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Last Name
Institution

Nikolaos K. Robakis

TitlePROFESSOR
InstitutionMount Sinai
DepartmentPsychiatry
Address
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentNeuroscience


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates aß clearance and attenuates cognitive deterioration in an Alzheimer mouse model. J Biol Chem. 2013 Nov 1; 288(44):32050-63.
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    2. Xuan Z, Barthet G, Shioi J, Xu J, Georgakopoulos A, Bruban J, Robakis NK. Presenilin-1/?-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B. J Biol Chem. 2013 Oct 18; 288(42):30495-501.
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    3. Barthet G, Georgakopoulos A, Robakis NK. Cellular mechanisms of ?-secretase substrate selection, processing and toxicity. Prog Neurobiol. 2012 Aug; 98(2):166-75.
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    4. Barthet G, Dunys J, Shao Z, Xuan Z, Ren Y, Xu J, Arbez N, Mauger G, Bruban J, Georgakopoulos A, Shioi J, Robakis NK. Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiol Aging. 2013 Feb; 34(2):499-510.
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    5. Xu J, Xilouri M, Bruban J, Shioi J, Shao Z, Papazoglou I, Vekrellis K, Robakis NK. Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling. Neurobiol Aging. 2011 Dec; 32(12):2326.e5-16.
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    6. Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G, Robakis NK. Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein. FASEB J. 2011 Oct; 25(10):3594-604.
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    7. Barthet G, Shioi J, Shao Z, Ren Y, Georgakopoulos A, Robakis NK. Inhibitors of ?-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates. FASEB J. 2011 Sep; 25(9):2937-46.
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    8. Roussos P, Giakoumaki SG, Georgakopoulos A, Robakis NK, Bitsios P. The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. Bipolar Disord. 2011 May; 13(3):250-9.
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    9. Michailidis IE, Rusinova R, Georgakopoulos A, Chen Y, Iyengar R, Robakis NK, Logothetis DE, Baki L. Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflugers Arch. 2011 Mar; 461(3):387-97.
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    10. Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci. 2010 Nov 10; 30(45):14946-54.
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    11. Robakis NK. Mechanisms of AD neurodegeneration may be independent of Aß and its derivatives. Neurobiol Aging. 2011 Mar; 32(3):372-9.
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    12. Robakis NK. Are Abeta and its derivatives causative agents or innocent bystanders in AD? Neurodegener Dis. 2010; 7(1-3):32-7.
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    13. Robakis NK. Alzheimer's disease: new light on etiology and management. Mt Sinai J Med. 2010 Jan-Feb; 77(1):1-2.
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    14. Xu J, Litterst C, Georgakopoulos A, Zaganas I, Robakis NK. Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors. J Biol Chem. 2009 Oct 2; 284(40):27220-8.
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    15. Eder-Colli L, Abad-Estarlich N, Pannetier C, Vallet PG, Walzer C, Elder GA, Robakis NK, Bouras C, Savioz A. The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells. Brain Res Bull. 2009 Oct 28; 80(4-5):296-301.
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    16. Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis. 2009; 16(4):731-40.
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    17. Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK. p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. J Biol Chem. 2009 Jan 23; 284(4):1954-61.
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    18. Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling. J Neurosci. 2008 Jan 9; 28(2):483-90.
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    19. Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK. Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J Biol Chem. 2007 Jun 1; 282(22):16155-63.
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    20. Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK. FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta. J Neurochem. 2007 May; 101(3):674-81.
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    21. Fassa A, Parisiadou L, Robakis NK, Efthimiopoulos S. Novel processing of Notch 1 within its intracellular domain by a cysteine protease. Neurodegener Dis. 2007; 4(2-3):148-55.
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    22. Robakis NK. The discovery and mapping to chromosome 21 of the Alzheimer's amyloid gene: history revised. J Alzheimers Dis. 2006 Dec; 10(4):453-5.
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    23. Arnaud L, Robakis NK, Figueiredo-Pereira ME. It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease. Neurodegener Dis. 2006; 3(6):313-9.
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    24. Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 2006 Mar 22; 25(6):1242-52.
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    25. Agiostratidou G, Muros RM, Shioi J, Marambaud P, Robakis NK. The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. J Neurochem. 2006 Feb; 96(4):1182-8.
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    26. Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK. Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. J Biol Chem. 2005 Oct 28; 280(43):36007-12.
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    27. Marambaud P, Robakis NK. Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation. Genes Brain Behav. 2005 Apr; 4(3):134-46.
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    28. Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol. 2004 Aug; 188(2):224-37.
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    29. Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 2004 Jul 7; 23(13):2586-96.
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    30. Umehara Y, Yamada S, Nishimura S, Shioi J, Robakis NK, Sugahara K. Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors. FEBS Lett. 2004 Jan 16; 557(1-3):233-8.
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    31. Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. J Biol Chem. 2003 Dec 19; 278(51):50970-7.
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    32. Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell. 2003 Sep 5; 114(5):635-45.
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    33. Robakis NK. An Alzheimer's disease hypothesis based on transcriptional dysregulation. Amyloid. 2003 Jun; 10(2):80-5.
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    34. Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiol Dis. 2002 Jun; 10(1):8-19.
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    35. Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002 Apr 15; 21(8):1948-56.
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    36. Wen PH, Friedrich VL, Shioi J, Robakis NK, Elder GA. Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice. Neurosci Lett. 2002 Jan 25; 318(2):53-6.
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    37. Bussière T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, Giannakopoulos P, Robakis NK, Morrison JH, Perl DP, Hof PR. Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience. 2002; 112(1):75-91.
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    38. Tsuchida K, Shioi J, Yamada S, Boghosian G, Wu A, Cai H, Sugahara K, Robakis NK. Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region. J Biol Chem. 2001 Oct 5; 276(40):37155-60.
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    39. Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2381-6.
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    40. Blitzer RD, Wong T, Giovannini MG, Pangalos MN, Robakis NK, Landau EM. Amyloid beta peptides activate the phosphoinositide signaling pathway in oocytes expressing rat brain RNA. Brain Res Mol Brain Res. 2000 Mar 10; 76(1):115-20.
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    41. Georgakopoulos A, Marambaud P, Friedrich VL, Shioi J, Efthimiopoulos S, Robakis NK. Presenilin-1: a component of synaptic and endothelial adherens junctions. Ann N Y Acad Sci. 2000; 920:209-14.
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    42. Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schütte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL, Robakis NK. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol Cell. 1999 Dec; 4(6):893-902.
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    43. Giannakopoulos P, Kövari E, Buée L, Shioi J, Hof PR, Robakis NK, Bouras C. Presenilin-1 expression in Pick's disease. Acta Neuropathol. 1999 Nov; 98(5):488-92.
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    44. Figueiredo-Pereira ME, Efthimiopoulos S, Tezapsidis N, Buku A, Ghiso J, Mehta P, Robakis NK. Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively. J Neurochem. 1999 Apr; 72(4):1417-22.
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    45. Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. J Biol Chem. 1999 Jan 29; 274(5):3165-72.
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    46. Jung MY, Skryabin BV, Arai M, Abbondanzo S, Fu D, Brosius J, Robakis NK, Polites HG, Pintar JE, Schmauss C. Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors. Neuroscience. 1999; 91(3):911-24.
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    47. Robakis NK, Efthimiopoulos S. Familial Alzheimer disease: changes in Abeta production may indicate a disturbance in protein transport or function caused by pleiotropic effects of FAD mutations. Neurobiol Aging. 1999 Jan-Feb; 20(1):81-3; discussion 87.
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    48. Bursztajn S, DeSouza R, McPhie DL, Berman SA, Shioi J, Robakis NK, Neve RL. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. J Neurosci. 1998 Dec 1; 18(23):9790-9.
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    49. Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook VY, Wisniewski T, Buee L, Robakis NK. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. J Neurochem. 1998 Dec; 71(6):2365-72.
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    50. Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. J Biol Chem. 1998 Mar 27; 273(13):7185-8.
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    51. Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook VY, Robakis NK. Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 1998 Feb 3; 37(5):1274-82.
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    52. Neve RL, Robakis NK. Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends Neurosci. 1998 Jan; 21(1):15-9.
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    53. Wu A, Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix. J Neurosci. 1997 Jul 1; 17(13):4987-93.
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    54. Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J Neurosci. 1997 Mar 1; 17(5):1683-90.
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    55. Giannakopoulos P, Bouras C, Kövari E, Shioi J, Tezapsidis N, Hof PR, Robakis NK. Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease. Am J Pathol. 1997 Feb; 150(2):429-36.
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    56. Pangalos MN, Shioi J, Efthimiopoulos S, Wu A, Robakis NK. Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein. Neurodegeneration. 1996 Dec; 5(4):445-51.
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    57. Efthimiopoulos S, Punj S, Manolopoulos V, Pangalos M, Wang GP, Refolo LM, Robakis NK. Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein. J Neurochem. 1996 Aug; 67(2):872-5.
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    58. Elder GA, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, Johnston JM, Efthimiopoulos S, Friedrich VL, Robakis NK. Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. J Neurosci Res. 1996 Aug 1; 45(3):308-20.
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    59. Efthimiopoulos S, Vassilacopoulou D, Ripellino JA, Tezapsidis N, Robakis NK. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):8046-50.
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    60. Bouras C, Giannakopoulos P, Schioi J, Tezapsidis N, Robakis NK. Presenilin-1 polymorphism and Alzheimer's disease. Lancet. 1996 Apr 27; 347(9009):1185-6.
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    61. Pangalos MN, Shioi J, Robakis NK. Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2. J Neurochem. 1995 Aug; 65(2):762-9.
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    62. Pappolla MA, Sambamurti K, Efthimiopoulos S, Refolo L, Omar RA, Robakis NK. Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins. Neurosci Lett. 1995 Jun 9; 192(2):105-8.
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    63. Fu D, Skryabin BV, Brosius J, Robakis NK. Molecular cloning and characterization of the mouse dopamine D3 receptor gene: an additional intron and an mRNA variant. DNA Cell Biol. 1995 Jun; 14(6):485-92.
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    64. Shioi J, Pangalos MN, Ripellino JA, Vassilacopoulou D, Mytilineou C, Margolis RU, Robakis NK. The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures. J Biol Chem. 1995 May 19; 270(20):11839-44.
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    65. Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene. J Biol Chem. 1995 May 5; 270(18):10388-91.
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    66. Vassilacopoulou D, Ripellino JA, Tezapsidis N, Hook VY, Robakis NK. Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism. J Neurochem. 1995 May; 64(5):2140-6.
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    67. Refolo LM, Sambamurti K, Efthimiopoulos S, Pappolla MA, Robakis NK. Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. J Neurosci Res. 1995 Apr 1; 40(5):694-706.
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    68. Ripellino JA, Vassilacopoulou D, Robakis NK. Solubilization of full-length amyloid precursor proteins from PC12 cell membranes. J Neurosci Res. 1994 Oct 1; 39(2):211-8.
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    69. Robakis NK, Pappolla MA. Oxygen-free radicals and amyloidosis in Alzheimer's disease: is there a connection? Neurobiol Aging. 1994 Jul-Aug; 15(4):457-9; discussion 473.
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    70. Shashidharan P, Michaelidis TM, Robakis NK, Kresovali A, Papamatheakis J, Plaitakis A. Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. J Biol Chem. 1994 Jun 17; 269(24):16971-6.
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    71. Efthimiopoulos S, Felsenstein KM, Sambamurti K, Robakis NK, Refolo LM. Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. J Neurosci Res. 1994 May 1; 38(1):81-90.
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    72. Roberts SB, Ripellino JA, Ingalls KM, Robakis NK, Felsenstein KM. Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase. J Biol Chem. 1994 Jan 28; 269(4):3111-6.
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    73. Robakis NK, Pangalos MN. Involvement of amyloid as a central step in the development of Alzheimer's disease. Neurobiol Aging. 1994; 15 Suppl 2:S127-9.
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    74. Buée L, Ding W, Anderson JP, Narindrasorasak S, Kisilevsky R, Boyle NJ, Robakis NK, Delacourte A, Greenberg B, Fillit HM. Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide. Brain Res. 1993 Nov 12; 627(2):199-204.
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    75. Robakis NK, Vassilacopoulou D, Efthimiopoulos S, Sambamurti K, Refolo LM, Shioi J. Cellular processing and proteoglycan nature of amyloid precursor proteins. Ann N Y Acad Sci. 1993 Sep 24; 695:132-8.
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    76. Shioi J, Refolo LM, Efthimiopoulos S, Robakis NK. Chondroitin sulfate proteoglycan form of cellular and cell-surface Alzheimer amyloid precursor. Neurosci Lett. 1993 May 14; 154(1-2):121-4.
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    77. Sambamurti K, Refolo LM, Shioi J, Pappolla MA, Robakis NK. The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Ann N Y Acad Sci. 1992 Dec 31; 674:118-28.
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    78. Anderson JP, Chen Y, Kim KS, Robakis NK. An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence. J Neurochem. 1992 Dec; 59(6):2328-31.
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    79. Pappolla MA, Omar RA, Sambamurti K, Anderson JP, Robakis NK. The genesis of the senile plaque. Further evidence in support of its neuronal origin. Am J Pathol. 1992 Nov; 141(5):1151-9.
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    80. Sambamurti K, Shioi J, Anderson JP, Pappolla MA, Robakis NK. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. J Neurosci Res. 1992 Oct; 33(2):319-29.
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    81. Shioi J, Anderson JP, Ripellino JA, Robakis NK. Chondroitin sulfate proteoglycan form of the Alzheimer's beta-amyloid precursor. J Biol Chem. 1992 Jul 15; 267(20):13819-22.
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    82. Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. Am J Pathol. 1992 Mar; 140(3):621-8.
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    83. Roch JM, Shapiro IP, Sundsmo MP, Otero DA, Refolo LM, Robakis NK, Saitoh T. Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor. J Biol Chem. 1992 Feb 5; 267(4):2214-21.
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    84. Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C. A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathol. 1992; 83(2):170-8.
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    85. Refolo LM, Wittenberg IS, Friedrich VL, Robakis NK. The Alzheimer amyloid precursor is associated with the detergent-insoluble cytoskeleton. J Neurosci. 1991 Dec; 11(12):3888-97.
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    86. Anderson JP, Esch FS, Keim PS, Sambamurti K, Lieberburg I, Robakis NK. Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett. 1991 Jul 8; 128(1):126-8.
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    87. Wallace WC, Bragin V, Robakis NK, Sambamurti K, VanderPutten D, Merril CR, Davis KL, Santucci AC, Haroutunian V. Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain Res Mol Brain Res. 1991 May; 10(2):173-8.
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    88. Lahiri DK, Robakis NK. The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences. Brain Res Mol Brain Res. 1991 Feb; 9(3):253-7.
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    89. Probst A, Langui D, Ipsen S, Robakis N, Ulrich J. Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques. Acta Neuropathol. 1991; 83(1):21-9.
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    90. Robakis NK, Anderson JP, Refolo LM, Wallace W. Expression of the Alzheimer amyloid precursor in brain tissue and effects of NGF and EGF on its metabolism. Clin Neuropharmacol. 1991; 14 Suppl 1:S15-23.
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    91. Robakis NK, Mohamadi M, Fu DY, Sambamurti K, Refolo LM. Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region. Nucleic Acids Res. 1990 Mar 11; 18(5):1299.
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    92. Berkenbosch F, Refolo LM, Friedrich VL, Casper D, Blum M, Robakis NK. The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia. J Neurosci Res. 1990 Mar; 25(3):431-40.
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    93. Harris MS, Devine-Gage E, Robakis NK. An AluI RFLP detected in the human prion protein (PrP) gene. Nucleic Acids Res. 1990 Jan 25; 18(2):385.
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    94. Brown HR, Goller NL, Rudelli RD, Merz GS, Wolfe GC, Wisniewski HM, Robakis NK. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. Acta Neuropathol. 1990; 80(1):1-6.
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    95. Anderson JP, Refolo LM, Wallace W, Mehta P, Krishnamurthi M, Gotlib J, Bierer L, Haroutunian V, Perl D, Robakis NK. Differential brain expression of the Alzheimer's amyloid precursor protein. EMBO J. 1989 Dec 1; 8(12):3627-32.
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    96. Refolo LM, Salton SR, Anderson JP, Mehta P, Robakis NK. Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures. Biochem Biophys Res Commun. 1989 Oct 31; 164(2):664-70.
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    97. La Fauci G, Lahiri DK, Salton SR, Robakis NK. Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene. Biochem Biophys Res Commun. 1989 Feb 28; 159(1):297-304.
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    98. Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Robakis NK, Wisniewski KE, Silverman WP, Reisberg B, Wisniewski HM. Beta-amyloid protein probe hybridized to chromosome 9 in 3 Alzheimer disease individuals. Prog Clin Biol Res. 1989; 317:269-75.
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    99. Jenkins EC, Devine-Gage EA, Robakis NK, Yao XL, Brown WT, Houck GE, Wolfe G, Ramakrishna N, Silverman WP, Wisniewski HM. Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein. Biochem Biophys Res Commun. 1988 Feb 29; 151(1):1-8.
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    100. Wu Y, Dobkin C, Devine-Gage E, Ramakrishna N, Brown WT, Wisniewski HM, Robakis NK. A high frequency NcoI RFLP detected in the Alzheimer amyloid peptide gene. Nucleic Acids Res. 1988 Feb 25; 16(4):1647.
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    101. Warren AC, Robakis NK, Ramakrishna N, Koo EH, Ross CA, Robb AS, Folstein MF, Price DL, Antonarakis SE. beta-Amyloid gene is not present in three copies in autopsy-validated Alzheimer's disease. Genomics. 1987 Dec; 1(4):307-12.
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    102. Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Wisniewski HM, Robakis NK. In-situ hybridisation of the beta-amyloid protein probe to chromosome 9 in patients with familial Alzheimer's disease. Lancet. 1987 Nov 14; 2(8568):1155-6.
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    103. David F, Robakis NK, Lucotte G. A new TaqI polymorphism detected by the cDNA encoding amyloid beta protein of Alzheimer's disease. Nucleic Acids Res. 1987 Nov 11; 15(21):9103.
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    104. Reeves RH, Robakis NK, Oster-Granite ML, Wisniewski HM, Coyle JT, Gearhart JD. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Res. 1987 Sep; 388(3):215-21.
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    105. Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):4190-4.
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    106. Wu Y, Brown WT, Robakis NK, Dobkin C, Devine-Gage E, Merz P, Wisniewski HM. A PvuII RFLP detected in the human prion protein (PrP) gene. Nucleic Acids Res. 1987 Apr 10; 15(7):3191.
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    107. Robakis NK, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yao XL, Ramakrishna N, Wolfe G, Silverman WP, Brown WT. Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet. 1987 Feb 14; 1(8529):384-5.
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    108. Robakis NK, Devine-Gage EA, Jenkins EC, Kascsak RJ, Brown WT, Krawczun MS, Silverman WP. Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain. Biochem Biophys Res Commun. 1986 Oct 30; 140(2):758-65.
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    109. Robakis NK, Sawh PR, Wolfe GC, Rubenstein R, Carp RI, Innis MA. Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues. Proc Natl Acad Sci U S A. 1986 Sep; 83(17):6377-81.
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    110. Kascsak RJ, Rubenstein R, Merz PA, Carp RI, Robakis NK, Wisniewski HM, Diringer H. Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol. 1986 Sep; 59(3):676-83.
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    111. Rubenstein R, Kascsak RJ, Merz PA, Papini MC, Carp RI, Robakis NK, Wisniewski HM. Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations. J Gen Virol. 1986 Apr; 67 ( Pt 4):671-81.
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    112. Robakis NK, Shapiro R, Szer W. Reversal of growth inhibition in Escherichia coli by bisulfite. Chem Biol Interact. 1983 Mar; 43(3):299-311.
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    113. Robakis NK, Rossman TG, Shapiro R, Szer W. The effects of bisulfite on growth and macromolecular synthesis in Escherichia coli. Chem Biol Interact. 1983 Mar; 43(3):289-98.
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    114. Robakis N, Cenatiempo Y, Meza-Basso L, Brot N, Weissbach H. A coupled DNA-directed in vitro system to study gene expression based on di- and tripeptide formation. Methods Enzymol. 1983; 101:690-706.
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    115. Cenatiempo Y, Robakis N, Reid BR, Weissbach H, Brot N. In vitro expression of Escherichia coli ribosomal protein L 10 gene: tripeptide synthesis as a measure of functional mRNA. Arch Biochem Biophys. 1982 Oct 15; 218(2):572-8.
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    116. Peacock S, Cenatiempo Y, Robakis N, Brot N, Weissbach H. In vitro synthesis of the first dipeptide of the beta subunit of Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A. 1982 Aug; 79(15):4609-12.
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    117. Boublik M, Robakis N, Hellmann W, Wall JS. Electron microscopic study of free and ribosome bound rRNAs from E. coli. Eur J Cell Biol. 1982 Jun; 27(2):177-84.
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    118. Cenatiempo Y, Robakis N, Meza-Basso L, Brot N, Weissbach H, Reid BR. Use of different tRNASer isoacceptor species in vitro to discriminate between the expression of plasmid genes. Proc Natl Acad Sci U S A. 1982 Mar; 79(5):1466-8.
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    119. Robakis N, Boublik M. Conformation of free and ribosome bound rRNAs and E. coli. Biochem Biophys Res Commun. 1981 Dec 31; 103(4):1401-8.
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    120. Meza-Basso L, Robakis N, Cenatiempo Y, Weissbach H, Brot N. Guanosine-5'-diphosphate-3'-diphosphate inhibits the in vitro synthesis of beta-lactamase from pBR322 DNA. Biochem Biophys Res Commun. 1981 Jul 30; 101(2):459-63.
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    121. Robakis N, Meza-Basso L, Brot N, Weissbach H. Translational control of ribosomal protein L10 synthesis occurs prior to formation of first peptide bond. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4261-4.
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