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Last Name
Institution

Robert Linhardt

TitleProfessor
InstitutionRensselaer Polytechnic Institute
DepartmentChemistry
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li G, Cai C, Li L, Fu L, Chang Y, Zhang F, Toida T, Xue C, Linhardt RJ. Method to detect contaminants in heparin using radical depolymerization and liquid chromatography-mass spectrometry. Anal Chem. 2014 Jan 7; 86(1):326-30.
      View in: PubMed
    2. Zhang B, Xiao W, Qiu H, Zhang F, Moniz HA, Jaworski A, Condac E, Gutierrez-Sanchez G, Heiss C, Clugston RD, Azadi P, Greer JJ, Bergmann C, Moremen KW, Li D, Linhardt RJ, Esko JD, Wang L. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 2014 Jan 2; 124(1):209-21.
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    3. Sterner E, Meli L, Kwon SJ, Dordick JS, Linhardt RJ. FGF-FGFR Signaling Mediated through Glycosaminoglycans in Microtiter Plate and Cell-Based Microarray Platforms. Biochemistry. 2013 Dec 17; 52(50):9009-19.
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    4. Datta P, Li G, Yang B, Zhao X, Baik JY, Gemmill TR, Sharfstein ST, Linhardt RJ. Bioengineered Chinese Hamster Ovary Cells with Golgi-targeted 3-O-Sulfotransferase-1 Biosynthesize Heparan Sulfate with an Antithrombin-binding Site. J Biol Chem. 2013 Dec 27; 288(52):37308-18.
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    5. Li G, Masuko S, Green DE, Xu Y, Li L, Zhang F, Xue C, Liu J, Deangelis PL, Linhardt RJ. N-sulfotestosteronan, a novel substrate for heparan sulfate 6-o-sulfotransferases and its analysis by oxidative degradation. Biopolymers. 2013 Oct; 99(10):675-85.
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    6. Chang Y, Cai C, Li L, Miao J, Ucakturk E, Li G, Ly M, Linhardt RJ. Ultrasensitive detection and quantification of acidic disaccharides using capillary electrophoresis and quantum dot-based fluorescence resonance energy transfer. Anal Chem. 2013 Oct 1; 85(19):9356-62.
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    7. Zhang F, Moniz HA, Walcott B, Moremen KW, Linhardt RJ, Wang L. Characterization of the interaction between Robo1 and heparin and other glycosaminoglycans. Biochimie. 2013 Dec; 95(12):2345-53.
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    8. Zhang F, Aguilera J, Beaudet JM, Xie Q, Lerch TF, Davulcu O, Colón W, Chapman MS, Linhardt RJ. Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-Associated Virus. Biochemistry. 2013 Sep 10; 52(36):6275-85.
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    9. Nicastri MC, Xega K, Li L, Xie J, Wang C, Linhardt RJ, Reitter JN, Mills KV. Internal disulfide bond acts as a switch for intein activity. Biochemistry. 2013 Aug 27; 52(34):5920-7.
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    10. Wang W, Englaender JA, Xu P, Mehta KK, Suwan J, Dordick JS, Zhang F, Yuan Q, Linhardt RJ, Koffas M. Expression of low endotoxin 3-O-sulfotransferase in Bacillus subtilis and Bacillus megaterium. Appl Biochem Biotechnol. 2013 Oct; 171(4):954-62.
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    11. Nolan K, Kattamuri C, Luedeke DM, Deng X, Jagpal A, Zhang F, Linhardt RJ, Kenny AP, Zorn AM, Thompson TB. Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism. Structure. 2013 Aug 6; 21(8):1417-29.
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    12. Xiong J, Bhaskar U, Li G, Fu L, Li L, Zhang F, Dordick JS, Linhardt RJ. Immobilized enzymes to convert N-sulfo, N-acetyl heparosan to a critical intermediate in the production of bioengineered heparin. J Biotechnol. 2013 Sep 10; 167(3):241-7.
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    13. Mora-Pale M, Sanchez-Rodriguez SP, Linhardt RJ, Dordick JS, Koffas MA. Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues. Plant Sci. 2013 Sep; 210:10-24.
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    14. Weyers A, Yang B, Park JH, Kim YS, Kim SM, Lee SE, Zhang F, Lee KB, Linhardt RJ. Microanalysis of stomach cancer glycosaminoglycans. Glycoconj J. 2013 Oct; 30(7):701-7.
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    15. Karamanos NK, Linhardt RJ. Special issue: Proteoglycans: signaling, targeting and therapeutics: introduction. FEBS J. 2013 May; 280(10):2119.
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    16. Zhao X, Yang B, Li L, Zhang F, Linhardt RJ. On-line separation and characterization of hyaluronan oligosaccharides derived from radical depolymerization. Carbohydr Polym. 2013 Jul 25; 96(2):503-9.
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    17. Hickey AM, Bhaskar U, Linhardt RJ, Dordick JS. Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5. J Biotechnol. 2013 Jun 10; 165(3-4):175-7.
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    18. Kamhi E, Joo EJ, Dordick JS, Linhardt RJ. Glycosaminoglycans in infectious disease. Biol Rev Camb Philos Soc. 2013 Nov; 88(4):928-43.
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    19. Fu L, Li G, Yang B, Onishi A, Li L, Sun P, Zhang F, Linhardt RJ. Structural characterization of pharmaceutical heparins prepared from different animal tissues. J Pharm Sci. 2013 May; 102(5):1447-57.
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    20. Zhang F, Walcott B, Zhou D, Gustchina A, Lasanajak Y, Smith DF, Ferreira RS, Correia MT, Paiva PM, Bovin NV, Wlodawer A, Oliva ML, Linhardt RJ. Structural Studies of the Interaction of Crataeva tapia Bark Protein with Heparin and Other Glycosaminoglycans. Biochemistry. 2013 Mar 26; 52(12):2148-56.
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    21. DeAngelis PL, Liu J, Linhardt RJ. Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains. Glycobiology. 2013 Jul; 23(7):764-77.
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    22. Weyers A, Linhardt RJ. Neoproteoglycans in tissue engineering. FEBS J. 2013 May; 280(10):2511-22.
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    23. Zhou X, Li L, Linhardt RJ, Liu J. Neutralizing the anticoagulant activity of ultra-low-molecular-weight heparins using N-acetylglucosamine 6-sulfatase. FEBS J. 2013 May; 280(10):2523-32.
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    24. Cai C, Edgar K, Liu J, Linhardt RJ. Preparation and application of a 'clickable' acceptor for enzymatic synthesis of heparin oligosaccharides. Carbohydr Res. 2013 May 3; 372:30-4.
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    25. Cress BF, Greene ZR, Linhardt RJ, Koffas MA. Draft Genome Sequence of Escherichia coli Strain ATCC 23502 (Serovar O5:K4:H4). Genome Announc. 2013 Mar-Apr; 1(2):e0004613.
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    26. Cress BF, Linhardt RJ, Koffas MA. Draft Genome Sequence of Escherichia coli Strain Nissle 1917 (Serovar O6:K5:H1). Genome Announc. 2013 Mar-Apr; 1(2):e0004713.
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    27. Cress BF, Greene ZR, Linhardt RJ, Koffas MA. Draft Genome Sequence of Escherichia coli Strain ATCC 23506 (Serovar O10:K5:H4). Genome Announc. 2013 Mar-Apr; 1(2):e0004913.
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    28. Weyers A, Yang B, Solakyildirim K, Yee V, Li L, Zhang F, Linhardt RJ. Isolation of bovine corneal keratan sulfate and its growth factor and morphogen binding. FEBS J. 2013 May; 280(10):2285-93.
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    29. Kailemia MJ, Li L, Xu Y, Liu J, Linhardt RJ, Amster IJ. Structurally informative tandem mass spectrometry of highly sulfated natural and chemoenzymatically synthesized heparin and heparan sulfate glycosaminoglycans. Mol Cell Proteomics. 2013 Apr; 12(4):979-90.
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    30. Zhao X, Yang B, Solakyildirim K, Solakylidirim K, Joo EJ, Toida T, Higashi K, Linhardt RJ, Li L. Sequence analysis and domain motifs in the porcine skin decorin glycosaminoglycan chain. J Biol Chem. 2013 Mar 29; 288(13):9226-37.
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    31. Kotlo K, Bhattacharyya S, Yang B, Feferman L, Tejaskumar S, Linhardt R, Danziger R, Tobacman JK. Impact of salt exposure on N-acetylgalactosamine-4-sulfatase (arylsulfatase B) activity, glycosaminoglycans, kininogen, and bradykinin. Glycoconj J. 2013 Oct; 30(7):667-76.
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    32. Datta P, Linhardt RJ, Sharfstein ST. An 'omics approach towards CHO cell engineering. Biotechnol Bioeng. 2013 May; 110(5):1255-71.
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    33. Restaino OF, Bhaskar U, Paul P, Li L, De Rosa M, Dordick JS, Linhardt RJ. High cell density cultivation of a recombinant E. coli strain expressing a key enzyme in bioengineered heparin production. Appl Microbiol Biotechnol. 2013 May; 97(9):3893-900.
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    34. Chang Y, Yang B, Weyers A, Linhardt RJ. Capillary electrophoresis for the analysis of glycosaminoglycan-derived disaccharides. Methods Mol Biol. 2013; 984:67-77.
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    35. Zhao X, Yang B, Linkens K, Datta P, Onishi A, Zhang F, Linhardt RJ. Microscale separation of heparosan, heparan sulfate, and heparin. Anal Biochem. 2013 Mar 15; 434(2):215-7.
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    36. Ziarek JJ, Veldkamp CT, Zhang F, Murray NJ, Kartz GA, Liang X, Su J, Baker JE, Linhardt RJ, Volkman BF. Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus. J Biol Chem. 2013 Jan 4; 288(1):737-46.
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    37. Suwan J, Torelli A, Onishi A, Dordick JS, Linhardt RJ. Addressing endotoxin issues in bioengineered heparin. Biotechnol Appl Biochem. 2012 Nov-Dec; 59(6):420-8.
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    38. Kwon SJ, Lee KB, Solakyildirim K, Masuko S, Ly M, Zhang F, Li L, Dordick JS, Linhardt RJ. Signal amplification by glyco-qPCR for ultrasensitive detection of carbohydrates: applications in glycobiology. Angew Chem Int Ed Engl. 2012 Nov 19; 51(47):11800-4.
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    39. Gasimli L, Stansfield HE, Nairn AV, Liu H, Paluh JL, Yang B, Dordick JS, Moremen KW, Linhardt RJ. Structural remodeling of proteoglycans upon retinoic acid-induced differentiation of NCCIT cells. Glycoconj J. 2013 Jul; 30(5):497-510.
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    40. Li L, Zhang F, Zaia J, Linhardt RJ. Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS. Anal Chem. 2012 Oct 16; 84(20):8822-9.
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    41. Meli L, Jordan ET, Clark DS, Linhardt RJ, Dordick JS. Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems. Biomaterials. 2012 Dec; 33(35):9087-96.
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    42. Zhang F, Beaudet JM, Luedeke DM, Walker RG, Thompson TB, Linhardt RJ. Analysis of the interaction between heparin and follistatin and heparin and follistatin-ligand complexes using surface plasmon resonance. Biochemistry. 2012 Aug 28; 51(34):6797-803.
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    43. Leach FE, Ly M, Laremore TN, Wolff JJ, Perlow J, Linhardt RJ, Amster IJ. Hexuronic acid stereochemistry determination in chondroitin sulfate glycosaminoglycan oligosaccharides by electron detachment dissociation. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1488-97.
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    44. Simmons TJ, Hashim DP, Zhan X, Bravo-Sanchez M, Hahm MG, López-Luna E, Linhardt RJ, Ajayan PM, Navarro-Contreras H, Vidal MA. Functionalization of nitrogen-doped carbon nanotubes with gallium to form Ga-CN(x)-multi-wall carbon nanotube hybrid materials. Nanotechnology. 2012 Aug 17; 23(32):325601.
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    45. Kailemia MJ, Li L, Ly M, Linhardt RJ, Amster IJ. Complete mass spectral characterization of a synthetic ultralow-molecular-weight heparin using collision-induced dissociation. Anal Chem. 2012 Jul 3; 84(13):5475-8.
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    46. Baik JY, Wang CL, Yang B, Linhardt RJ, Sharfstein S. Toward a bioengineered heparin: challenges and strategies for metabolic engineering of mammalian cells. Bioengineered. 2012 Jul-Aug; 3(4):227-31.
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    47. Volpi N, Maccari F, Suwan J, Linhardt RJ. Electrophoresis for the analysis of heparin purity and quality. Electrophoresis. 2012 Jun; 33(11):1531-7.
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    48. Chang Y, Yang B, Zhao X, Linhardt RJ. Analysis of glycosaminoglycan-derived disaccharides by capillary electrophoresis using laser-induced fluorescence detection. Anal Biochem. 2012 Aug 1; 427(1):91-8.
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    49. Li L, Ly M, Linhardt RJ. Proteoglycan sequence. Mol Biosyst. 2012 Jun; 8(6):1613-25.
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    50. Paul P, Suwan J, Liu J, Dordick JS, Linhardt RJ. Recent advances in sulfotransferase enzyme activity assays. Anal Bioanal Chem. 2012 Jun; 403(6):1491-500.
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    51. Moon AF, Xu Y, Woody SM, Krahn JM, Linhardt RJ, Liu J, Pedersen LC. Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin. Proc Natl Acad Sci U S A. 2012 Apr 3; 109(14):5265-70.
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    52. Sudha T, Phillips P, Kanaan C, Linhardt RJ, Borsig L, Mousa SA. Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model. Clin Exp Metastasis. 2012 Jun; 29(5):431-9.
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    53. Yang B, Bhattacharyya S, Linhardt R, Tobacman J. Exposure to common food additive carrageenan leads to reduced sulfatase activity and increase in sulfated glycosaminoglycans in human epithelial cells. Biochimie. 2012 Jun; 94(6):1309-16.
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    54. Masuko S, Linhardt RJ. Chemoenzymatic synthesis of the next generation of ultralow MW heparin therapeutics. Future Med Chem. 2012 Mar; 4(3):289-96.
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    55. Weyers A, Yang B, Yoon DS, Park JH, Zhang F, Lee KB, Linhardt RJ. A structural analysis of glycosaminoglycans from lethal and nonlethal breast cancer tissues: toward a novel class of theragnostics for personalized medicine in oncology? OMICS. 2012 Mar; 16(3):79-89.
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    56. Miao J, Miyauchi M, Dordick JS, Linhardt RJ. Preparation and characterization of electrospun core sheath nanofibers from multi-walled carbon nanotubes and poly(vinyl pyrrolidone). J Nanosci Nanotechnol. 2012 Mar; 12(3):2387-93.
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    57. Gasimli L, Linhardt RJ, Dordick JS. Proteoglycans in stem cells. Biotechnol Appl Biochem. 2012 Mar-Apr; 59(2):65-76.
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    58. Miao J, Zhang F, Takieddin M, Mousa S, Linhardt RJ. Adsorption of doxorubicin on poly(methyl methacrylate)-chitosan-heparin-coated activated carbon beads. Langmuir. 2012 Mar 6; 28(9):4396-403.
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    59. Linhardt RJ, Liu J. Synthetic heparin. Curr Opin Pharmacol. 2012 Apr; 12(2):217-9.
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    60. Baik JY, Gasimli L, Yang B, Datta P, Zhang F, Glass CA, Esko JD, Linhardt RJ, Sharfstein ST. Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin. Metab Eng. 2012 Mar; 14(2):81-90.
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    61. Zhao W, McCallum SA, Xiao Z, Zhang F, Linhardt RJ. Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides. Biosci Rep. 2012 Feb; 32(1):71-81.
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    62. Chen W, Li L, Du Z, Liu J, Reitter JN, Mills KV, Linhardt RJ, Wang C. Intramolecular disulfide bond between catalytic cysteines in an intein precursor. J Am Chem Soc. 2012 Feb 8; 134(5):2500-3.
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    63. Masuko S, Bera S, Green DE, Weïwer M, Liu J, DeAngelis PL, Linhardt RJ. Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans. J Org Chem. 2012 Feb 3; 77(3):1449-56.
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    64. Otto NJ, Green DE, Masuko S, Mayer A, Tanner ME, Linhardt RJ, DeAngelis PL. Structure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and engineering novel catalysts. J Biol Chem. 2012 Mar 2; 287(10):7203-12.
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    65. Mora-Pale M, Kwon SJ, Linhardt RJ, Dordick JS. Trimer hydroxylated quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase. Free Radic Biol Med. 2012 Mar 1; 52(5):962-9.
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    66. Yang B, Chang Y, Weyers AM, Sterner E, Linhardt RJ. Disaccharide analysis of glycosaminoglycan mixtures by ultra-high-performance liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Feb 17; 1225:91-8.
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    67. Vongchan P, Kothan S, Wutti-In Y, Linhardt RJ. Inhibition of human tumor xenograft growth in nude mice by a novel monoclonal anti-HSPG isolated from human liver. Anticancer Res. 2011 Dec; 31(12):4067-74.
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    68. Zhang F, Liang X, Pu D, George KI, Holland PJ, Walsh ST, Linhardt RJ. Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR. Biochimie. 2012 Jan; 94(1):242-9.
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    69. Bhaskar U, Sterner E, Hickey AM, Onishi A, Zhang F, Dordick JS, Linhardt RJ. Engineering of routes to heparin and related polysaccharides. Appl Microbiol Biotechnol. 2012 Jan; 93(1):1-16.
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    70. Xu Y, Masuko S, Takieddin M, Xu H, Liu R, Jing J, Mousa SA, Linhardt RJ, Liu J. Chemoenzymatic synthesis of homogeneous ultralow molecular weight heparins. Science. 2011 Oct 28; 334(6055):498-501.
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    71. Ly M, Leach FE, Laremore TN, Toida T, Amster IJ, Linhardt RJ. The proteoglycan bikunin has a defined sequence. Nat Chem Biol. 2011 Nov; 7(11):827-33.
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    72. Miao J, Pangule RC, Paskaleva EE, Hwang EE, Kane RS, Linhardt RJ, Dordick JS. Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications. Biomaterials. 2011 Dec; 32(36):9557-67.
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    73. Zhang F, Yang B, Ly M, Solakyildirim K, Xiao Z, Wang Z, Beaudet JM, Torelli AY, Dordick JS, Linhardt RJ. Structural characterization of heparins from different commercial sources. Anal Bioanal Chem. 2011 Nov; 401(9):2793-803.
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    74. Wang Z, Li J, Cheong S, Bhaskar U, Akihiro O, Zhang F, Dordick JS, Linhardt RJ. Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin. J Biotechnol. 2011 Dec 10; 156(3):188-96.
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    75. Park Y, Hong YN, Weyers A, Kim YS, Linhardt RJ. Polysaccharides and phytochemicals: a natural reservoir for the green synthesis of gold and silver nanoparticles. IET Nanobiotechnol. 2011 Sep; 5(3):69-78.
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    76. Wu H, Mora-Pale M, Miao J, Doherty TV, Linhardt RJ, Dordick JS. Facile pretreatment of lignocellulosic biomass at high loadings in room temperature ionic liquids. Biotechnol Bioeng. 2011 Dec; 108(12):2865-75.
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    77. Garg HG, Mrabat H, Yu L, Hales CA, Li B, Moore CN, Zhang F, Linhardt RJ. Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells. Glycoconj J. 2011 Aug; 28(6):419-26.
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    78. Zhao W, Garron ML, Yang B, Xiao Z, Esko JD, Cygler M, Linhardt RJ. Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfoglucosamine residue. FEBS Lett. 2011 Aug 4; 585(15):2461-6.
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    79. Masuko S, Higashi K, Wang Z, Bhaskar U, Hickey AM, Zhang F, Toida T, Dordick JS, Linhardt RJ. Ozonolysis of the double bond of the unsaturated uronate residue in low-molecular-weight heparin and K5 heparosan. Carbohydr Res. 2011 Sep 27; 346(13):1962-6.
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    80. Mora-Pale M, Meli L, Doherty TV, Linhardt RJ, Dordick JS. Room temperature ionic liquids as emerging solvents for the pretreatment of lignocellulosic biomass. Biotechnol Bioeng. 2011 Jun; 108(6):1229-45.
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    81. Otto NJ, Solakyildirim K, Linhardt RJ, DeAngelis PL. Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog. Glycobiology. 2011 Oct; 21(10):1331-40.
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    82. Miyauchi M, Simmons TJ, Miao J, Gagner JE, Shriver ZH, Aich U, Dordick JS, Linhardt RJ. Electrospun polyvinylpyrrolidone fibers with high concentrations of ferromagnetic and superparamagnetic nanoparticles. ACS Appl Mater Interfaces. 2011 Jun; 3(6):1958-64.
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    83. Yang B, Weyers A, Baik JY, Sterner E, Sharfstein S, Mousa SA, Zhang F, Dordick JS, Linhardt RJ. Ultra-performance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis. Anal Biochem. 2011 Aug 1; 415(1):59-66.
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    84. Wang Z, Yang B, Zhang Z, Ly M, Takieddin M, Mousa S, Liu J, Dordick JS, Linhardt RJ. Control of the heparosan N-deacetylation leads to an improved bioengineered heparin. Appl Microbiol Biotechnol. 2011 Jul; 91(1):91-9.
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    85. Bera S, Linhardt RJ. Design and synthesis of unnatural heparosan and chondroitin building blocks. J Org Chem. 2011 May 6; 76(9):3181-93.
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    86. Beaudet JM, Weyers A, Solakyildirim K, Yang B, Takieddin M, Mousa S, Zhang F, Linhardt RJ. Impact of autoclave sterilization on the activity and structure of formulated heparin. J Pharm Sci. 2011 Aug; 100(8):3396-404.
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    87. Khurana A, Liu P, Mellone P, Lorenzon L, Vincenzi B, Datta K, Yang B, Linhardt RJ, Lingle W, Chien J, Baldi A, Shridhar V. HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells. Cancer Res. 2011 Mar 15; 71(6):2152-61.
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    88. Leach FE, Wolff JJ, Xiao Z, Ly M, Laremore TN, Arungundram S, Al-Mafraji K, Venot A, Boons GJ, Linhardt RJ, Amster IJ. Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates. Eur J Mass Spectrom (Chichester, Eng). 2011; 17(2):167-76.
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    89. Li B, Liu H, Zhang Z, Stansfield HE, Dordick JS, Linhardt RJ. Analysis of glycosaminoglycans in stem cell glycomics. Methods Mol Biol. 2011; 690:285-300.
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    90. Wang Z, Dordick JS, Linhardt RJ. Escherichia coli K5 heparosan fermentation and improvement by genetic engineering. Bioeng Bugs. 2011 Jan-Feb; 2(1):63-7.
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    91. Anand G, Zhang F, Linhardt RJ, Belfort G. Protein-associated water and secondary structure effect removal of blood proteins from metallic substrates. Langmuir. 2011 Mar 1; 27(5):1830-6.
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    92. Xiao Z, Tappen BR, Ly M, Zhao W, Canova LP, Guan H, Linhardt RJ. Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin. J Med Chem. 2011 Jan 27; 54(2):603-10.
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    93. Wang Z, Ly M, Zhang F, Zhong W, Suen A, Hickey AM, Dordick JS, Linhardt RJ. E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor. Biotechnol Bioeng. 2010 Dec 15; 107(6):964-73.
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    94. Wang Z, Flax LA, Kemp MM, Linhardt RJ, Baron MJ. Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses in Drosophila melanogaster. Infect Immun. 2011 Feb; 79(2):606-16.
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    95. Liu Z, Masuko S, Solakyildirim K, Pu D, Linhardt RJ, Zhang F. Glycosaminoglycans of the porcine central nervous system. Biochemistry. 2010 Nov 16; 49(45):9839-47.
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    96. Laremore TN, Ly M, Zhang Z, Solakyildirim K, McCallum SA, Owens RT, Linhardt RJ. Domain structure elucidation of human decorin glycosaminoglycans. Biochem J. 2010 Oct 15; 431(2):199-205.
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    97. Yang B, Solakyildirim K, Chang Y, Linhardt RJ. Hyphenated techniques for the analysis of heparin and heparan sulfate. Anal Bioanal Chem. 2011 Jan; 399(2):541-57.
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    98. Liu Z, Xiao Z, Masuko S, Zhao W, Sterner E, Bansal V, Fareed J, Dordick J, Zhang F, Linhardt RJ. Mass balance analysis of contaminated heparin product. Anal Biochem. 2011 Jan 1; 408(1):147-56.
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    99. Miyauchi M, Miao J, Simmons TJ, Lee JW, Doherty TV, Dordick JS, Linhardt RJ. Conductive cable fibers with insulating surface prepared by coaxial electrospinning of multiwalled nanotubes and cellulose. Biomacromolecules. 2010 Sep 13; 11(9):2440-5.
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    100. Miao J, Miyauchi M, Simmons TJ, Dordick JS, Linhardt RJ. Electrospinning of nanomaterials and applications in electronic components and devices. J Nanosci Nanotechnol. 2010 Sep; 10(9):5507-19.
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    101. Liu R, Xu Y, Chen M, Weïwer M, Zhou X, Bridges AS, DeAngelis PL, Zhang Q, Linhardt RJ, Liu J. Chemoenzymatic design of heparan sulfate oligosaccharides. J Biol Chem. 2010 Oct 29; 285(44):34240-9.
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    102. Xiao Z, Zhao W, Yang B, Zhang Z, Guan H, Linhardt RJ. Heparinase 1 selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-alpha-D-glucopyranose (1,4) 2-O-sulfo-alpha-L-idopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages. Glycobiology. 2011 Jan; 21(1):13-22.
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    103. Cai C, Liu J, Du Y, Linhardt RJ. Stereoselective total synthesis of (-)-cleistenolide. J Org Chem. 2010 Aug 20; 75(16):5754-6.
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    104. Ly M, Laremore TN, Linhardt RJ. Proteoglycomics: recent progress and future challenges. OMICS. 2010 Aug; 14(4):389-99.
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    105. Joo EJ, Yang H, Park Y, Park NY, Toida T, Linhardt RJ, Kim YS. Induction of nucleolin translocation by acharan sulfate in A549 human lung adenocarcinoma. J Cell Biochem. 2010 Aug 1; 110(5):1272-8.
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    211. Mousa SA, Feng X, Xie J, Du Y, Hua Y, He H, O'Connor L, Linhardt RJ. Synthetic oligosaccharide stimulates and stabilizes angiogenesis: structure-function relationships and potential mechanisms. J Cardiovasc Pharmacol. 2006 Aug; 48(2):6-13.
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    212. Shao C, Zhang F, Kemp MM, Linhardt RJ, Waisman DM, Head JF, Seaton BA. Crystallographic analysis of calcium-dependent heparin binding to annexin A2. J Biol Chem. 2006 Oct 20; 281(42):31689-95.
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    213. Ma Q, Tobu M, Schultz C, Jeske W, Hoppensteadt D, Walenga J, Cornelli U, Lee J, Linhardt R, Hanin I, Fareed J. Molecular weight dependent tissue factor pathway inhibitor release by heparin and heparin oligosaccharides. Thromb Res. 2007; 119(5):653-61.
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    214. Daniels B, Linhardt RJ, Zhang F, Mao W, Wice SM, Hiebert LM. In vivo antithrombotic synergy of oral heparin and arginine: endothelial thromboresistance without changes in coagulation parameters. Thromb Haemost. 2006 May; 95(5):865-72.
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    215. Muñoz E, Xu D, Kemp M, Zhang F, Liu J, Linhardt RJ. Affinity, kinetic, and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate. Biochemistry. 2006 Apr 25; 45(16):5122-8.
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    216. Sakai S, Akiyama H, Sato Y, Yoshioka Y, Linhardt RJ, Goda Y, Maitani T, Toida T. Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice. J Biol Chem. 2006 Jul 21; 281(29):19872-80.
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    217. Murugesan S, Park TJ, Yang H, Mousa S, Linhardt RJ. Blood compatible carbon nanotubes--nano-based neoproteoglycans. Langmuir. 2006 Apr 11; 22(8):3461-3.
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    218. Laremore TN, Murugesan S, Park TJ, Avci FY, Zagorevski DV, Linhardt RJ. Matrix-assisted laser desorption/ionization mass spectrometric analysis of uncomplexed highly sulfated oligosaccharides using ionic liquid matrices. Anal Chem. 2006 Mar 15; 78(6):1774-9.
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    219. Chi L, Munoz EM, Choi HS, Ha YW, Kim YS, Toida T, Linhardt RJ. Preparation and structural determination of large oligosaccharides derived from acharan sulfate. Carbohydr Res. 2006 May 22; 341(7):864-9.
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    220. Suk JY, Zhang F, Balch WE, Linhardt RJ, Kelly JW. Heparin accelerates gelsolin amyloidogenesis. Biochemistry. 2006 Feb 21; 45(7):2234-42.
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    221. Zhang F, Sun P, Muñoz E, Chi L, Sakai S, Toida T, Zhang H, Mousa S, Linhardt RJ. Microscale isolation and analysis of heparin from plasma using an anion-exchange spin column. Anal Biochem. 2006 Jun 15; 353(2):284-6.
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    222. Du Y, Liu J, Linhardt RJ. Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B) from D-xylose. J Org Chem. 2006 Feb 3; 71(3):1251-3.
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    223. Viswanathan G, Murugesan S, Pushparaj V, Nalamasu O, Ajayan PM, Linhardt RJ. Preparation of biopolymer fibers by electrospinning from room temperature ionic liquids. Biomacromolecules. 2006 Feb; 7(2):415-8.
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    224. Linhardt RJ, Avci FY, Toida T, Kim YS, Cygler M. CS lyases: structure, activity, and applications in analysis and the treatment of diseases. Adv Pharmacol. 2006; 53:187-215.
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    225. Toida T, Sakai S, Akiyama H, Linhardt RJ. Immunological activity of chondroitin sulfate. Adv Pharmacol. 2006; 53:403-15.
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    226. Olsen SK, Li JY, Bromleigh C, Eliseenkova AV, Ibrahimi OA, Lao Z, Zhang F, Linhardt RJ, Joyner AL, Mohammadi M. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev. 2006 Jan 15; 20(2):185-98.
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    227. Warda M, Linhardt RJ. Dromedary glycosaminoglycans: molecular characterization of camel lung and liver heparan sulfate. Comp Biochem Physiol B Biochem Mol Biol. 2006 Jan; 143(1):37-43.
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    228. Muñoz E, Xu D, Avci F, Kemp M, Liu J, Linhardt RJ. Enzymatic synthesis of heparin related polysaccharides on sensor chips: rapid screening of heparin-protein interactions. Biochem Biophys Res Commun. 2006 Jan 13; 339(2):597-602.
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    229. Chen J, Avci FY, Muñoz EM, McDowell LM, Chen M, Pedersen LC, Zhang L, Linhardt RJ, Liu J. Enzymatic redesigning of biologically active heparan sulfate. J Biol Chem. 2005 Dec 30; 280(52):42817-25.
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    230. Hirano K, Sakai S, Ishikawa T, Avci FY, Linhardt RJ, Toida T. Preparation of the methyl ester of hyaluronan and its enzymatic degradation. Carbohydr Res. 2005 Oct 17; 340(14):2297-304.
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    231. Ress DK, Baytas SN, Wang Q, Muñoz EM, Tokuzoki K, Tomiyama H, Linhardt RJ. Synthesis of double C-glycoside analogue of sTn. J Org Chem. 2005 Sep 30; 70(20):8197-200.
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    232. Yu H, Muñoz EM, Edens RE, Linhardt RJ. Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonance. Biochim Biophys Acta. 2005 Nov 15; 1726(2):168-76.
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    233. Yu X, Ibrahimi OA, Goetz R, Zhang F, Davis SI, Garringer HJ, Linhardt RJ, Ornitz DM, Mohammadi M, White KE. Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology. 2005 Nov; 146(11):4647-56.
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    234. Muñoz EM, Yu H, Hallock J, Edens RE, Linhardt RJ. Poly(ethylene glycol)-based biosensor chip to study heparin-protein interactions. Anal Biochem. 2005 Aug 1; 343(1):176-8.
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    235. Sim JS, Jun G, Toida T, Cho SY, Choi DW, Chang SY, Linhardt RJ, Kim YS. Quantitative analysis of chondroitin sulfate in raw materials, ophthalmic solutions, soft capsules and liquid preparations. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Apr 25; 818(2):133-9.
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    236. Ha YW, Jeon BT, Moon SH, Toyoda H, Toida T, Linhardt RJ, Kim YS. Characterization of heparan sulfate from the unossified antler of Cervus elaphus. Carbohydr Res. 2005 Feb 28; 340(3):411-6.
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    237. Ibrahimi OA, Yeh BK, Eliseenkova AV, Zhang F, Olsen SK, Igarashi M, Aaronson SA, Linhardt RJ, Mohammadi M. Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization. Mol Cell Biol. 2005 Jan; 25(2):671-84.
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    238. Yuan X, Linhardt RJ. Recent advances in the synthesis of C-oligosaccharides. Curr Top Med Chem. 2005; 5(14):1393-430.
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    239. Zhang F, Bries AD, Lang SC, Wang Q, Murhammer DW, Weiler JM, Linhardt RJ. Metabolic alteration of the N-glycan structure of a protein from patients with a heterozygous protein deficiency. Biochim Biophys Acta. 2004 Dec 24; 1739(1):43-9.
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    240. Vongchan P, Warda M, Toyoda H, Toida T, Marks RM, Linhardt RJ. Structural characterization of human liver heparan sulfate. Biochim Biophys Acta. 2005 Jan 18; 1721(1-3):1-8.
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    241. Baytas SN, Wang Q, Karst NA, Dordick JS, Linhardt RJ. Solid-phase chemoenzymatic synthesis of C-sialosides. J Org Chem. 2004 Oct 1; 69(20):6900-3.
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    242. Joo EJ, ten Dam GB, van Kuppevelt TH, Toida T, Linhardt RJ, Kim YS. Nucleolin: acharan sulfate-binding protein on the surface of cancer cells. Glycobiology. 2005 Jan; 15(1):1-9.
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    243. Akiyama H, Sakai S, Linhardt RJ, Goda Y, Toida T, Maitani T. Chondroitin sulphate structure affects its immunological activities on murine splenocytes sensitized with ovalbumin. Biochem J. 2004 Aug 15; 382(Pt 1):269-78.
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    244. Moon AF, Edavettal SC, Krahn JM, Munoz EM, Negishi M, Linhardt RJ, Liu J, Pedersen LC. Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. J Biol Chem. 2004 Oct 22; 279(43):45185-93.
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    245. Gu G, Du Y, Linhardt RJ. Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors. J Org Chem. 2004 Aug 6; 69(16):5497-500.
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    246. Ibrahimi OA, Zhang F, Eliseenkova AV, Itoh N, Linhardt RJ, Mohammadi M. Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. Hum Mol Genet. 2004 Oct 1; 13(19):2313-24.
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    247. Zhang F, Wu Y, Ma Q, Hoppensteadt D, Fareed J, Linhardt RJ. Studies on the effect of calcium in interactions between heparin and heparin cofactor II using surface plasmon resonance. Clin Appl Thromb Hemost. 2004 Jul; 10(3):249-57.
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    248. Linhardt RJ, Toida T. Role of glycosaminoglycans in cellular communication. Acc Chem Res. 2004 Jul; 37(7):431-8.
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    249. Muñoz EM, Linhardt RJ. Heparin-binding domains in vascular biology. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1549-57.
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    250. Michel G, Pojasek K, Li Y, Sulea T, Linhardt RJ, Raman R, Prabhakar V, Sasisekharan R, Cygler M. The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery. J Biol Chem. 2004 Jul 30; 279(31):32882-96.
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    251. Zhang F, Ronca F, Linhardt RJ, Margolis RU. Structural determinants of heparan sulfate interactions with Slit proteins. Biochem Biophys Res Commun. 2004 Apr 30; 317(2):352-7.
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    252. Ibrahimi OA, Zhang F, Hrstka SC, Mohammadi M, Linhardt RJ. Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly. Biochemistry. 2004 Apr 27; 43(16):4724-30.
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    253. Edavettal SC, Lee KA, Negishi M, Linhardt RJ, Liu J, Pedersen LC. Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. J Biol Chem. 2004 Jun 11; 279(24):25789-97.
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    254. Linhardt RJ. Heparin-induced cancer cell death. Chem Biol. 2004 Apr; 11(4):420-2.
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    255. Du Y, Wei G, Linhardt RJ. Total synthesis of quercetin 3-sophorotrioside. J Org Chem. 2004 Mar 19; 69(6):2206-9.
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    256. Lunin VV, Li Y, Linhardt RJ, Miyazono H, Kyogashima M, Kaneko T, Bell AW, Cygler M. High-resolution crystal structure of Arthrobacter aurescens chondroitin AC lyase: an enzyme-substrate complex defines the catalytic mechanism. J Mol Biol. 2004 Mar 19; 337(2):367-86.
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    257. Olsen SK, Ibrahimi OA, Raucci A, Zhang F, Eliseenkova AV, Yayon A, Basilico C, Linhardt RJ, Schlessinger J, Mohammadi M. Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):935-40.
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    258. Peterson FC, Elgin ES, Nelson TJ, Zhang F, Hoeger TJ, Linhardt RJ, Volkman BF. Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin. J Biol Chem. 2004 Mar 26; 279(13):12598-604.
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    259. Li DW, Lee IS, Sim JS, Toida T, Linhardt RJ, Kim YS. Long duration of anticoagulant activity and protective effects of acharan sulfate in vivo. Thromb Res. 2004; 113(1):67-73.
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    260. Karst NA, Islam TF, Linhardt RJ. Sulfo-protected hexosamine monosaccharides: potentially versatile building blocks for glycosaminoglycan synthesis. Org Lett. 2003 Dec 11; 5(25):4839-42.
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    261. Cho SY, Sim JS, Kang SS, Jeong CS, Linhardt RJ, Kim YS. Enhancement of heparin and heparin disaccharide absorption by the Phytolacca americana saponins. Arch Pharm Res. 2003 Dec; 26(12):1102-8.
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    262. Warda M, Gouda EM, Toida T, Chi L, Linhardt RJ. Isolation and characterization of raw heparin from dromedary intestine: evaluation of a new source of pharmaceutical heparin. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Dec; 136(4):357-65.
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    263. Garg HG, Yu L, Hales CA, Toida T, Islam T, Linhardt RJ. Sulfation patterns in heparin and heparan sulfate: effects on the proliferation of bovine pulmonary artery smooth muscle cells. Biochim Biophys Acta. 2003 Nov 20; 1639(3):225-31.
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    264. Ibrahimi OA, Zhang F, Eliseenkova AV, Linhardt RJ, Mohammadi M. Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity. Hum Mol Genet. 2004 Jan 1; 13(1):69-78.
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    265. Thanawiroon C, Rice KG, Toida T, Linhardt RJ. Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides. J Biol Chem. 2004 Jan 23; 279(4):2608-15.
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    266. Gunay NS, Linhardt RJ. Capillary electrophoretic separation of heparin oligosaccharides under conditions amenable to mass spectrometric detection. J Chromatogr A. 2003 Oct 3; 1014(1-2):225-33.
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    267. Thanawiroon C, Linhardt RJ. Separation of a complex mixture of heparin-derived oligosaccharides using reversed-phase high-performance liquid chromatography. J Chromatogr A. 2003 Oct 3; 1014(1-2):215-23.
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    268. Du Y, Gu G, Wei G, Hua Y, Linhardt RJ. Synthesis of saponins using partially protected glycosyl donors. Org Lett. 2003 Oct 2; 5(20):3627-30.
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    269. Karst NA, Linhardt RJ. Recent chemical and enzymatic approaches to the synthesis of glycosaminoglycan oligosaccharides. Curr Med Chem. 2003 Oct; 10(19):1993-2031.
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    270. Avci FY, Toida T, Linhardt RJ. Chondroitin O-methyl ester: an unusual substrate for chondroitin AC lyase. Carbohydr Res. 2003 Sep 26; 338(20):2101-4.
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    271. Rathore D, Hrstka SC, Sacci JB, De la Vega P, Linhardt RJ, Kumar S, McCutchan TF. Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein. J Biol Chem. 2003 Oct 17; 278(42):40905-10.
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    272. Barth H, Schafer C, Adah MI, Zhang F, Linhardt RJ, Toyoda H, Kinoshita-Toyoda A, Toida T, Van Kuppevelt TH, Depla E, Von Weizsacker F, Blum HE, Baumert TF. Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate. J Biol Chem. 2003 Oct 17; 278(42):41003-12.
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    273. Gunay NS, Tadano-Aritomi K, Toida T, Ishizuka I, Linhardt RJ. Evaluation of counterions for electrospray ionization mass spectral analysis of a highly sulfated carbohydrate, sucrose octasulfate. Anal Chem. 2003 Jul 1; 75(13):3226-31.
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    274. Linhardt RJ. 2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity. J Med Chem. 2003 Jun 19; 46(13):2551-64.
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    275. Kuberan B, Sikkander SA, Tomiyama H, Linhardt RJ. Synthesis of a C-glycoside analogue of sTn: an HIV- and tumor-associated antigen. Angew Chem Int Ed Engl. 2003 May 9; 42(18):2073-5.
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    276. Wang Q, Dordick JS, Linhardt RJ. Chemoenzymatic synthesis of neuraminic acid containing C-glycoside polymers. Org Lett. 2003 Apr 17; 5(8):1187-9.
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    277. Wang Q, Linhardt RJ. Synthesis of a serine-based neuraminic acid C-glycoside. J Org Chem. 2003 Apr 4; 68(7):2668-72.
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    278. Lee YS, Yang HO, Shin KH, Choi HS, Jung SH, Kim YM, Oh DK, Linhardt RJ, Kim YS. Suppression of tumor growth by a new glycosaminoglycan isolated from the African giant snail Achatina fulica. Eur J Pharmacol. 2003 Mar 28; 465(1-2):191-8.
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    279. Koketsu M, Sakuragawa E, Linhardt RJ, Ishihara H. Distribution of N-acetylneuraminic acid and sialylglycan in eggs of the Silky fowl. Br Poult Sci. 2003 Mar; 44(1):145-8.
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    280. Polat T, Linhardt RJ. Zinc triflate-benzoyl bromide: a versatile reagent for the conversion of ether into benzoate protecting groups and ether glycosides into glycosyl bromides. Carbohydr Res. 2003 Feb 14; 338(5):447-9.
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    281. Linhardt RJ, Toida T. Characterization of glycosaminoglycans by capillary electrophoresis. Methods Mol Biol. 2003; 213:131-44.
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    282. Warda M, Mao W, Toida T, Linhardt RJ. Turkey intestine as a commercial source of heparin? Comparative structural studies of intestinal avian and mammalian glycosaminoglycans. Comp Biochem Physiol B Biochem Mol Biol. 2003 Jan; 134(1):189-97.
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    283. Avci FY, Karst NA, Linhardt RJ. Synthetic oligosaccharides as heparin-mimetics displaying anticoagulant properties. Curr Pharm Des. 2003; 9(28):2323-35.
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    284. Islam T, Butler M, Sikkander SA, Toida T, Linhardt RJ. Further evidence that periodate cleavage of heparin occurs primarily through the antithrombin binding site. Carbohydr Res. 2002 Nov 19; 337(21-23):2239-43.
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    285. Garg HG, Cindhuchao N, Quinn DA, Hales CA, Thanawiroon C, Capila I, Linhardt RJ. Heparin oligosaccharide sequence and size essential for inhibition of pulmonary artery smooth muscle cell proliferation. Carbohydr Res. 2002 Nov 19; 337(21-23):2359-64.
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    286. Linhardt RJ, Toida T. Tech.Sight. Capillary electrophoresis. Ultra-high resolution separation comes of age. Science. 2002 Nov 15; 298(5597):1441-2.
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    287. Yu G, Gunay NS, Linhardt RJ, Toida T, Fareed J, Hoppensteadt DA, Shadid H, Ferro V, Li C, Fewings K, Palermo MC, Podger D. Preparation and anticoagulant activity of the phosphosulfomannan PI-88. Eur J Med Chem. 2002 Oct; 37(10):783-91.
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    288. Yeh BK, Eliseenkova AV, Plotnikov AN, Green D, Pinnell J, Polat T, Gritli-Linde A, Linhardt RJ, Mohammadi M. Structural basis for activation of fibroblast growth factor signaling by sucrose octasulfate. Mol Cell Biol. 2002 Oct; 22(20):7184-92.
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    289. DeAngelis PL, Gunay NS, Toida T, Mao WJ, Linhardt RJ. Identification of the capsular polysaccharides of Type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively. Carbohydr Res. 2002 Sep 27; 337(17):1547-52.
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    290. Bürgermeister J, Paper DH, Vogl H, Linhardt RJ, Franz G. LaPSvS1, a (1-->3)-beta-galactan sulfate and its effect on angiogenesis in vivo and in vitro. Carbohydr Res. 2002 Sep 9; 337(16):1459-66.
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    291. Bazin HG, Marques MA, Owens AP, Linhardt RJ, Crutcher KA. Inhibition of apolipoprotein E-related neurotoxicity by glycosaminoglycans and their oligosaccharides. Biochemistry. 2002 Jun 25; 41(25):8203-11.
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    292. Liu J, Shriver Z, Pope RM, Thorp SC, Duncan MB, Copeland RJ, Raska CS, Yoshida K, Eisenberg RJ, Cohen G, Linhardt RJ, Sasisekharan R. Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. J Biol Chem. 2002 Sep 6; 277(36):33456-67.
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    293. Chaidedgumjorn A, Suzuki A, Toyoda H, Toida T, Imanari T, Linhardt RJ. Conductivity detection for molecular mass estimation of per-O-sulfonated glycosaminoglycans separated by high-performance size-exclusion chromatography. J Chromatogr A. 2002 Jun 14; 959(1-2):95-102.
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    294. Capila I, Wu Y, Rethwisch DW, Matte A, Cygler M, Linhardt RJ. Role of arginine 292 in the catalytic activity of chondroitin AC lyase from Flavobacterium heparinum. Biochim Biophys Acta. 2002 Jun 3; 1597(2):260-70.
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    295. Zhang F, Murhammer DW, Linhardt RJ. Enzyme kinetics and glycan structural characterization of secreted alkaline phosphatase prepared using the baculovirus expression vector system. Appl Biochem Biotechnol. 2002 Jun; 101(3):197-210.
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    296. Hiebert LM, Wice SM, Ping T, Hileman RE, Polat T, Linhardt RJ. Tissue distribution of [14C]sucrose octasulfate following oral administration to rats. Pharm Res. 2002 Jun; 19(6):838-44.
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    297. Hernaiz MJ, LeBrun LA, Wu Y, Sen JW, Linhardt RJ, Heegaard NH. Characterization of heparin binding by a peptide from amyloid P component using capillary electrophoresis, surface plasmon resonance and isothermal titration calorimetry. Eur J Biochem. 2002 Jun; 269(12):2860-7.
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    298. Zhang F, Fath M, Marks R, Linhardt RJ. A highly stable covalent conjugated heparin biochip for heparin-protein interaction studies. Anal Biochem. 2002 May 15; 304(2):271-3.
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    299. van de Westerlo EM, Smetsers TF, Dennissen MA, Linhardt RJ, Veerkamp JH, van Muijen GN, van Kuppevelt TH. Human single chain antibodies against heparin: selection, characterization, and effect on coagulation. Blood. 2002 Apr 1; 99(7):2427-33.
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    300. Mao W, Thanawiroon C, Linhardt RJ. Capillary electrophoresis for the analysis of glycosaminoglycans and glycosaminoglycan-derived oligosaccharides. Biomed Chromatogr. 2002 Apr; 16(2):77-94.
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    301. Sakai S, Onose J, Nakamura H, Toyoda H, Toida T, Imanari T, Linhardt RJ. Pretreatment procedure for the microdetermination of chondroitin sulfate in plasma and urine. Anal Biochem. 2002 Mar 15; 302(2):169-74.
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    302. Yu G, Guan H, Ioanoviciu AS, Sikkander SA, Thanawiroon C, Tobacman JK, Toida T, Linhardt RJ. Structural studies on kappa-carrageenan derived oligosaccharides. Carbohydr Res. 2002 Mar 1; 337(5):433-40.
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    303. Ma Q, Dudas B, Daud A, Iqbal O, Hoppensteadt D, Jeske W, Cornelli U, Lee J, Lorens S, Mervis R, Hanin I, Capila I, Linhardt R, Fareed J. Molecular and biochemical profiling of a heparin-derived oligosaccharide, C3. Thromb Res. 2002 Feb 15; 105(4):303-9.
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    304. Ferro V, Li C, Fewings K, Palermo MC, Linhardt RJ, Toida T. Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC. Carbohydr Res. 2002 Feb 5; 337(2):139-46.
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    305. Cho SY, Kim JS, Li H, Shim C, Linhardt RJ, Kim YS. Enhancement of paracellular transport of heparin disaccharide across Caco-2 cell monolayers. Arch Pharm Res. 2002 Feb; 25(1):86-92.
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    306. Capila I, Linhardt RJ. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1; 41(3):391-412.
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    307. Zhang F, Saarinen MA, Itle LJ, Lang SC, Murhammer DW, Linhardt RJ. The effect of dissolved oxygen (DO) concentration on the glycosylation of recombinant protein produced by the insect cell-baculovirus expression system. Biotechnol Bioeng. 2002 Jan 20; 77(2):219-24.
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    308. Ye S, Luo Y, Lu W, Jones RB, Linhardt RJ, Capila I, Toida T, Kan M, Pelletier H, McKeehan WL. Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs. Biochemistry. 2001 Dec 4; 40(48):14429-39.
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    309. Jeong J, Toida T, Muneta Y, Kosiishi I, Imanari T, Linhardt RJ, Choi HS, Wu SJ, Kim YS. Localization and characterization of acharan sulfate in the body of the giant African snail Achatina fulica. Comp Biochem Physiol B Biochem Mol Biol. 2001 Dec; 130(4):513-9.
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    310. Mulloy B, Linhardt RJ. Order out of complexity--protein structures that interact with heparin. Curr Opin Struct Biol. 2001 Oct; 11(5):623-8.
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    311. Rathore D, McCutchan TF, Garboczi DN, Toida T, Hernáiz MJ, LeBrun LA, Lang SC, Linhardt RJ. Direct measurement of the interactions of glycosaminoglycans and a heparin decasaccharide with the malaria circumsporozoite protein. Biochemistry. 2001 Sep 25; 40(38):11518-24.
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    312. Libeu CP, Lund-Katz S, Phillips MC, Wehrli S, Hernáiz MJ, Capila I, Linhardt RJ, Raffaï RL, Newhouse YM, Zhou F, Weisgraber KH. New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E. J Biol Chem. 2001 Oct 19; 276(42):39138-44.
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    313. Wolff MW, Zhang F, Roberg JJ, Caldwell EE, Kaul PR, Serrahn JN, Murhammer DW, Linhardt RJ, Weiler JM. Expression of C1 esterase inhibitor by the baculovirus expression vector system: preparation, purification, and characterization. Protein Expr Purif. 2001 Aug; 22(3):414-21.
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    314. Edens RE, LeBrun LA, Linhardt RJ, Kaul PR, Weiler JM. Certain high molecular weight heparin chains have high affinity for vitronectin. Arch Biochem Biophys. 2001 Jul 15; 391(2):278-85.
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    315. Marks RM, Lu H, Sundaresan R, Toida T, Suzuki A, Imanari T, Hernáiz MJ, Linhardt RJ. Probing the interaction of dengue virus envelope protein with heparin: assessment of glycosaminoglycan-derived inhibitors. J Med Chem. 2001 Jun 21; 44(13):2178-87.
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    316. Linhardt RJ. Analysis of glycosaminoglycans with polysaccharide lyases. Curr Protoc Mol Biol. 2001 May; Chapter 17:Unit17.13B.
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    317. Demir M, Iqbal O, Hoppensteadt DA, Piccolo P, Ahmad S, Schultz CL, Linhardt RJ, Fareed J. Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88). Clin Appl Thromb Hemost. 2001 Apr; 7(2):131-40.
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    318. Dong J, Peters-Libeu CA, Weisgraber KH, Segelke BW, Rupp B, Capila I, Hernáiz MJ, LeBrun LA, Linhardt RJ. Interaction of the N-terminal domain of apolipoprotein E4 with heparin. Biochemistry. 2001 Mar 6; 40(9):2826-34.
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    319. Huang W, Boju L, Tkalec L, Su H, Yang HO, Gunay NS, Linhardt RJ, Kim YS, Matte A, Cygler M. Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis. Biochemistry. 2001 Feb 27; 40(8):2359-72.
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    320. Zhang F, Wolff MW, Williams D, Busch K, Lang SC, Murhammer DW, Linhardt RJ. Affinity purification of secreted alkaline phosphatase produced by baculovirus expression vector system. Appl Biochem Biotechnol. 2001 Feb; 90(2):125-36.
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    321. Koketsu M, Linhardt RJ. X-ray diffraction and high-resolution NMR spectroscopic analysis of 2,4,7,8-tetra-O-acetyl-3-deoxy-alpha-D-manno-2-octulopyranosono-1,5-lactone. Carbohydr Res. 2001 Jan 15; 330(1):145-7.
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    322. Capila I, Hernáiz MJ, Mo YD, Mealy TR, Campos B, Dedman JR, Linhardt RJ, Seaton BA. Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces. Structure. 2001 Jan 10; 9(1):57-64.
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    323. LeBrun LA, Linhardt RJ. Degradation of heparan sulfate with heparin lyases. Methods Mol Biol. 2001; 171:353-61.
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    324. Hernáiz MJ, Linhardt RJ. Degradation of chondroitin sulfate and dermatan sulfate with chondroitin lyases. Methods Mol Biol. 2001; 171:363-71.
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    325. Yu G, LeBrun L, Gunay NS, Hoppensteadt D, Walenga JM, Fareed J, Linhardt RJ. Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site. Thromb Res. 2000 Dec 15; 100(6):549-56.
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    326. Choe J, Zhang F, Wolff MW, Murhammer DW, Linhardt RJ, Dordick JS. Separation of alpha-acid glycoprotein glycoforms using affinity-based reversed micellar extraction and separation. Biotechnol Bioeng. 2000 Dec 5; 70(5):484-90.
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    327. Dasgupta F, Masada RI, Starr CM, Kuberan B, Yang HO, Linhardt RJ. Chemoenzymatic preparation of dermatan sulfate oligosaccharides as arylsulfatase B and alpha-L-iduronidase substrates. Glycoconj J. 2000 Dec; 17(12):829-34.
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    328. Koketsu M, Kuberan B, Linhardt RJ. Stereoselective synthesis of the alpha-glycoside of a KDO "C"-disaccharide. Org Lett. 2000 Oct 19; 2(21):3361-3.
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    329. Yang HO, Gunay NS, Toida T, Kuberan B, Yu G, Kim YS, Linhardt RJ. Preparation and structural determination of dermatan sulfate-derived oligosaccharides. Glycobiology. 2000 Oct; 10(10):1033-9.
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    330. Hernaiz M, Liu J, Rosenberg RD, Linhardt RJ. Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III. Biochem Biophys Res Commun. 2000 Sep 16; 276(1):292-7.
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    331. Shriver Z, Raman R, Venkataraman G, Drummond K, Turnbull J, Toida T, Linhardt R, Biemann K, Sasisekharan R. Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding site. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10359-64.
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    332. Shriver Z, Sundaram M, Venkataraman G, Fareed J, Linhardt R, Biemann K, Sasisekharan R. Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10365-70.
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    333. Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, Linhardt RJ, Mohammadi M. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 2000 Sep; 6(3):743-50.
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    334. Koketsu M, Linhardt RJ. Electrophoresis for the analysis of acidic oligosaccharides. Anal Biochem. 2000 Aug 1; 283(2):136-45.
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    335. Kim BT, Kim WS, Kim YS, Linhardt RJ, Kim DH. Purification and characterization of a novel heparinase from Bacteroides stercoris HJ-15. J Biochem. 2000 Aug; 128(2):323-8.
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    336. Kilpelainen I, Kaksonen M, Kinnunen T, Avikainen H, Fath M, Linhardt RJ, Raulo E, Rauvala H. Heparin-binding growth-associated molecule contains two heparin-binding beta -sheet domains that are homologous to the thrombospondin type I repeat. J Biol Chem. 2000 May 5; 275(18):13564-70.
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    337. Wang Q, Wolff M, Polat T, Du Y, Linhardt RJ. Inhibition of neuraminidase with neuraminic acid C-glycosides. Bioorg Med Chem Lett. 2000 May 1; 10(9):941-4.
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    338. Hiebert LM, Wice SM, Ping T, Hileman RE, Capila I, Linhardt RJ. Tissue distribution and antithrombotic activity of unlabeled or 14C-labeled porcine intestinal mucosal heparin following administration to rats by the oral route. Can J Physiol Pharmacol. 2000 Apr; 78(4):307-20.
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    339. Huang W, Matte A, Li Y, Kim YS, Linhardt RJ, Su H, Cygler M. Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution. J Mol Biol. 1999 Dec 17; 294(5):1257-69.
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    340. Park Y, Yu G, Gunay NS, Linhardt RJ. Purification and characterization of heparan sulphate proteoglycan from bovine brain. Biochem J. 1999 Dec 15; 344 Pt 3:723-30.
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    341. Toida T, Maruyama T, Ogita Y, Suzuki A, Toyoda H, Imanari T, Linhardt RJ. Preparation and anticoagulant activity of fully O-sulphonated glycosaminoglycans. Int J Biol Macromol. 1999 Dec 1; 26(4):233-41.
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    342. Wolff MW, Murhammer DW, Jarvis DL, Linhardt RJ. Electrophoretic analysis of glycoprotein glycans produced by lepidopteran insect cells infected with an immediate early recombinant baculovirus encoding mammalian beta1,4-galactosyltransferase. Glycoconj J. 1999 Dec; 16(12):753-6.
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    343. Garg HG, Joseph PA, Thompson BT, Hales CA, Toida T, Imanari T, Capila I, Linhardt RJ. Effect of fully sulfated glycosaminoglycans on pulmonary artery smooth muscle cell proliferation. Arch Biochem Biophys. 1999 Nov 15; 371(2):228-33.
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    344. Amornrut C, Toida T, Imanari T, Woo ER, Park H, Linhardt R, Wu SJ, Kim YS. A new sulfated beta-galactan from clams with anti-HIV activity. Carbohydr Res. 1999 Sep 15; 321(1-2):121-7.
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    345. Mikhailov D, Young HC, Linhardt RJ, Mayo KH. Heparin dodecasaccharide binding to platelet factor-4 and growth-related protein-alpha. Induction of a partially folded state and implications for heparin-induced thrombocytopenia. J Biol Chem. 1999 Sep 3; 274(36):25317-29.
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    346. Fath M, VanderNoot V, Kilpeläinen I, Kinnunen T, Rauvala H, Linhardt RJ. Interaction of soluble and surface-bound heparin binding growth-associated molecule with heparin. FEBS Lett. 1999 Jul 2; 454(1-2):105-8.
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    347. Kuberan B, Gunay NS, Dordick JS, Linhardt RJ. Preparation and isolation of neoglycoconjugates using biotin-streptavidin complexes. Glycoconj J. 1999 Jun; 16(6):271-81.
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    348. Gunay NS, Linhardt RJ. Heparinoids: structure, biological activities and therapeutic applications. Planta Med. 1999 May; 65(4):301-6.
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    349. Capila I, VanderNoot VA, Mealy TR, Seaton BA, Linhardt RJ. Interaction of heparin with annexin V. FEBS Lett. 1999 Mar 12; 446(2-3):327-30.
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    350. Wolff MW, Murhammer DW, Linhardt RJ. Release and preparation of intact and unreduced N-linked oligosaccharides from Sf-9 insect cells. Prep Biochem Biotechnol. 1999 Feb; 29(1):1-21.
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    351. Caldwell EE, Andreasen AM, Blietz MA, Serrahn JN, VanderNoot V, Park Y, Yu G, Linhardt RJ, Weiler JM. Heparin binding and augmentation of C1 inhibitor activity. Arch Biochem Biophys. 1999 Jan 15; 361(2):215-22.
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    352. Linhardt RJ, Gunay NS. Production and chemical processing of low molecular weight heparins. Semin Thromb Hemost. 1999; 25 Suppl 3:5-16.
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    353. Wu SJ, Chun MW, Shin KH, Toida T, Park Y, Linhardt RJ, Kim YS. Chemical sulfonation and anticoagulant activity of acharan sulfate. Thromb Res. 1998 Dec 15; 92(6):273-81.
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    354. Hileman RE, Siegel MM, Tabei K, Balagurunathan K, Linhardt RJ. Isolation and characterization of beta-cyclodextrin sulfates by preparative gradient polyacrylamide gel electrophoresis, capillary electrophoresis and electrospray ionization - mass spectrometry. Electrophoresis. 1998 Nov; 19(15):2677-81.
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    355. Wu X, Linhardt RJ. Capillary affinity chromatography and affinity capillary electrophoresis of heparin binding proteins. Electrophoresis. 1998 Nov; 19(15):2650-3.
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    356. Hileman RE, Jennings RN, Linhardt RJ. Thermodynamic analysis of the heparin interaction with a basic cyclic peptide using isothermal titration calorimetry. Biochemistry. 1998 Oct 27; 37(43):15231-7.
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    357. Faham S, Linhardt RJ, Rees DC. Diversity does make a difference: fibroblast growth factor-heparin interactions. Curr Opin Struct Biol. 1998 Oct; 8(5):578-86.
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    358. Kim YS, Ahn MY, Wu SJ, Kim DH, Toida T, Teesch LM, Park Y, Yu G, Lin J, Linhardt RJ. Determination of the structure of oligosaccharides prepared from acharan sulfate. Glycobiology. 1998 Sep; 8(9):869-77.
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    359. Bazin HG, Capila I, Linhardt RJ. Conformational study of synthetic delta 4-uronate monosaccharides and glycosaminoglycan-derived disaccharides. Carbohydr Res. 1998 Jun; 309(2):135-44.
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    360. Fath MA, Wu X, Hileman RE, Linhardt RJ, Kashem MA, Nelson RM, Wright CD, Abraham WM. Interaction of secretory leukocyte protease inhibitor with heparin inhibits proteases involved in asthma. J Biol Chem. 1998 May 29; 273(22):13563-9.
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    361. Ahn MY, Shin KH, Kim DH, Jung EA, Toida T, Linhardt RJ, Kim YS. Characterization of a Bacteroides species from human intestine that degrades glycosaminoglycans. Can J Microbiol. 1998 May; 44(5):423-9.
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    362. Wu X, Loganathan D, Linhardt RJ. Sensitive method for the quantification of beta-glucuronidase activity in human urine using capillary electrophoresis with fluorescence detection. J Chromatogr B Biomed Sci Appl. 1998 Apr 24; 708(1-2):61-6.
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    363. VanderNoot VA, Hileman RE, Dordick JS, Linhardt RJ. Affinity capillary electrophoresis employing immobilized glycosaminoglycan to resolve heparin-binding peptides. Electrophoresis. 1998 Mar; 19(3):437-41.
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    364. Koenig A, Norgard-Sumnicht K, Linhardt R, Varki A. Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents. J Clin Invest. 1998 Feb 15; 101(4):877-89.
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    365. Hileman RE, Fromm JR, Weiler JM, Linhardt RJ. Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins. Bioessays. 1998 Feb; 20(2):156-67.
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    366. Martin BD, Linhardt RJ, Dordick JS. Highly swelling hydrogels from ordered galactose-based polyacrylates. Biomaterials. 1998 Jan-Feb; 19(1-3):69-76.
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    367. Maruyama T, Toida T, Imanari T, Yu G, Linhardt RJ. Conformational changes and anticoagulant activity of chondroitin sulfate following its O-sulfonation. Carbohydr Res. 1998 Jan; 306(1-2):35-43.
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    368. Mikhailov D, Linhardt RJ, Mayo KH. NMR solution conformation of heparin-derived hexasaccharide. Biochem J. 1997 Nov 15; 328 ( Pt 1):51-61.
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    369. Toida T, Shima M, Azumaya S, Maruyama T, Toyoda H, Imanari T, Linhardt RJ. Detection of glycosaminoglycans as a copper(II) complex in high-performance liquid chromatography. J Chromatogr A. 1997 Nov 7; 787(1-2):266-70.
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    370. Fromm JR, Hileman RE, Weiler JM, Linhardt RJ. Interaction of fibroblast growth factor-1 and related peptides with heparan sulfate and its oligosaccharides. Arch Biochem Biophys. 1997 Oct 15; 346(2):252-62.
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    371. Toida T, Huang Y, Washio Y, Maruyama T, Toyoda H, Imanari T, Linhardt RJ. Chemical microdetermination of heparin in plasma. Anal Biochem. 1997 Sep 5; 251(2):219-26.
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    372. Nadkarni VD, Linhardt RJ. Directional immobilization of heparin onto the nonporous surface of polystyrene microplates. Biotechniques. 1997 Sep; 23(3):382-5.
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    373. Chen Y, Maguire T, Hileman RE, Fromm JR, Esko JD, Linhardt RJ, Marks RM. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nat Med. 1997 Aug; 3(8):866-71.
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    374. Fromm JR, Hileman RE, Caldwell EE, Weiler JM, Linhardt RJ. Pattern and spacing of basic amino acids in heparin binding sites. Arch Biochem Biophys. 1997 Jul 1; 343(1):92-100.
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    375. Siegel MM, Tabei K, Kagan MZ, Vlahov IR, Hileman RE, Linhardt RJ. Polysulfated carbohydrates analyzed as ion-paired complexes with basic peptides and proteins using electrospray negative ionization mass spectrometry. J Mass Spectrom. 1997 Jul; 32(7):760-72.
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    376. Choe J, VanderNoot VA, Linhardt RJ, Dordick JS. Parameters affecting the efficiency of affinity-based reversed micellar extraction and separation (ARMES) in glycoprotein purification. Biotechnol Prog. 1997 Jul-Aug; 13(4):440-5.
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    377. Wang H, Toida T, Kim YS, Capila I, Hileman RE, Bernfield M, Linhardt RJ. Glycosaminoglycans can influence fibroblast growth factor-2 mitogenicity without significant growth factor binding. Biochem Biophys Res Commun. 1997 Jun 18; 235(2):369-73.
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    378. Zhou FY, Kan M, Owens RT, McKeehan WL, Thompson JA, Linhardt RJ, Höök M. Heparin-dependent fibroblast growth factor activities: effects of defined heparin oligosaccharides. Eur J Cell Biol. 1997 May; 73(1):71-80.
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    379. Hileman RE, Smith AE, Toida T, Linhardt RJ. Preparation and structure of heparin lyase-derived heparan sulfate oligosaccharides. Glycobiology. 1997 Mar; 7(2):231-9.
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    380. Toida T, Yoshida H, Toyoda H, Koshiishi I, Imanari T, Hileman RE, Fromm JR, Linhardt RJ. Structural differences and the presence of unsubstituted amino groups in heparan sulphates from different tissues and species. Biochem J. 1997 Mar 1; 322 ( Pt 2):499-506.
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    381. Park Y, Cho S, Linhardt RJ. Exploration of the action pattern of Streptomyces hyaluronate lyase using high-resolution capillary electrophoresis. Biochim Biophys Acta. 1997 Feb 8; 1337(2):217-26.
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    382. Dougher AM, Wasserstrom H, Torley L, Shridaran L, Westdock P, Hileman RE, Fromm JR, Anderberg R, Lyman S, Linhardt RJ, Kaplan J, Terman BI. Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor. Growth Factors. 1997; 14(4):257-68.
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    383. Toida T, Hileman RE, Smith AE, Vlahova PI, Linhardt RJ. Enzymatic preparation of heparin oligosaccharides containing antithrombin III binding sites. J Biol Chem. 1996 Dec 13; 271(50):32040-7.
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    384. Booth BA, Boes M, Dake BL, Linhardt RJ, Caldwell EE, Weiler JM, Bar RS. Structure-function relationships in the heparin-binding C-terminal region of insulin-like growth factor binding protein-3. Growth Regul. 1996 Dec; 6(4):206-13.
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    385. Nadkarni VD, Toida T, Van Gorp CL, Schubert RL, Weiler JM, Hansen KP, Caldwell EE, Linhardt RJ. Preparation and biological activity of N-sulfonated chondroitin and dermatan sulfate derivatives. Carbohydr Res. 1996 Aug 26; 290(1):87-96.
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    386. Mikhailov D, Mayo KH, Vlahov IR, Toida T, Pervin A, Linhardt RJ. NMR solution conformation of heparin-derived tetrasaccharide. Biochem J. 1996 Aug 15; 318 ( Pt 1):93-102.
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    387. Kim YS, Jo YY, Chang IM, Toida T, Park Y, Linhardt RJ. A new glycosaminoglycan from the giant African snail Achatina fulica. J Biol Chem. 1996 May 17; 271(20):11750-5.
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    388. Mikhailov D, Mayo KH, Pervin A, Linhardt RJ. 13C-NMR relation study of heparin-disaccharide interactions with tripeptides GRG and GKG. Biochem J. 1996 Apr 15; 315 ( Pt 2):447-54.
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    389. Faham S, Hileman RE, Fromm JR, Linhardt RJ, Rees DC. Heparin structure and interactions with basic fibroblast growth factor. Science. 1996 Feb 23; 271(5252):1116-20.
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    390. Toida T, Linhardt RJ. Detection of glycosaminoglycans as a copper (II) complex in capillary electrophoresis. Electrophoresis. 1996 Feb; 17(2):341-6.
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    391. Caldwell EE, Nadkarni VD, Fromm JR, Linhardt RJ, Weiler JM. Importance of specific amino acids in protein binding sites for heparin and heparan sulfate. Int J Biochem Cell Biol. 1996 Feb; 28(2):203-16.
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    392. Linhardt RJ, Pervin A. Separation of negatively charged carbohydrates by capillary electrophoresis. J Chromatogr A. 1996 Jan 12; 720(1-2):323-35.
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    393. Jandik KA, Kruep D, Cartier M, Linhardt RJ. Accelerated stability studies of heparin. J Pharm Sci. 1996 Jan; 85(1):45-51.
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    394. Liu J, Desai UR, Han XJ, Toida T, Linhardt RJ. Strategy for the sequence analysis of heparin. Glycobiology. 1995 Dec; 5(8):765-74.
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    395. Gu K, Linhardt RJ, Laliberté M, Gu K, Zimmermann J. Purification, characterization and specificity of chondroitin lyases and glycuronidase from Flavobacterium heparinum. Biochem J. 1995 Dec 1; 312 ( Pt 2):569-77.
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    396. Fromm JR, Hileman RE, Caldwell EE, Weiler JM, Linhardt RJ. Differences in the interaction of heparin with arginine and lysine and the importance of these basic amino acids in the binding of heparin to acidic fibroblast growth factor. Arch Biochem Biophys. 1995 Nov 10; 323(2):279-87.
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    397. Griffin CC, Linhardt RJ, Van Gorp CL, Toida T, Hileman RE, Schubert RL, Brown SE. Isolation and characterization of heparan sulfate from crude porcine intestinal mucosal peptidoglycan heparin. Carbohydr Res. 1995 Oct 16; 276(1):183-97.
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    398. Desai UR, Vlahov IR, Pervin A, Linhardt RJ. Conformational analysis of sucrose octasulfate by high resolution nuclear magnetic resonance spectroscopy. Carbohydr Res. 1995 Oct 2; 275(2):391-401.
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    399. Kerns RJ, Linhardt RJ. Separation of hydroxyl protected heparin derived disaccharides using reversed-phase high-performance liquid chromatography. J Chromatogr A. 1995 Jun 30; 705(2):369-73.
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    400. Linhardt RJ, Han XJ, Fromm JR. Lectin affinity electrophoresis. Mol Biotechnol. 1995 Jun; 3(3):191-7.
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    401. Nadkarni VD, Linhardt RJ. Modified assay for the measurement of biotin in the presence of heparin. Anal Biochem. 1995 May 20; 227(2):402-4.
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    402. Linhardt RJ, Hileman RE. Dermatan sulfate as a potential therapeutic agent. Gen Pharmacol. 1995 May; 26(3):443-51.
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    403. Kim YS, Liu J, Han XJ, Pervin A, Linhardt RJ. Analysis of fluorescently labeled sugars by reversed-phase ion-pairing high-performance liquid chromatography. J Chromatogr Sci. 1995 Apr; 33(4):162-7.
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    404. Booth BA, Boes M, Andress DL, Dake BL, Kiefer MC, Maack C, Linhardt RJ, Bar K, Caldwell EE, Weiler J, et al. IGFBP-3 and IGFBP-5 association with endothelial cells: role of C-terminal heparin binding domain. Growth Regul. 1995 Mar; 5(1):1-17.
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    405. Newburg DS, Linhardt RJ, Ampofo SA, Yolken RH. Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor. J Nutr. 1995 Mar; 125(3):419-24.
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    406. Edens RE, Fromm JR, Fromm SJ, Linhardt RJ, Weiler JM. Two-dimensional affinity resolution electrophoresis demonstrates that three distinct heparin populations interact with antithrombin III. Biochemistry. 1995 Feb 28; 34(8):2400-7.
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    407. Kerns RJ, Vlahov IR, Linhardt RJ. Capillary electrophoresis for monitoring chemical reactions: sulfation and synthetic manipulation of sulfated carbohydrates. Carbohydr Res. 1995 Feb 1; 267(1):143-52.
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    408. Pervin A, Gallo C, Jandik KA, Han XJ, Linhardt RJ. Preparation and structural characterization of large heparin-derived oligosaccharides. Glycobiology. 1995 Feb; 5(1):83-95.
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    409. Desai UR, Linhardt RJ. Molecular weight of heparin using 13C nuclear magnetic resonance spectroscopy. J Pharm Sci. 1995 Feb; 84(2):212-5.
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    410. Nelson RM, Venot A, Bevilacqua MP, Linhardt RJ, Stamenkovic I. Carbohydrate-protein interactions in vascular biology. Annu Rev Cell Dev Biol. 1995; 11:601-31.
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    411. Nadkarni VD, Pervin A, Linhardt RJ. Directional immobilization of heparin onto beaded supports. Anal Biochem. 1994 Oct; 222(1):59-67.
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    412. Pervin A, al-Hakim A, Linhardt RJ. Separation of glycosaminoglycan-derived oligosaccharides by capillary electrophoresis using reverse polarity. Anal Biochem. 1994 Aug 15; 221(1):182-8.
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    413. Liu J, Pervin A, Gallo CM, Desai UR, Van Gorp CL, Linhardt RJ. New approaches for the preparation of hydrophobic heparin derivatives. J Pharm Sci. 1994 Jul; 83(7):1034-9.
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    414. Bae J, Desai UR, Pervin A, Caldwell EE, Weiler JM, Linhardt RJ. Interaction of heparin with synthetic antithrombin III peptide analogues. Biochem J. 1994 Jul 1; 301 ( Pt 1):121-9.
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    415. Lin WJ, Flanagan DR, Linhardt RJ. Accelerated degradation of poly(epsilon-caprolactone) by organic amines. Pharm Res. 1994 Jul; 11(7):1030-4.
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    416. Jandik KA, Gu K, Linhardt RJ. Action pattern of polysaccharide lyases on glycosaminoglycans. Glycobiology. 1994 Jun; 4(3):289-96.
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    417. Linhardt RJ, Desai UR, Liu J, Pervin A, Hoppensteadt D, Fareed J. Low molecular weight dermatan sulfate as an antithrombotic agent. Structure-activity relationship studies. Biochem Pharmacol. 1994 Mar 29; 47(7):1241-52.
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    418. Desai UR, Linhardt RJ. Molecular weight of low molecular weight heparins by 13C nuclear magnetic resonance spectroscopy. Carbohydr Res. 1994 Mar 4; 255:193-212.
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    419. Edens RE, Linhardt RJ, Bell CS, Weiler JM. Heparin and derivatized heparin inhibit zymosan and cobra venom factor activation of complement in serum. Immunopharmacology. 1994 Mar-Apr; 27(2):145-53.
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    420. Linhardt RJ. Capillary electrophoresis of oligosaccharides. Methods Enzymol. 1994; 230:265-80.
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    421. Nelson RM, Cecconi O, Roberts WG, Aruffo A, Linhardt RJ, Bevilacqua MP. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood. 1993 Dec 1; 82(11):3253-8.
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    422. Desai UR, Wang HM, Linhardt RJ. Substrate specificity of the heparin lyases from Flavobacterium heparinum. Arch Biochem Biophys. 1993 Nov 1; 306(2):461-8.
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    423. Desai UR, Wang HM, Linhardt RJ. Specificity studies on the heparin lyases from Flavobacterium heparinum. Biochemistry. 1993 Aug 17; 32(32):8140-5.
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    424. Desai UR, Wang H, Ampofo SA, Linhardt RJ. Oligosaccharide composition of heparin and low-molecular-weight heparins by capillary electrophoresis. Anal Biochem. 1993 Aug 15; 213(1):120-7.
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    425. Gu K, Liu J, Pervin A, Linhardt RJ. Comparison of the activity of two chondroitin AC lyases on dermatan sulfate. Carbohydr Res. 1993 Jun 21; 244(2):369-77.
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    426. Mach H, Volkin DB, Burke CJ, Middaugh CR, Linhardt RJ, Fromm JR, Loganathan D, Mattsson L. Nature of the interaction of heparin with acidic fibroblast growth factor. Biochemistry. 1993 May 25; 32(20):5480-9.
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    427. Desai UR, Wang HM, Kelly TR, Linhardt RJ. Structure elucidation of a novel acidic tetrasaccharide and hexasaccharide derived from a chemically modified heparin. Carbohydr Res. 1993 Mar 17; 241:249-59.
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    428. Gu K, Edens RE, Jandik KA, Linhardt RJ. Monoclonal antibodies prepared against heparin lyase I and their reactivity toward heparin lyase I, II and III. Int J Biochem. 1993 Mar; 25(3):331-6.
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    429. Schmitt EA, Flanagan DR, Linhardt RJ. Degradation and release properties of pellets fabricated from three commercial poly(D,L-lactide-co-glycolide) biodegradable polymers. J Pharm Sci. 1993 Mar; 82(3):326-9.
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    430. Pervin A, Gu K, Linhardt RJ. Capillary electrophoresis to measure sulfoesterase activity on chondroitin sulfate and heparin derived disaccharides. Appl Theor Electrophor. 1993; 3(6):297-303.
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    431. Volkin DB, Tsai PK, Dabora JM, Gress JO, Burke CJ, Linhardt RJ, Middaugh CR. Physical stabilization of acidic fibroblast growth factor by polyanions. Arch Biochem Biophys. 1993 Jan; 300(1):30-41.
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    432. Linhardt RJ, Ampofo SA, Fareed J, Hoppensteadt D, Mulliken JB, Folkman J. Isolation and characterization of human heparin. Biochemistry. 1992 Dec 15; 31(49):12441-5.
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    433. Lohse DL, Linhardt RJ. Purification and characterization of heparin lyases from Flavobacterium heparinum. J Biol Chem. 1992 Dec 5; 267(34):24347-55.
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    434. Lamb DJ, Wang HM, Mallis LM, Linhardt RJ. Negative ion fast-atom bombardment tandem mass spectrometry to determine sulfate and linkage position in glycosaminoglycan-derived disaccharides. J Am Soc Mass Spectrom. 1992 Nov; 3(8):797-803.
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    435. Lee KB, Desai UR, Palcic MM, Hindsgaul O, Linhardt RJ. An electrophoresis-based assay for glycosyltransferase activity. Anal Biochem. 1992 Aug 15; 205(1):108-14.
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    436. Edens RE, al-Hakim A, Weiler JM, Rethwisch DG, Fareed J, Linhardt RJ. Gradient polyacrylamide gel electrophoresis for determination of molecular weights of heparin preparations and low-molecular-weight heparin derivatives. J Pharm Sci. 1992 Aug; 81(8):823-7.
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    437. Lee KB, Kim YS, Linhardt RJ. Lectin affinity electrophoresis for the separation of fluorescently labeled sugar derivatives. Anal Biochem. 1992 Jun; 203(2):206-10.
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    438. Weiler JM, Edens RE, Linhardt RJ, Kapelanski DP. Heparin and modified heparin inhibit complement activation in vivo. J Immunol. 1992 May 15; 148(10):3210-5.
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    439. Linhardt RJ, Wang HM, Loganathan D, Lamb DJ, Mallis LM. Analysis of glycosaminoglycan-derived oligosaccharides using fast-atom-bombardment mass-spectrometry. Carbohydr Res. 1992 Feb 17; 225(1):137-45.
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    440. Linhardt RJ, Wang HM, Loganathan D, Bae JH. Search for the heparin antithrombin III-binding site precursor. J Biol Chem. 1992 Feb 5; 267(4):2380-7.
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    441. Linhardt RJ, Wang HM, Ampofo SA. New methodologies in heparin structure analysis and the generation of LMW heparins. Adv Exp Med Biol. 1992; 313:37-47.
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    442. Ampofo SA, Wang HM, Linhardt RJ. Disaccharide compositional analysis of heparin and heparan sulfate using capillary zone electrophoresis. Anal Biochem. 1991 Dec; 199(2):249-55.
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    443. Linhardt RJ, al-Hakim A, Liu JA, Hoppensteadt D, Mascellani G, Bianchini P, Fareed J. Structural features of dermatan sulfates and their relationship to anticoagulant and antithrombotic activities. Biochem Pharmacol. 1991 Sep 27; 42(8):1609-19.
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    444. Wang HM, Loganathan D, Linhardt RJ. Determination of the pKa of glucuronic acid and the carboxy groups of heparin by 13C-nuclear-magnetic-resonance spectroscopy. Biochem J. 1991 Sep 15; 278 ( Pt 3):689-95.
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    445. Lee KB, Kim YS, Linhardt RJ. Capillary zone electrophoresis for the quantitation of oligosaccharides formed through the action of chitinase. Electrophoresis. 1991 Sep; 12(9):636-40.
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    446. Lee KB, al-Hakim A, Loganathan D, Linhardt RJ. A new method for sequencing linear oligosaccharides on gels using charged, fluorescent conjugates. Carbohydr Res. 1991 Jul 18; 214(1):155-68.
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    447. Weiler JM, Linhardt RJ. Antithrombin III regulates complement activity in vitro. J Immunol. 1991 Jun 1; 146(11):3889-94.
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    448. al-Hakim A, Linhardt RJ. Capillary electrophoresis for the analysis of chondroitin sulfate- and dermatan sulfate-derived disaccharides. Anal Biochem. 1991 May 15; 195(1):68-73.
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    449. al-Hakim A, Linhardt RJ. Electrophoresis and detection of nanogram quantities of exogenous and endogenous glycosaminoglycans in biological fluids. Appl Theor Electrophor. 1991; 1(6):305-12.
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    450. Linhardt RJ, al-Hakim A, Liu SY, Kim YS, Fareed J. Molecular profile and mapping of dermatan sulfates from different origins. Semin Thromb Hemost. 1991; 17 Suppl 1:15-22.
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    451. Gordon DL, Linhardt R, Adams HP. Low-molecular-weight heparins and heparinoids and their use in acute or progressing ischemic stroke. Clin Neuropharmacol. 1990 Dec; 13(6):522-43.
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    452. Wang HT, Palmer H, Linhardt RJ, Flanagan DR, Schmitt E. Degradation of poly(ester) microspheres. Biomaterials. 1990 Nov; 11(9):679-85.
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    453. Edens RE, Linhardt RJ, Weiler JM. Immobilization of C3b with retention of functional activity. J Immunol Methods. 1990 Oct 4; 133(1):67-70.
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    454. Linhardt RJ, Loganathan D, al-Hakim A, Wang HM, Walenga JM, Hoppensteadt D, Fareed J. Oligosaccharide mapping of low molecular weight heparins: structure and activity differences. J Med Chem. 1990 Jun; 33(6):1639-45.
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    455. Loganathan D, Wang HM, Mallis LM, Linhardt RJ. Structural variation in the antithrombin III binding site region and its occurrence in heparin from different sources. Biochemistry. 1990 May 8; 29(18):4362-8.
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    456. Linhardt RJ, Turnbull JE, Wang HM, Loganathan D, Gallagher JT. Examination of the substrate specificity of heparin and heparan sulfate lyases. Biochemistry. 1990 Mar 13; 29(10):2611-7.
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    457. Linhardt RJ, Baenziger NC, Ronsen B. Structure of amiprilose hydrochloride, a novel anti-inflammatory agent. J Pharm Sci. 1990 Feb; 79(2):158-62.
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    458. Cohen DM, Linhardt RJ. Randomness in the heparin polymer: computer simulations of alternative action patterns of heparin lyase. Biopolymers. 1990; 30(7-8):733-41.
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    459. al-Hakim A, Linhardt RJ. Isolation and recovery of acidic oligosaccharides from polyacrylamide gels by semi-dry electrotransfer. Electrophoresis. 1990 Jan; 11(1):23-8.
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    460. Lee KB, Loganathan D, Merchant ZM, Linhardt RJ. Carbohydrate analysis of glycoproteins. A review. Appl Biochem Biotechnol. 1990 Jan; 23(1):53-80.
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    461. Linhardt RJ, Gu KN, Loganathan D, Carter SR. Analysis of glycosaminoglycan-derived oligosaccharides using reversed-phase ion-pairing and ion-exchange chromatography with suppressed conductivity detection. Anal Biochem. 1989 Sep; 181(2):288-96.
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    462. Rice KG, Linhardt RJ. Study of structurally defined oligosaccharide substrates of heparin and heparan monosulfate lyases. Carbohydr Res. 1989 Jul 15; 190(2):219-33.
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    463. Mallis LM, Wang HM, Loganathan D, Linhardt RJ. Sequence analysis of highly sulfated, heparin-derived oligosaccharides using fast atom bombardment mass spectrometry. Anal Chem. 1989 Jul 1; 61(13):1453-8.
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    464. Linhardt RJ, Cohen DM, Rice KG. Nonrandom structural features in the heparin polymer. Biochemistry. 1989 Apr 4; 28(7):2888-94.
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    465. Weiler JM, Linhardt RJ. Comparison of the activity of polyanions and polycations on the classical and alternative pathways of complement. Immunopharmacology. 1989 Mar-Apr; 17(2):65-72.
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    466. Biller J, Massey EW, Marler JR, Adams HP, Davis JN, Bruno A, Henriksen RA, Linhardt RJ, Goldstein LB, Alberts M, et al. A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke. Neurology. 1989 Feb; 39(2 Pt 1):262-5.
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    467. Larsen AK, Rice KG, Linhardt RJ, Wogan G, Langer R. Resistance of heparinase-derived heparin fragments to biotransformation. J Biol Chem. 1989 Jan 25; 264(3):1570-7.
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    468. Linhardt RJ, Bakhit R, Daniels L, Mayerl F, Pickenhagen W. Microbially produced rhamnolipid as a source of rhamnose. Biotechnol Bioeng. 1989 Jan 15; 33(3):365-8.
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    469. Kim YS, Linhardt RJ. Structural features of heparin and their effect on heparin cofactor II mediated inhibition of thrombin. Thromb Res. 1989 Jan 1; 53(1):55-71.
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    470. Linhardt RJ, Rice KG, Kim YS, Engelken JD, Weiler JM. Homogeneous, structurally defined heparin-oligosaccharides with low anticoagulant activity inhibit the generation of the amplification pathway C3 convertase in vitro. J Biol Chem. 1988 Sep 15; 263(26):13090-6.
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    471. Linhardt RJ, Rice KG, Kim YS, Lohse DL, Wang HM, Loganathan D. Mapping and quantification of the major oligosaccharide components of heparin. Biochem J. 1988 Sep 15; 254(3):781-7.
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    472. Kim YS, Lee KB, Linhardt RJ. Microheterogeneity of plasma glycoproteins heparin cofactor II and antithrombin III and their carbohydrate analysis. Thromb Res. 1988 Jul 1; 51(1):97-104.
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    473. Linhardt RJ. Bioassays. Patents and literature. Appl Biochem Biotechnol. 1987 Oct; 15(3):279-95.
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    474. Rice KG, Rottink MK, Linhardt RJ. Fractionation of heparin-derived oligosaccharides by gradient polyacrylamide-gel electrophoresis. Biochem J. 1987 Jun 15; 244(3):515-22.
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    475. Linhardt RJ. Monoclonal antibodies and immobilized antibodies. Patents and literature. Appl Biochem Biotechnol. 1987 Jun; 15(1):53-80.
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    476. Linhardt RJ, Langer R. New approaches for anticoagulation in extracorporeal therapy. Biomater Artif Cells Artif Organs. 1987; 15(1):91-100.
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    477. Linhardt RJ. Microbial transformations and bioconversions. Patents and literature. Appl Biochem Biotechnol. 1986 Dec; 13(3):249-62.
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    478. Linhardt RJ, Rice KG, Merchant ZM, Kim YS, Lohse DL. Structure and activity of a unique heparin-derived hexasaccharide. J Biol Chem. 1986 Nov 5; 261(31):14448-54.
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    479. Merchant ZM, Erbe EE, Eddy WP, Patel D, Linhardt RJ. Effect of very low molecular weight heparin-derived oligosaccharides on lipoprotein lipase release in rabbits. Atherosclerosis. 1986 Nov; 62(2):151-8.
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    480. Linhardt RJ. Mammalian cell culture. Patents and literature. Appl Biochem Biotechnol. 1986 Oct; 13(2):167-74.
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    481. Beck DW, Olson JJ, Linhardt RJ. Effect of heparin, heparin fragments, and corticosteroids on cerebral endothelial cell growth in vitro and in vivo. J Neuropathol Exp Neurol. 1986 Sep; 45(5):503-12.
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    482. Linhardt RJ. Protein engineering and site-directed mutagenesis. Patents and literature. Appl Biochem Biotechnol. 1986 Aug; 13(1):75-83.
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    483. Linhardt RJ. DNA probes for clinical applications. Patents and literature. Appl Biochem Biotechnol. 1986 Jun; 12(3):301-10.
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    484. Bryan BA, Linhardt RJ, Daniels L. Variation in composition and yield of exopolysaccharides produced by Klebsiella sp. strain K32 and Acinetobacter calcoaceticus BD4. Appl Environ Microbiol. 1986 Jun; 51(6):1304-8.
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    485. Linhardt RJ, Galliher PM, Cooney CL. Polysaccharide lyases. Appl Biochem Biotechnol. 1986 Apr; 12(2):135-76.
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    486. Linhardt RJ. Applications of polysaccharides. Patents and literature. Appl Biochem Biotechnol. 1986 Apr; 12(2):177-97.
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    487. Linhardt RJ, Merchant ZM, Rice KG, Kim YS, Fitzgerald GL, Grant AC, Langer R. Evidence of random structural features in the heparin polymer. Biochemistry. 1985 Dec 17; 24(26):7805-10.
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    488. Linhardt RJ. Bioassays. Patents and literature. Appl Biochem Biotechnol. 1985 Dec; 11(6):465-87.
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    489. Rice KG, Kim YS, Grant AC, Merchant ZM, Linhardt RJ. High-performance liquid chromatographic separation of heparin-derived oligosaccharides. Anal Biochem. 1985 Nov 1; 150(2):325-31.
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    490. Linhardt RJ. Affinity separation. Patents and literature. Appl Biochem Biotechnol. 1985 Oct; 11(5):409-26.
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    491. Linhardt RJ. Nucleic acid technology. Patents and literature. Appl Biochem Biotechnol. 1985 Aug; 11(4):333-48.
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    492. Merchant ZM, Kim YS, Rice KG, Linhardt RJ. Structure of heparin-derived tetrasaccharides. Biochem J. 1985 Jul 15; 229(2):369-77.
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    493. Linhardt RJ. Monoclonal antibodies and immobilized antibodies. Patents and literature. Appl Biochem Biotechnol. 1985 Jun; 11(3):233-48.
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    494. Sharath MD, Merchant ZM, Kim YS, Rice KG, Linhardt RJ, Weiler JM. Small heparin fragments regulate the amplification pathway of complement. Immunopharmacology. 1985 Apr; 9(2):73-80.
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    495. Yang VC, Linhardt RJ, Bernstein H, Cooney CL, Langer R. Purification and characterization of heparinase from Flavobacterium heparinum. J Biol Chem. 1985 Feb 10; 260(3):1849-57.
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    496. Linhardt RJ, Merchant ZM, Persinger DW. Immuno-affinity purification of heparinase. Int J Biochem. 1985; 17(11):1179-83.
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    497. Larsen AK, Linhardt RJ, Tapper D, Klein M, Langer R. Effect of extracorporeal enzymatic deheparinization on formed blood components. Artif Organs. 1984 May; 8(2):198-203.
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    498. Grant AC, Linhardt RJ, Fitzgerald GL, Park JJ, Langer R. Metachromatic activity of heparin and heparin fragments. Anal Biochem. 1984 Feb; 137(1):25-32.
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    499. Linhardt RJ, Cooney CL, Tapper D, Zannetos CA, Larsen AK, Langer R. An immobilized microbial heparinase for blood deheparinization. Appl Biochem Biotechnol. 1984 Feb; 9(1):41-55.
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    500. Klein MD, Drongowski RA, Linhardt RJ, Cooney CL, Langer RS. Heparinase: in vivo activity and immunogenicity in rabbits. J Lab Clin Med. 1983 Nov; 102(5):828-37.
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    501. Folkman J, Langer R, Linhardt RJ, Haudenschild C, Taylor S. Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science. 1983 Aug 19; 221(4612):719-25.
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    502. Rosen HB, Chang J, Wnek GE, Linhardt RJ, Langer R. Bioerodible polyanhydrides for controlled drug delivery. Biomaterials. 1983 Apr; 4(2):131-3.
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    503. Langer R, Linhardt RJ, Hoffberg S, Larsen AK, Cooney CL, Tapper D, Klein M. An enzymatic system for removing heparin in extracorporeal therapy. Science. 1982 Jul 16; 217(4556):261-3.
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    504. Klein MD, Drongowski RA, Linhardt RJ, Langer RS. A colorimetric assay for chemical heparin in plasma. Anal Biochem. 1982 Jul 15; 124(1):59-64.
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    505. Linhardt RJ, Grant A, Cooney CL, Langer R. Differential anticoagulant activity of heparin fragments prepared using microbial heparinase. J Biol Chem. 1982 Jul 10; 257(13):7310-3.
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    506. Linhardt RJ, Fitzgerald GL, Cooney CL, Langer R. Mode of action of heparin lyase on heparin. Biochim Biophys Acta. 1982 Apr 3; 702(2):197-203.
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    507. Langer R, Linhardt RJ, Larsen AK, Cooney CL, Tapper D, Klein M. In vivo activity of microbial heparinase. Trans Am Soc Artif Intern Organs. 1982; 28:387-90.
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    508. Galliher PM, Cooney CL, Langer R, Linhardt RJ. Heparinase production by Flavobacterium heparinum. Appl Environ Microbiol. 1981 Feb; 41(2):360-5.
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    509. Linhardt R, Belian C. [Results of surgery for superficial varicose veins]. Zentralbl Chir. 1973 Mar 23; 98(12):433-9.
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