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Janina A. Longtine

TitleSENIOR FACULTY
InstitutionMount Sinai
DepartmentPathology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gong JZ, Cook JR, Greiner TC, Hedvat C, Hill CE, Lim MS, Longtine JA, Sabath D, Wang YL. Laboratory practice guidelines for detecting and reporting JAK2 and MPL mutations in myeloproliferative neoplasms: a report of the Association for Molecular Pathology. J Mol Diagn. 2013 Nov; 15(6):733-44.
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    2. Howitt BE, Herfs M, Brister K, Oliva E, Longtine J, Hecht JL, Nucci MR. Intestinal-type endocervical adenocarcinoma in situ: an immunophenotypically distinct subset of AIS affecting older women. Am J Surg Pathol. 2013 May; 37(5):625-33.
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    3. Morikawa T, Shima K, Kuchiba A, Yamauchi M, Tanaka N, Imamura Y, Liao X, Qian ZR, Brahmandam M, Longtine JA, Lindeman NI, Fuchs CS, Ogino S. No evidence for interference of h&e staining in DNA testing: usefulness of DNA extraction from H&E-stained archival tissue sections. Am J Clin Pathol. 2012 Jul; 138(1):122-9.
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    4. Brown JR, Hanna M, Tesar B, Pochet N, Vartanov A, Fernandes SM, Werner L, Ash M, Roden CA, MacConaill L, Hainz U, Longtine J, Wang YE, Correll M, Van de Peer Y, Regev A, Wu C, Neuberg D, Freedman AS. Germline copy number variation associated with Mendelian inheritance of CLL in two families. Leukemia. 2012 Jul; 26(7):1710-3.
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    5. Weigert O, Kopp N, Lane AA, Yoda A, Dahlberg SE, Neuberg D, Bahar AY, Chapuy B, Kutok JL, Longtine JA, Kuo FC, Haley T, Salois M, Sullivan TJ, Fisher DC, Fox EA, Rodig SJ, Antin JH, Weinstock DM. Molecular ontogeny of donor-derived follicular lymphomas occurring after hematopoietic cell transplantation. Cancer Discov. 2012 Jan; 2(1):47-55.
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    6. Mega JL, Hochholzer W, Frelinger AL, Kluk MJ, Angiolillo DJ, Kereiakes DJ, Isserman S, Rogers WJ, Ruff CT, Contant C, Pencina MJ, Scirica BM, Longtine JA, Michelson AD, Sabatine MS. Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease. JAMA. 2011 Nov 23; 306(20):2221-8.
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    7. Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL. Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn. 2011 Nov; 13(6):669-77.
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    8. Anderson KS, Wong J, D'Souza G, Riemer AB, Lorch J, Haddad R, Pai SI, Longtine J, McClean M, LaBaer J, Kelsey KT, Posner M. Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer. Br J Cancer. 2011 Jun 7; 104(12):1896-905.
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    9. Leon A, Staropoli JF, Hernandez JM, Longtine JA, Kuo FC, Dal Cin P. Translocation t(1;9) is a recurrent cytogenetic abnormality associated with progression of essential thrombocythemia patients displaying the JAK2 V617F mutation. Leuk Res. 2011 Sep; 35(9):1188-92.
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    10. Melanson SE, Stevenson K, Kim H, Antin JH, Court MH, Ho VT, Ritz J, Soiffer RJ, Kuo FC, Longtine JA, Jarolim P. Allelic variations in CYP2B6 and CYP2C19 and survival of patients receiving cyclophosphamide prior to myeloablative hematopoietic stem cell transplantation. Am J Hematol. 2010 Dec; 85(12):967-71.
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    11. Sholl LM, Longtine J. Molecular analysis of gene rearrangements and mutations in acute leukemias and myeloproliferative neoplasms. Curr Protoc Hum Genet. 2010 Oct; Chapter 10:Unit 10.4.
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    12. Bush ZM, Longtine JA, Cunningham T, Schiff D, Jane JA, Vance ML, Thorner MO, Laws ER, Lopes MB. Temozolomide treatment for aggressive pituitary tumors: correlation of clinical outcome with O(6)-methylguanine methyltransferase (MGMT) promoter methylation and expression. J Clin Endocrinol Metab. 2010 Nov; 95(11):E280-90.
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    13. Sholl LM, Longtine J. Molecular analysis of genetic markers for non-Hodgkin lymphomas. Curr Protoc Hum Genet. 2010 Apr; Chapter 10:Unit 10.14.1-25.
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    14. Geyer JT, Ferry JA, Harris NL, Young RH, Longtine JA, Zukerberg LR. Florid reactive lymphoid hyperplasia of the lower female genital tract (lymphoma-like lesion): a benign condition that frequently harbors clonal immunoglobulin heavy chain gene rearrangements. Am J Surg Pathol. 2010 Feb; 34(2):161-8.
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    15. Geyer JT, Ferry JA, Longtine JA, Flotte TJ, Harris NL, Zukerberg LR. Characteristics of cutaneous marginal zone lymphomas with marked plasmacytic differentiation and a T cell-rich background. Am J Clin Pathol. 2010 Jan; 133(1):59-69.
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    16. Wu D, Dutra B, Lindeman N, Takahashi H, Takeyama K, Harris NL, Pinkus GS, Longtine J, Shipp M, Kutok JL. No evidence for the JAK2 (V617F) or JAK2 exon 12 mutations in primary mediastinal large B-cell lymphoma. Diagn Mol Pathol. 2009 Sep; 18(3):144-9.
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    17. Cannizzo E, Sohani AR, Ferry JA, Hochberg EP, Kluk MJ, Dorn ME, Sadowski C, Bucci JJ, Ackerman AM, Longtine JA, Carulli G, Preffer FI. Carcinoma and multiple lymphomas in one patient: establishing the diagnoses and analyzing risk factors. J Hematop. 2009; 2(3):163-70.
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    18. Slack GW, Ferry JA, Hasserjian RP, Sohani AR, Longtine JA, Harris NL, Zukerberg LR. Lymphocyte depleted Hodgkin lymphoma: an evaluation with immunophenotyping and genetic analysis. Leuk Lymphoma. 2009 Jun; 50(6):937-43.
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    19. Ferry JA, Sohani AR, Longtine JA, Schwartz RA, Harris NL. HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma. Mod Pathol. 2009 May; 22(5):618-26.
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    20. Rahemtullah A, Longtine JA, Harris NL, Dorn M, Zembowicz A, Quintanilla-Fend L, Preffer FI, Ferry JA. CD20+ T-cell lymphoma: clinicopathologic analysis of 9 cases and a review of the literature. Am J Surg Pathol. 2008 Nov; 32(11):1593-607.
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    21. Herskovits AZ, Lemire SJ, Longtine J, Dorfman DM. Comparison of Russell viper venom-based and activated partial thromboplastin time-based screening assays for resistance to activated protein C. Am J Clin Pathol. 2008 Nov; 130(5):796-804.
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    22. Nosho K, Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Zepf D, Yan L, Longtine JA, Fuchs CS, Ogino S. PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. Neoplasia. 2008 Jun; 10(6):534-41.
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    23. Abel GA, DeAngelo DJ, Connors JM, Sholl LM, McCaffrey RP, Longtine JA. Clinical JAK2V617F mutation testing: Limited utility for general hospital patients with venous and arterial thromboses in common locations. Am J Hematol. 2008 Jun; 83(6):519-20.
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    24. Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY. Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol. 2008 Jun; 10(3):300-8.
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    25. Williams Z, Zepf D, Longtine J, Anchan R, Broadman B, Missmer SA, Hornstein MD. Foreign fetal cells persist in the maternal circulation. Fertil Steril. 2009 Jun; 91(6):2593-5.
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    26. Waisbren SE, Bowles H, Hasan T, Zou KH, Emans SJ, Goldberg C, Gould S, Levine D, Lieberman E, Loeken M, Longtine J, Nadelson C, Patenaude AF, Quinn D, Randolph AG, Solet JM, Ullrich N, Walensky R, Weitzman P, Christou H. Gender differences in research grant applications and funding outcomes for medical school faculty. J Womens Health (Larchmt). 2008 Mar; 17(2):207-14.
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    27. Rodig SJ, Payne EG, Degar BA, Rollins B, Feldman AL, Jaffe ES, Androkites A, Silverman LB, Longtine JA, Kutok JL, Fleming MD, Aster JC. Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1. Am J Hematol. 2008 Feb; 83(2):116-21.
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    28. Seliem RM, Griffith RC, Harris NL, Beheshti J, Schiffman FJ, Longtine J, Kutok J, Ferry JA. HHV-8+, EBV+ multicentric plasmablastic microlymphoma in an HIV+ Man: the spectrum of HHV-8+ lymphoproliferative disorders expands. Am J Surg Pathol. 2007 Sep; 31(9):1439-45.
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    29. Kuo FC, Hall D, Longtine JA. A novel method for interpretation of T-cell receptor gamma gene rearrangement assay by capillary gel electrophoresis based on normal distribution. J Mol Diagn. 2007 Feb; 9(1):12-9.
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    30. Sequist LV, Joshi VA, Jänne PA, Bell DW, Fidias P, Lindeman NI, Louis DN, Lee JC, Mark EJ, Longtine J, Verlander P, Kucherlapati R, Meyerson M, Haber DA, Johnson BE, Lynch TJ. Epidermal growth factor receptor mutation testing in the care of lung cancer patients. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 2):4403s-4408s.
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    31. Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J. Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes. J Neurol Sci. 2006 Sep 25; 247(2):208-16.
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    32. Hughes T, Deininger M, Hochhaus A, Branford S, Radich J, Kaeda J, Baccarani M, Cortes J, Cross NC, Druker BJ, Gabert J, Grimwade D, Hehlmann R, Kamel-Reid S, Lipton JH, Longtine J, Martinelli G, Saglio G, Soverini S, Stock W, Goldman JM. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood. 2006 Jul 1; 108(1):28-37.
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    33. Jacobsen E, Lomo L, Briccetti F, Longtine J, Freedman A. Follicular lymphoma with bilateral testicular and epididymal involvement: case report and review of the literature. Leuk Lymphoma. 2005 Nov; 46(11):1663-6.
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    34. DeAngelo DJ, Hochberg EP, Alyea EP, Longtine J, Lee S, Galinsky I, Parekkedon B, Ritz J, Antin JH, Stone RM, Soiffer RJ. Extended follow-up of patients treated with imatinib mesylate (gleevec) for chronic myelogenous leukemia relapse after allogeneic transplantation: durable cytogenetic remission and conversion to complete donor chimerism without graft-versus-host disease. Clin Cancer Res. 2004 Aug 1; 10(15):5065-71.
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    35. Joffe HV, Xu R, Johnson FB, Longtine J, Kucher N, Goldhaber SZ. Warfarin dosing and cytochrome P450 2C9 polymorphisms. Thromb Haemost. 2004 Jun; 91(6):1123-8.
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    36. Baehring JM, Longtine J, Hochberg FH. A new approach to the diagnosis and treatment of intravascular lymphoma. J Neurooncol. 2003 Feb; 61(3):237-48.
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    37. Aster JC, Longtine JA. Detection of BCL2 rearrangements in follicular lymphoma. Am J Pathol. 2002 Mar; 160(3):759-63.
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    38. de Leval L, Harris NL, Longtine J, Ferry JA, Duncan LM. Cutaneous b-cell lymphomas of follicular and marginal zone types: use of Bcl-6, CD10, Bcl-2, and CD21 in differential diagnosis and classification. Am J Surg Pathol. 2001 Jun; 25(6):732-41.
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    39. Longtine J, Fox E, Reynolds C, Sklar J. Molecular analysis of DNA rearrangements in leukemias and non-Hodgkin's lymphomas. Curr Protoc Hum Genet. 2001 May; Chapter 10:Unit 10.4.
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    40. de Leval L, Savilo E, Longtine J, Ferry JA, Harris NL. Peripheral T-cell lymphoma with follicular involvement and a CD4+/bcl-6+ phenotype. Am J Surg Pathol. 2001 Mar; 25(3):395-400.
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    41. Vern TZ, Alles AJ, Kowal-Vern A, Longtine J, Roberts DJ. Frequency of factor V(Leiden) and prothrombin G20210A in placentas and their relationship with placental lesions. Hum Pathol. 2000 Sep; 31(9):1036-43.
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    42. Wexler EJ, Gravallese EM, Czerniak PM, Devenny JJ, Longtine J, Wong MK, Slee AM, Kerr JS. Tumor biology: use of tiled images in conjunction with measurements of cellular proliferation and death in response to drug treatments. Clin Cancer Res. 2000 Aug; 6(8):3361-70.
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    43. Goyal A, Langer JC, Zutter M, Swanson P, Kraus MD, Bartlett N, Shackelford GD, Longtine JA, Perlmutter DH. Primary gastric plasmacytoma: a rare cause of hypertrophic gastritis in an adolescent. J Pediatr Gastroenterol Nutr. 1999 Oct; 29(4):424-30.
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    44. Vargas SO, Cannon ME, Benjamin RJ, Longtine JA. Transfusion with blood from a donor with chronic myelogenous leukemia: persistence of the bcr/abl translocation in the recipient. Transfusion. 1999 Apr; 39(4):387-91.
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    45. Montes MA, Fox EA, Longtine JA, Dorfman DM. Comparison of functional testing for resistance to activated protein C and molecular biological testing for factor V R506Q in 370 patients. Arch Pathol Lab Med. 1998 Apr; 122(4):325-9.
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    46. Kraus MD, Crawford DF, Kaleem Z, Shenoy S, MacArthur CA, Longtine JA. T gamma/delta hepatosplenic lymphoma in a heart transplant patient after an Epstein-Barr virus positive lymphoproliferative disorder: a case report. Cancer. 1998 Mar 1; 82(5):983-92.
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    47. Donaldson MC, Belkin M, Whittemore AD, Mannick JA, Longtine JA, Dorfman DM. Impact of activated protein C resistance on general vascular surgical patients. J Vasc Surg. 1997 Jun; 25(6):1054-60.
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    48. Dorfman DM, Longtine JA, Fox EA, Weinberg DS, Pinkus GS. T-cell blast crisis in chronic myelogenous leukemia. Immunophenotypic and molecular biologic findings. Am J Clin Pathol. 1997 Feb; 107(2):168-76.
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    49. Rothenberg ME, Weber WE, Longtine JA, Hafler DA. Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. Clin Immunol Immunopathol. 1996 Sep; 80(3 Pt 1):266-72.
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    50. Robert ME, Kuo FC, Longtine JA, Sklar JL, Schrock T, Weidner N. Diffuse colonic mantle cell lymphoma in a patient with presumed ulcerative colitis: detection of a precursor monoclonal lymphoid population using polymerase chain reaction and immunohistochemistry. Am J Surg Pathol. 1996 Aug; 20(8):1024-31.
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    51. Mentzer SJ, Longtine J, Fingeroth J, Reilly JJ, DeCamp MM, O'Donnell W, Swanson SJ, Faller DV, Sugarbaker DJ. Immunoblastic lymphoma of donor origin in the allograft after lung transplantation. Transplantation. 1996 Jun 27; 61(12):1720-5.
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    52. Weinberg DS, Allaert FA, Dusserre P, Drouot F, Retailliau B, Welch WR, Longtine J, Brodsky G, Folkerth R, Doolittle M. Telepathology diagnosis by means of digital still images: an international validation study. Hum Pathol. 1996 Feb; 27(2):111-8.
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    53. Fletcher JA, Longtine J, Wallace K, Mentzer SJ, Sugarbaker DJ. Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: evidence for a pathogenetic relationship with lipomas and leiomyomas. Genes Chromosomes Cancer. 1995 Mar; 12(3):220-3.
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    54. Gravallese EM, Winalski CS, Longtine J, Helfgott SM. Polyarthritis in a 78-year-old woman. Arthritis Rheum. 1994 Jul; 37(7):1087-95.
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    55. Dorfman DM, Longtine JA, Weinberg DS, Pinkus GS. Small lymphocytic non-Hodgkin's lymphoma of suppressor/cytotoxic T-cell phenotype [CD4(-), CD8(+)]. Hum Pathol. 1993 Nov; 24(11):1253-6.
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    56. Fletcher JA, Pinkus GS, Donovan K, Naeem R, Sugarbaker DJ, Mentzer S, Pinkus JL, Longtine J. Clonal rearrangement of chromosome band 6p21 in the mesenchymal component of pulmonary chondroid hamartoma. Cancer Res. 1992 Nov 15; 52(22):6224-8.
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    57. Sklar J, Longtine J. The clinical significance of antigen receptor gene rearrangements in lymphoid neoplasia. Cancer. 1992 Sep 15; 70(6 Suppl):1710-8.
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    58. Gribben JG, Freedman As, Woo SD, Blake K, Shu RS, Freeman G, Longtine JA, Pinkus GS, Nadler LM. All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment. Blood. 1991 Dec 15; 78(12):3275-80.
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    59. Penny RJ, Blaustein JC, Longtine JA, Pinkus GS. Ki-1-positive large cell lymphomas, a heterogenous group of neoplasms. Morphologic, immunophenotypic, genotypic, and clinical features of 24 cases. Cancer. 1991 Jul 15; 68(2):362-73.
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    60. Caligiuri MA, Murray C, Levine H, Longtine JA, Ritz J. Clonal evidence for the induction of NKH1 on activated human thymocytes. Functional changes associated with antigen expression. Eur J Immunol. 1989 Sep; 19(9):1735-9.
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    61. Robb-Nicholson C, Chang RW, Anderson S, Roberts WN, Longtine J, Corson J, Larson M, George D, Green J, Bryant G, et al. Diagnostic value of the history and examination in giant cell arteritis: a clinical pathological study of 81 temporal artery biopsies. J Rheumatol. 1988 Dec; 15(12):1793-6.
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    62. Rogers LA, Longtine JA, Garnick MB, Pinkus GS. Silicone lymphadenopathy in a long distance runner: complication of a silastic prosthesis. Hum Pathol. 1988 Oct; 19(10):1237-9.
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    63. Williams DA, Lim B, Spooncer E, Longtine J, Dexter TM. Restriction of expression of an integrated recombinant retrovirus in primary but not immortalized murine hematopoietic stem cells. Blood. 1988 Jun; 71(6):1738-43.
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    64. Li FP, Gimbrere K, Ritz J, Saito H, Longtine JA. Lymphoma with clonal T-cell receptor gene rearrangement in a 25-year survivor of Hodgkin's disease. Cancer. 1987 Nov 1; 60(9):2213-8.
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    65. Warhol MJ, Longtine JA. A low-temperature embedding colloidal gold technique for immunoelectron microscopy. Diagn Immunol. 1986; 4(1):47-55.
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    66. Warhol MJ, Longtine JA. The ultrastructural localization of prostatic specific antigen and prostatic acid phosphatase in hyperplastic and neoplastic human prostates. J Urol. 1985 Sep; 134(3):607-13.
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    67. Longtine JA, Pinkus GS, Fujiwara K, Corson JM. Immunohistochemical localization of smooth muscle myosin in normal human tissues. J Histochem Cytochem. 1985 Mar; 33(3):179-84.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067