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Last Name
Institution

Rupangi Vasavada

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentEndocrinology, Diabetes and Bone Disease
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Alvarez-Perez JC, Ernst S, Demirci C, Casinelli GP, Mellado-Gil JM, Rausell-Palamos F, Vasavada RC, Garcia-Ocaña A. Hepatocyte Growth Factor/c-Met Signaling Is Required for ß-Cell Regeneration. Diabetes. 2014 Jan; 63(1):216-23.
      View in: PubMed
    2. Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. ChREBP mediates glucose-stimulated pancreatic ß-cell proliferation. Diabetes. 2012 Aug; 61(8):2004-15.
      View in: PubMed
    3. Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, García-Ocana A. Loss of HGF/c-Met signaling in pancreatic ß-cells leads to incomplete maternal ß-cell adaptation and gestational diabetes mellitus. Diabetes. 2012 May; 61(5):1143-52.
      View in: PubMed
    4. Kondegowda NG, Mozar A, Chin C, Otero A, Garcia-Ocaña A, Vasavada RC. Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling. Diabetologia. 2012 Jun; 55(6):1721-32.
      View in: PubMed
    5. Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A. Activation of protein kinase C-? in pancreatic ß-cells in vivo improves glucose tolerance and induces ß-cell expansion via mTOR activation. Diabetes. 2011 Oct; 60(10):2546-59.
      View in: PubMed
    6. Williams K, Abanquah D, Joshi-Gokhale S, Otero A, Lin H, Guthalu NK, Zhang X, Mozar A, Bisello A, Stewart AF, Garcia-Ocaña A, Vasavada RC. Systemic and acute administration of parathyroid hormone-related peptide(1-36) stimulates endogenous beta cell proliferation while preserving function in adult mice. Diabetologia. 2011 Nov; 54(11):2867-77.
      View in: PubMed
    7. Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes. 2011 Feb; 60(2):525-36.
      View in: PubMed
    8. Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC. Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes. 2010 Dec; 59(12):3131-8.
      View in: PubMed
    9. González-Pertusa JA, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña A. Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis. Endocrinology. 2010 Apr; 151(4):1487-98.
      View in: PubMed
    10. Zhang H, Zhang J, Pope CF, Crawford LA, Vasavada RC, Jagasia SM, Gannon M. Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes. 2010 Jan; 59(1):143-52.
      View in: PubMed
    11. Harb G, Vasavada RC, Cobrinik D, Stewart AF. The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells. Diabetes. 2009 Aug; 58(8):1852-62.
      View in: PubMed
    12. Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF. Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. Diabetes. 2008 Nov; 57(11):3056-68.
      View in: PubMed
    13. Fujinaka Y, Takane K, Yamashita H, Vasavada RC. Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation. J Biol Chem. 2007 Oct 19; 282(42):30707-17.
      View in: PubMed
    14. Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A. Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis. Diabetes. 2007 Nov; 56(11):2732-43.
      View in: PubMed
    15. Vasavada RC, Cozar-Castellano I, Sipula D, Stewart AF. Tissue-specific deletion of the retinoblastoma protein in the pancreatic beta-cell has limited effects on beta-cell replication, mass, and function. Diabetes. 2007 Jan; 56(1):57-64.
      View in: PubMed
    16. Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocaña A, Vasavada R, Stewart AF. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev. 2006 Jun; 27(4):356-70.
      View in: PubMed
    17. Vasavada RC, Gonzalez-Pertusa JA, Fujinaka Y, Fiaschi-Taesch N, Cozar-Castellano I, Garcia-Ocaña A. Growth factors and beta cell replication. Int J Biochem Cell Biol. 2006; 38(5-6):931-50.
      View in: PubMed
    18. Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes. 2005 Jul; 54(7):2090-102.
      View in: PubMed
    19. Fujinaka Y, Sipula D, Garcia-Ocaña A, Vasavada RC. Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta-cell survival. Diabetes. 2004 Dec; 53(12):3120-30.
      View in: PubMed
    20. Rao P, Cozar-Castellano I, Roccisana J, Vasavada RC, Garcia-Ocaña A. Hepatocyte growth factor gene therapy for islet transplantation. Expert Opin Biol Ther. 2004 Apr; 4(4):507-18.
      View in: PubMed
    21. Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem. 2003 Jan 3; 278(1):343-51.
      View in: PubMed
    22. Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC. Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro. Diabetes. 2002 Oct; 51(10):3003-13.
      View in: PubMed
    23. García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF. Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes. 2001 Dec; 50(12):2752-62.
      View in: PubMed
    24. García-Ocaña A, Vasavada RC, Takane KK, Cebrian A, Lopez-Talavera JC, Stewart AF. Using beta-cell growth factors to enhance human pancreatic Islet transplantation. J Clin Endocrinol Metab. 2001 Mar; 86(3):984-8.
      View in: PubMed
    25. Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann P, Syed M, Ogren L, Talamantes F, Stewart AF. Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. J Biol Chem. 2000 May 19; 275(20):15399-406.
      View in: PubMed
    26. Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem. 2000 Jan 14; 275(2):1226-32.
      View in: PubMed
    27. Lin YH, Vasavada RC. Studies on microencapsulation of 5-fluorouracil with poly(ortho ester) polymers. J Microencapsul. 2000 Jan-Feb; 17(1):1-11.
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    28. Porter SE, Sorenson RL, Dann P, Garcia-Ocana A, Stewart AF, Vasavada RC. Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse. Endocrinology. 1998 Sep; 139(9):3743-51.
      View in: PubMed
    29. Vasavada RC, Garcia-Ocana A, Massfelder T, Dann P, Stewart AF. Parathyroid hormone-related protein in the pancreatic islet and the cardiovascular system. Recent Prog Horm Res. 1998; 53:305-38; discussion 338-40.
      View in: PubMed
    30. Massfelder T, Dann P, Wu TL, Vasavada R, Helwig JJ, Stewart AF. Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: a critical role for nuclear targeting. Proc Natl Acad Sci U S A. 1997 Dec 9; 94(25):13630-5.
      View in: PubMed
    31. Reddy D, Pollock AS, Clark SA, Sooy K, Vasavada RC, Stewart AF, Honeyman T, Christakos S. Transfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38). Proc Natl Acad Sci U S A. 1997 Mar 4; 94(5):1961-6.
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    32. Wu TL, Vasavada RC, Yang K, Massfelder T, Ganz M, Abbas SK, Care AD, Stewart AF. Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein. J Biol Chem. 1996 Oct 4; 271(40):24371-81.
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    33. Wysolmerski JJ, Vasavada R, Foley J, Weir EC, Burtis WJ, Kukreja SC, Guise TA, Broadus AE, Philbrick WM. Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice. Cancer Res. 1996 Mar 1; 56(5):1043-9.
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    34. Vasavada RC, Cavaliere C, D'Ercole AJ, Dann P, Burtis WJ, Madlener AL, Zawalich K, Zawalich W, Philbrick W, Stewart AF. Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia. J Biol Chem. 1996 Jan 12; 271(2):1200-8.
      View in: PubMed
    35. Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev. 1996 Jan; 76(1):127-73.
      View in: PubMed
    36. Orloff JJ, Kats Y, Urena P, Schipani E, Vasavada RC, Philbrick WM, Behal A, Abou-Samra AB, Segre GV, Jüppner H. Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines. Endocrinology. 1995 Jul; 136(7):3016-23.
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    37. Holt EH, Vasavada RC, Bander NH, Broadus AE, Philbrick WM. Region-specific methylation of the parathyroid hormone-related peptide gene determines its expression in human renal carcinoma cell lines. J Biol Chem. 1993 Sep 25; 268(27):20639-45.
      View in: PubMed
    38. Takeuchi Y, Yasukawa H, Yamaoka Y, Takahashi N, Tamura C, Morimoto Y, Fukushima S, Vasavada RC. Effects of oleic acid/propylene glycol on rat abdominal stratum corneum: lipid extraction and appearance of propylene glycol in the dermis measured by Fourier transform infrared/attenuated total reflectance (FT-IR/ATR) spectroscopy. Chem Pharm Bull (Tokyo). 1993 Aug; 41(8):1434-7.
      View in: PubMed
    39. Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Mol Endocrinol. 1993 Feb; 7(2):273-82.
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    40. Patel RA, Vasavada RC. Transdermal delivery of isoproterenol HCl: an investigation of stability, solubility, partition coefficient, and vehicle effects. Pharm Res. 1988 Feb; 5(2):116-9.
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    41. Vasavada R, Eager KB, Barbanti-Brodano G, Caputo A, Ricciardi RP. Adenovirus type 12 early region 1A proteins repress class I HLA expression in transformed human cells. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5257-61.
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    42. Khan AR, Iyer BV, Cirelli RA, Vasavada RC. In vitro release of salicylic acid from lanolin alcohols-ethylcellulose films. J Pharm Sci. 1984 Mar; 73(3):302-5.
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    43. Iyer BV, Vasavada RC. Evaluation of lanolin alcohol films and kinetics of triamcinolone acetonide release. J Pharm Sci. 1979 Jun; 68(6):782-7.
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    44. Vasavada RC. Competency characteristics of the industrial pharmacist. Am J Pharm Educ. 1977 Aug; 41(3):303-5.
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    45. Vasavada RC, Turcotte JG. Synthesis of enantiomeric chloroacetylcarnitine chlorides. J Med Chem. 1971 Nov; 14(11):1142.
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    46. Cutroneo KR, Louis-Ferdinand RT, Vasavada RC, Turcotte JG, DeFanti DR. Vagotomy and atropine antagonism of (plus or minus)-chloroacetyl carnitine chloride mediated blood pressure reduction in the rat. J Pharm Pharmacol. 1970 Dec; 22(12):940-1.
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    47. Louis-Ferdinand RT, Cutroneo KR, Kosegarten DC, Vasavada RC, Turcotte JG, DeFanti DR. Flow decrease through rat hind limb vasculature by (plus or minus)-carnitine, (plus or minus)-acetylcarnitine and (plus or minss)-chloroacetylcarnitine chlorides. J Pharm Pharmacol. 1970 Sep; 22(9):704-5.
      View in: PubMed
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