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James C. Iatridis

TitlePROFESSOR
InstitutionMount Sinai
DepartmentOrthopaedics
Address
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentNeurosurgery


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Illien-Junger S, Grosjean F, Laudier DM, Vlassara H, Striker GE, Iatridis JC. Combined anti-inflammatory and anti-age drug treatments have a protective effect on intervertebral discs in mice with diabetes. PLoS One. 2013; 8(5):e64302.
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    2. Abbott RD, Purmessur D, Monsey RD, Brigstock DR, Laudier DM, Iatridis JC. Degenerative grade affects the responses of human nucleus pulposus cells to link-N, CTGF, and TGFß3. J Spinal Disord Tech. 2013 May; 26(3):E86-94.
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    3. Antoniou J, Epure LM, Michalek AJ, Grant MP, Iatridis JC, Mwale F. Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration. J Magn Reson Imaging. 2013 Dec; 38(6):1402-14.
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    4. Mayer JE, Iatridis JC, Chan D, Qureshi SA, Gottesman O, Hecht AC. Genetic polymorphisms associated with intervertebral disc degeneration. Spine J. 2013 Mar; 13(3):299-317.
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    5. Purmessur D, Walter BA, Roughley PJ, Laudier DM, Hecht AC, Iatridis J. A role for TNFa in intervertebral disc degeneration: a non-recoverable catabolic shift. Biochem Biophys Res Commun. 2013 Mar 29; 433(1):151-6.
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    6. Iatridis JC, Nicoll SB, Michalek AJ, Walter BA, Gupta MS. Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair? Spine J. 2013 Mar; 13(3):243-62.
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    7. Schuchman EH, Ge Y, Lai A, Borisov Y, Faillace M, Eliyahu E, He X, Iatridis J, Vlassara H, Striker G, Simonaro CM. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses. PLoS One. 2013; 8(1):e54459.
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    8. Guterl CC, See EY, Blanquer SB, Pandit A, Ferguson SJ, Benneker LM, Grijpma DW, Sakai D, Eglin D, Alini M, Iatridis JC, Grad S. Challenges and strategies in the repair of ruptured annulus fibrosus. Eur Cell Mater. 2013; 25:1-21.
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    9. Abbott RD, Koptiuch C, Iatridis JC, Howe AK, Badger GJ, Langevin HM. Stress and matrix-responsive cytoskeletal remodeling in fibroblasts. J Cell Physiol. 2013 Jan; 228(1):50-7.
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    10. Lai A, Simonaro CM, Schuchman EH, Ge Y, Laudier DM, Iatridis JC. Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome). J Orthop Res. 2013 Apr; 31(4):621-31.
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    11. Michalek AJ, Iatridis JC. Height and torsional stiffness are most sensitive to annular injury in large animal intervertebral discs. Spine J. 2012 May; 12(5):425-32.
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    12. Abbott RD, Howe AK, Langevin HM, Iatridis JC. Live free or die: stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted. Biochem Biophys Res Commun. 2012 May 4; 421(2):361-6.
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    13. Iatridis JC, Hecht AC. Commentary: Does needle injection cause disc degeneration? News in the continuing debate regarding pathophysiology associated with intradiscal injections. Spine J. 2012 Apr; 12(4):336-8.
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    14. Michalek AJ, Gardner-Morse MG, Iatridis JC. Large residual strains are present in the intervertebral disc annulus fibrosus in the unloaded state. J Biomech. 2012 Apr 30; 45(7):1227-31.
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    15. Abbott RD, Purmessur D, Monsey RD, Iatridis JC. Regenerative potential of TGFß3?+?Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells. J Orthop Res. 2012 Mar; 30(3):482-8.
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    16. Michalek AJ, Iatridis JC. Penetrating annulus fibrosus injuries affect dynamic compressive behaviors of the intervertebral disc via altered fluid flow: an analytical interpretation. J Biomech Eng. 2011 Aug; 133(8):084502.
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    17. Purmessur D, Schek RM, Abbott RD, Ballif BA, Godburn KE, Iatridis JC. Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells. Arthritis Res Ther. 2011; 13(3):R81.
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    18. Langevin HM, Bouffard NA, Fox JR, Palmer BM, Wu J, Iatridis JC, Barnes WD, Badger GJ, Howe AK. Fibroblast cytoskeletal remodeling contributes to connective tissue tension. J Cell Physiol. 2011 May; 226(5):1166-75.
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    19. Walter BA, Korecki CL, Purmessur D, Roughley PJ, Michalek AJ, Iatridis JC. Complex loading affects intervertebral disc mechanics and biology. Osteoarthritis Cartilage. 2011 Aug; 19(8):1011-8.
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    20. Schek RM, Michalek AJ, Iatridis JC. Genipin-crosslinked fibrin hydrogels as a potential adhesive to augment intervertebral disc annulus repair. Eur Cell Mater. 2011; 21:373-83.
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    21. Barbir A, Godburn KE, Michalek AJ, Lai A, Monsey RD, Iatridis JC. Effects of torsion on intervertebral disc gene expression and biomechanics, using a rat tail model. Spine (Phila Pa 1976). 2011 Apr 15; 36(8):607-14.
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    22. Michalek AJ, Buckley MR, Bonassar LJ, Cohen I, Iatridis JC. The effects of needle puncture injury on microscale shear strain in the intervertebral disc annulus fibrosus. Spine J. 2010 Dec; 10(12):1098-105.
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    23. Stokes IA, Laible JP, Gardner-Morse MG, Costi JJ, Iatridis JC. Refinement of elastic, poroelastic, and osmotic tissue properties of intervertebral disks to analyze behavior in compression. Ann Biomed Eng. 2011 Jan; 39(1):122-31.
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    24. Korecki CL, Taboas JM, Tuan RS, Iatridis JC. Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem Cell Res Ther. 2010; 1(2):18.
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    25. Michalek AJ, Funabashi KL, Iatridis JC. Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently. Eur Spine J. 2010 Dec; 19(12):2110-6.
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    26. Stokes IA, Chegini S, Ferguson SJ, Gardner-Morse MG, Iatridis JC, Laible JP. Limitation of finite element analysis of poroelastic behavior of biological tissues undergoing rapid loading. Ann Biomed Eng. 2010 May; 38(5):1780-8.
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    27. Barbir A, Michalek AJ, Abbott RD, Iatridis JC. Effects of enzymatic digestion on compressive properties of rat intervertebral discs. J Biomech. 2010 Apr 19; 43(6):1067-73.
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    28. Iatridis JC. Tissue engineering: Function follows form. Nat Mater. 2009 Dec; 8(12):923-4.
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    29. Wuertz K, Godburn K, MacLean JJ, Barbir A, Donnelly JS, Roughley PJ, Alini M, Iatridis JC. In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression. J Orthop Res. 2009 Sep; 27(9):1235-42.
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    30. Michalek AJ, Buckley MR, Bonassar LJ, Cohen I, Iatridis JC. Measurement of local strains in intervertebral disc anulus fibrosus tissue under dynamic shear: contributions of matrix fiber orientation and elastin content. J Biomech. 2009 Oct 16; 42(14):2279-85.
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    31. Korecki CL, Kuo CK, Tuan RS, Iatridis JC. Intervertebral disc cell response to dynamic compression is age and frequency dependent. J Orthop Res. 2009 Jun; 27(6):800-6.
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    32. Iatridis JC, Furukawa M, Stokes IA, Gardner-Morse MG, Laible JP. Spatially resolved streaming potentials of human intervertebral disk motion segments under dynamic axial compression. J Biomech Eng. 2009 Mar; 131(3):031006.
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    33. Wuertz K, Godburn K, Iatridis JC. MSC response to pH levels found in degenerating intervertebral discs. Biochem Biophys Res Commun. 2009 Feb 20; 379(4):824-9.
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    34. Mwale F, Iatridis JC, Antoniou J. Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity. Eur Spine J. 2008 Dec; 17 Suppl 4:432-40.
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    35. Wuertz K, Godburn K, Neidlinger-Wilke C, Urban J, Iatridis JC. Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc. Spine (Phila Pa 1976). 2008 Aug 1; 33(17):1843-9.
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    36. Costi JJ, Stokes IA, Gardner-Morse MG, Iatridis JC. Frequency-dependent behavior of the intervertebral disc in response to each of six degree of freedom dynamic loading: solid phase and fluid phase contributions. Spine (Phila Pa 1976). 2008 Jul 15; 33(16):1731-8.
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    37. Korecki CL, MacLean JJ, Iatridis JC. Dynamic compression effects on intervertebral disc mechanics and biology. Spine (Phila Pa 1976). 2008 Jun 1; 33(13):1403-9.
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    38. MacLean JJ, Roughley PJ, Monsey RD, Alini M, Iatridis JC. In vivo intervertebral disc remodeling: kinetics of mRNA expression in response to a single loading event. J Orthop Res. 2008 May; 26(5):579-88.
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    39. Rogers R, Norian J, Malik M, Christman G, Abu-Asab M, Chen F, Korecki C, Iatridis J, Catherino WH, Tuan RS, Dhillon N, Leppert P, Segars JH. Mechanical homeostasis is altered in uterine leiomyoma. Am J Obstet Gynecol. 2008 Apr; 198(4):474.e1-11.
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    40. Mwale F, Demers CN, Michalek AJ, Beaudoin G, Goswami T, Beckman L, Iatridis JC, Antoniou J. Evaluation of quantitative magnetic resonance imaging, biochemical and mechanical properties of trypsin-treated intervertebral discs under physiological compression loading. J Magn Reson Imaging. 2008 Mar; 27(3):563-73.
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    41. Korecki CL, Costi JJ, Iatridis JC. Needle puncture injury affects intervertebral disc mechanics and biology in an organ culture model. Spine (Phila Pa 1976). 2008 Feb 1; 33(3):235-41.
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    42. Masuoka K, Michalek AJ, MacLean JJ, Stokes IA, Iatridis JC. Different effects of static versus cyclic compressive loading on rat intervertebral disc height and water loss in vitro. Spine (Phila Pa 1976). 2007 Aug 15; 32(18):1974-9.
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    43. Iatridis JC, MacLean JJ, O'Brien M, Stokes IA. Measurements of proteoglycan and water content distribution in human lumbar intervertebral discs. Spine (Phila Pa 1976). 2007 Jun 15; 32(14):1493-7.
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    44. Korecki CL, MacLean JJ, Iatridis JC. Characterization of an in vitro intervertebral disc organ culture system. Eur Spine J. 2007 Jul; 16(7):1029-37.
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    45. Costi JJ, Stokes IA, Gardner-Morse M, Laible JP, Scoffone HM, Iatridis JC. Direct measurement of intervertebral disc maximum shear strain in six degrees of freedom: motions that place disc tissue at risk of injury. J Biomech. 2007; 40(11):2457-66.
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    46. Michalek AJ, Iatridis JC. A numerical study to determine pericellular matrix modulus and evaluate its effects on the micromechanical environment of chondrocytes. J Biomech. 2007; 40(6):1405-9.
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    47. Perie DS, Maclean JJ, Owen JP, Iatridis JC. Correlating material properties with tissue composition in enzymatically digested bovine annulus fibrosus and nucleus pulposus tissue. Ann Biomed Eng. 2006 May; 34(5):769-77.
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    48. Iatridis JC, MacLean JJ, Roughley PJ, Alini M. Effects of mechanical loading on intervertebral disc metabolism in vivo. J Bone Joint Surg Am. 2006 Apr; 88 Suppl 2:41-6.
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    49. Lee CR, Iatridis JC, Poveda L, Alini M. In vitro organ culture of the bovine intervertebral disc: effects of vertebral endplate and potential for mechanobiology studies. Spine (Phila Pa 1976). 2006 Mar 1; 31(5):515-22.
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    50. MacLean JJ, Owen JP, Iatridis JC. Role of endplates in contributing to compression behaviors of motion segments and intervertebral discs. J Biomech. 2007; 40(1):55-63.
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    51. Périé D, Iatridis JC, Demers CN, Goswami T, Beaudoin G, Mwale F, Antoniou J. Assessment of compressive modulus, hydraulic permeability and matrix content of trypsin-treated nucleus pulposus using quantitative MRI. J Biomech. 2006; 39(8):1392-400.
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    52. Lee CR, Grad S, Maclean JJ, Iatridis JC, Alini M. Effect of mechanical loading on mRNA levels of common endogenous controls in articular chondrocytes and intervertebral disk. Anal Biochem. 2005 Jun 15; 341(2):372-5.
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    53. MacLean JJ, Lee CR, Alini M, Iatridis JC. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc. J Orthop Res. 2005 Sep; 23(5):1120-7.
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    54. Iatridis JC, MaClean JJ, Ryan DA. Mechanical damage to the intervertebral disc annulus fibrosus subjected to tensile loading. J Biomech. 2005 Mar; 38(3):557-65.
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    55. Périé D, Korda D, Iatridis JC. Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability. J Biomech. 2005 Nov; 38(11):2164-71.
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    56. An HS, Anderson PA, Haughton VM, Iatridis JC, Kang JD, Lotz JC, Natarajan RN, Oegema TR, Roughley P, Setton LA, Urban JP, Videman T, Andersson GB, Weinstein JN. Introduction: disc degeneration: summary. Spine (Phila Pa 1976). 2004 Dec 1; 29(23):2677-8.
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    57. Stokes IA, Iatridis JC. Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization. Spine (Phila Pa 1976). 2004 Dec 1; 29(23):2724-32.
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    58. Maclean JJ, Lee CR, Alini M, Iatridis JC. Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression. J Orthop Res. 2004 Nov; 22(6):1193-200.
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    59. Langevin HM, Bouffard NA, Badger GJ, Iatridis JC, Howe AK. Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo. Am J Physiol Cell Physiol. 2005 Mar; 288(3):C747-56.
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    60. Iatridis JC, ap Gwynn I. Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus. J Biomech. 2004 Aug; 37(8):1165-75.
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    61. MacLean JJ, Lee CR, Grad S, Ito K, Alini M, Iatridis JC. Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo. Spine (Phila Pa 1976). 2003 May 15; 28(10):973-81.
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    62. Iatridis JC, Laible JP, Krag MH. Influence of fixed charge density magnitude and distribution on the intervertebral disc: applications of a poroelastic and chemical electric (PEACE) model. J Biomech Eng. 2003 Feb; 125(1):12-24.
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    63. Iatridis JC, Wu J, Yandow JA, Langevin HM. Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tension. Connect Tissue Res. 2003; 44(5):208-17.
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    64. Stokes IA, Mente PL, Iatridis JC, Farnum CE, Aronsson DD. Enlargement of growth plate chondrocytes modulated by sustained mechanical loading. J Bone Joint Surg Am. 2002 Oct; 84-A(10):1842-8.
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    65. Stokes IA, Mente PL, Iatridis JC, Farnum CE, Aronsson DD. Growth plate chondrocyte enlargement modulated by mechanical loading. Stud Health Technol Inform. 2002; 88:378-81.
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    66. Gu WY, Mao XG, Rawlins BA, Iatridis JC, Foster RJ, Sun DN, Weidenbaum M, Mow VC. Streaming potential of human lumbar anulus fibrosus is anisotropic and affected by disc degeneration. J Biomech. 1999 Nov; 32(11):1177-82.
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    67. Iatridis JC, Kumar S, Foster RJ, Weidenbaum M, Mow VC. Shear mechanical properties of human lumbar annulus fibrosus. J Orthop Res. 1999 Sep; 17(5):732-7.
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    68. Mente PL, Aronsson DD, Stokes IA, Iatridis JC. Mechanical modulation of growth for the correction of vertebral wedge deformities. J Orthop Res. 1999 Jul; 17(4):518-24.
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    69. Iatridis JC, Mente PL, Stokes IA, Aronsson DD, Alini M. Compression-induced changes in intervertebral disc properties in a rat tail model. Spine (Phila Pa 1976). 1999 May 15; 24(10):996-1002.
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    70. Stokes IA, Aronsson DD, Spence H, Iatridis JC. Mechanical modulation of intervertebral disc thickness in growing rat tails. J Spinal Disord. 1998 Jun; 11(3):261-5.
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    71. Iatridis JC, Setton LA, Foster RJ, Rawlins BA, Weidenbaum M, Mow VC. Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression. J Biomech. 1998 Jun; 31(6):535-44.
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    72. Iatridis JC, Setton LA, Weidenbaum M, Mow VC. The viscoelastic behavior of the non-degenerate human lumbar nucleus pulposus in shear. J Biomech. 1997 Oct; 30(10):1005-13.
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    73. Iatridis JC, Setton LA, Weidenbaum M, Mow VC. Alterations in the mechanical behavior of the human lumbar nucleus pulposus with degeneration and aging. J Orthop Res. 1997 Mar; 15(2):318-22.
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    74. Zhu W, Iatridis JC, Hlibczuk V, Ratcliffe A, Mow VC. Determination of collagen-proteoglycan interactions in vitro. J Biomech. 1996 Jun; 29(6):773-83.
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    75. Iatridis JC, Weidenbaum M, Setton LA, Mow VC. Is the nucleus pulposus a solid or a fluid? Mechanical behaviors of the nucleus pulposus of the human intervertebral disc. Spine (Phila Pa 1976). 1996 May 15; 21(10):1174-84.
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    76. Ebara S, Iatridis JC, Setton LA, Foster RJ, Mow VC, Weidenbaum M. Tensile properties of nondegenerate human lumbar anulus fibrosus. Spine (Phila Pa 1976). 1996 Feb 15; 21(4):452-61.
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    77. Acaroglu ER, Iatridis JC, Setton LA, Foster RJ, Mow VC, Weidenbaum M. Degeneration and aging affect the tensile behavior of human lumbar anulus fibrosus. Spine (Phila Pa 1976). 1995 Dec 15; 20(24):2690-701.
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    78. Skaggs DL, Weidenbaum M, Iatridis JC, Ratcliffe A, Mow VC. Regional variation in tensile properties and biochemical composition of the human lumbar anulus fibrosus. Spine (Phila Pa 1976). 1994 Jun 15; 19(12):1310-9.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067