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Last Name
Institution

Georges Belfort

TitleProfessor
InstitutionRensselaer Polytechnic Institute
DepartmentChemical and Biological Engineering
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Radhakrishna M, Grimaldi J, Belfort G, Kumar SK. Stability of proteins inside a hydrophobic cavity. Langmuir. 2013 Jul 16; 29(28):8922-8.
      View in: PubMed
    2. Sorci M, Dassa B, Liu H, Anand G, Dutta AK, Pietrokovski S, Belfort M, Belfort G. Oriented covalent immobilization of antibodies for measurement of intermolecular binding forces between zipper-like contact surfaces of split inteins. Anal Chem. 2013 Jun 18; 85(12):6080-8.
      View in: PubMed
    3. Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C. Tranilast binds to aß monomers and promotes aß fibrillation. Biochemistry. 2013 Jun 11; 52(23):3995-4002.
      View in: PubMed
    4. Gu M, Vegas AJ, Anderson DG, Langer RS, Kilduff JE, Belfort G. Combinatorial synthesis with high throughput discovery of protein-resistant membrane surfaces. Biomaterials. 2013 Aug; 34(26):6133-8.
      View in: PubMed
    5. Sorci M, Gu M, Heldt CL, Grafeld E, Belfort G. A multi-dimensional approach for fractionating proteins using charged membranes. Biotechnol Bioeng. 2013 Jun; 110(6):1704-13.
      View in: PubMed
    6. Zonca MR, Yune PS, Heldt CL, Belfort G, Xie Y. High-throughput screening of substrate chemistry for embryonic stem cell attachment, expansion, and maintaining pluripotency. Macromol Biosci. 2013 Feb; 13(2):177-90.
      View in: PubMed
    7. Gu M, Yildiz H, Carrier R, Belfort G. Discovery of low mucus adhesion surfaces. Acta Biomater. 2013 Feb; 9(2):5201-7.
      View in: PubMed
    8. Gu M, Kilduff JE, Belfort G. High throughput atmospheric pressure plasma-induced graft polymerization for identifying protein-resistant surfaces. Biomaterials. 2012 Feb; 33(5):1261-70.
      View in: PubMed
    9. Heldt CL, Kurouski D, Sorci M, Grafeld E, Lednev IK, Belfort G. Isolating toxic insulin amyloid reactive species that lack ß-sheets and have wide pH stability. Biophys J. 2011 Jun 8; 100(11):2792-800.
      View in: PubMed
    10. Sorci M, Silkworth W, Gehan T, Belfort G. Evaluating nuclei concentration in amyloid fibrillation reactions using back-calculation approach. PLoS One. 2011; 6(5):e20072.
      View in: PubMed
    11. Shemella PT, Topilina NI, Soga I, Pereira B, Belfort G, Belfort M, Nayak SK. Electronic structure of neighboring extein residue modulates intein C-terminal cleavage activity. Biophys J. 2011 May 4; 100(9):2217-25.
      View in: PubMed
    12. Heldt CL, Sorci M, Posada D, Hirsa A, Belfort G. Detection and reduction of microaggregates in insulin preparations. Biotechnol Bioeng. 2011 Jan; 108(1):237-41.
      View in: PubMed
    13. Anand G, Zhang F, Linhardt RJ, Belfort G. Protein-associated water and secondary structure effect removal of blood proteins from metallic substrates. Langmuir. 2011 Mar 1; 27(5):1830-6.
      View in: PubMed
    14. Pereira B, Shemella PT, Amitai G, Belfort G, Nayak SK, Belfort M. Spontaneous proton transfer to a conserved intein residue determines on-pathway protein splicing. J Mol Biol. 2011 Feb 25; 406(3):430-42.
      View in: PubMed
    15. Pease LF, Sorci M, Guha S, Tsai DH, Zachariah MR, Tarlov MJ, Belfort G. Probing the nucleus model for oligomer formation during insulin amyloid fibrillogenesis. Biophys J. 2010 Dec 15; 99(12):3979-85.
      View in: PubMed
    16. Heldt CL, Zhang S, Belfort G. Asymmetric amyloid fibril elongation: a new perspective on a symmetric world. Proteins. 2011 Jan; 79(1):92-8.
      View in: PubMed
    17. Anand G, Sharma S, Dutta AK, Kumar SK, Belfort G. Conformational transitions of adsorbed proteins on surfaces of varying polarity. Langmuir. 2010 Jul 6; 26(13):10803-11.
      View in: PubMed
    18. Anand G, Jamadagni SN, Garde S, Belfort G. Self-assembly of TMAO at hydrophobic interfaces and its effect on protein adsorption: insights from experiments and simulations. Langmuir. 2010 Jun 15; 26(12):9695-702.
      View in: PubMed
    19. Skaat H, Sorci M, Belfort G, Margel S. Effect of maghemite nanoparticles on insulin amyloid fibril formation: selective labeling, kinetics, and fibril removal by a magnetic field. J Biomed Mater Res A. 2009 Nov; 91(2):342-51.
      View in: PubMed
    20. Sorci M, Grassucci RA, Hahn I, Frank J, Belfort G. Time-dependent insulin oligomer reaction pathway prior to fibril formation: cooling and seeding. Proteins. 2009 Oct; 77(1):62-73.
      View in: PubMed
    21. Hiraga K, Soga I, Dansereau JT, Pereira B, Derbyshire V, Du Z, Wang C, Van Roey P, Belfort G, Belfort M. Selection and structure of hyperactive inteins: peripheral changes relayed to the catalytic center. J Mol Biol. 2009 Nov 13; 393(5):1106-17.
      View in: PubMed
    22. Nayak A, Lee CC, McRae GJ, Belfort G. Osmolyte controlled fibrillation kinetics of insulin: New insight into fibrillation using the preferential exclusion principle. Biotechnol Prog. 2009 Sep-Oct; 25(5):1508-14.
      View in: PubMed
    23. Du Z, Shemella PT, Liu Y, McCallum SA, Pereira B, Nayak SK, Belfort G, Belfort M, Wang C. Highly conserved histidine plays a dual catalytic role in protein splicing: a pKa shift mechanism. J Am Chem Soc. 2009 Aug 19; 131(32):11581-9.
      View in: PubMed
    24. Amitai G, Callahan BP, Stanger MJ, Belfort G, Belfort M. Modulation of intein activity by its neighboring extein substrates. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):11005-10.
      View in: PubMed
    25. Zhou M, Liu H, Kilduff JE, Langer R, Anderson DG, Belfort G. High-throughput membrane surface modification to control NOM fouling. Environ Sci Technol. 2009 May 15; 43(10):3865-71.
      View in: PubMed
    26. Skaat H, Belfort G, Margel S. Synthesis and characterization of fluorinated magnetic core-shell nanoparticles for inhibition of insulin amyloid fibril formation. Nanotechnology. 2009 Jun 3; 20(22):225106.
      View in: PubMed
    27. Anand G, Sharma S, Kumar SK, Belfort G. Stability of tethered proteins. Langmuir. 2009 May 5; 25(9):4998-5005.
      View in: PubMed
    28. Nayak A, Sorci M, Krueger S, Belfort G. A universal pathway for amyloid nucleus and precursor formation for insulin. Proteins. 2009 Feb 15; 74(3):556-65.
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    29. Venkiteshwaran A, Heider P, Teysseyre L, Belfort G. Selective precipitation-assisted recovery of immunoglobulins from bovine serum using controlled-fouling crossflow membrane microfiltration. Biotechnol Bioeng. 2008 Dec 1; 101(5):957-66.
      View in: PubMed
    30. Du Z, Liu Y, Zheng Y, McCallum S, Dansereau J, Derbyshire V, Belfort M, Belfort G, Van Roey P, Wang C. 1H, 13C, and 15N NMR assignments of an engineered intein based on Mycobacterium tuberculosis RecA. Biomol NMR Assign. 2008 Dec; 2(2):111-3.
      View in: PubMed
    31. Dutta AK, Nayak A, Belfort G. Viscoelastic properties of adsorbed and cross-linked polypeptide and protein layers at a solid-liquid interface. J Colloid Interface Sci. 2008 Aug; 324(1-2):55-60.
      View in: PubMed
    32. Nayak A, Dutta AK, Belfort G. Surface-enhanced nucleation of insulin amyloid fibrillation. Biochem Biophys Res Commun. 2008 May 2; 369(2):303-7.
      View in: PubMed
    33. Venkiteshwaran A, Heider P, Matosevic S, Bogsnes A, Staby A, Sharfstein S, Belfort G. Optimized removal of soluble host cell proteins for the recovery of met-human growth hormone inclusion bodies from Escherichia coli cell lysate using crossflow microfiltration. Biotechnol Prog. 2007 May-Jun; 23(3):667-72.
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    34. Lee CC, Nayak A, Sethuraman A, Belfort G, McRae GJ. A three-stage kinetic model of amyloid fibrillation. Biophys J. 2007 May 15; 92(10):3448-58.
      View in: PubMed
    35. Dutta AK, Belfort G. Adsorbed gels versus brushes: viscoelastic differences. Langmuir. 2007 Mar 13; 23(6):3088-94.
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    36. Yan Y, Liu Y, Sorci M, Belfort G, Lustbader JW, Yan SS, Wang C. Surface plasmon resonance and nuclear magnetic resonance studies of ABAD-Abeta interaction. Biochemistry. 2007 Feb 20; 46(7):1724-31.
      View in: PubMed
    37. Shemella P, Pereira B, Zhang Y, Van Roey P, Belfort G, Garde S, Nayak SK. Mechanism for intein C-terminal cleavage: a proposal from quantum mechanical calculations. Biophys J. 2007 Feb 1; 92(3):847-53.
      View in: PubMed
    38. Nayak A, Liu H, Belfort G. An optically reversible switching membrane surface. Angew Chem Int Ed Engl. 2006 Jun 19; 45(25):4094-8.
      View in: PubMed
    39. Baruah GL, Nayak A, Winkelman E, Belfort G. Purification of monoclonal antibodies derived from transgenic goat milk by ultrafiltration. Biotechnol Bioeng. 2006 Mar 5; 93(4):747-54.
      View in: PubMed
    40. Baruah GL, Venkiteshwaran A, Belfort G. Global model for optimizing crossflow microfiltration and ultrafiltration processes: a new predictive and design tool. Biotechnol Prog. 2005 Jul-Aug; 21(4):1013-25.
      View in: PubMed
    41. Miao J, Wu W, Spielmann T, Belfort M, Derbyshire V, Belfort G. Single-step affinity purification of toxic and non-toxic proteins on a fluidics platform. Lab Chip. 2005 Mar; 5(3):248-53.
      View in: PubMed
    42. Sethuraman A, Belfort G. Protein structural perturbation and aggregation on homogeneous surfaces. Biophys J. 2005 Feb; 88(2):1322-33.
      View in: PubMed
    43. Sethuraman A, Vedantham G, Imoto T, Przybycien T, Belfort G. Protein unfolding at interfaces: slow dynamics of alpha-helix to beta-sheet transition. Proteins. 2004 Sep 1; 56(4):669-78.
      View in: PubMed
    44. Sethuraman A, Han M, Kane RS, Belfort G. Effect of surface wettability on the adhesion of proteins. Langmuir. 2004 Aug 31; 20(18):7779-88.
      View in: PubMed
    45. Baruah GL, Belfort G. Optimized recovery of monoclonal antibodies from transgenic goat milk by microfiltration. Biotechnol Bioeng. 2004 Aug 5; 87(3):274-85.
      View in: PubMed
    46. Baruah GL, Belfort G. A predictive aggregate transport model for microfiltration of combined macromolecular solutions and poly-disperse suspensions: model development. Biotechnol Prog. 2003 Sep-Oct; 19(5):1524-32.
      View in: PubMed
    47. Baruah GL, Couto D, Belfort G. A predictive aggregate transport model for microfiltration of combined macromolecular solutions and poly-disperse suspensions: testing model with transgenic goat milk. Biotechnol Prog. 2003 Sep-Oct; 19(5):1533-40.
      View in: PubMed
    48. Taniguchi M, Kilduff JE, Belfort G. Modes of natural organic matter fouling during ultrafiltration. Environ Sci Technol. 2003 Apr 15; 37(8):1676-83.
      View in: PubMed
    49. Wu W, Wood DW, Belfort G, Derbyshire V, Belfort M. Intein-mediated purification of cytotoxic endonuclease I-TevI by insertional inactivation and pH-controllable splicing. Nucleic Acids Res. 2002 Nov 15; 30(22):4864-71.
      View in: PubMed
    50. Frank BP, Belfort G. Adhesion of Mytilus edulis foot protein 1 on silica: ionic effects on biofouling. Biotechnol Prog. 2002 May-Jun; 18(3):580-6.
      View in: PubMed
    51. Schutyser M, Rupp R, Wideman J, Belfort G. Dean vortex membrane microfiltration and diafiltration of rBDNF E. coli inclusion bodies. Biotechnol Prog. 2002 Mar-Apr; 18(2):322-9.
      View in: PubMed
    52. Wood DW, Derbyshire V, Wu W, Chartrain M, Belfort M, Belfort G. Optimized single-step affinity purification with a self-cleaving intein applied to human acidic fibroblast growth factor. Biotechnol Prog. 2000 Nov-Dec; 16(6):1055-63.
      View in: PubMed
    53. Kluge T, Rezende C, Wood D, Belfort G. Protein transmission during Dean vortex microfiltration of yeast suspensions. Biotechnol Bioeng. 1999 Dec 20; 65(6):649-58.
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    54. Luque S, Mallubhotla H, Gehlert G, Kuriyel R, Dzengeleski S, Pearl S, Belfort G. A new coiled hollow-fiber module design for enhanced microfiltration performance in biotechnology. Biotechnol Bioeng. 1999 Nov 5; 65(3):247-57.
      View in: PubMed
    55. Wood DW, Wu W, Belfort G, Derbyshire V, Belfort M. A genetic system yields self-cleaving inteins for bioseparations. Nat Biotechnol. 1999 Sep; 17(9):889-92.
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    56. Gehlert G, Luque S, Belfort G. Comparison of ultra- and microfiltration in the presence and absence of secondary flow with polysaccharides, proteins, and yeast suspensions. Biotechnol Prog. 1998 Nov-Dec; 14(6):931-42.
      View in: PubMed
    57. Mallubhotla H, Nunes E, Belfort G. Microfiltration of yeast suspensions with self-cleaning spiral vortices: possibilities for a new membrane module design. Biotechnol Bioeng. 1995 Nov 20; 48(4):375-85.
      View in: PubMed
    58. McKinney KL, Dilwith R, Belfort G. Optimizing antibody production in batch hybridoma cell culture. J Biotechnol. 1995 May 15; 40(1):31-48.
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    59. Yokoi H, Belfort G. High-rate membrane supported aqueous-phase enzymatic conversion in organic solvent. Bioseparation. 1994 Jun; 4(3):213-20.
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    60. Serafica GC, Belfort G, Pimbley J. Protein fractionation using fast flow immobilized metal chelate affinity membranes. Biotechnol Bioeng. 1994 Jan 5; 43(1):21-36.
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    61. Tescione L, Belfort G. Construction and evaluation of a metal ion biosensor. Biotechnol Bioeng. 1993 Oct; 42(8):945-52.
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    62. Wu DR, Cramer SM, Belfort G. Kinetic resolution of racemic glycidyl butyrate using a multiphase membrane enzyme reactor: experiments and model verification. Biotechnol Bioeng. 1993 Apr 25; 41(10):979-90.
      View in: PubMed
    63. Belfort G, Lee CS. Attractive and repulsive interactions between and within adsorbed ribonuclease A layers. Proc Natl Acad Sci U S A. 1991 Oct 15; 88(20):9146-50.
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    64. McKinney KL, Dilwith R, Belfort G. Manipulation of heterogeneous hybridoma cultures for overproduction of monoclonal antibodies. Biotechnol Prog. 1991 Sep-Oct; 7(5):445-54.
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    65. Chan WK, Belfort M, Belfort G. Protein overproduction in Escherichia coli: RNA stabilization, cell disruption and recovery with a cross-flow microfiltration membrane. J Biotechnol. 1991 May; 18(3):225-42.
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    66. Heath CA, Belfort G. Diffusion and convection in membrane bioreactors. Biotechnology. 1991; 17:357-71.
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    67. Heath C, Dilwith R, Belfort G. Methods for increasing monoclonal antibody production in suspension and entrapped cell cultures: biochemical and flow cytometric analysis as a function of medium serum content. J Biotechnol. 1990 Jul; 15(1-2):71-89.
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    68. Hammer BE, Heath CA, Mirer SD, Belfort G. Quantitative flow measurements in bioreactors by nuclear magnetic resonance imaging. Biotechnology (N Y). 1990 Apr; 8(4):327-30.
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    69. Lee CS, Belfort G. Changing activity of ribonuclease A during adsorption: a molecular explanation. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8392-6.
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    70. Nagata N, Herouvis KJ, Dziewulski DM, Belfort G. Cross-flow membrane microfiltration of a bacteriol fermentation broth. Biotechnol Bioeng. 1989 Aug 5; 34(4):447-66.
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    71. Belfort G. Membranes and bioreactors: a technical challenge in biotechnology. Biotechnol Bioeng. 1989 Mar; 33(8):1047-66.
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    72. Chan WK, Belfort G, Belfort M. Stability of group I intron RNA in Escherichia coli and its potential application in a novel expression vector. Gene. 1988 Dec 20; 73(2):295-304.
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    73. Heath C, Belfort G. Immobilization of suspended mammalian cells: analysis of hollow fiber and microcapsule bioreactors. Adv Biochem Eng Biotechnol. 1987; 34:1-31.
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    74. Altshuler GL, Dziewulski DM, Sowek JA, Belfort G. Continuous hybridoma growth and monoclonal antibody production in hollow fiber reactors-separators. Biotechnol Bioeng. 1986 May; 28(5):646-58.
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    75. Belfort G. Reply to comments. Adsorption on carbon: theoretical considerations and solvent effects on adsorption. Environ Sci Technol. 1981 May 1; 15(5):601-2.
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