Keywords
Last Name
Institution

Kevin Costa

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentCardiology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gianella A, Mieszawska AJ, Hoeben FJ, Janssen HM, Jarzyna PA, Cormode DP, Costa KD, Rao S, Farokhzad OC, Langer R, Fayad ZA, Mulder WJ. Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform. Chem Commun (Camb). 2013 Oct 21; 49(82):9392-4.
      View in: PubMed
    2. Boycott HE, Barbier CS, Eichel CA, Costa KD, Martins RP, Louault F, Dilanian G, Coulombe A, Hatem SN, Balse E. Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes. Proc Natl Acad Sci U S A. 2013 Oct 8; 110(41):E3955-64.
      View in: PubMed
    3. Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 2013 Nov; 34(35):8878-86.
      View in: PubMed
    4. Cashman TJ, Gouon-Evans V, Costa KD. Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms. Stem Cell Rev. 2013 Jun; 9(3):254-65.
      View in: PubMed
    5. Schure R, Costa KD, Rezaei R, Lee W, Laschinger C, Tenenbaum HC, McCulloch CA. Impact of matrix metalloproteinases on inhibition of mineralization by fetuin. J Periodontal Res. 2013 Jun; 48(3):357-66.
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    6. Serrao GW, Turnbull IC, Ancukiewicz D, Kim do E, Kao E, Cashman TJ, Hadri L, Hajjar RJ, Costa KD. Myocyte-depleted engineered cardiac tissues support therapeutic potential of mesenchymal stem cells. Tissue Eng Part A. 2012 Jul; 18(13-14):1322-33.
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    7. Costa KD, Kleinstein SH, Hershberg U. Biomedical model fitting and error analysis. Sci Signal. 2011 Sep 27; 4(192):tr9.
      View in: PubMed
    8. Wang X, Chen S, Kong M, Wang Z, Costa KD, Li RA, Sun D. Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies. Lab Chip. 2011 Nov 7; 11(21):3656-62.
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    9. Turnbull IC, Hadri L, Rapti K, Sadek M, Liang L, Shin HJ, Costa KD, Marin ML, Hajjar RJ, Faries PL. Aortic implantation of mesenchymal stem cells after aneurysm injury in a porcine model. J Surg Res. 2011 Sep; 170(1):e179-88.
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    10. Ladage D, Turnbull IC, Ishikawa K, Takewa Y, Rapti K, Morel C, Karakikes I, Hadri L, Müller-Ehmsen J, Costa KD, Hajjar RJ, Kawase Y. Delivery of gelfoam-enabled cells and vectors into the pericardial space using a percutaneous approach in a porcine model. Gene Ther. 2011 Oct; 18(10):979-85.
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    11. Azeloglu EU, Costa KD. Atomic force microscopy in mechanobiology: measuring microelastic heterogeneity of living cells. Methods Mol Biol. 2011; 736:303-29.
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    12. Huo B, Lu XL, Costa KD, Xu Q, Guo XE. An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation. Cell Calcium. 2010 Mar; 47(3):234-41.
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    13. Azeloglu EU, Costa KD. Cross-bridge cycling gives rise to spatiotemporal heterogeneity of dynamic subcellular mechanics in cardiac myocytes probed with atomic force microscopy. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H853-60.
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    14. Ateshian GA, Costa KD, Azeloglu EU, Morrison B, Hung CT. Continuum modeling of biological tissue growth by cell division, and alteration of intracellular osmolytes and extracellular fixed charge density. J Biomech Eng. 2009 Oct; 131(10):101001.
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    15. Park S, Costa KD, Ateshian GA, Hong KS. Mechanical properties of bovine articular cartilage under microscale indentation loading from atomic force microscopy. Proc Inst Mech Eng H. 2009 Apr; 223(3):339-47.
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    16. Ateshian GA, Costa KD. A frame-invariant formulation of Fung elasticity. J Biomech. 2009 Apr 16; 42(6):781-5.
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    17. Azeloglu EU, Kaushik G, Costa KD. Developing a hybrid computational model of AFM indentation for analysis of mechanically heterogeneous samples. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4273-6.
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    18. Azeloglu EU, Costa KD. Dynamic AFM elastography reveals phase dependent mechanical heterogeneity of beating cardiac myocytes. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:7180-3.
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    19. Cheung YK, Azeloglu EU, Shiovitz DA, Costa KD, Seliktar D, Sia SK. Microscale control of stiffness in a cell-adhesive substrate using microfluidics-based lithography. Angew Chem Int Ed Engl. 2009; 48(39):7188-92.
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    20. Duan Q, Angelini ED, Herz SL, Ingrassia CM, Costa KD, Holmes JW, Homma S, Laine AF. Region-based endocardium tracking on real-time three-dimensional ultrasound. Ultrasound Med Biol. 2009 Feb; 35(2):256-65.
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    21. Azeloglu EU, Bhattacharya J, Costa KD. Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness. J Appl Physiol (1985). 2008 Aug; 105(2):652-61.
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    22. Lee EJ, Holmes JW, Costa KD. Remodeling of engineered tissue anisotropy in response to altered loading conditions. Ann Biomed Eng. 2008 Aug; 36(8):1322-34.
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    23. Lee EJ, Kim do E, Azeloglu EU, Costa KD. Engineered cardiac organoid chambers: toward a functional biological model ventricle. Tissue Eng Part A. 2008 Feb; 14(2):215-25.
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    24. Azeloglu EU, Albro MB, Thimmappa VA, Ateshian GA, Costa KD. Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1197-205.
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    25. Lee WN, Ingrassia CM, Fung-Kee-Fung SD, Costa KD, Holmes JW, Konofagou EE. Theoretical quality assessment of myocardial elastography with in vivo validation. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Nov; 54(11):2233-45.
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    26. Cheng RK, Asai T, Tang H, Dashoush NH, Kara RJ, Costa KD, Naka Y, Wu EX, Wolgemuth DJ, Chaudhry HW. Cyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure. Circ Res. 2007 Jun 22; 100(12):1741-8.
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    27. Elkin BS, Azeloglu EU, Costa KD, Morrison B. Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation. J Neurotrauma. 2007 May; 24(5):812-22.
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    28. Guo XE, Takai E, Jiang X, Xu Q, Whitesides GM, Yardley JT, Hung CT, Chow EM, Hantschel T, Costa KD. Intracellular calcium waves in bone cell networks under single cell nanoindentation. Mol Cell Biomech. 2006 Sep; 3(3):95-107.
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    29. Ateshian GA, Costa KD, Hung CT. A theoretical analysis of water transport through chondrocytes. Biomech Model Mechanobiol. 2007 Jan; 6(1-2):91-101.
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    30. Costa KD, Sim AJ, Yin FC. Non-Hertzian approach to analyzing mechanical properties of endothelial cells probed by atomic force microscopy. J Biomech Eng. 2006 Apr; 128(2):176-84.
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    31. Costa KD. Imaging and probing cell mechanical properties with the atomic force microscope. Methods Mol Biol. 2006; 319:331-61.
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    32. Herz SL, Ingrassia CM, Costa KD, Holmes JW. Model-based screening of wall motion measures for detection of ischemia in three-dimensional cardiac images. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:628-31.
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    33. Holmes JW, Costa KD. Imaging cardiac mechanics: what information do we need to extract from cardiac images? Conf Proc IEEE Eng Med Biol Soc. 2006; 1:1545-7.
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    34. Kim do E, Lee EJ, Martens TP, Kara R, Chaudhry HW, Itescu S, Costa KD. Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:849-52.
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    35. Herz SL, Ingrassia CM, Homma S, Costa KD, Holmes JW. Parameterization of left ventricular wall motion for detection of regional ischemia. Ann Biomed Eng. 2005 Jul; 33(7):912-9.
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    36. Takai E, Costa KD, Shaheen A, Hung CT, Guo XE. Osteoblast elastic modulus measured by atomic force microscopy is substrate dependent. Ann Biomed Eng. 2005 Jul; 33(7):963-71.
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    37. Duan Q, Herz S, Ingrassia C, Costa K, Holmes J, Laine A, Angelini E, Gerard O, Homma S. Dynamic cardiac information from optical flow using four dimensional ultrasound. Conf Proc IEEE Eng Med Biol Soc. 2005; 4:4465-8.
      View in: PubMed
    38. Ng KW, Wang CC, Mauck RL, Kelly TA, Chahine NO, Costa KD, Ateshian GA, Hung CT. A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs. J Orthop Res. 2005 Jan; 23(1):134-41.
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    39. Mathiyakom W, McNitt-Gray JL, Requejo P, Costa K. Modifying center of mass trajectory during sit-to-stand tasks redistributes the mechanical demand across the lower extremity joints. Clin Biomech (Bristol, Avon). 2005 Jan; 20(1):105-11.
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    40. Krishnan R, Caligaris M, Mauck RL, Hung CT, Costa KD, Ateshian GA. Removal of the superficial zone of bovine articular cartilage does not increase its frictional coefficient. Osteoarthritis Cartilage. 2004 Dec; 12(12):947-55.
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    41. Park S, Costa KD, Ateshian GA. Microscale frictional response of bovine articular cartilage from atomic force microscopy. J Biomech. 2004 Nov; 37(11):1679-87.
      View in: PubMed
    42. Chao PG, Tang Z, Angelini E, West AC, Costa KD, Hung CT. Dynamic osmotic loading of chondrocytes using a novel microfluidic device. J Biomech. 2005 Jun; 38(6):1273-81.
      View in: PubMed
    43. Costa KD, Lee EJ, Holmes JW. Creating alignment and anisotropy in engineered heart tissue: role of boundary conditions in a model three-dimensional culture system. Tissue Eng. 2003 Aug; 9(4):567-77.
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    44. Costa KD. Single-cell elastography: probing for disease with the atomic force microscope. Dis Markers. 2003-2004; 19(2-3):139-54.
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    45. Costa KD, Hucker WJ, Yin FC. Buckling of actin stress fibers: a new wrinkle in the cytoskeletal tapestry. Cell Motil Cytoskeleton. 2002 Aug; 52(4):266-74.
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    46. Takayama Y, Costa KD, Covell JW. Contribution of laminar myofiber architecture to load-dependent changes in mechanics of LV myocardium. Am J Physiol Heart Circ Physiol. 2002 Apr; 282(4):H1510-20.
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    47. Arts T, Costa KD, Covell JW, McCulloch AD. Relating myocardial laminar architecture to shear strain and muscle fiber orientation. Am J Physiol Heart Circ Physiol. 2001 May; 280(5):H2222-9.
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    48. Guccione JM, Moonly SM, Moustakidis P, Costa KD, Moulton MJ, Ratcliffe MB, Pasque MK. Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study. Ann Thorac Surg. 2001 Feb; 71(2):654-62.
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    49. Wei Z, Costa K, Al-Mehdi AB, Dodia C, Muzykantov V, Fisher AB. Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling. Circ Res. 1999 Oct 15; 85(8):682-9.
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    50. Costa KD, Yin FC. Analysis of indentation: implications for measuring mechanical properties with atomic force microscopy. J Biomech Eng. 1999 Oct; 121(5):462-71.
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    51. Costa KD, Takayama Y, McCulloch AD, Covell JW. Laminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium. Am J Physiol. 1999 Feb; 276(2 Pt 2):H595-607.
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    52. Al-Mehdi AB, Zhao G, Dodia C, Tozawa K, Costa K, Muzykantov V, Ross C, Blecha F, Dinauer M, Fisher AB. Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+. Circ Res. 1998 Oct 5; 83(7):730-7.
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    53. Costa KD, May-Newman K, Farr D, O'Dell WG, McCulloch AD, Omens JH. Three-dimensional residual strain in midanterior canine left ventricle. Am J Physiol. 1997 Oct; 273(4 Pt 2):H1968-76.
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    54. Costa KD, Hunter PJ, Rogers JM, Guccione JM, Waldman LK, McCulloch AD. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: I--Cylindrical and spherical polar coordinates. J Biomech Eng. 1996 Nov; 118(4):452-63.
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    55. Costa KD, Hunter PJ, Wayne JS, Waldman LK, Guccione JM, McCulloch AD. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: II--Prolate spheroidal coordinates. J Biomech Eng. 1996 Nov; 118(4):464-72.
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    56. Guccione JM, Costa KD, McCulloch AD. Finite element stress analysis of left ventricular mechanics in the beating dog heart. J Biomech. 1995 Oct; 28(10):1167-77.
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    57. Lutchen KR, Costa KD. Physiological interpretations based on lumped element models fit to respiratory impedance data: use of forward-inverse modeling. IEEE Trans Biomed Eng. 1990 Nov; 37(11):1076-86.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067