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Susan Gilbert

TitleProfessor
InstitutionRensselaer Polytechnic Institute
DepartmentBiology
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gonzalez MA, Cope J, Rank KC, Chen CJ, Tittmann P, Rayment I, Gilbert SP, Hoenger A. Common mechanistic themes for the powerstroke of kinesin-14 motors. J Struct Biol. 2013 Nov; 184(2):335-44.
      View in: PubMed
    2. Cope J, Rank KC, Gilbert SP, Rayment I, Hoenger A. Kar3Vik1 uses a minus-end directed powerstroke for movement along microtubules. PLoS One. 2013; 8(1):e53792.
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    3. Chen CJ, Porche K, Rayment I, Gilbert SP. The ATPase pathway that drives the kinesin-14 Kar3Vik1 powerstroke. J Biol Chem. 2012 Oct 26; 287(44):36673-82.
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    4. Rank KC, Chen CJ, Cope J, Porche K, Hoenger A, Gilbert SP, Rayment I. Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern. J Cell Biol. 2012 Jun 25; 197(7):957-70.
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    5. Sardar HS, Gilbert SP. Microtubule capture by mitotic kinesin centromere protein E (CENP-E). J Biol Chem. 2012 Jul 20; 287(30):24894-904.
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    6. Chen CJ, Rayment I, Gilbert SP. Kinesin Kar3Cik1 ATPase pathway for microtubule cross-linking. J Biol Chem. 2011 Aug 19; 286(33):29261-72.
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    7. Sardar HS, Luczak VG, Lopez MM, Lister BC, Gilbert SP. Mitotic kinesin CENP-E promotes microtubule plus-end elongation. Curr Biol. 2010 Sep 28; 20(18):1648-53.
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    8. Krzysiak TC, Grabe M, Gilbert SP. Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. J Biol Chem. 2008 Jan 25; 283(4):2078-87.
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    9. Allingham JS, Sproul LR, Rayment I, Gilbert SP. Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site. Cell. 2007 Mar 23; 128(6):1161-72.
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    10. Valentine MT, Gilbert SP. To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5. Curr Opin Cell Biol. 2007 Feb; 19(1):75-81.
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    11. Krzysiak TC, Gilbert SP. Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis. J Biol Chem. 2006 Dec 22; 281(51):39444-54.
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    12. Cochran JC, Krzysiak TC, Gilbert SP. Pathway of ATP hydrolysis by monomeric kinesin Eg5. Biochemistry. 2006 Oct 10; 45(40):12334-44.
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    13. Krzysiak TC, Wendt T, Sproul LR, Tittmann P, Gross H, Gilbert SP, Hoenger A. A structural model for monastrol inhibition of dimeric kinesin Eg5. EMBO J. 2006 May 17; 25(10):2263-73.
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    14. Valentine MT, Fordyce PM, Krzysiak TC, Gilbert SP, Block SM. Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro. Nat Cell Biol. 2006 May; 8(5):470-6.
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    15. Cochran JC, Gilbert SP. ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol. Biochemistry. 2005 Dec 20; 44(50):16633-48.
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    16. Hertzer KM, Ems-McClung SC, Kline-Smith SL, Lipkin TG, Gilbert SP, Walczak CE. Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK. Mol Biol Cell. 2006 Feb; 17(2):700-10.
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    17. Cui W, Sproul LR, Gustafson SM, Matthies HJ, Gilbert SP, Hawley RS. Drosophila Nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitro. Mol Biol Cell. 2005 Nov; 16(11):5400-9.
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    18. Sproul LR, Anderson DJ, Mackey AT, Saunders WS, Gilbert SP. Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends. Curr Biol. 2005 Aug 9; 15(15):1420-7.
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    19. Cochran JC, Gatial JE, Kapoor TM, Gilbert SP. Monastrol inhibition of the mitotic kinesin Eg5. J Biol Chem. 2005 Apr 1; 280(13):12658-67.
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    20. Mackey AT, Sproul LR, Sontag CA, Satterwhite LL, Correia JJ, Gilbert SP. Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3. J Biol Chem. 2004 Dec 3; 279(49):51354-61.
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    21. Cochran JC, Sontag CA, Maliga Z, Kapoor TM, Correia JJ, Gilbert SP. Mechanistic analysis of the mitotic kinesin Eg5. J Biol Chem. 2004 Sep 10; 279(37):38861-70.
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    22. Klumpp LM, Brendza KM, Gatial JE, Hoenger A, Saxton WM, Gilbert SP. Microtubule-kinesin interface mutants reveal a site critical for communication. Biochemistry. 2004 Mar 16; 43(10):2792-803.
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    23. Klumpp LM, Hoenger A, Gilbert SP. Kinesin's second step. Proc Natl Acad Sci U S A. 2004 Mar 9; 101(10):3444-9.
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    24. Skiniotis G, Cochran JC, Müller J, Mandelkow E, Gilbert SP, Hoenger A. Modulation of kinesin binding by the C-termini of tubulin. EMBO J. 2004 Mar 10; 23(5):989-99.
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    25. Klumpp LM, Mackey AT, Farrell CM, Rosenberg JM, Gilbert SP. A kinesin switch I arginine to lysine mutation rescues microtubule function. J Biol Chem. 2003 Oct 3; 278(40):39059-67.
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    26. Klumpp LM, Brendza KM, Rosenberg JM, Hoenger A, Gilbert SP. Motor domain mutation traps kinesin as a microtubule rigor complex. Biochemistry. 2003 Mar 11; 42(9):2595-606.
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    27. Mackey AT, Gilbert SP. The ATPase cross-bridge cycle of the Kar3 motor domain. Implications for single head motility. J Biol Chem. 2003 Feb 7; 278(6):3527-35.
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    28. Farrell CM, Mackey AT, Klumpp LM, Gilbert SP. The role of ATP hydrolysis for kinesin processivity. J Biol Chem. 2002 May 10; 277(19):17079-87.
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    29. Gilbert SP. High-performance fungal motors. Nature. 2001 Dec 6; 414(6864):597-8.
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    30. Foster KA, Mackey AT, Gilbert SP. A mechanistic model for Ncd directionality. J Biol Chem. 2001 Jun 1; 276(22):19259-66.
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    31. Gilbert SP, Mackey AT. Kinetics: a tool to study molecular motors. Methods. 2000 Dec; 22(4):337-54.
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    32. Brendza KM, Sontag CA, Saxton WM, Gilbert SP. A kinesin mutation that uncouples motor domains and desensitizes the gamma-phosphate sensor. J Biol Chem. 2000 Jul 21; 275(29):22187-95.
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    33. Foster KA, Gilbert SP. Kinetic studies of dimeric Ncd: evidence that Ncd is not processive. Biochemistry. 2000 Feb 22; 39(7):1784-91.
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    34. Mackey AT, Gilbert SP. Moving a microtubule may require two heads: a kinetic investigation of monomeric Ncd. Biochemistry. 2000 Feb 15; 39(6):1346-55.
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    35. Brendza KM, Rose DJ, Gilbert SP, Saxton WM. Lethal kinesin mutations reveal amino acids important for ATPase activation and structural coupling. J Biol Chem. 1999 Oct 29; 274(44):31506-14.
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    36. Iyadurai SJ, Li MG, Gilbert SP, Hays TS. Evidence for cooperative interactions between the two motor domains of cytoplasmic dynein. Curr Biol. 1999 Jul 15; 9(14):771-4.
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    37. Foster KA, Correia JJ, Gilbert SP. Equilibrium binding studies of non-claret disjunctional protein (Ncd) reveal cooperative interactions between the motor domains. J Biol Chem. 1998 Dec 25; 273(52):35307-18.
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    38. Gilbert SP, Moyer ML, Johnson KA. Alternating site mechanism of the kinesin ATPase. Biochemistry. 1998 Jan 20; 37(3):792-9.
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    39. Moyer ML, Gilbert SP, Johnson KA. Pathway of ATP hydrolysis by monomeric and dimeric kinesin. Biochemistry. 1998 Jan 20; 37(3):800-13.
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    40. Moyer ML, Gilbert SP, Johnson KA. Purification and characterization of two monomeric kinesin constructs. Biochemistry. 1996 May 21; 35(20):6321-9.
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    41. Johnson KA, Gilbert SP. Pathway of the microtubule-kinesin ATPase. Biophys J. 1995 Apr; 68(4 Suppl):173S-176S; discussion 176S-179S.
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    42. Gilbert SP, Webb MR, Brune M, Johnson KA. Pathway of processive ATP hydrolysis by kinesin. Nature. 1995 Feb 23; 373(6516):671-6.
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    43. Gilbert SP, Johnson KA. Pre-steady-state kinetics of the microtubule-kinesin ATPase. Biochemistry. 1994 Feb 22; 33(7):1951-60.
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    44. Gilbert SP, Johnson KA. Expression, purification, and characterization of the Drosophila kinesin motor domain produced in Escherichia coli. Biochemistry. 1993 May 4; 32(17):4677-84.
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    45. Harrison BC, Marchese-Ragona SP, Gilbert SP, Cheng N, Steven AC, Johnson KA. Decoration of the microtubule surface by one kinesin head per tubulin heterodimer. Nature. 1993 Mar 4; 362(6415):73-5.
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    46. Gilbert SP, Sloboda RD. A squid dynein isoform promotes axoplasmic vesicle translocation. J Cell Biol. 1989 Nov; 109(5):2379-94.
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    47. Gilbert SP, Sloboda RD. Identification of a MAP 2-like ATP-binding protein associated with axoplasmic vesicles that translocate on isolated microtubules. J Cell Biol. 1986 Sep; 103(3):947-56.
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