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Last Name
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Arvin Dar

TitleASSISTANT PROFESSOR
InstitutionMount Sinai
DepartmentOncological Sciences
Address
    Other Positions
    TitleASSISTANT PROFESSOR
    InstitutionMount Sinai
    DepartmentStructural and Chemical Biology


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dar AC. A pickup in pseudokinase activity. Biochem Soc Trans. 2013 Aug; 41(4):987-94.
      View in: PubMed
    2. Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol. 2013 Sep 20; 8(9):1931-8.
      View in: PubMed
    3. Dar AC, Das TK, Shokat KM, Cagan RL. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 7; 486(7401):80-4.
      View in: PubMed
    4. Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature. 2011 Apr 21; 472(7343):366-9.
      View in: PubMed
    5. Dar AC, Shokat KM. The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annu Rev Biochem. 2011; 80:769-95.
      View in: PubMed
    6. Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Curr Protoc Chem Biol. 2010 Mar 1; 2(1):15-36.
      View in: PubMed
    7. Seo EJ, Liu F, Kawagishi-Kobayashi M, Ung TL, Cao C, Dar AC, Sicheri F, Dever TE. Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44):16894-9.
      View in: PubMed
    8. Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol. 2008 Oct 20; 15(10):1015-22.
      View in: PubMed
    9. Yartsev S, Dar A, Woodford C, Wong E, Bauman G, Van Dyk J. Initial experience in treating lung cancer with helical tomotherapy. Biomed Imaging Interv J. 2007 Jan; 3(1):e2.
      View in: PubMed
    10. Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE. Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell. 2005 Sep 23; 122(6):901-13.
      View in: PubMed
    11. Dar AC, Dever TE, Sicheri F. Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell. 2005 Sep 23; 122(6):887-900.
      View in: PubMed
    12. Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE. PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Mol Cell Biol. 2005 Apr; 25(8):3063-75.
      View in: PubMed
    13. Zigmond SH, Evangelista M, Boone C, Yang C, Dar AC, Sicheri F, Forkey J, Pring M. Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol. 2003 Oct 14; 13(20):1820-3.
      View in: PubMed
    14. Pearson CE, Tam M, Wang YH, Montgomery SE, Dar AC, Cleary JD, Nichol K. Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions. Nucleic Acids Res. 2002 Oct 15; 30(20):4534-47.
      View in: PubMed
    15. Dar AC, Sicheri F. X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. Mol Cell. 2002 Aug; 10(2):295-305.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067