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Last Name
Institution

Jerry Chipuk

TitleASSISTANT PROFESSOR
InstitutionMount Sinai
DepartmentOncological Sciences
Address
    Other Positions
    TitleASSISTANT PROFESSOR
    InstitutionMount Sinai
    DepartmentDermatology


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Elkholi R, Chipuk JE. How do I kill thee? Let me count the ways: p53 regulates PARP-1 dependent necrosis. Bioessays. 2014 Jan; 36(1):46-51.
      View in: PubMed
    2. Beverly LJ, Howell LA, Hernandez-Corbacho M, Casson L, Chipuk JE, Siskind LJ. BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. Biochem J. 2013 May 15; 452(1):111-9.
      View in: PubMed
    3. Fink MY, Chipuk JE. Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers. Genes Cancer. 2013 May; 4(5-6):187-95.
      View in: PubMed
    4. Renault TT, Floros KV, Chipuk JE. BAK/BAX activation and cytochrome c release assays using isolated mitochondria. Methods. 2013 Jun 1; 61(2):146-55.
      View in: PubMed
    5. Renault TT, Chipuk JE. Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann N Y Acad Sci. 2013 May; 1285:59-79.
      View in: PubMed
    6. Renault TT, Chipuk JE. Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis. Commun Integr Biol. 2013 Mar 1; 6(2):e22872.
      View in: PubMed
    7. Follis AV, Chipuk JE, Fisher JC, Yun MK, Grace CR, Nourse A, Baran K, Ou L, Min L, White SW, Green DR, Kriwacki RW. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat Chem Biol. 2013 Mar; 9(3):163-8.
      View in: PubMed
    8. Anvekar RA, Asciolla JJ, Lopez-Rivera E, Floros KV, Izadmehr S, Elkholi R, Belbin G, Sikora AG, Chipuk JE. Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens. Cell Death Dis. 2012; 3:e420.
      View in: PubMed
    9. Asciolla JJ, Renault TT, Chipuk JE. Examining BCL-2 family function with large unilamellar vesicles. J Vis Exp. 2012; (68).
      View in: PubMed
    10. Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity. 2012 Jun 29; 36(6):1031-46.
      View in: PubMed
    11. Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, Obeid LM, Green DR. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell. 2012 Mar 2; 148(5):988-1000.
      View in: PubMed
    12. Garrison SP, Phillips DC, Jeffers JR, Chipuk JE, Parsons MJ, Rehg JE, Opferman JT, Green DR, Zambetti GP. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell Death Differ. 2012 Apr; 19(4):642-9.
      View in: PubMed
    13. Elkholi R, Floros KV, Chipuk JE. The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment. Genes Cancer. 2011 May; 2(5):523-37.
      View in: PubMed
    14. Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T. BH3 domains other than Bim and Bid can directly activate Bax/Bak. J Biol Chem. 2011 Jan 7; 286(1):491-501.
      View in: PubMed
    15. McAuley JL, Chipuk JE, Boyd KL, Van De Velde N, Green DR, McCullers JA. PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology. PLoS Pathog. 2010; 6(7):e1001014.
      View in: PubMed
    16. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. The BCL-2 family reunion. Mol Cell. 2010 Feb 12; 37(3):299-310.
      View in: PubMed
    17. Chipuk JE, Green DR. PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis. Cell Cycle. 2009 Sep 1; 8(17):2692-6.
      View in: PubMed
    18. Schafer B, Quispe J, Choudhary V, Chipuk JE, Ajero TG, Du H, Schneiter R, Kuwana T. Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation. Mol Biol Cell. 2009 Apr; 20(8):2276-85.
      View in: PubMed
    19. Chipuk JE, Fisher JC, Dillon CP, Kriwacki RW, Kuwana T, Green DR. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20327-32.
      View in: PubMed
    20. Green DR, Chipuk JE. Apoptosis: Stabbed in the BAX. Nature. 2008 Oct 23; 455(7216):1047-9.
      View in: PubMed
    21. Chipuk JE, Green DR. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 2008 Apr; 18(4):157-64.
      View in: PubMed
    22. Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR, Nunnari J. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb; 14(2):193-204.
      View in: PubMed
    23. Green DR, Chipuk JE. p53 and metabolism: Inside the TIGAR. Cell. 2006 Jul 14; 126(1):30-2.
      View in: PubMed
    24. Chipuk JE, Green DR. Dissecting p53-dependent apoptosis. Cell Death Differ. 2006 Jun; 13(6):994-1002.
      View in: PubMed
    25. Chipuk JE, Bouchier-Hayes L, Green DR. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 2006 Aug; 13(8):1396-402.
      View in: PubMed
    26. Spierings D, McStay G, Saleh M, Bender C, Chipuk J, Maurer U, Green DR. Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science. 2005 Oct 7; 310(5745):66-7.
      View in: PubMed
    27. Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science. 2005 Sep 9; 309(5741):1732-5.
      View in: PubMed
    28. Chipuk JE, Green DR. Do inducers of apoptosis trigger caspase-independent cell death? Nat Rev Mol Cell Biol. 2005 Mar; 6(3):268-75.
      View in: PubMed
    29. Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005 Feb 18; 17(4):525-35.
      View in: PubMed
    30. Chipuk JE, Green DR. Cytoplasmic p53: bax and forward. Cell Cycle. 2004 Apr; 3(4):429-31.
      View in: PubMed
    31. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004 Feb 13; 303(5660):1010-4.
      View in: PubMed
    32. Chipuk JE, Maurer U, Green DR, Schuler M. Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell. 2003 Nov; 4(5):371-81.
      View in: PubMed
    33. Chipuk JE, Green DR. p53's believe it or not: lessons on transcription-independent death. J Clin Immunol. 2003 Sep; 23(5):355-61.
      View in: PubMed
    34. Chipuk JE, Stewart LV, Ranieri A, Song K, Danielpour D. Identification and characterization of a novel rat ov-serpin family member, trespin. J Biol Chem. 2002 Jul 19; 277(29):26412-21.
      View in: PubMed
    35. Chipuk JE, Cornelius SC, Pultz NJ, Jorgensen JS, Bonham MJ, Kim SJ, Danielpour D. The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3. J Biol Chem. 2002 Jan 11; 277(2):1240-8.
      View in: PubMed
    36. Chipuk JE, Bhat M, Hsing AY, Ma J, Danielpour D. Bcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells. J Biol Chem. 2001 Jul 13; 276(28):26614-21.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067