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Yiannis Ioannou

TitlePROFESSOR
InstitutionMount Sinai
DepartmentGenetics and Genomic Sciences
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tamari F, Chen FW, Li C, Chaudhari J, Ioannou YA. PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport. PLoS One. 2013; 8(8):e74169.
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    2. Liapis A, Chen FW, Davies JP, Wang R, Ioannou YA. MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site. PLoS One. 2012; 7(4):e34424.
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    3. Pericleous C, Miles J, Esposito D, Garza-Garcia A, Driscoll PC, Lambrianides A, Latchman D, Isenberg D, Rahman A, Ioannou Y, Giles I. Evaluating the conformation of recombinant domain I of ß(2)-glycoprotein I and its interaction with human monoclonal antibodies. Mol Immunol. 2011 Oct; 49(1-2):56-63.
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    4. Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutiérrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL. An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease. J Biol Chem. 2011 Jul 8; 286(27):23842-51.
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    5. Seested T, Appa RS, Christensen EI, Ioannou YA, Krogh TN, Karpf DM, Nielsen HM. In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver. Thromb Res. 2011 Apr; 127(4):356-62.
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    6. Chen FW, Li C, Ioannou YA. Cyclodextrin induces calcium-dependent lysosomal exocytosis. PLoS One. 2010; 5(11):e15054.
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    7. Passam FH, Rahgozar S, Qi M, Raftery MJ, Wong JW, Tanaka K, Ioannou Y, Zhang JY, Gemmell R, Qi JC, Giannakopoulos B, Hughes WE, Hogg PJ, Krilis SA. Redox control of ß2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1. J Thromb Haemost. 2010 Aug; 8(8):1754-62.
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    8. Ioannou Y, Zhang JY, Passam FH, Rahgozar S, Qi JC, Giannakopoulos B, Qi M, Yu P, Yu DM, Hogg PJ, Krilis SA. Naturally occurring free thiols within beta 2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury. Blood. 2010 Sep 16; 116(11):1961-70.
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    9. Ioannou Y, Rahman A. Domain I of beta2-glycoprotein I: its role as an epitope and the potential to be developed as a specific target for the treatment of the antiphospholipid syndrome. Lupus. 2010 Apr; 19(4):400-5.
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    10. Walter M, Chen FW, Tamari F, Wang R, Ioannou YA. Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment. Biol Cell. 2009 Mar; 101(3):141-52.
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    11. Temel RE, Brown JM, Ma Y, Tang W, Rudel LL, Ioannou YA, Davies JP, Yu L. Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent. J Lipid Res. 2009 May; 50(5):915-23.
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    12. Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L. Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8. J Lipid Res. 2009 Feb; 50(2):293-300.
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    13. Labonté ED, Camarota LM, Rojas JC, Jandacek RJ, Gilham DE, Davies JP, Ioannou YA, Tso P, Hui DY, Howles PN. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4):G776-83.
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    14. Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L. Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):448-54.
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    15. Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson LM, Yu L. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007 Jul; 117(7):1968-78.
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    16. Lambrianides A, Giles I, Ioannou Y, Mason L, Latchman DS, Manson JJ, Isenberg DA, Rahman A. Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome. Arthritis Rheum. 2007 Jul; 56(7):2392-401.
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    17. Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H. Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Biochim Biophys Acta. 2007 Sep; 1771(9):1140-7.
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    18. Ioannou YA. Niemann-Pick C proteins in sterol transport and absorption: flies in the ointment. Dev Cell. 2007 Apr; 12(4):481-3.
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    19. Labonté ED, Howles PN, Granholm NA, Rojas JC, Davies JP, Ioannou YA, Hui DY. Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles. Biochim Biophys Acta. 2007 Sep; 1771(9):1132-9.
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    20. Suzuki M, Sugimoto Y, Ohsaki Y, Ueno M, Kato S, Kitamura Y, Hosokawa H, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H. Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain. J Neurosci. 2007 Feb 21; 27(8):1879-91.
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    21. Ioannou Y, Pericleous C, Giles I, Latchman DS, Isenberg DA, Rahman A. Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: mutation studies including residues R39 to R43. Arthritis Rheum. 2007 Jan; 56(1):280-90.
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    22. Ohsaki Y, Sugimoto Y, Suzuki M, Hosokawa H, Yoshimori T, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H. Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. J Cell Sci. 2006 Jul 1; 119(Pt 13):2643-53.
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    23. Davies JP, Ioannou YA. The role of the Niemann-Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis. Curr Opin Lipidol. 2006 Jun; 17(3):221-6.
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    24. Ioannou Y, Giles I, Lambrianides A, Richardson C, Pearl LH, Latchman DS, Isenberg DA, Rahman A. A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli. BMC Biotechnol. 2006; 6:8.
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    25. Ioannou YA. Guilty until proven innocent: the case of NPC1 and cholesterol. Trends Biochem Sci. 2005 Sep; 30(9):498-505.
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    26. Chen FW, Gordon RE, Ioannou YA. NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein. Biochem J. 2005 Sep 1; 390(Pt 2):549-61.
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    27. Davies JP, Scott C, Oishi K, Liapis A, Ioannou YA. Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. J Biol Chem. 2005 Apr 1; 280(13):12710-20.
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    28. Ioannou Y, Bowman SJ, Rahman A, Giles IP. Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. Lupus. 2005; 14(6):467-78.
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    29. Scott C, Ioannou YA. The NPC1 protein: structure implies function. Biochim Biophys Acta. 2004 Oct 11; 1685(1-3):8-13.
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    30. Scott C, Higgins ME, Davies JP, Ioannou YA. Targeting of NPC1 to late endosomes involves multiple signals, including one residing within the putative sterol-sensing domain. J Biol Chem. 2004 Nov 12; 279(46):48214-23.
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    31. Ohsaki Y, Sugimoto Y, Suzuki M, Kaidoh T, Shimada Y, Ohno-Iwashita Y, Davies JP, Ioannou YA, Ohno K, Ninomiya H. Reduced sensitivity of Niemann-Pick C1-deficient cells to theta-toxin (perfringolysin O): sequestration of toxin to raft-enriched membrane vesicles. Histochem Cell Biol. 2004 Apr; 121(4):263-72.
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    32. Ioannou YA, Enriquez A, Benjamin C. Gene therapy for lysosomal storage disorders. Expert Opin Biol Ther. 2003 Aug; 3(5):789-801.
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    33. Choy EH, Isenberg DA, Garrood T, Farrow S, Ioannou Y, Bird H, Cheung N, Williams B, Hazleman B, Price R, Yoshizaki K, Nishimoto N, Kishimoto T, Panayi GS. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum. 2002 Dec; 46(12):3143-50.
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    34. Walter M, Davies JP, Ioannou YA. Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes. J Lipid Res. 2003 Feb; 44(2):243-53.
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    35. Oishi K, Hofmann S, Diaz GA, Brown T, Manwani D, Ng L, Young R, Vlassara H, Ioannou YA, Forrest D, Gelb BD. Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice. Hum Mol Genet. 2002 Nov 1; 11(23):2951-60.
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    36. Ziegler RJ, Li C, Cherry M, Zhu Y, Hempel D, van Rooijen N, Ioannou YA, Desnick RJ, Goldberg MA, Yew NS, Cheng SH. Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease. Hum Gene Ther. 2002 May 20; 13(8):935-45.
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    37. Stern AS, Klotman ME, Ioannou YA, Burrow CR, Wilson PD, Klotman PE, Lipkowitz MS. Polarity of alpha-galactosidase A uptake by renal tubule cells. Kidney Int. 2002 Jan; 61(1 Suppl):S52-5.
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    38. Higgins ME, Ioannou YA. Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes. J Lipid Res. 2001 Dec; 42(12):1939-46.
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    39. Sugimoto Y, Ninomiya H, Ohsaki Y, Higaki K, Davies JP, Ioannou YA, Ohno K. Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12391-6.
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    40. Ioannou YA. Multidrug permeases and subcellular cholesterol transport. Nat Rev Mol Cell Biol. 2001 Sep; 2(9):657-68.
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    41. Davies JP, Chen FW, Ioannou YA. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science. 2000 Dec 22; 290(5500):2295-8.
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    42. Ioannou YA, Zeidner KM, Gordon RE, Desnick RJ. Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice. Am J Hum Genet. 2001 Jan; 68(1):14-25.
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    43. Ioannou YA. The structure and function of the Niemann-Pick C1 protein. Mol Genet Metab. 2000 Sep-Oct; 71(1-2):175-81.
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    44. Davies JP, Ioannou YA. Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating protein. J Biol Chem. 2000 Aug 11; 275(32):24367-74.
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    45. Ioannou YA. Gene therapy for lysosomal storage disorders with neuropathology. J Am Soc Nephrol. 2000 Aug; 11(8):1542-7.
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    46. Davies JP, Levy B, Ioannou YA. Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1. Genomics. 2000 Apr 15; 65(2):137-45.
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    47. Ohta M, Ohnishi T, Ioannou YA, Hodgson ME, Matsuura F, Desnick RJ. Human alpha-N-acetylgalactosaminidase: site occupancy and structure of N-linked oligosaccharides. Glycobiology. 2000 Mar; 10(3):251-61.
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    48. Higgins ME, Davies JP, Chen FW, Ioannou YA. Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network. Mol Genet Metab. 1999 Sep; 68(1):1-13.
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    49. Ziegler RJ, Yew NS, Li C, Cherry M, Berthelette P, Romanczuk H, Ioannou YA, Zeidner KM, Desnick RJ, Cheng SH. Correction of enzymatic and lysosomal storage defects in Fabry mice by adenovirus-mediated gene transfer. Hum Gene Ther. 1999 Jul 1; 10(10):1667-82.
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    50. Zeidner KM, Desnick RJ, Ioannou YA. Quantitative determination of globotriaosylceramide by immunodetection of glycolipid-bound recombinant verotoxin B subunit. Anal Biochem. 1999 Feb 1; 267(1):104-13.
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    51. Chen FW, Ioannou YA. Ribosomal proteins in cell proliferation and apoptosis. Int Rev Immunol. 1999; 18(5-6):429-48.
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    52. Shefer S, Salen G, Honda A, Batta AK, Nguyen LB, Tint GS, Ioannou YA, Desnick R. Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation. J Lipid Res. 1998 Dec; 39(12):2471-6.
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    53. Wang AM, Ioannou YA, Zeidner KM, Desnick RJ. Murine alpha-N-acetylgalactosaminidase: isolation and expression of a full-length cDNA and genomic organization: further evidence of an alpha-galactosidase gene family. Mol Genet Metab. 1998 Oct; 65(2):165-73.
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    54. Chen FW, Davies JP, Ioannou YA. Differential gene expression in apoptosis: identification of ribosomal protein 23K, a cell proliferation inhibitor. Mol Genet Metab. 1998 Aug; 64(4):271-82.
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    55. Ioannou YA, Zeidner KM, Grace ME, Desnick RJ. Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility. Biochem J. 1998 Jun 15; 332 ( Pt 3):789-97.
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    56. Matsuura F, Ohta M, Ioannou YA, Desnick RJ. Human alpha-galactosidase A: characterization of the N-linked oligosaccharides on the intracellular and secreted glycoforms overexpressed by Chinese hamster ovary cells. Glycobiology. 1998 Apr; 8(4):329-39.
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    57. Osman N, McKenzie IF, Ostenried K, Ioannou YA, Desnick RJ, Sandrin MS. Combined transgenic expression of alpha-galactosidase and alpha1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galalpha(1,3)Gal. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14677-82.
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    58. Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, Comly M, Cooney A, Brown A, Kaneski CR, Blanchette-Mackie EJ, Dwyer NK, Neufeld EB, Chang TY, Liscum L, Strauss JF, Ohno K, Zeigler M, Carmi R, Sokol J, Markie D, O'Neill RR, van Diggelen OP, Elleder M, Patterson MC, Brady RO, Vanier MT, Pentchev PG, Tagle DA. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science. 1997 Jul 11; 277(5323):228-31.
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    59. Davies JP, Cotter PD, Ioannou YA. Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. Genomics. 1997 Apr 1; 41(1):131-4.
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    60. Gotlib RW, Bishop DF, Wang AM, Zeidner KM, Ioannou YA, Adler DA, Disteche CM, Desnick RJ. The entire genomic sequence and cDNA expression of mouse alpha-galactosidase A. Biochem Mol Med. 1996 Apr; 57(2):139-48.
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    61. Ioannou YA, Chen FW. Quantitation of DNA fragmentation in apoptosis. Nucleic Acids Res. 1996 Mar 1; 24(5):992-3.
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    62. Murali R, Ioannou YA, Desnick RJ, Burnett RM. Crystallization and preliminary X-ray analysis of human alpha-galactosidase A complex. J Mol Biol. 1994 Jun 17; 239(4):578-80.
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    63. Berg-Fussman A, Grace ME, Ioannou Y, Grabowski GA. Human acid beta-glucosidase. N-glycosylation site occupancy and the effect of glycosylation on enzymatic activity. J Biol Chem. 1993 Jul 15; 268(20):14861-6.
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    64. Ioannou YA, Bishop DF, Desnick RJ. Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion. J Cell Biol. 1992 Dec; 119(5):1137-50.
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    65. Nomeir AA, Ioannou YM, Sanders JM, Matthews HB. Comparative metabolism and disposition of ethyl carbamate (urethane) in male Fischer 344 rats and male B6C3F1 mice. Toxicol Appl Pharmacol. 1989 Feb; 97(2):203-15.
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    66. Ioannou YM, Sanders JM, Matthews HB. Methyl carbamate. Species-dependent variations in metabolism and clearance in rats and mice. Drug Metab Dispos. 1988 May-Jun; 16(3):435-40.
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    67. Ioannou YM, Burka LT, Sanders JM, Moorman MP, Matthews HB. Absorption, distribution, metabolism, and excretion of 1,2-dihydro-2,2,4-trimethylquinoline in the male F344 rat. Drug Metab Dispos. 1987 May-Jun; 15(3):367-73.
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    68. Ioannou YM, Matthews HB. p-Phenylenediamine dihydrochloride: comparative disposition in male and female rats and mice. J Toxicol Environ Health. 1985; 16(2):299-313.
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    69. Ioannou YM, Matthews HB. 2,6-Dichloro-p-phenylenediamine: comparative disposition in male and female rats and mice. J Toxicol Environ Health. 1985; 16(2):285-97.
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    70. Ioannou YM, Burka LT, Matthews HB. Allyl isothiocyanate: comparative disposition in rats and mice. Toxicol Appl Pharmacol. 1984 Sep 15; 75(2):173-81.
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