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Last Name
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E. Premkumar Reddy

TitlePROFESSOR
InstitutionMount Sinai
DepartmentOncological Sciences
Address
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentStructural and Chemical Biology


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Baker SJ, Reddy EP. Understanding the temporal sequence of genetic events that lead to prostate cancer progression and metastasis. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):14819-20.
      View in: PubMed
    2. Reddy MV, Mallireddigari MR, Pallela VR, Cosenza SC, Billa VK, Akula B, Subbaiah DR, Bharathi EV, Padgaonkar A, Lv H, Gallo JM, Reddy EP. Design, Synthesis, and Biological Evaluation of (E)-N-Aryl-2-arylethenesulfonamide Analogues as Potent and Orally Bioavailable Microtubule-Targeted Anticancer Agents. J Med Chem. 2013 Jul 11; 56(13):5562-86.
      View in: PubMed
    3. Kang AD, Cosenza SC, Bonagura M, Manair M, Reddy MV, Reddy EP. ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013; 8(3):e58355.
      View in: PubMed
    4. Pallela VR, Mallireddigari MR, Cosenza SC, Akula B, Subbaiah DR, Reddy EP, Reddy MV. Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent. Org Biomol Chem. 2013 Mar 28; 11(12):1964-77.
      View in: PubMed
    5. Cho SY, Cosenza SC, Pallela V, Panda G, Reddy MV, Reddy EP, Roboz J. Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal. 2013 Mar 5; 75:138-44.
      View in: PubMed
    6. Lv H, Zhang X, Sharma J, Reddy MV, Reddy EP, Gallo JM. Integrated pharmacokinetic-driven approach to screen candidate anticancer drugs for brain tumor chemotherapy. AAPS J. 2013 Jan; 15(1):250-7.
      View in: PubMed
    7. Prasad A, Shrivastava A, Papadopoulos E, Kuzontkoski PM, Reddy MV, Gillum AM, Kumar R, Reddy EP, Groopman JE. Combined administration of rituximab and on 013105 induces apoptosis in mantle cell lymphoma cells and reduces tumor burden in a mouse model of mantle cell lymphoma. Clin Cancer Res. 2013 Jan 1; 19(1):85-95.
      View in: PubMed
    8. Baker SJ, Reddy EP. CDK4: A Key Player in the Cell Cycle, Development, and Cancer. Genes Cancer. 2012 Nov; 3(11-12):658-69.
      View in: PubMed
    9. Adams BD, Guo S, Bai H, Guo Y, Megyola CM, Cheng J, Heydari K, Xiao C, Reddy EP, Lu J. An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response. Cell Rep. 2012 Oct 25; 2(4):1048-60.
      View in: PubMed
    10. Wang H, Zhao C, Zhang M, Lee CM, Reddy EP, Kung SK. A novel role of the scaffolding protein JLP in tuning CD40-induced activation of dendritic cells. Immunobiology. 2013 Jun; 218(6):835-43.
      View in: PubMed
    11. Lieu YK, Reddy EP. Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout mice. Cell Cycle. 2012 Sep 15; 11(18):3504-12.
      View in: PubMed
    12. Nuthalapati S, Zhou Q, Guo P, Lv H, Cosenza S, Reddy MV, Reddy EP, Gallo JM. Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapy. Pharm Res. 2012 Sep; 29(9):2499-511.
      View in: PubMed
    13. Bongers G, Muniz LR, Pacer ME, Iuga AC, Thirunarayanan N, Slinger E, Smit MJ, Reddy EP, Mayer L, Furtado GC, Harpaz N, Lira SA. A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. Gastroenterology. 2012 Sep; 143(3):730-40.
      View in: PubMed
    14. Reddy MV, Akula B, Cosenza SC, Lee CM, Mallireddigari MR, Pallela VR, Subbaiah DR, Udofa A, Reddy EP. (Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies. J Med Chem. 2012 Jun 14; 55(11):5174-87.
      View in: PubMed
    15. Reddy EP, Aggarwal AK. The ins and outs of bcr-abl inhibition. Genes Cancer. 2012 May; 3(5-6):447-54.
      View in: PubMed
    16. Lv H, Wang F, Reddy MV, Zhou Q, Zhang X, Reddy EP, Gallo JM. Screening candidate anticancer drugs for brain tumor chemotherapy: pharmacokinetic-driven approach for a series of (E)-N-(substituted aryl)-3-(substituted phenyl)propenamide analogues. Invest New Drugs. 2012 Dec; 30(6):2263-73.
      View in: PubMed
    17. Reddy MV, Venkatapuram P, Mallireddigari MR, Pallela VR, Cosenza SC, Robell KA, Akula B, Hoffman BS, Reddy EP. Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. J Med Chem. 2011 Sep 22; 54(18):6254-76.
      View in: PubMed
    18. Nuthalapati S, Guo P, Zhou Q, Reddy MV, Reddy EP, Gallo JM. Application of a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to the pharmacokinetics of ON01910 in brain tumor-bearing mice. J Pharm Biomed Anal. 2011 Dec 15; 56(5):1117-20.
      View in: PubMed
    19. Oussenko IA, Holland JF, Reddy EP, Ohnuma T. Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation. Cancer Res. 2011 Jul 15; 71(14):4968-76.
      View in: PubMed
    20. Kashef K, Radhakrishnan R, Lee CM, Reddy EP, Dhanasekaran DN. Neoplastic transformation induced by the gep oncogenes involves the scaffold protein JNK-interacting leucine zipper protein. Neoplasia. 2011 Apr; 13(4):358-64.
      View in: PubMed
    21. Baker SJ, Reddy EP. Targeted inhibition of kinases in cancer therapy. Mt Sinai J Med. 2010 Nov-Dec; 77(6):573-86.
      View in: PubMed
    22. Jatiani SS, Baker SJ, Silverman LR, Reddy EP. Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies. Genes Cancer. 2010 Oct; 1(10):979-93.
      View in: PubMed
    23. Chawla R, Procknow JA, Tantravahi RV, Khurana JS, Litvin J, Reddy EP. Cooperativity of Cdk4R24C and Ras in melanoma development. Cell Cycle. 2010 Aug 15; 9(16):3305-14.
      View in: PubMed
    24. Abedin ZR, Ma Z, Reddy EP. Increased angiogenesis in Cdk4(R24C/R24C):Apc(+/Min) intestinal tumors. Cell Cycle. 2010 Jun 15; 9(12):2456-63.
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    25. Baker SJ, Kumar A, Reddy EP. p89c-Myb is not required for fetal or adult hematopoiesis. Genesis. 2010 May; 48(5):309-16.
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    26. Jatiani SS, Cosenza SC, Reddy MV, Ha JH, Baker SJ, Samanta AK, Olnes MJ, Pfannes L, Sloand EM, Arlinghaus RB, Reddy EP. A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition. Genes Cancer. 2010 Apr; 1(4):331-45.
      View in: PubMed
    27. Samanta AK, Chakraborty SN, Wang Y, Schlette E, Reddy EP, Arlinghaus RB. Destabilization of Bcr-Abl/Jak2 Network by a Jak2/Abl Kinase Inhibitor ON044580 Overcomes Drug Resistance in Blast Crisis Chronic Myelogenous Leukemia (CML). Genes Cancer. 2010 Apr; 1(4):346-59.
      View in: PubMed
    28. Reddy MV, Pallela VR, Cosenza SC, Mallireddigari MR, Patti R, Bonagura M, Truongcao M, Akula B, Jatiani SS, Reddy EP. Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase. Bioorg Med Chem. 2010 Mar 15; 18(6):2317-26.
      View in: PubMed
    29. Reddy HK, Graña X, Dhanasekaran DN, Litvin J, Reddy EP. Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation. Genes Cancer. 2010 Jan; 1(1):69-80.
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    30. Reddy EP. Editorial. Genes Cancer. 2010 Jan; 1(1):5.
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    31. Xu H, Dhanasekaran DN, Lee CM, Reddy EP. Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10. J Biol Chem. 2010 Feb 5; 285(6):3548-53.
      View in: PubMed
    32. Lieu YK, Reddy EP. Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21689-94.
      View in: PubMed
    33. Reddy MV, Billa VK, Pallela VR, Mallireddigari MR, Boominathan R, Gabriel JL, Reddy EP. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. Bioorg Med Chem. 2008 Apr 1; 16(7):3907-16.
      View in: PubMed
    34. Reddy MV, Mallireddigari MR, Cosenza SC, Pallela VR, Iqbal NM, Robell KA, Kang AD, Reddy EP. Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents. J Med Chem. 2008 Jan 10; 51(1):86-100.
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    35. Carbone CJ, Graña X, Reddy EP, Haines DS. p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts. Cancer Res. 2007 May 1; 67(9):4130-7.
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    36. Takaesu G, Kang JS, Bae GU, Yi MJ, Lee CM, Reddy EP, Krauss RS. Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo. J Cell Biol. 2006 Nov 6; 175(3):383-8.
      View in: PubMed
    37. Kashef K, Xu H, Reddy EP, Dhanasekaran DN. Endodermal differentiation of murine embryonic carcinoma cells by retinoic acid requires JLP, a JNK-scaffolding protein. J Cell Biochem. 2006 Jul 1; 98(4):715-22.
      View in: PubMed
    38. Reddy HK, Mettus RV, Rane SG, Graña X, Litvin J, Reddy EP. Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res. 2005 Nov 15; 65(22):10174-8.
      View in: PubMed
    39. Kashef K, Lee CM, Ha JH, Reddy EP, Dhanasekaran DN. JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway. Biochemistry. 2005 Nov 1; 44(43):14090-6.
      View in: PubMed
    40. Nguyen Q, Lee CM, Le A, Reddy EP. JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain. J Biol Chem. 2005 Aug 26; 280(34):30185-91.
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    41. Tang Y, Katuri V, Srinivasan R, Fogt F, Redman R, Anand G, Said A, Fishbein T, Zasloff M, Reddy EP, Mishra B, Mishra L. Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis. Cancer Res. 2005 May 15; 65(10):4228-37.
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    42. Reddy NS, Gumireddy K, Mallireddigari MR, Cosenza SC, Venkatapuram P, Bell SC, Reddy EP, Reddy MV. Novel coumarin-3-(N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1. Bioorg Med Chem. 2005 May 2; 13(9):3141-7.
      View in: PubMed
    43. Reddy MV, Mallireddigari MR, Pallela VR, Venkatapuram P, Boominathan R, Bell SC, Reddy EP. Design, synthesis, and biological evaluation of (E)- and (Z)-styryl-2-acetoxyphenyl sulfides and sulfones as cyclooxygenase-2 inhibitors. Bioorg Med Chem. 2005 Mar 1; 13(5):1715-23.
      View in: PubMed
    44. Gumireddy K, Reddy MV, Cosenza SC, Boominathan R, Boomi Nathan R, Baker SJ, Papathi N, Jiang J, Holland J, Reddy EP. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar; 7(3):275-86.
      View in: PubMed
    45. Gumireddy K, Baker SJ, Cosenza SC, John P, Kang AD, Robell KA, Reddy MV, Reddy EP. A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc Natl Acad Sci U S A. 2005 Feb 8; 102(6):1992-7.
      View in: PubMed
    46. Mangan JK, Reddy EP. Activation of the Jak3 pathway and myeloid differentiation. Leuk Lymphoma. 2005 Jan; 46(1):21-7.
      View in: PubMed
    47. Lieu YK, Kumar A, Pajerowski AG, Rogers TJ, Reddy EP. Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14853-8.
      View in: PubMed
    48. Reddy NS, Mallireddigari MR, Cosenza S, Gumireddy K, Bell SC, Reddy EP, Reddy MV. Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity. Bioorg Med Chem Lett. 2004 Aug 2; 14(15):4093-7.
      View in: PubMed
    49. Song JS, Sainz IM, Cosenza SC, Isordia-Salas I, Bior A, Bradford HN, Guo YL, Pixley RA, Reddy EP, Colman RW. Inhibition of tumor angiogenesis in vivo by a monoclonal antibody targeted to domain 5 of high molecular weight kininogen. Blood. 2004 Oct 1; 104(7):2065-72.
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    50. Mangan JK, Rane SG, Kang AD, Amanullah A, Wong BC, Reddy EP. Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation. Blood. 2004 Jun 1; 103(11):4093-101.
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    51. Kumar A, Baker SJ, Lee CM, Reddy EP. Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb. Mol Cell Biol. 2003 Sep; 23(18):6631-45.
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    52. Kumar A, Lee CM, Reddy EP. c-Myc is essential but not sufficient for c-Myb-mediated block of granulocytic differentiation. J Biol Chem. 2003 Mar 28; 278(13):11480-8.
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    53. Reddy EP. Payoff of molecular oncology research. Cancer Biol Ther. 2003 Jan-Feb; 2(1):115-8.
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    54. Shore SK, Tantravahi RV, Reddy EP. Transforming pathways activated by the v-Abl tyrosine kinase. Oncogene. 2002 Dec 9; 21(56):8568-76.
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    55. Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14189-94.
      View in: PubMed
    56. Rane SG, Mangan JK, Amanullah A, Wong BC, Vora RK, Liebermann DA, Hoffman B, Graña X, Reddy EP. Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells. Blood. 2002 Oct 15; 100(8):2753-62.
      View in: PubMed
    57. Rane SG, Cosenza SC, Mettus RV, Reddy EP. Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. Mol Cell Biol. 2002 Jan; 22(2):644-56.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067