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David H. Bechhofer

TitlePROFESSOR
InstitutionMount Sinai
DepartmentPharmacology and Systems Therapeutics
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    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentMedical Education


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bechhofer DH. Nucleotide specificity in bacterial mRNA recycling. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):8765-6.
      View in: PubMed
    2. Richards J, Liu Q, Pellegrini O, Celesnik H, Yao S, Bechhofer DH, Condon C, Belasco JG. An RNA pyrophosphohydrolase triggers 5'-exonucleolytic degradation of mRNA in Bacillus subtilis. Mol Cell. 2011 Sep 16; 43(6):940-9.
      View in: PubMed
    3. Yao S, Richards J, Belasco JG, Bechhofer DH. Decay of a model mRNA in Bacillus subtilis by a combination of RNase J1 5' exonuclease and RNase Y endonuclease activities. J Bacteriol. 2011 Nov; 193(22):6384-6.
      View in: PubMed
    4. Deikus G, Bechhofer DH. 5' End-independent RNase J1 endonuclease cleavage of Bacillus subtilis model RNA. J Biol Chem. 2011 Oct 7; 286(40):34932-40.
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    5. Condon C, Bechhofer DH. Regulated RNA stability in the Gram positives. Curr Opin Microbiol. 2011 Apr; 14(2):148-54.
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    6. Bechhofer DH. Bacillus subtilis mRNA decay: new parts in the toolkit. Wiley Interdiscip Rev RNA. 2011 May-Jun; 2(3):387-94.
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    7. Yao S, Bechhofer DH. Initiation of decay of Bacillus subtilis rpsO mRNA by endoribonuclease RNase Y. J Bacteriol. 2010 Jul; 192(13):3279-86.
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    8. Yao S, Sharp JS, Bechhofer DH. Bacillus subtilis RNase J1 endonuclease and 5' exonuclease activities in the turnover of DeltaermC mRNA. RNA. 2009 Dec; 15(12):2331-9.
      View in: PubMed
    9. Deikus G, Bechhofer DH. Bacillus subtilis trp Leader RNA: RNase J1 endonuclease cleavage specificity and PNPase processing. J Biol Chem. 2009 Sep 25; 284(39):26394-401.
      View in: PubMed
    10. Yao S, Bechhofer DH. Processing and stability of inducibly expressed rpsO mRNA derivatives in Bacillus subtilis. J Bacteriol. 2009 Sep; 191(18):5680-9.
      View in: PubMed
    11. Cardenas PP, Carrasco B, Sanchez H, Deikus G, Bechhofer DH, Alonso JC. Bacillus subtilis polynucleotide phosphorylase 3'-to-5' DNase activity is involved in DNA repair. Nucleic Acids Res. 2009 Jul; 37(12):4157-69.
      View in: PubMed
    12. Bechhofer DH. Messenger RNA decay and maturation in Bacillus subtilis. Prog Mol Biol Transl Sci. 2009; 85:231-73.
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    13. Yao S, Blaustein JB, Bechhofer DH. Erythromycin-induced ribosome stalling and RNase J1-mediated mRNA processing in Bacillus subtilis. Mol Microbiol. 2008 Sep; 69(6):1439-49.
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    14. Deikus G, Condon C, Bechhofer DH. Role of Bacillus subtilis RNase J1 endonuclease and 5'-exonuclease activities in trp leader RNA turnover. J Biol Chem. 2008 Jun 20; 283(25):17158-67.
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    15. Redko Y, Bechhofer DH, Condon C. Mini-III, an unusual member of the RNase III family of enzymes, catalyses 23S ribosomal RNA maturation in B. subtilis. Mol Microbiol. 2008 Jun; 68(5):1096-106.
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    16. Tardos JG, Eisenreich A, Deikus G, Bechhofer DH, Chandradas S, Zafar U, Rauch U, Bogdanov VY. SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells. J Thromb Haemost. 2008 May; 6(5):877-84.
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    17. Bechhofer DH, Oussenko IA, Deikus G, Yao S, Mathy N, Condon C. Analysis of mRNA decay in Bacillus subtilis. Methods Enzymol. 2008; 447:259-76.
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    18. Condon C, Pellegrini O, Mathy N, Bénard L, Redko Y, Oussenko IA, Deikus G, Bechhofer DH. Assay of Bacillus subtilis ribonucleases in vitro. Methods Enzymol. 2008; 447:277-308.
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    19. Yao S, Blaustein JB, Bechhofer DH. Processing of Bacillus subtilis small cytoplasmic RNA: evidence for an additional endonuclease cleavage site. Nucleic Acids Res. 2007; 35(13):4464-73.
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    20. Deikus G, Bechhofer DH. Initiation of decay of Bacillus subtilis trp leader RNA. J Biol Chem. 2007 Jul 13; 282(28):20238-44.
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    21. Wei Y, Deikus G, Powers B, Shelden V, Krulwich TA, Bechhofer DH. Adaptive gene expression in Bacillus subtilis strains deleted for tetL. J Bacteriol. 2006 Oct; 188(20):7090-100.
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    22. Sharp JS, Bechhofer DH. Effect of 5'-proximal elements on decay of a model mRNA in Bacillus subtilis. Mol Microbiol. 2005 Jul; 57(2):484-95.
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    23. Campos-Guillén J, Bralley P, Jones GH, Bechhofer DH, Olmedo-Alvarez G. Addition of poly(A) and heteropolymeric 3' ends in Bacillus subtilis wild-type and polynucleotide phosphorylase-deficient strains. J Bacteriol. 2005 Jul; 187(14):4698-706.
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    24. Wen T, Oussenko IA, Pellegrini O, Bechhofer DH, Condon C. Ribonuclease PH plays a major role in the exonucleolytic maturation of CCA-containing tRNA precursors in Bacillus subtilis. Nucleic Acids Res. 2005; 33(11):3636-43.
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    25. Oussenko IA, Abe T, Ujiie H, Muto A, Bechhofer DH. Participation of 3'-to-5' exoribonucleases in the turnover of Bacillus subtilis mRNA. J Bacteriol. 2005 Apr; 187(8):2758-67.
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    26. Oussenko IA, Sanchez R, Bechhofer DH. Bacillus subtilis YhcR, a high-molecular-weight, nonspecific endonuclease with a unique domain structure. J Bacteriol. 2004 Aug; 186(16):5376-83.
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    27. Deikus G, Babitzke P, Bechhofer DH. Recycling of a regulatory protein by degradation of the RNA to which it binds. Proc Natl Acad Sci U S A. 2004 Mar 2; 101(9):2747-51.
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    28. Sharp JS, Bechhofer DH. Effect of translational signals on mRNA decay in Bacillus subtilis. J Bacteriol. 2003 Sep; 185(18):5372-9.
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    29. Hicks DB, Wang Z, Wei Y, Kent R, Guffanti AA, Banciu H, Bechhofer DH, Krulwich TA. A tenth atp gene and the conserved atpI gene of a Bacillus atp operon have a role in Mg2+ uptake. Proc Natl Acad Sci U S A. 2003 Sep 2; 100(18):10213-8.
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    30. Oussenko IA, Sanchez R, Bechhofer DH. Bacillus subtilis YhaM, a member of a new family of 3'-to-5' exonucleases in gram-positive bacteria. J Bacteriol. 2002 Nov; 184(22):6250-9.
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    31. Jin J, Guffanti AA, Bechhofer DH, Krulwich TA. Tet(L) and tet(K) tetracycline-divalent metal/H+ antiporters: characterization of multiple catalytic modes and a mutagenesis approach to differences in their efflux substrate and coupling ion preferences. J Bacteriol. 2002 Sep; 184(17):4722-32.
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    32. Drider D, DiChiara JM, Wei J, Sharp JS, Bechhofer DH. Endonuclease cleavage of messenger RNA in Bacillus subtilis. Mol Microbiol. 2002 Mar; 43(5):1319-29.
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    33. Wei Y, Bechhofer DH. Tetracycline induces stabilization of mRNA in Bacillus subtilis. J Bacteriol. 2002 Feb; 184(4):889-94.
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    34. Herskovitz MA, Bechhofer DH. Endoribonuclease RNase III is essential in Bacillus subtilis. Mol Microbiol. 2000 Dec; 38(5):1027-33.
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    35. Oussenko IA, Bechhofer DH. The yvaJ gene of Bacillus subtilis encodes a 3'-to-5' exoribonuclease and is not essential in a strain lacking polynucleotide phosphorylase. J Bacteriol. 2000 May; 182(9):2639-42.
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    36. Farr GA, Oussenko IA, Bechhofer DH. Protection against 3'-to-5' RNA decay in Bacillus subtilis. J Bacteriol. 1999 Dec; 181(23):7323-30.
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    37. Stasinopoulos SJ, Farr GA, Bechhofer DH. Bacillus subtilis tetA(L) gene expression: evidence for regulation by translational reinitiation. Mol Microbiol. 1998 Dec; 30(5):923-32.
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    38. Bechhofer DH, Wang W. Decay of ermC mRNA in a polynucleotide phosphorylase mutant of Bacillus subtilis. J Bacteriol. 1998 Nov; 180(22):5968-77.
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    39. Oguro A, Kakeshita H, Nakamura K, Yamane K, Wang W, Bechhofer DH. Bacillus subtilis RNase III cleaves both 5'- and 3'-sites of the small cytoplasmic RNA precursor. J Biol Chem. 1998 Jul 31; 273(31):19542-7.
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    40. Bechhofer DH, Stasinopoulos SJ. tetA(L) mutants of a tetracycline-sensitive strain of Bacillus subtilis with the polynucleotide phosphorylase gene deleted. J Bacteriol. 1998 Jul; 180(13):3470-3.
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    41. Wang W, Bechhofer DH. Bacillus subtilis RNase III gene: cloning, function of the gene in Escherichia coli, and construction of Bacillus subtilis strains with altered rnc loci. J Bacteriol. 1997 Dec; 179(23):7379-85.
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    42. Cheng J, Guffanti AA, Wang W, Krulwich TA, Bechhofer DH. Chromosomal tetA(L) gene of Bacillus subtilis: regulation of expression and physiology of a tetA(L) deletion strain. J Bacteriol. 1996 May; 178(10):2853-60.
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    43. Wang W, Bechhofer DH. Properties of a Bacillus subtilis polynucleotide phosphorylase deletion strain. J Bacteriol. 1996 Apr; 178(8):2375-82.
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    44. Mitra S, Hue K, Bechhofer DH. In vitro processing activity of Bacillus subtilis polynucleotide phosphorylase. Mol Microbiol. 1996 Jan; 19(2):329-42.
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    45. Hue KK, Cohen SD, Bechhofer DH. A polypurine sequence that acts as a 5' mRNA stabilizer in Bacillus subtilis. J Bacteriol. 1995 Jun; 177(12):3465-71.
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    46. Mitra S, Bechhofer DH. Substrate specificity of an RNase III-like activity from Bacillus subtilis. J Biol Chem. 1994 Dec 16; 269(50):31450-6.
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    47. Bechhofer DH, Hue KK, Shub DA. An intron in the thymidylate synthase gene of Bacillus bacteriophage beta 22: evidence for independent evolution of a gene, its group I intron, and the intron open reading frame. Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24):11669-73.
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    48. DiMari JF, Bechhofer DH. Initiation of mRNA decay in Bacillus subtilis. Mol Microbiol. 1993 Mar; 7(5):705-17.
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    49. Hue KK, Bechhofer DH. Regulation of the macrolide-lincosamide-streptogramin B resistance gene ermD. J Bacteriol. 1992 Sep; 174(18):5860-8.
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    50. Hue KK, Bechhofer DH. Effect of ermC leader region mutations on induced mRNA stability. J Bacteriol. 1991 Jun; 173(12):3732-40.
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    51. Bechhofer DH. A method for sequencing polymerase chain reaction products can be used to sequence Bacillus subtilis "miniprep" plasmid DNA. Biotechniques. 1991 Jan; 10(1):17-9, 20.
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    52. Bechhofer DH. Triple post-transcriptional control. Mol Microbiol. 1990 Sep; 4(9):1419-23.
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    53. Bechhofer DH, Zen KH. Mechanism of erythromycin-induced ermC mRNA stability in Bacillus subtilis. J Bacteriol. 1989 Nov; 171(11):5803-11.
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    54. Schmidhauser TJ, Bechhofer DH, Figurski DH, Helinski DR. Host-specific effects of the korA-korB operon and oriT region on the maintenance of miniplasmid derivatives of broad host-range plasmid RK2. Plasmid. 1989 Mar; 21(2):99-112.
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    55. Villafane R, Bechhofer DH, Narayanan CS, Dubnau D. Replication control genes of plasmid pE194. J Bacteriol. 1987 Oct; 169(10):4822-9.
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    56. Bechhofer DH, Dubnau D. Induced mRNA stability in Bacillus subtilis. Proc Natl Acad Sci U S A. 1987 Jan; 84(2):498-502.
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    57. Denoya CD, Bechhofer DH, Dubnau D. Translational autoregulation of ermC 23S rRNA methyltransferase expression in Bacillus subtilis. J Bacteriol. 1986 Dec; 168(3):1133-41.
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    58. Bechhofer DH, Kornacki JA, Firshein W, Figurski DH. Gene control in broad host range plasmid RK2: expression, polypeptide product, and multiple regulatory functions of korB. Proc Natl Acad Sci U S A. 1986 Jan; 83(2):394-8.
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    59. Schreiner HC, Bechhofer DH, Pohlman RF, Young C, Borden PA, Figurski DH. Replication control in promiscuous plasmid RK2: kil and kor functions affect expression of the essential replication gene trfA. J Bacteriol. 1985 Jul; 163(1):228-37.
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    60. Figurski DH, Young C, Schreiner HC, Pohlman RF, Bechhofer DH, Prince AS, D'Amico TF. Genetic interactions of broad host-range plasmid RK2: evidence for a complex replication regulon. Basic Life Sci. 1985; 30:227-41.
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    61. Young C, Bechhofer DH, Figurski DH. Gene regulation in plasmid RK2: positive control by korA in the expression of korC. J Bacteriol. 1984 Jan; 157(1):247-52.
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    62. Barth PT, Ellis K, Bechhofer DH, Figurski DH. Involvement of kil and kor genes in the phenotype of a host-range mutant of RP4. Mol Gen Genet. 1984; 197(2):236-43.
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    63. Bechhofer DH, Figurski DH. Map location and nucleotide sequence of korA, a key regulatory gene of promiscuous plasmid RK2. Nucleic Acids Res. 1983 Nov 11; 11(21):7453-69.
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    64. Figurski DH, Pohlman RF, Bechhofer DH, Prince AS, Kelton CA. Broad host range plasmid RK2 encodes multiple kil genes potentially lethal to Escherichia coli host cells. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):1935-9.
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