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Mattheos Koffas

TitleAssociate Professor
InstitutionRensselaer Polytechnic Institute
DepartmentChemical and Biological Engineering
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang W, Englaender JA, Xu P, Mehta KK, Suwan J, Dordick JS, Zhang F, Yuan Q, Linhardt RJ, Koffas M. Expression of low endotoxin 3-O-sulfotransferase in Bacillus subtilis and Bacillus megaterium. Appl Biochem Biotechnol. 2013 Oct; 171(4):954-62.
      View in: PubMed
    2. Mora-Pale M, Sanchez-Rodriguez SP, Linhardt RJ, Dordick JS, Koffas MA. Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues. Plant Sci. 2013 Sep; 210:10-24.
      View in: PubMed
    3. Bhan N, Xu P, Koffas MA. Pathway and protein engineering approaches to produce novel and commodity small molecules. Curr Opin Biotechnol. 2013 Dec; 24(6):1137-43.
      View in: PubMed
    4. Cress BF, Linhardt RJ, Koffas MA. Draft Genome Sequence of Escherichia coli Strain Nissle 1917 (Serovar O6:K5:H1). Genome Announc. 2013 Mar-Apr; 1(2):e0004713.
      View in: PubMed
    5. Cress BF, Greene ZR, Linhardt RJ, Koffas MA. Draft Genome Sequence of Escherichia coli Strain ATCC 23506 (Serovar O10:K5:H4). Genome Announc. 2013 Mar-Apr; 1(2):e0004913.
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    6. Cress BF, Greene ZR, Linhardt RJ, Koffas MA. Draft Genome Sequence of Escherichia coli Strain ATCC 23502 (Serovar O5:K4:H4). Genome Announc. 2013 Mar-Apr; 1(2):e0004613.
      View in: PubMed
    7. Cress BF, Erkert KA, Barquera B, Koffas MA. Draft Genome Sequence of Pseudoalteromonas luteoviolacea Strain B (ATCC 29581). Genome Announc. 2013 Mar-Apr; 1(2):e0004813.
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    8. Xu P, Koffas MA. Assembly of multi-gene pathways and combinatorial pathway libraries through ePathBrick vectors. Methods Mol Biol. 2013; 1073:107-29.
      View in: PubMed
    9. Xu P, Gu Q, Wang W, Wong L, Bower AG, Collins CH, Koffas MA. Modular optimization of multi-gene pathways for fatty acids production in E. coli. Nat Commun. 2013; 4:1409.
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    10. Xu P, Bhan N, Koffas MA. Engineering plant metabolism into microbes: from systems biology to synthetic biology. Curr Opin Biotechnol. 2013 Apr; 24(2):291-9.
      View in: PubMed
    11. Xu P, Vansiri A, Bhan N, Koffas MA. ePathBrick: a synthetic biology platform for engineering metabolic pathways in E. coli. ACS Synth Biol. 2012 Jul 20; 1(7):256-66.
      View in: PubMed
    12. Malla S, Koffas MA, Kazlauskas RJ, Kim BG. Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli. Appl Environ Microbiol. 2012 Feb; 78(3):684-94.
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    13. Fowler ZL, Shah K, Panepinto JC, Jacobs A, Koffas MA. Development of non-natural flavanones as antimicrobial agents. PLoS One. 2011; 6(10):e25681.
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    14. Xu P, Ranganathan S, Fowler ZL, Maranas CD, Koffas MA. Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. Metab Eng. 2011 Sep; 13(5):578-87.
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    15. Lim CG, Fowler ZL, Hueller T, Schaffer S, Koffas MA. High-yield resveratrol production in engineered Escherichia coli. Appl Environ Microbiol. 2011 May; 77(10):3451-60.
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    16. Santos CN, Koffas M, Stephanopoulos G. Optimization of a heterologous pathway for the production of flavonoids from glucose. Metab Eng. 2011 Jul; 13(4):392-400.
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    17. Fowler ZL, Baron CM, Panepinto JC, Koffas MA. Melanization of flavonoids by fungal and bacterial laccases. Yeast. 2011 Mar; 28(3):181-8.
      View in: PubMed
    18. Chemler JA, Lim CG, Daiss JL, Koffas MA. A versatile microbial system for biosynthesis of novel polyphenols with altered estrogen receptor binding activity. Chem Biol. 2010 Apr 23; 17(4):392-401.
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    19. Bedekar A, Shah K, Koffas M. Natural products for type II diabetes treatment. Adv Appl Microbiol. 2010; 71:21-73.
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    20. Fowler ZL, Gikandi WW, Koffas MA. Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production. Appl Environ Microbiol. 2009 Sep; 75(18):5831-9.
      View in: PubMed
    21. Chemler JA, Fowler ZL, McHugh KP, Koffas MA. Improving NADPH availability for natural product biosynthesis in Escherichia coli by metabolic engineering. Metab Eng. 2010 Mar; 12(2):96-104.
      View in: PubMed
    22. Fowler ZL, Koffas MA. Biosynthesis and biotechnological production of flavanones: current state and perspectives. Appl Microbiol Biotechnol. 2009 Jul; 83(5):799-808.
      View in: PubMed
    23. Koffas MA. Expanding the repertoire of biofuel alternatives through metabolic pathway evolution. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):965-6.
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    24. Chemier JA, Fowler ZL, Koffas MA, Leonard E. Trends in microbial synthesis of natural products and biofuels. Adv Enzymol Relat Areas Mol Biol. 2009; 76:151-217.
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    25. Chemler JA, Koffas MA. Metabolic engineering for plant natural product biosynthesis in microbes. Curr Opin Biotechnol. 2008 Dec; 19(6):597-605.
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    26. Yan Y, Li Z, Koffas MA. High-yield anthocyanin biosynthesis in engineered Escherichia coli. Biotechnol Bioeng. 2008 May 1; 100(1):126-40.
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    27. Leonard E, Yan Y, Fowler ZL, Li Z, Lim CG, Lim KH, Koffas MA. Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids. Mol Pharm. 2008 Mar-Apr; 5(2):257-65.
      View in: PubMed
    28. Chemler JA, Lock LT, Koffas MA, Tzanakakis ES. Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion. Appl Microbiol Biotechnol. 2007 Dec; 77(4):797-807.
      View in: PubMed
    29. Yan Y, Huang L, Koffas MA. Biosynthesis of 5-deoxyflavanones in microorganisms. Biotechnol J. 2007 Oct; 2(10):1250-62.
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    30. Leonard E, Koffas MA. Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli. Appl Environ Microbiol. 2007 Nov; 73(22):7246-51.
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    31. Leonard E, Lim KH, Saw PN, Koffas MA. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. Appl Environ Microbiol. 2007 Jun; 73(12):3877-86.
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    32. Chemler JA, Yan Y, Leonard E, Koffas MA. Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms. Org Lett. 2007 May 10; 9(10):1855-8.
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    33. Chemler JA, Yan Y, Koffas MA. Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. Microb Cell Fact. 2006; 5:20.
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    34. Leonard E, Yan Y, Koffas MA. Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli. Metab Eng. 2006 Mar; 8(2):172-81.
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    35. Leonard E, Yan Y, Lim KH, Koffas MA. Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae. Appl Environ Microbiol. 2005 Dec; 71(12):8241-8.
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    36. Yan Y, Kohli A, Koffas MA. Biosynthesis of natural flavanones in Saccharomyces cerevisiae. Appl Environ Microbiol. 2005 Sep; 71(9):5610-3.
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    37. Leonard E, Chemler J, Lim KH, Koffas MA. Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. Appl Microbiol Biotechnol. 2006 Mar; 70(1):85-91.
      View in: PubMed
    38. Yan Y, Chemler J, Huang L, Martens S, Koffas MA. Metabolic engineering of anthocyanin biosynthesis in Escherichia coli. Appl Environ Microbiol. 2005 Jul; 71(7):3617-23.
      View in: PubMed
    39. Koffas M, Stephanopoulos G. Strain improvement by metabolic engineering: lysine production as a case study for systems biology. Curr Opin Biotechnol. 2005 Jun; 16(3):361-6.
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    40. Koffas MA, Jung GY, Stephanopoulos G. Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression. Metab Eng. 2003 Jan; 5(1):32-41.
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    41. Koffas MA, Jung GY, Aon JC, Stephanopoulos G. Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum. Appl Environ Microbiol. 2002 Nov; 68(11):5422-8.
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    42. Koffas M, Roberge C, Lee K, Stephanopoulos G. Metabolic engineering. Annu Rev Biomed Eng. 1999; 1:535-57.
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    43. Koffas MA, Ramamoorthi R, Pine WA, Sinskey AJ, Stephanopoulos G. Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene. Appl Microbiol Biotechnol. 1998 Sep; 50(3):346-52.
      View in: PubMed
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