Keywords
Last Name
Institution

Stuart C. Sealfon

TitlePROFESSOR & CHAIR
InstitutionMount Sinai
DepartmentNeurology
Address
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentNeuroscience

    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentPharmacology and Systems Therapeutics


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tabbaa OP, Nudelman G, Sealfon SC, Hayot F, Jayaprakash C. Noise propagation through extracellular signaling leads to fluctuations in gene expression. BMC Syst Biol. 2013; 7:94.
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    2. Zaslavsky E, Nudelman G, Marquez S, Hershberg U, Hartmann BM, Thakar J, Sealfon SC, Kleinstein SH. Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection. BMC Bioinformatics. 2013; 14 Suppl 6:S1.
      View in: PubMed
    3. Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett. 2013 Mar 1; 536:69-73.
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    4. Wang Q, Chikina M, Zaslavsky E, Pincas H, Sealfon SC. ß-catenin regulates GnRH-induced FSHß gene expression. Mol Endocrinol. 2013 Feb; 27(2):224-37.
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    5. Zaslavsky E, Hayot F, Sealfon SC. Computational approaches to understanding dendritic cell responses to influenza virus infection. Immunol Res. 2012 Dec; 54(1-3):160-8.
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    6. Hartmann BM, Li W, Jia J, Patil S, Marjanovic N, Martínez-Romero C, Albrecht RA, Hayot F, García-Sastre A, Wetmur JG, Moran TM, Sealfon SC. Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent. J Virol. 2013 Feb; 87(3):1916-8.
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    7. Braun DA, Fribourg M, Sealfon SC. Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation. J Biol Chem. 2013 Feb 1; 288(5):2986-93.
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    8. Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem. 2012 Dec 28; 287(53):44301-19.
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    9. Nair VD, Ge Y, Balasubramaniyan N, Kim J, Okawa Y, Chikina M, Troyanskaya O, Sealfon SC. Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells. Mol Cell Biol. 2012 Dec; 32(23):4861-76.
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    10. González-Maeso J, Sealfon SC. Functional selectivity in GPCR heterocomplexes. Mini Rev Med Chem. 2012 Aug; 12(9):851-5.
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    11. Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan; 225(1):217-26.
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    12. Ge Y, Sealfon SC. flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding. Bioinformatics. 2012 Aug 1; 28(15):2052-8.
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    13. Choi SG, Jia J, Pfeffer RL, Sealfon SC. G proteins and autocrine signaling differentially regulate gonadotropin subunit expression in pituitary gonadotrope. J Biol Chem. 2012 Jun 15; 287(25):21550-60.
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    14. Shimoni Y, Nudelman G, Hayot F, Sealfon SC. Multi-scale stochastic simulation of diffusion-coupled agents and its application to cell culture simulation. PLoS One. 2011; 6(12):e29298.
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    15. Yuen T, Choi SG, Pincas H, Waring DW, Sealfon SC, Turgeon JL. Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes. Mol Cell Endocrinol. 2012 Mar 5; 350(1):10-9.
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    16. Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell. 2011 Nov 23; 147(5):1011-23.
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    17. Sugár IP, González-Lergier J, Sealfon SC. Authors response to correspondence about an improved compensation method. Cytometry A. 2011 Dec; 79(12):975-8.
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    18. Bowles R, Patil S, Pincas H, Sealfon SC. Optimized protocol for efficient transfection of dendritic cells without cell maturation. J Vis Exp. 2011; (53):e2766.
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    19. Albizu L, Holloway T, González-Maeso J, Sealfon SC. Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology. 2011 Sep; 61(4):770-7.
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    20. Sugár IP, González-Lergier J, Sealfon SC. Improved compensation in flow cytometry by multivariable optimization. Cytometry A. 2011 May; 79(5):356-60.
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    21. Choi SG, Ruf-Zamojski F, Pincas H, Roysam B, Sealfon SC. Characterization of a MAPK scaffolding protein logic gate in gonadotropes. Mol Endocrinol. 2011 Jun; 25(6):1027-39.
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    22. Shtilbans A, Choi SG, Fowkes ME, Khitrov G, Shahbazi M, Ting J, Zhang W, Sun Y, Sealfon SC, Lange DJ. Differential gene expression in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 Jul; 12(4):250-6.
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    23. Hu J, Nudelman G, Shimoni Y, Kumar M, Ding Y, López C, Hayot F, Wetmur JG, Sealfon SC. Role of cell-to-cell variability in activating a positive feedback antiviral response in human dendritic cells. PLoS One. 2011; 6(2):e16614.
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    24. Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett. 2011 Apr 15; 493(3):76-9.
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    25. Sealfon SC, Chu TT. RNA and DNA microarrays. Methods Mol Biol. 2011; 671:3-34.
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    26. Albizu L, Moreno JL, González-Maeso J, Sealfon SC. Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics. CNS Neurol Disord Drug Targets. 2010 Nov; 9(5):636-50.
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    27. Sugár IP, Sealfon SC. Misty Mountain clustering: application to fast unsupervised flow cytometry gating. BMC Bioinformatics. 2010; 11:502.
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    28. Patil S, Pincas H, Seto J, Nudelman G, Nudelman I, Sealfon SC. Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase. BMC Syst Biol. 2010; 4:137.
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    29. Bowles R, Patil S, Pincas H, Sealfon SC. Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation. J Immunol Methods. 2010 Dec 15; 363(1):21-8.
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    30. Seto J, Qiao L, Guenzel CA, Xiao S, Shaw ML, Hayot F, Sealfon SC. Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study. J Virol. 2010 Nov; 84(21):10965-73.
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    31. Fink MY, Pincas H, Choi SG, Nudelman G, Sealfon SC. Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase. Mol Endocrinol. 2010 Sep; 24(9):1863-71.
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    32. Shimoni Y, Fink MY, Choi SG, Sealfon SC. Plato's cave algorithm: inferring functional signaling networks from early gene expression shadows. PLoS Comput Biol. 2010 Jun; 6(6):e1000828.
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    33. Nudelman G, Ge Y, Hu J, Kumar M, Seto J, Duke JL, Kleinstein SH, Hayot F, Sealfon SC, Wetmur JG. Coregulation mapping based on individual phenotypic variation in response to virus infection. Immunome Res. 2010; 6:2.
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    34. Zaslavsky E, Hershberg U, Seto J, Pham AM, Marquez S, Duke JL, Wetmur JG, Tenoever BR, Sealfon SC, Kleinstein SH. Antiviral response dictated by choreographed cascade of transcription factors. J Immunol. 2010 Mar 15; 184(6):2908-17.
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    35. Qiao L, Phipps-Yonas H, Hartmann B, Moran TM, Sealfon SC, Hayot F. Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells. Biophys J. 2010 Feb 17; 98(4):505-14.
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    36. Ge Y, Sealfon SC, Speed TP. Multiple testing and its applications to microarrays. Stat Methods Med Res. 2009 Dec; 18(6):543-63.
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    37. Hu J, Iyer-Biswas S, Sealfon SC, Wetmur J, Jayaprakash C, Hayot F. Power-laws in interferon-B mRNA distribution in virus-infected dendritic cells. Biophys J. 2009 Oct 7; 97(7):1984-9.
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    38. Moreno JL, Sealfon SC, González-Maeso J. Group II metabotropic glutamate receptors and schizophrenia. Cell Mol Life Sci. 2009 Dec; 66(23):3777-85.
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    39. Sugár IP, Sealfon SC. Model of autocrine/paracrine signaling in epithelial layer: geometrical regulation of intercellular communication. J Phys Chem B. 2009 Aug 6; 113(31):10946-56.
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    40. González-Maeso J, Sealfon SC. Psychedelics and schizophrenia. Trends Neurosci. 2009 Apr; 32(4):225-32.
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    41. Yuen T, Ruf F, Chu T, Sealfon SC. Microtranscriptome regulation by gonadotropin-releasing hormone. Mol Cell Endocrinol. 2009 Apr 10; 302(1):12-7.
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    42. González-Maeso J, Sealfon SC. Agonist-trafficking and hallucinogens. Curr Med Chem. 2009; 16(8):1017-27.
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    43. Bordería AV, Hartmann BM, Fernandez-Sesma A, Moran TM, Sealfon SC. Antiviral-activated dendritic cells: a paracrine-induced response state. J Immunol. 2008 Nov 15; 181(10):6872-81.
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    44. Viswanathan G, Jayaprakash C, Sealfon SC, Hayot F. Shared kinase fluctuations between two enzymatic reactions. Phys Biol. 2008; 5(4):046002.
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    45. Phipps-Yonas H, Seto J, Sealfon SC, Moran TM, Fernandez-Sesma A. Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. PLoS Pathog. 2008 Oct; 4(10):e1000193.
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    46. Phipps-Yonas H, Jiang K, Hartmann BM, Ge Y, Sealfon SC, Moran TM. A comprehensive evaluation of human plasmacytoid dendritic cells using small volumes of human blood. J Interferon Cytokine Res. 2008 Aug; 28(8):501-7.
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    47. Sealfon SC, González-Maeso J. Receptor pair for schizophrenia. Pediatr Res. 2008 Jul; 64(1):1.
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    48. Berezhkovskii AM, Coppey M, Sealfon SC, Shvartsman S. Cell-to-cell communication: time and length scales of ligand internalization in cultures of suspended cells. J Chem Phys. 2008 Jun 14; 128(22):225102.
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    49. Arsov I, Li X, Matthews G, Coradin J, Hartmann B, Simon AK, Sealfon SC, Yue Z. BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death Differ. 2008 Sep; 15(9):1385-95.
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    50. González-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, López-Giménez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008 Mar 6; 452(7183):93-7.
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    51. Viswanathan GA, Seto J, Patil S, Nudelman G, Sealfon SC. Getting started in biological pathway construction and analysis. PLoS Comput Biol. 2008 Feb; 4(2):e16.
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    52. Coppey M, Berezhkovskii AM, Sealfon SC, Shvartsman SY. Time and length scales of autocrine signals in three dimensions. Biophys J. 2007 Sep 15; 93(6):1917-22.
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    53. Ruf F, Hayot F, Park MJ, Ge Y, Lin G, Roysam B, Sealfon SC. Noise propagation and scaling in regulation of gonadotrope biosynthesis. Biophys J. 2007 Dec 15; 93(12):4474-80.
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    54. Hu J, Sealfon SC, Hayot F, Jayaprakash C, Kumar M, Pendleton AC, Ganee A, Fernandez-Sesma A, Moran TM, Wetmur JG. Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells. Nucleic Acids Res. 2007; 35(15):5232-41.
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    55. Viswanathan GA, Nudelman G, Patil S, Sealfon SC. BioPP: a tool for web-publication of biological networks. BMC Bioinformatics. 2007; 8:168.
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    56. Chu TT, Fink MY, Mong JA, John G, Auger AP, Ge Y, Sealfon SC. Effective use of microarrays in neuroendocrine research. J Neuroendocrinol. 2007 Mar; 19(3):145-61.
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    57. Ge RS, Chen GR, Dong Q, Akingbemi B, Sottas CM, Santos M, Sealfon SC, Bernard DJ, Hardy MP. Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. J Androl. 2007 Jul-Aug; 28(4):513-20.
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    58. Lee KB, Khivansara V, Santos MM, Lamba P, Yuen T, Sealfon SC, Bernard DJ. Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription. J Mol Endocrinol. 2007 Feb; 38(1-2):315-30.
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    59. González-Maeso J, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, Lira A, Bradley-Moore M, Ge Y, Zhou Q, Sealfon SC, Gingrich JA. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron. 2007 Feb 1; 53(3):439-52.
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    60. Nair VD, McNaught KS, González-Maeso J, Sealfon SC, Olanow CW. p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J Biol Chem. 2006 Dec 22; 281(51):39550-60.
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    61. Ruf F, Park MJ, Hayot F, Lin G, Roysam B, Ge Y, Sealfon SC. Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone. J Biol Chem. 2006 Oct 13; 281(41):30967-78.
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    62. Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science. 2006 Jul 28; 313(5786):536-40.
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    63. Fernandez-Sesma A, Marukian S, Ebersole BJ, Kaminski D, Park MS, Yuen T, Sealfon SC, García-Sastre A, Moran TM. Influenza virus evades innate and adaptive immunity via the NS1 protein. J Virol. 2006 Jul; 80(13):6295-304.
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    64. Grisotto MG, Garin A, Martin AP, Jensen KK, Chan P, Sealfon SC, Lira SA. The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells. J Clin Invest. 2006 May; 116(5):1264-73.
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    65. Busse PJ, Zhang TF, Srivastava K, Lin BP, Schofield B, Sealfon SC, Li XM. Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo. J Allergy Clin Immunol. 2005 Dec; 116(6):1256-63.
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    66. Chan P, Yuen T, Ruf F, Gonzalez-Maeso J, Sealfon SC. Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization. Nucleic Acids Res. 2005; 33(18):e161.
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    67. Xie J, Bliss SP, Nett TM, Ebersole BJ, Sealfon SC, Roberson MS. Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone. Mol Endocrinol. 2005 Oct; 19(10):2624-38.
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    68. Tsokas P, Grace EA, Chan P, Ma T, Sealfon SC, Iyengar R, Landau EM, Blitzer RD. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. J Neurosci. 2005 Jun 15; 25(24):5833-43.
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    69. Sealfon SC. Teaching resources. G-protein-coupled receptors. Sci STKE. 2005 Apr 12; 2005(279):tr11.
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    70. Mastaitis JW, Wurmbach E, Cheng H, Sealfon SC, Mobbs CV. Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia. Diabetes. 2005 Apr; 54(4):952-8.
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    71. Omari KM, John GR, Sealfon SC, Raine CS. CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. Brain. 2005 May; 128(Pt 5):1003-15.
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    72. Chan P, Gonzalez-Maeso J, Ruf F, Bishop DF, Hof PR, Sealfon SC. Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain. J Comp Neurol. 2005 Jan 31; 482(1):50-73.
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    73. Ruf F, Sealfon SC. Genomics view of gonadotrope signaling circuits. Trends Endocrinol Metab. 2004 Sep; 15(7):331-8.
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    74. Mobbs CV, Yen K, Mastaitis J, Nguyen H, Watson E, Wurmbach E, Sealfon SC, Brooks A, Salton SR. Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochem Res. 2004 Jun; 29(6):1093-103.
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    75. Gibson WT, Ebersole BJ, Bhattacharyya S, Clayton P, Farooqi IS, Sealfon SC, O'Rahilly S. Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity. Can J Physiol Pharmacol. 2004 Jun; 82(6):426-9.
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    76. Nair VD, Yuen T, Olanow CW, Sealfon SC. Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress. J Biol Chem. 2004 Jun 25; 279(26):27494-501.
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    77. Wurmbach E, Yuen T, Sealfon SC. Focused microarray analysis. Methods. 2003 Dec; 31(4):306-16.
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    78. González-Maeso J, Yuen T, Ebersole BJ, Wurmbach E, Lira A, Zhou M, Weisstaub N, Hen R, Gingrich JA, Sealfon SC. Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex. J Neurosci. 2003 Oct 1; 23(26):8836-43.
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    79. Nair VD, Sealfon SC. Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor. J Biol Chem. 2003 Nov 21; 278(47):47053-61.
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    80. Ruf F, Fink MY, Sealfon SC. Structure of the GnRH receptor-stimulated signaling network: insights from genomics. Front Neuroendocrinol. 2003 Jul; 24(3):181-99.
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    81. Nair VD, Olanow CW, Sealfon SC. Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines. Biochem J. 2003 Jul 1; 373(Pt 1):25-32.
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    82. Ebersole BJ, Visiers I, Weinstein H, Sealfon SC. Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy. Mol Pharmacol. 2003 Jan; 63(1):36-43.
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    83. Krakauer DC, Page KM, Sealfon S. Module dynamics of the GnRH signal transduction network. J Theor Biol. 2002 Oct 21; 218(4):457-70.
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    84. Wurmbach E, González-Maeso J, Yuen T, Ebersole BJ, Mastaitis JW, Mobbs CV, Sealfon SC. Validated genomic approach to study differentially expressed genes in complex tissues. Neurochem Res. 2002 Oct; 27(10):1027-33.
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    85. Yu WH, Karanth S, Mastronardi CA, Sealfon S, Dean C, Dees WL, McCann SM. Lamprey GnRH-III acts on its putative receptor via nitric oxide to release follicle-stimulating hormone specifically. Exp Biol Med (Maywood). 2002 Oct; 227(9):786-93.
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    86. Prioleau C, Visiers I, Ebersole BJ, Weinstein H, Sealfon SC. Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations. J Biol Chem. 2002 Sep 27; 277(39):36577-84.
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    87. Song ZM, Undie AS, Koh PO, Fang YY, Zhang L, Dracheva S, Sealfon SC, Lidow MS. D1 dopamine receptor regulation of microtubule-associated protein-2 phosphorylation in developing cerebral cortical neurons. J Neurosci. 2002 Jul 15; 22(14):6092-105.
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    88. Yuen T, Wurmbach E, Ebersole BJ, Ruf F, Pfeffer RL, Sealfon SC. Coupling of GnRH concentration and the GnRH receptor-activated gene program. Mol Endocrinol. 2002 Jun; 16(6):1145-53.
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    89. Yuen T, Wurmbach E, Pfeffer RL, Ebersole BJ, Sealfon SC. Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays. Nucleic Acids Res. 2002 May 15; 30(10):e48.
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    90. Yuen T, Zhang W, Ebersole BJ, Sealfon SC. Monitoring G-protein-coupled receptor signaling with DNA microarrays and real-time polymerase chain reaction. Methods Enzymol. 2002; 345:556-69.
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    91. Ebersole BJ, Sealfon SC. Strategies for mapping the binding site of the serotonin 5-HT2A receptor. Methods Enzymol. 2002; 343:123-36.
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    92. Wurmbach E, Yuen T, Ebersole BJ, Sealfon SC. Gonadotropin-releasing hormone receptor-coupled gene network organization. J Biol Chem. 2001 Dec 14; 276(50):47195-201.
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    93. Sealfon SC. Polymorphisms 'r us. Clin Auton Res. 2001 Apr; 11(2):59-60.
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    94. Kitanovic S, Yuen T, Flanagan CA, Ebersole BJ, Sealfon SC. Insertional mutagenesis of the arginine cage domain of the gonadotropin-releasing hormone receptor. Mol Endocrinol. 2001 Mar; 15(3):390-7.
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    95. Sun YM, Flanagan CA, Illing N, Ott TR, Sellar R, Fromme BJ, Hapgood J, Sharp P, Sealfon SC, Millar RP. A chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists. Identification of D-Lys(6) in the ligand and extracellular loop two of the receptor as determinants. J Biol Chem. 2001 Mar 16; 276(11):7754-61.
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    96. Rosendorff A, Ebersole BJ, Sealfon SC. Conserved helix 7 tyrosine functions as an activation relay in the serotonin 5HT(2C) receptor. Brain Res Mol Brain Res. 2000 Dec 8; 84(1-2):90-6.
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    97. Sealfon SC, Olanow CW. Dopamine receptors: from structure to behavior. Trends Neurosci. 2000 Oct; 23(10 Suppl):S34-40.
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    98. Flanagan CA, Rodic V, Konvicka K, Yuen T, Chi L, Rivier JE, Millar RP, Weinstein H, Sealfon SC. Multiple interactions of the Asp(2.61(98)) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction. Biochemistry. 2000 Jul 18; 39(28):8133-41.
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    99. Sealfon SC. Dopamine receptors and locomotor responses: molecular aspects. Ann Neurol. 2000 Apr; 47(4 Suppl 1):S12-9; discussion S19-21.
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    100. Klein C, Gurvich N, Sena-Esteves M, Bressman S, Brin MF, Ebersole BJ, Fink S, Forsgren L, Friedman J, Grimes D, Holmgren G, Kyllerman M, Lang AE, de Leon D, Leung J, Prioleau C, Raymond D, Sanner G, Saunders-Pullman R, Vieregge P, Wahlström J, Breakefield XO, Kramer PL, Ozelius LJ, Sealfon SC. Evaluation of the role of the D2 dopamine receptor in myoclonus dystonia. Ann Neurol. 2000 Mar; 47(3):369-73.
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    101. Flanagan CA, Zhou W, Chi L, Yuen T, Rodic V, Robertson D, Johnson M, Holland P, Millar RP, Weinstein H, Mitchell R, Sealfon SC. The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor. J Biol Chem. 1999 Oct 8; 274(41):28880-6.
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    102. Millar R, Conklin D, Lofton-Day C, Hutchinson E, Troskie B, Illing N, Sealfon SC, Hapgood J. A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript. J Endocrinol. 1999 Jul; 162(1):117-26.
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    103. Dracheva S, Xu M, Kelley KA, Haroutunian V, Holstein GR, Haun S, Silverstein JH, Sealfon SC. Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice. Exp Neurol. 1999 May; 157(1):169-79.
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    104. Shashidharan P, Chalmers-Redman RM, Carlile GW, Rodic V, Gurvich N, Yuen T, Tatton WG, Sealfon SC. Nuclear translocation of GAPDH-GFP fusion protein during apoptosis. Neuroreport. 1999 Apr 6; 10(5):1149-53.
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    105. Troskie B, Illing N, Rumbak E, Sun YM, Hapgood J, Sealfon S, Conklin D, Millar R. Identification of three putative GnRH receptor subtypes in vertebrates. Gen Comp Endocrinol. 1998 Dec; 112(3):296-302.
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    106. Ballesteros J, Kitanovic S, Guarnieri F, Davies P, Fromme BJ, Konvicka K, Chi L, Millar RP, Davidson JS, Weinstein H, Sealfon SC. Functional microdomains in G-protein-coupled receptors. The conserved arginine-cage motif in the gonadotropin-releasing hormone receptor. J Biol Chem. 1998 Apr 24; 273(17):10445-53.
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    107. Mitchell R, McCulloch D, Lutz E, Johnson M, MacKenzie C, Fennell M, Fink G, Zhou W, Sealfon SC. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature. 1998 Mar 26; 392(6674):411-4.
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    108. Sealfon SC, Weinstein H, Millar RP. Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor. Endocr Rev. 1997 Apr; 18(2):180-205.
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    109. Gillo B, Sealfon SC, Minke B. Pharmacology of a capacitative Ca2+ entry in Xenopus oocytes. J Photochem Photobiol B. 1996 Aug; 35(1-2):77-82.
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    110. Almaula N, Ebersole BJ, Ballesteros JA, Weinstein H, Sealfon SC. Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the same locus. Mol Pharmacol. 1996 Jul; 50(1):34-42.
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    111. Almaula N, Ebersole BJ, Zhang D, Weinstein H, Sealfon SC. Mapping the binding site pocket of the serotonin 5-Hydroxytryptamine2A receptor. Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of lysergic acid diethylamide or bufotenin. J Biol Chem. 1996 Jun 21; 271(25):14672-5.
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    112. Zhou W, Rodic V, Kitanovic S, Flanagan CA, Chi L, Weinstein H, Maayani S, Millar RP, Sealfon SC. A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites. J Biol Chem. 1995 Aug 11; 270(32):18853-7.
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    113. Sealfon SC, Chi L, Ebersole BJ, Rodic V, Zhang D, Ballesteros JA, Weinstein H. Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor. J Biol Chem. 1995 Jul 14; 270(28):16683-8.
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    114. Tojo K, Ichinose M, Nakayama M, Yamamoto H, Hasegawa T, Kawaguchi Y, Sealfon SC, Sakai O. A new family of Boucher-Neuhäuser syndrome: coexistence of Holmes type cerebellar atrophy, hypogonadotropic hypogonadism and retinochoroidal degeneration: case reports and review of literature. Endocr J. 1995 Jun; 42(3):367-76.
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    115. Sealfon SC, Millar RP. The gonadotrophin-releasing hormone receptor: structural determinants and regulatory control. Hum Reprod Update. 1995 May; 1(3):216-30.
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    116. Tsutsumi M, Laws SC, Rodic V, Sealfon SC. Translational regulation of the gonadotropin-releasing hormone receptor in alpha T3-1 cells. Endocrinology. 1995 Mar; 136(3):1128-36.
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    117. Davidson JS, Flanagan CA, Zhou W, Becker II, Elario R, Emeran W, Sealfon SC, Millar RP. Identification of N-glycosylation sites in the gonadotropin-releasing hormone receptor: role in receptor expression but not ligand binding. Mol Cell Endocrinol. 1995 Feb; 107(2):241-5.
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    118. Sealfon SC, Millar RP. Functional domains of the gonadotropin-releasing hormone receptor. Cell Mol Neurobiol. 1995 Feb; 15(1):25-42.
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    119. Flanagan CA, Becker II, Davidson JS, Wakefield IK, Zhou W, Sealfon SC, Millar RP. Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone. J Biol Chem. 1994 Sep 9; 269(36):22636-41.
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    120. Zhou W, Sealfon SC. Structure of the mouse gonadotropin-releasing hormone receptor gene: variant transcripts generated by alternative processing. DNA Cell Biol. 1994 Jun; 13(6):605-14.
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    121. Davidson JS, Flanagan CA, Becker II, Illing N, Sealfon SC, Millar RP. Molecular function of the gonadotropin-releasing hormone receptor: insights from site-directed mutagenesis. Mol Cell Endocrinol. 1994 Apr; 100(1-2):9-14.
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    122. Wu JC, Sealfon SC, Miller WL. Gonadal hormones and gonadotropin-releasing hormone (GnRH) alter messenger ribonucleic acid levels for GnRH receptors in sheep. Endocrinology. 1994 Apr; 134(4):1846-50.
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    123. Zhou W, Flanagan C, Ballesteros JA, Konvicka K, Davidson JS, Weinstein H, Millar RP, Sealfon SC. A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol Pharmacol. 1994 Feb; 45(2):165-70.
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    124. Tsutsumi M, Laws SC, Sealfon SC. Homologous up-regulation of the gonadotropin-releasing hormone receptor in alpha T3-1 cells is associated with unchanged receptor messenger RNA (mRNA) levels and altered mRNA activity. Mol Endocrinol. 1993 Dec; 7(12):1625-33.
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    125. Illing N, Jacobs GF, Becker II, Flanagan CA, Davidson JS, Eales A, Zhou W, Sealfon SC, Millar RP. Comparative sequence analysis and functional characterization of the cloned sheep gonadotropin-releasing hormone receptor reveal differences in primary structure and ligand specificity among mammalian receptors. Biochem Biophys Res Commun. 1993 Oct 29; 196(2):745-51.
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    126. Spyraki C, Sealfon SC. Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine. Brain Res Mol Brain Res. 1993 Sep; 19(4):313-7.
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    127. Rappaport MS, Sealfon SC, Prikhozhan A, Huntley GW, Morrison JH. Heterogeneous distribution of D1, D2 and D5 receptor mRNAs in monkey striatum. Brain Res. 1993 Jul 9; 616(1-2):242-50.
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    128. Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Golembo M, Illing N, Millar RP, Sealfon SC. Cloning and characterization of the human GnRH receptor. Mol Cell Endocrinol. 1993 Feb; 91(1-2):R1-6.
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    129. Huntley GW, Morrison JH, Prikhozhan A, Sealfon SC. Localization of multiple dopamine receptor subtype mRNAs in human and monkey motor cortex and striatum. Brain Res Mol Brain Res. 1992 Oct; 15(3-4):181-8.
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    130. Tsutsumi M, Zhou W, Millar RP, Mellon PL, Roberts JL, Flanagan CA, Dong K, Gillo B, Sealfon SC. Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol. 1992 Jul; 6(7):1163-9.
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    131. Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC. Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol. 1992 Jan-Feb; 11(1):1-20.
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    132. Snyder LA, Roberts JL, Sealfon SC. Alternative transcripts of the rat and human dopamine D3 receptor. Biochem Biophys Res Commun. 1991 Oct 31; 180(2):1031-5.
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    133. McChesney R, Sealfon SC, Tsutsumi M, Dong KW, Roberts JL, Bancroft C. Either isoform of the dopamine D2 receptor can mediate dopaminergic repression of the rat prolactin promoter. Mol Cell Endocrinol. 1991 Aug; 79(1-3):R1-7.
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    134. Snyder LA, Roberts JL, Sealfon SC. Distribution of dopamine D2 receptor mRNA splice variants in the rat by solution hybridization/protection assay. Neurosci Lett. 1991 Jan 14; 122(1):37-40.
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    135. Sealfon SC, Laws SC, Wu JC, Gillo B, Miller WL. Hormonal regulation of gonadotropin-releasing hormone receptors and messenger RNA activity in ovine pituitary culture. Mol Endocrinol. 1990 Dec; 4(12):1980-7.
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    136. Sealfon SC, Mundamattom S, Gillo B. Modulation of calcium mobilization by guanosine 5'-O-(2-thiodiphosphate) in Xenopus oocytes. FEBS Lett. 1990 Aug 20; 269(1):135-8.
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    137. Sealfon SC, Gillo B, Mundamattom S, Mellon PL, Windle JJ, Landau E, Roberts JL. Gonadotropin-releasing hormone receptor expression in Xenopus oocytes. Mol Endocrinol. 1990 Jan; 4(1):119-24.
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    138. Autelitano DJ, Snyder L, Sealfon SC, Roberts JL. Dopamine D2-receptor messenger RNA is differentially regulated by dopaminergic agents in rat anterior and neurointermediate pituitary. Mol Cell Endocrinol. 1989 Nov; 67(1):101-5.
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    139. Gillo B, Landau EM, Moriarty TM, Roberts JL, Sealfon SC. A novel calcium-dependent chloride current in Xenopus oocytes injected with brain messenger RNA. J Physiol. 1989 Oct; 417:47-61.
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    140. Moriarty TM, Sealfon SC, Carty DJ, Roberts JL, Iyengar R, Landau EM. Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin-sensitive and -insensitive pathways. Cross-talk through heterotrimeric G-proteins. J Biol Chem. 1989 Aug 15; 264(23):13524-30.
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    141. Moriarty TM, Gillo B, Sealfon S, Landau EM. Activation of ionic currents in Xenopus oocytes by corticotropin-releasing peptides. Brain Res. 1988 Nov; 464(3):201-5.
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    142. Call GK, Fleming MC, Sealfon S, Levine H, Kistler JP, Fisher CM. Reversible cerebral segmental vasoconstriction. Stroke. 1988 Sep; 19(9):1159-70.
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    143. Moriarty TM, Gillo B, Sealfon S, Roberts JL, Blitzer RD, Landau EM. Functional expression of brain cholecystokinin and bombesin receptors in Xenopus oocytes. Brain Res. 1988 Aug; 464(1):75-9.
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