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James J. Bieker

TitlePROFESSOR
InstitutionMount Sinai
DepartmentDevelopmental and Regenerative Biology
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jaffray JA, Mitchell WB, Gnanapragasam MN, Seshan SV, Guo X, Westhoff CM, Bieker JJ, Manwani D. Erythroid transcription factor EKLF/KLF1 mutation causing congenital dyserythropoietic anemia type IV in a patient of Taiwanese origin: review of all reported cases and development of a clinical diagnostic paradigm. Blood Cells Mol Dis. 2013 Aug; 51(2):71-5.
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    2. Yien YY, Bieker JJ. EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination. Mol Cell Biol. 2013 Jan; 33(1):4-13.
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    3. Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT. T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem. 2012 Oct 26; 287(44):36720-31.
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    4. Yien YY, Bieker JJ. Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cß. J Biol Chem. 2012 May 4; 287(19):15193-204.
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    5. Migliaccio AR, Bieker JJ. GATA2 finds its macrophage niche. Blood. 2011 Sep 8; 118(10):2647-9.
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    6. Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG. Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10484-9.
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    7. Siatecka M, Bieker JJ. The multifunctional role of EKLF/KLF1 during erythropoiesis. Blood. 2011 Aug 25; 118(8):2044-54.
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    8. Chen J, Peterson KR, Iancu-Rubin C, Bieker JJ. Design of embedded chimeric peptide nucleic acids that efficiently enter and accurately reactivate gene expression in vivo. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):16846-51.
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    9. Bieker JJ. Putting a finger on the switch. Nat Genet. 2010 Sep; 42(9):733-4.
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    10. Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL. Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15151-6.
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    11. Siatecka M, Lohmann F, Bao S, Bieker JJ. EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation. Mol Cell Biol. 2010 Jun; 30(11):2811-22.
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    12. Schoenfelder S, Sexton T, Chakalova L, Cope NF, Horton A, Andrews S, Kurukuti S, Mitchell JA, Umlauf D, Dimitrova DS, Eskiw CH, Luo Y, Wei CL, Ruan Y, Bieker JJ, Fraser P. Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nat Genet. 2010 Jan; 42(1):53-61.
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    13. Sengupta T, Cohet N, Morlé F, Bieker JJ. Distinct modes of gene regulation by a cell-specific transcriptional activator. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4213-8.
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    14. Perrine SP, Mankidy R, Boosalis MS, Bieker JJ, Faller DV. Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives. Eur J Haematol. 2009 Jun; 82(6):466-76.
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    15. Bieker JJ. Blood group antigens reveal their maker. Blood. 2008 Sep 1; 112(5):1554-5.
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    16. Sengupta T, Chen K, Milot E, Bieker JJ. Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus. Mol Cell Biol. 2008 Oct; 28(20):6160-70.
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    17. Lohmann F, Bieker JJ. Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment. Development. 2008 Jun; 135(12):2071-82.
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    18. Quadrini KJ, Gruzglin E, Bieker JJ. Non-random subcellular distribution of variant EKLF in erythroid cells. Exp Cell Res. 2008 Apr 15; 314(7):1595-604.
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    19. Bieker JJ. Red cell development. Preface. Curr Top Dev Biol. 2008; 82:XI-XV.
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    20. Manwani D, Bieker JJ. The erythroblastic island. Curr Top Dev Biol. 2008; 82:23-53.
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    21. Siatecka M, Xue L, Bieker JJ. Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Mol Cell Biol. 2007 Dec; 27(24):8547-60.
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    22. Frontelo P, Manwani D, Galdass M, Karsunky H, Lohmann F, Gallagher PG, Bieker JJ. Novel role for EKLF in megakaryocyte lineage commitment. Blood. 2007 Dec 1; 110(12):3871-80.
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    23. Manwani D, Galdass M, Bieker JJ. Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor. Exp Hematol. 2007 Jan; 35(1):39-47.
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    24. Quadrini KJ, Bieker JJ. EKLF/KLF1 is ubiquitinated in vivo and its stability is regulated by activation domain sequences through the 26S proteasome. FEBS Lett. 2006 Apr 17; 580(9):2285-93.
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    25. Im H, Grass JA, Johnson KD, Kim SI, Boyer ME, Imbalzano AN, Bieker JJ, Bresnick EH. Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17065-70.
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    26. Bieker JJ. Probing the onset and regulation of erythroid cell-specific gene expression. Mt Sinai J Med. 2005 Sep; 72(5):333-8.
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    27. Chen X, Bieker JJ. Stage-specific repression by the EKLF transcriptional activator. Mol Cell Biol. 2004 Dec; 24(23):10416-24.
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    28. Luo Q, Ma X, Wahl SM, Bieker JJ, Crossley M, Montaner LJ. Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages. J Biol Chem. 2004 Apr 30; 279(18):18451-6.
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    29. Xue L, Chen X, Chang Y, Bieker JJ. Regulatory elements of the EKLF gene that direct erythroid cell-specific expression during mammalian development. Blood. 2004 Jun 1; 103(11):4078-83.
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    30. Quadrini KJ, Bieker JJ. Krüppel-like zinc fingers bind to nuclear import proteins and are required for efficient nuclear localization of erythroid Krüppel-like factor. J Biol Chem. 2002 Aug 30; 277(35):32243-52.
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    31. Adelman CA, Chattopadhyay S, Bieker JJ. The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media. Development. 2002 Jan; 129(2):539-49.
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    32. Bieker JJ. Krüppel-like factors: three fingers in many pies. J Biol Chem. 2001 Sep 14; 276(37):34355-8.
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    33. Chen X, Bieker JJ. Unanticipated repression function linked to erythroid Krüppel-like factor. Mol Cell Biol. 2001 May; 21(9):3118-25.
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    34. Zhang W, Kadam S, Emerson BM, Bieker JJ. Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol. 2001 Apr; 21(7):2413-22.
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    35. Armstrong JA, Bieker JJ, Emerson BM. A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell. 1998 Oct 2; 95(1):93-104.
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    36. Chen X, Reitman M, Bieker JJ. Chromatin structure and transcriptional control elements of the erythroid Krüppel-like factor (EKLF) gene. J Biol Chem. 1998 Sep 25; 273(39):25031-40.
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    37. Spadaccini A, Tilbrook PA, Sarna MK, Crossley M, Bieker JJ, Klinken SP. Transcription factor erythroid Krüppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation. J Biol Chem. 1998 Sep 11; 273(37):23793-8.
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    38. Ouyang L, Chen X, Bieker JJ. Regulation of erythroid Krüppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain. J Biol Chem. 1998 Sep 4; 273(36):23019-25.
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    39. Zhang W, Bieker JJ. Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9855-60.
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    40. Bieker JJ, Ouyang L, Chen X. Transcriptional factors for specific globin genes. Ann N Y Acad Sci. 1998 Jun 30; 850:64-9.
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    41. Bieker JJ. Erythroid-specific transcription. Curr Opin Hematol. 1998 Mar; 5(2):145-50.
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    42. Jenkins NA, Gilbert DJ, Copeland NG, Gruzglin E, Bieker JJ. Erythroid Krüppel-like transcription factor (Eklf) maps to a region of mouse chromosome 8 syntenic with human chromosome 19. Mamm Genome. 1998 Feb; 9(2):174-6.
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    43. Lim SK, Bieker JJ, Lin CS, Costantini F. A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains. Blood. 1997 Aug 1; 90(3):1291-9.
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    44. Chen X, Bieker JJ. Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions. EMBO J. 1996 Nov 1; 15(21):5888-96.
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    45. Southwood CM, Downs KM, Bieker JJ. Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev Dyn. 1996 Jul; 206(3):248-59.
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    46. Bieker JJ. Isolation, genomic structure, and expression of human erythroid Krüppel-like factor (EKLF). DNA Cell Biol. 1996 May; 15(5):347-52.
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    47. Gregory RC, Taxman DJ, Seshasayee D, Kensinger MH, Bieker JJ, Wojchowski DM. Functional interaction of GATA1 with erythroid Krüppel-like factor and Sp1 at defined erythroid promoters. Blood. 1996 Mar 1; 87(5):1793-801.
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    48. Bieker JJ, Southwood CM. The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter. Mol Cell Biol. 1995 Feb; 15(2):852-60.
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    49. Donze D, Townes TM, Bieker JJ. Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching. J Biol Chem. 1995 Jan 27; 270(4):1955-9.
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    50. Crossley M, Tsang AP, Bieker JJ, Orkin SH. Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. J Biol Chem. 1994 Jun 3; 269(22):15440-4.
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    51. Feng WC, Southwood CM, Bieker JJ. Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor. J Biol Chem. 1994 Jan 14; 269(2):1493-500.
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    52. Miller IJ, Bieker JJ. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol Cell Biol. 1993 May; 13(5):2776-86.
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    53. Bieker JJ, Yazdani-Buicky M. Distribution of type II collagen mRNA in Xenopus embryos visualized by whole-mount in situ hybridization. J Histochem Cytochem. 1992 Aug; 40(8):1117-20.
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    54. Bieker JJ, Yazdani-Buicky M. The multiple beta-tubulin genes of Xenopus: isolation and developmental expression of a germ-cell isotype beta-tubulin gene. Differentiation. 1992 May; 50(1):15-23.
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    55. Su MW, Suzuki HR, Bieker JJ, Solursh M, Ramirez F. Expression of two nonallelic type II procollagen genes during Xenopus laevis embryogenesis is characterized by stage-specific production of alternatively spliced transcripts. J Cell Biol. 1991 Oct; 115(2):565-75.
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    56. Bieker JJ, Roeder RG. Characterization of the nucleotide requirement for elimination of the rate-limiting step in 5 S RNA gene transcription. J Biol Chem. 1986 Jul 25; 261(21):9732-8.
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    57. Bieker JJ, Martin PL, Roeder RG. Formation of a rate-limiting intermediate in 5S RNA gene transcription. Cell. 1985 Jan; 40(1):119-27.
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    58. Bieker JJ, Roeder RG. Physical properties and DNA-binding stoichiometry of a 5 S gene-specific transcription factor. J Biol Chem. 1984 May 25; 259(10):6158-64.
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    59. Singh H, Bieker JJ, Dumas LB. Genetic transformation of Saccharomyces cerevisiae with single-stranded circular DNA vectors. Gene. 1982 Dec; 20(3):441-9.
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    60. Bieker JJ, Dumas LB. The single-strands of yeast autonomously replicating DNA segments are not recognized as origins of replication by Escherichia coli DNA replication proteins. Biochem Biophys Res Commun. 1981 Jul 16; 101(1):194-200.
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    61. Bieker JJ, Dumas LB. An easy, quantitative method for detection of endonuclease activity. Anal Biochem. 1980 Nov 1; 108(2):285-9.
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