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Last Name
Institution

Karen K. Takane

TitleASSISTANT PROFESSOR
InstitutionMount Sinai
DepartmentEndocrinology, Diabetes and Bone Disease
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fiaschi-Taesch NM, Kleinberger JW, Salim FG, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Scott DK, Stewart AF. Human pancreatic ß-cell G1/S molecule cell cycle atlas. Diabetes. 2013 Jul; 62(7):2450-9.
      View in: PubMed
    2. Fiaschi-Taesch NM, Kleinberger JW, Salim FG, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Srinivas H, Scott DK, Stewart AF. Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human ß-cell replication: a revised model of human ß-cell G1/S control. Diabetes. 2013 Jul; 62(7):2460-70.
      View in: PubMed
    3. Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH. Overexpression of hepatocyte nuclear factor-4a initiates cell cycle entry, but is not sufficient to promote ß-cell expansion in human islets. Mol Endocrinol. 2012 Sep; 26(9):1590-602.
      View in: PubMed
    4. Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. ChREBP mediates glucose-stimulated pancreatic ß-cell proliferation. Diabetes. 2012 Aug; 61(8):2004-15.
      View in: PubMed
    5. Takane KK, Kleinberger JW, Salim FG, Fiaschi-Taesch NM, Stewart AF. Regulated and reversible induction of adult human ß-cell replication. Diabetes. 2012 Feb; 61(2):418-24.
      View in: PubMed
    6. Sicari BM, Troxell R, Salim F, Tanwir M, Takane KK, Fiaschi-Taesch N. c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein. Endocrinology. 2012 Feb; 153(2):861-72.
      View in: PubMed
    7. Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK. A human islet cell culture system for high-throughput screening. J Biomol Screen. 2012 Apr; 17(4):509-18.
      View in: PubMed
    8. Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A. Activation of protein kinase C-? in pancreatic ß-cells in vivo improves glucose tolerance and induces ß-cell expansion via mTOR activation. Diabetes. 2011 Oct; 60(10):2546-59.
      View in: PubMed
    9. Karslioglu E, Kleinberger JW, Salim FG, Cox AE, Takane KK, Scott DK, Stewart AF. cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. Mol Endocrinol. 2011 Oct; 25(10):1760-72.
      View in: PubMed
    10. Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC. Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes. 2010 Dec; 59(12):3131-8.
      View in: PubMed
    11. Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF. Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes. 2010 Aug; 59(8):1926-36.
      View in: PubMed
    12. González-Pertusa JA, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña A. Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis. Endocrinology. 2010 Apr; 151(4):1487-98.
      View in: PubMed
    13. Blouin CM, Prado C, Takane KK, Lasnier F, Garcia-Ocana A, Ferré P, Dugail I, Hajduch E. Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling. Diabetes. 2010 Mar; 59(3):600-10.
      View in: PubMed
    14. Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, Harb G, Selk K, Cozar-Castellano I, Stewart AF. Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes. 2009 Apr; 58(4):882-93.
      View in: PubMed
    15. Fiaschi-Taesch N, Sicari B, Ubriani K, Cozar-Castellano I, Takane KK, Stewart AF. Mutant parathyroid hormone-related protein, devoid of the nuclear localization signal, markedly inhibits arterial smooth muscle cell cycle and neointima formation by coordinate up-regulation of p15Ink4b and p27kip1. Endocrinology. 2009 Mar; 150(3):1429-39.
      View in: PubMed
    16. Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF. Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets. Diabetes. 2008 Oct; 57(10):2745-54.
      View in: PubMed
    17. Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF. Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. Diabetes. 2008 Nov; 57(11):3056-68.
      View in: PubMed
    18. Fujinaka Y, Takane K, Yamashita H, Vasavada RC. Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation. J Biol Chem. 2007 Oct 19; 282(42):30707-17.
      View in: PubMed
    19. Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A. Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis. Diabetes. 2007 Nov; 56(11):2732-43.
      View in: PubMed
    20. Fiaschi-Taesch N, Sicari BM, Ubriani K, Bigatel T, Takane KK, Cozar-Castellano I, Bisello A, Law B, Stewart AF. Cellular mechanism through which parathyroid hormone-related protein induces proliferation in arterial smooth muscle cells: definition of an arterial smooth muscle PTHrP/p27kip1 pathway. Circ Res. 2006 Oct 27; 99(9):933-42.
      View in: PubMed
    21. Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocaña A, Vasavada R, Stewart AF. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev. 2006 Jun; 27(4):356-70.
      View in: PubMed
    22. Rao P, Roccisana J, Takane KK, Bottino R, Zhao A, Trucco M, García-Ocaña A. Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes. 2005 Jun; 54(6):1664-75.
      View in: PubMed
    23. Fiaschi-Taesch N, Takane KK, Masters S, Lopez-Talavera JC, Stewart AF. Parathyroid-hormone-related protein as a regulator of pRb and the cell cycle in arterial smooth muscle. Circulation. 2004 Jul 13; 110(2):177-85.
      View in: PubMed
    24. Cozar-Castellano I, Takane KK, Bottino R, Balamurugan AN, Stewart AF. Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes. 2004 Jan; 53(1):149-59.
      View in: PubMed
    25. Lopez-Talavera JC, Garcia-Ocaña A, Sipula I, Takane KK, Cozar-Castellano I, Stewart AF. Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation. Endocrinology. 2004 Feb; 145(2):467-74.
      View in: PubMed
    26. Nakagawa T, Takane K, Sugimoto T, Izui K, Kouchi H, Hata S. Regulatory regions and nuclear factors involved in nodule-enhanced expression of a soybean phosphoenolpyruvate carboxylase gene: implications for molecular evolution. Mol Genet Genomics. 2003 May; 269(2):163-72.
      View in: PubMed
    27. Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem. 2003 Jan 3; 278(1):343-51.
      View in: PubMed
    28. Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC. Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro. Diabetes. 2002 Oct; 51(10):3003-13.
      View in: PubMed
    29. García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF. Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes. 2001 Dec; 50(12):2752-62.
      View in: PubMed
    30. Clemens TL, Cormier S, Eichinger A, Endlich K, Fiaschi-Taesch N, Fischer E, Friedman PA, Karaplis AC, Massfelder T, Rossert J, Schlüter KD, Silve C, Stewart AF, Takane K, Helwig JJ. Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. Br J Pharmacol. 2001 Nov; 134(6):1113-36.
      View in: PubMed
    31. de Miguel F, Fiaschi-Taesch N, López-Talavera JC, Takane KK, Massfelder T, Helwig JJ, Stewart AF. The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. Endocrinology. 2001 Sep; 142(9):4096-105.
      View in: PubMed
    32. García-Ocaña A, Vasavada RC, Takane KK, Cebrian A, Lopez-Talavera JC, Stewart AF. Using beta-cell growth factors to enhance human pancreatic Islet transplantation. J Clin Endocrinol Metab. 2001 Mar; 86(3):984-8.
      View in: PubMed
    33. Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem. 2000 Jan 14; 275(2):1226-32.
      View in: PubMed
    34. Cheng XG, Nomura M, Takane K, Kouchi H, Tajima S. Expression of two uricase (Nodulin-35 genes in a non-ureide type legume, Medicago sativa. Plant Cell Physiol. 2000 Jan; 41(1):104-9.
      View in: PubMed
    35. Kouchi H, Takane K, So RB, Ladha JK, Reddy PM. Rice ENOD40: isolation and expression analysis in rice and transgenic soybean root nodules. Plant J. 1999 Apr; 18(2):121-9.
      View in: PubMed
    36. Takane K, Tajima S, Kouchi H. Two distinct uricase II (nodulin 35) genes are differentially expressed in soybean plants. Mol Plant Microbe Interact. 1997 Aug; 10(6):735-41.
      View in: PubMed
    37. Takane K, Tanaka K, Tajima S, Okazaki K, Kouchi H. Expression of a gene for uricase II (nodulin-35) in cotyledons of soybean plants. Plant Cell Physiol. 1997 Feb; 38(2):149-54.
      View in: PubMed
    38. Takane KK, Wilson JD, McPhaul MJ. Decreased levels of the androgen receptor in the mature rat phallus are associated with decreased levels of androgen receptor messenger ribonucleic acid. Endocrinology. 1991 Aug; 129(2):1093-100.
      View in: PubMed
    39. Takane KK, Husmann DA, McPhaul MJ, Wilson JD. Androgen receptor levels in the rat penis are controlled differently in distinctive cell types. Endocrinology. 1991 May; 128(5):2234-8.
      View in: PubMed
    40. Sugita K, Nakazawa S, Takane K, Kinoshita A, Suzuki T, Abe T, Nishino K, Mori T, Osano M. [Detection of cytoplasmic mu chain by the double PAP method in cell lines and childhood non-T, non-B ALL cells]. Nihon Ketsueki Gakkai Zasshi. 1986 May; 49(3):686-95.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067