47. Smolyar A, Osman R. Role of threonine 342 in helix 7 of the 5-hydroxytryptamine type 1D receptor in ligand binding: an indirect mechanism for receptor selectivity. Mol Pharmacol. 1993 Oct; 44(4):882-5.
      View in: PubMed
    48. Pardo L, Ballesteros JA, Osman R, Weinstein H. On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors. Proc Natl Acad Sci U S A. 1992 May 1; 89(9):4009-12.
      View in: PubMed
    49. Ben-Harari RR, Dalton BA, Osman R, Maayani S. Kinetic characterization of 5-hydroxytryptamine receptor desensitization in isolated guinea-pig trachea and rabbit aorta. J Pharmacol Exp Ther. 1991 Apr; 257(1):416-24.
      View in: PubMed
    50. Osman R, Miaskiewicz K, Weinstein H. Structure-function relations in radiation damaged DNA. Basic Life Sci. 1991; 58:423-47; discussion 447-52.
      View in: PubMed
    51. Osman R, Pardo L, Banfelder J, Mazurek AP, Shvartzman L, Strauss R, Weinstein H. Molecular mechanisms of radiation induced DNA damage: H-addition to bases, direct ionization and double strand break. Free Radic Res Commun. 1991; 12-13 Pt 2:465-7.
      View in: PubMed
    52. Pardo L, Osman R, Banfelder J, Mazurek AP, Weinstein H. Molecular mechanisms of radiation induced DNA damage: H-abstraction and beta-cleavage. Free Radic Res Commun. 1991; 12-13 Pt 2:461-3.
      View in: PubMed
    53. Osman R, Weinstein H. A mechanistic basis for design of selective agonists for 5-HT receptors. NIDA Res Monogr. 1991; 112:21-42.
      View in: PubMed
    54. Keitz SA, Osman R, Clarke WP, Goldfarb J, Maayani S. Functional interactions in smooth muscle: kinetic characterization of the relaxation and desensitization responses to a beta adrenergic agonist in the rabbit aorta. J Pharmacol Exp Ther. 1990 Nov; 255(2):650-6.
      View in: PubMed
    55. Weinstein H, Osman R. On the structural and mechanistic basis of function, classification, and ligand design for 5-HT receptors. Neuropsychopharmacology. 1990 Oct-Dec; 3(5-6):397-409.
      View in: PubMed
    56. Osman R, Keitz SA, Goldfarb J, Maayani S. Kinetics of response and drug action. Neuropsychopharmacology. 1990 Oct-Dec; 3(5-6):417-25.
      View in: PubMed
    57. Mercier GA, Osman R, Weinstein H. A molecular theoretical model of recognition and activation at a 5-HT receptor. Prog Clin Biol Res. 1989; 289:399-410.
      View in: PubMed
    58. Osman R, Clark WJ, Mazurek AP, Weinstein H. Theoretical studies of molecular mechanisms of DNA damage induced by hydroxyl radicals. Free Radic Res Commun. 1989; 6(2-3):131-2.
      View in: PubMed
    59. Mercier GA, Osman R, Weinstein H. Role of primary and secondary protein structure in neurotransmitter receptor activation mechanisms. Protein Eng. 1988 Oct; 2(4):261-70.
      View in: PubMed
    60. Weinstein H, Osman R, Mercier G. Recognition and activation of a 5-HT receptor by hallucinogens and indole derivatives. NIDA Res Monogr. 1988; 90:243-55.
      View in: PubMed
    61. Osman R, Topiol S, Rubenstein L, Weinstein H. A molecular model for activation of a 5-hydroxytryptamine receptor. Mol Pharmacol. 1987 Nov; 32(5):699-705.
      View in: PubMed
    62. Namboodiri K, Osman R, Weinstein H, Rabinowitz JR. Analysis of the molecular electrostatic potential for the prediction of N-oxidation and biological activity of substituted pyridines. Mol Toxicol. 1987 Apr-Sep; 1(2-3):131-41.
      View in: PubMed
    Osman's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts
    _
    Co-Authors
    _
    Similar People
    _
    Same Department
     
    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067