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Paul Slesinger

TitlePROFESSOR
InstitutionMount Sinai
DepartmentNeuroscience
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bodhinathan K, Slesinger PA. Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels. Proc Natl Acad Sci U S A. 2013 Nov 5; 110(45):18309-14.
      View in: PubMed
    2. Kang JY, Kawaguchi D, Coin I, Xiang Z, O'Leary DD, Slesinger PA, Wang L. In Vivo expression of a light-activatable potassium channel using unnatural amino acids. Neuron. 2013 Oct 16; 80(2):358-70.
      View in: PubMed
    3. Balana B, Bahima L, Bodhinathan K, Taura JJ, Taylor NM, Nettleton MY, Ciruela F, Slesinger PA. Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. PLoS One. 2013; 8(3):e59800.
      View in: PubMed
    4. Polák P, Freibergerová M, Husa P, Slesinger P, Svoboda R, Stásek J, Frola L, Machácek C. [Warning about risk of invasive infections in splenectomized patients. Experiences from University Hospital Brno, Czech Republic, in 2011]. Vnitr Lek. 2012 Sep; 58(9):665-7.
      View in: PubMed
    5. Klammt C, Maslennikov I, Bayrhuber M, Eichmann C, Vajpai N, Chiu EJ, Blain KY, Esquivies L, Kwon JH, Balana B, Pieper U, Sali A, Slesinger PA, Kwiatkowski W, Riek R, Choe S. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. Nat Methods. 2012 Aug; 9(8):834-9.
      View in: PubMed
    6. Padgett CL, Lalive AL, Tan KR, Terunuma M, Munoz MB, Pangalos MN, Martínez-Hernández J, Watanabe M, Moss SJ, Luján R, Lüscher C, Slesinger PA. Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Neuron. 2012 Mar 8; 73(5):978-89.
      View in: PubMed
    7. Laviv T, Vertkin I, Berdichevsky Y, Fogel H, Riven I, Bettler B, Slesinger PA, Slutsky I. Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. J Neurosci. 2011 Aug 31; 31(35):12523-32.
      View in: PubMed
    8. Howard RJ, Slesinger PA, Davies DL, Das J, Trudell JR, Harris RA. Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res. 2011 Sep; 35(9):1561-73.
      View in: PubMed
    9. Hurtado de Mendoza T, Balana B, Slesinger PA, Verma IM. Organotypic cerebellar cultures: apoptotic challenges and detection. J Vis Exp. 2011; (51).
      View in: PubMed
    10. Balana B, Maslennikov I, Kwiatkowski W, Stern KM, Bahima L, Choe S, Slesinger PA. Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Proc Natl Acad Sci U S A. 2011 Apr 5; 108(14):5831-6.
      View in: PubMed
    11. Nassirpour R, Bahima L, Lalive AL, Lüscher C, Luján R, Slesinger PA. Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. J Neurosci. 2010 Oct 6; 30(40):13419-30.
      View in: PubMed
    12. Balana B, Taylor N, Slesinger PA. Mutagenesis and functional analysis of ion channels heterologously expressed in mammalian cells. J Vis Exp. 2010; (44).
      View in: PubMed
    13. Laviv T, Riven I, Dolev I, Vertkin I, Balana B, Slesinger PA, Slutsky I. Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses. Neuron. 2010 Jul 29; 67(2):253-67.
      View in: PubMed
    14. Boyer SB, Slesinger PA. Probing novel GPCR interactions using a combination of FRET and TIRF. Commun Integr Biol. 2010 Jul; 3(4):343-6.
      View in: PubMed
    15. Lüscher C, Slesinger PA. Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci. 2010 May; 11(5):301-15.
      View in: PubMed
    16. Padgett CL, Slesinger PA. GABAB receptor coupling to G-proteins and ion channels. Adv Pharmacol. 2010; 58:123-47.
      View in: PubMed
    17. Boyer SB, Clancy SM, Terunuma M, Revilla-Sanchez R, Thomas SM, Moss SJ, Slesinger PA. Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling. J Neurosci. 2009 Dec 16; 29(50):15796-809.
      View in: PubMed
    18. Aryal P, Dvir H, Choe S, Slesinger PA. A discrete alcohol pocket involved in GIRK channel activation. Nat Neurosci. 2009 Aug; 12(8):988-95.
      View in: PubMed
    19. Boyer SB, Slesinger PA, Jones SV. Regulation of Kir2.1 channels by the Rho-GTPase, Rac1. J Cell Physiol. 2009 Feb; 218(2):385-93.
      View in: PubMed
    20. Lomazzi M, Slesinger PA, Lüscher C. Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins. Trends Pharmacol Sci. 2008 Nov; 29(11):544-9.
      View in: PubMed
    21. Labouèbe G, Lomazzi M, Cruz HG, Creton C, Luján R, Li M, Yanagawa Y, Obata K, Watanabe M, Wickman K, Boyer SB, Slesinger PA, Lüscher C. RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Nat Neurosci. 2007 Dec; 10(12):1559-68.
      View in: PubMed
    22. Nassirpour R, Slesinger PA. Subunit-specific regulation of Kir3 channels by sorting nexin 27. Channels (Austin). 2007 Sep-Oct; 1(5):331-3.
      View in: PubMed
    23. Lunn ML, Nassirpour R, Arrabit C, Tan J, McLeod I, Arias CM, Sawchenko PE, Yates JR, Slesinger PA. A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nat Neurosci. 2007 Oct; 10(10):1249-59.
      View in: PubMed
    24. Kurata HT, Cheng WW, Arrabit C, Slesinger PA, Nichols CG. The role of the cytoplasmic pore in inward rectification of Kir2.1 channels. J Gen Physiol. 2007 Aug; 130(2):145-55.
      View in: PubMed
    25. Wang W, Takimoto JK, Louie GV, Baiga TJ, Noel JP, Lee KF, Slesinger PA, Wang L. Genetically encoding unnatural amino acids for cellular and neuronal studies. Nat Neurosci. 2007 Aug; 10(8):1063-72.
      View in: PubMed
    26. Clancy SM, Boyer SB, Slesinger PA. Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. J Neurosci. 2007 Jun 13; 27(24):6388-99.
      View in: PubMed
    27. Pegan S, Tan J, Huang A, Slesinger PA, Riek R, Choe S. NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95. Biochemistry. 2007 May 8; 46(18):5315-22.
      View in: PubMed
    28. Fowler CE, Aryal P, Suen KF, Slesinger PA. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. J Physiol. 2007 Apr 1; 580(Pt 1):51-65.
      View in: PubMed
    29. Pegan S, Arrabit C, Slesinger PA, Choe S. Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. Biochemistry. 2006 Jul 18; 45(28):8599-606.
      View in: PubMed
    30. Husa P, Slesinger P, Stroblová H, Svobodník A. [The effect of patient's body weight, gender and baseline viral load on the efficacy of hepatitis C therapy]. Vnitr Lek. 2006 Jun; 52(6):590-5.
      View in: PubMed
    31. Husa P, Slesinger P, Stroblová H, Svobodník A. [The meaning of viral kinetics in the beginning of the pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C]. Vnitr Lek. 2006 Feb; 52(2):153-9.
      View in: PubMed
    32. Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger PA, Choe S. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat Neurosci. 2005 Mar; 8(3):279-87.
      View in: PubMed
    33. Clancy SM, Fowler CE, Finley M, Suen KF, Arrabit C, Berton F, Kosaza T, Casey PJ, Slesinger PA. Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. Mol Cell Neurosci. 2005 Feb; 28(2):375-89.
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    34. Mutneja M, Berton F, Suen KF, Lüscher C, Slesinger PA. Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cells. Pflugers Arch. 2005 Apr; 450(1):61-73.
      View in: PubMed
    35. Panicker S, Cruz H, Arrabit C, Suen KF, Slesinger PA. Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor. J Biol Chem. 2004 Jul 2; 279(27):28149-58.
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    36. Cruz HG, Ivanova T, Lunn ML, Stoffel M, Slesinger PA, Lüscher C. Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system. Nat Neurosci. 2004 Feb; 7(2):153-9.
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    37. Finley M, Arrabit C, Fowler C, Suen KF, Slesinger PA. betaL-betaM loop in the C-terminal domain of G protein-activated inwardly rectifying K(+) channels is important for G(betagamma) subunit activation. J Physiol. 2004 Mar 16; 555(Pt 3):643-57.
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    38. Panicker S, Cruz H, Arrabit C, Slesinger PA. Evidence for a centrally located gate in the pore of a serotonin-gated ion channel. J Neurosci. 2002 Mar 1; 22(5):1629-39.
      View in: PubMed
    39. Zhou W, Arrabit C, Choe S, Slesinger PA. Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6482-7.
      View in: PubMed
    40. Slesinger PA. Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J. 2001 Feb; 80(2):707-18.
      View in: PubMed
    41. Husa P, Chalupa P, Stroblová H, Husová L, Slesinger P, Zajíc J. Autoantibodies to asialoglycoprotein receptor in chronic hepatitis C patients. Acta Virol. 2001 Feb; 45(1):7-11.
      View in: PubMed
    42. Husa P, Chalupa P, Stroblová H, Husová L, Slesinger P. Efficacy of alpha-interferon therapy of chronic hepatitis patients infected with wild type hepatitis B virus and HBEAG-minus mutant. Acta Virol. 2001; 45(5-6):293-7.
      View in: PubMed
    43. Slesinger PA, Stoffel M, Jan YN, Jan LY. Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):12210-7.
      View in: PubMed
    44. Slesinger PA, Lansman JB. Reopening of single L-type Ca2+ channels in mouse cerebellar granule cells: dependence on voltage and ion concentration. J Physiol. 1996 Mar 1; 491 ( Pt 2):335-45.
      View in: PubMed
    45. Slesinger PA, Patil N, Liao YJ, Jan YN, Jan LY, Cox DR. Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels. Neuron. 1996 Feb; 16(2):321-31.
      View in: PubMed
    46. Huang CL, Slesinger PA, Casey PJ, Jan YN, Jan LY. Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. Neuron. 1995 Nov; 15(5):1133-43.
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    47. Slesinger PA, Reuveny E, Jan YN, Jan LY. Identification of structural elements involved in G protein gating of the GIRK1 potassium channel. Neuron. 1995 Nov; 15(5):1145-56.
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    48. Reuveny E, Slesinger PA, Inglese J, Morales JM, Iñiguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY. Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature. 1994 Jul 14; 370(6485):143-6.
      View in: PubMed
    49. Slesinger PA, Jan YN, Jan LY. The S4-S5 loop contributes to the ion-selective pore of potassium channels. Neuron. 1993 Oct; 11(4):739-49.
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    50. Kubo Y, Reuveny E, Slesinger PA, Jan YN, Jan LY. Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature. 1993 Aug 26; 364(6440):802-6.
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    51. Haws CM, Slesinger PA, Lansman JB. Dihydropyridine- and omega-conotoxin-sensitive Ca2+ currents in cerebellar neurons: persistent block of L-type channels by a pertussis toxin-sensitive G-protein. J Neurosci. 1993 Mar; 13(3):1148-56.
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    52. Chalupa P, Slesinger P, Krchnáková A, Prásek J. [IgA antibodies against Epstein-Barr virus capsid antigen]. Cas Lek Cesk. 1992 Sep 10; 131(17):526-9.
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    53. Slesinger PA, Lansman JB. Reopening of Ca2+ channels in mouse cerebellar neurons at resting membrane potentials during recovery from inactivation. Neuron. 1991 Nov; 7(5):755-62.
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    54. Slesinger PA, Lansman JB. Inactivating and non-inactivating dihydropyridine-sensitive Ca2+ channels in mouse cerebellar granule cells. J Physiol. 1991 Aug; 439:301-23.
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    55. Slesinger PA, Lansman JB. Inactivation of calcium currents in granule cells cultured from mouse cerebellum. J Physiol. 1991 Apr; 435:101-21.
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    56. Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Raskin LS, Price DL, Coyle JT. Compartment-specific changes in the density of choline and dopamine uptake sites and muscarinic and dopaminergic receptors during the development of the baboon striatum: a quantitative receptor autoradiographic study. J Comp Neurol. 1989 Oct 15; 288(3):428-46.
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    57. Searles CD, Slesinger PA, Singer HS. Effects of anticonvulsants on cholinergic and GABAergic properties in the neuronal cell clone NG108-15. Neurochem Res. 1988 Oct; 13(10):1007-13.
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    58. Slesinger PA, Lowenstein PR, Singer HS, Walker LC, Casanova MF, Price DL, Coyle JT. Development of beta 1 and beta 2 adrenergic receptors in baboon brain: an autoradiographic study using [125I]iodocyanopindolol. J Comp Neurol. 1988 Jul 15; 273(3):318-29.
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    59. Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Price DL, Coyle JT. An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system. Brain Res. 1987 Aug; 431(2):291-7.
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    60. Slesinger PA, Singer HS. Effects of anticonvulsants on cell growth and enzymatic and receptor binding activity in a neuroblastoma x glioma hybrid cell culture. Epilepsia. 1987 May-Jun; 28(3):214-21.
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    61. Singer HS, Tiemeyer M, Slesinger PA, Sinnott ML. Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease. Ann Neurol. 1987 May; 21(5):497-503.
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    62. Singer HS, Searles C, Slesinger P. Effect of anticonvulsants on the neuroblastoma x glioma hybrid cell line NG108-15. Prog Clin Biol Res. 1987; 253:339-47.
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    63. Slesinger P, Bell CC. Primary afferent fibers conduct impulses in both directions under physiological stimulus conditions. J Comp Physiol A. 1985 Jul; 157(1):15-22.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067