Keywords
Last Name
Institution

Samuel E. Gandy

TitlePROFESSOR
InstitutionMount Sinai
DepartmentNeurology
Address5 East 98th Street, 7th Floor
NYC NY 10029
Phone212-241-7076
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentPsychiatry


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates aß clearance and attenuates cognitive deterioration in an Alzheimer mouse model. J Biol Chem. 2013 Nov 1; 288(44):32050-63.
      View in: PubMed
    2. Gandy S, Heppner FL. Microglia as dynamic and essential components of the amyloid hypothesis. Neuron. 2013 May 22; 78(4):575-7.
      View in: PubMed
    3. Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S. Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-ß peptide. J Neurosci. 2013 Apr 17; 33(16):7099-107.
      View in: PubMed
    4. Gandy S, Haroutunian V, DeKosky ST, Sano M, Schadt EE. CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease. Biol Psychiatry. 2013 Mar 1; 73(5):393-5.
      View in: PubMed
    5. Gandy S, DeKosky ST. Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress. Annu Rev Med. 2013; 64:367-83.
      View in: PubMed
    6. Gandy S, DeKosky ST. 2012: the year in dementia. Lancet Neurol. 2013 Jan; 12(1):4-6.
      View in: PubMed
    7. De Gasperi R, Gama Sosa MA, Kim SH, Steele JW, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Dekosky ST, McCarron RM, Nambiar MP, Gandy S, Ahlers ST, Elder GA. Acute blast injury reduces brain abeta in two rodent species. Front Neurol. 2012; 3:177.
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    8. Kim SH, Knight EM, Saunders EL, Cuevas AK, Popovech M, Chen LC, Gandy S. Rapid doubling of Alzheimer's amyloid-ß40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution. F1000Res. 2012; 1.
      View in: PubMed
    9. Brautigam H, Steele JW, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease. Mol Neurodegener. 2012; 7:58.
      View in: PubMed
    10. Zhu L, Su M, Lucast L, Liu L, Netzer WJ, Gandy SE, Cai D. Dynamin 1 regulates amyloid generation through modulation of BACE-1. PLoS One. 2012; 7(9):e45033.
      View in: PubMed
    11. Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S. Latrepirdine stimulates autophagy and reduces accumulation of a-synuclein in cells and in mouse brain. Mol Psychiatry. 2013 Aug; 18(8):882-8.
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    12. Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry. 2013 Aug; 18(8):889-97.
      View in: PubMed
    13. Caesar I, Gandy S. Evidence that an APOE e4 'double whammy' increases risk for Alzheimer's disease. BMC Med. 2012; 10:36.
      View in: PubMed
    14. Keilani S, Lun Y, Stevens AC, Williams HN, Sjoberg ER, Khanna R, Valenzano KJ, Checler F, Buxbaum JD, Yanagisawa K, Lockhart DJ, Wustman BA, Gandy S. Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-ß peptide. J Neurosci. 2012 Apr 11; 32(15):5223-36.
      View in: PubMed
    15. Ehrlich ME, Gandy S. Chromatin plasticity and the pathogenesis of Huntington disease. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16867-8.
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    16. Gandy S. Perspective: prevention is better than cure. Nature. 2011 Jul 14; 475(7355):S15.
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    17. Sohrabi HR, Weinborn M, Badcock J, Bates KA, Clarnette R, Trivedi D, Verdile G, Sutton T, Lenzo NP, Gandy SE, Martins RN. New lexicon and criteria for the diagnosis of Alzheimer's disease. Lancet Neurol. 2011 Apr; 10(4):299-300; author reply 300-1.
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    18. Lane RF, Gatson JW, Small SA, Ehrlich ME, Gandy S. Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. Mol Neurodegener. 2010; 5:62.
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    19. Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci. 2010 Sep 29; 30(39):13110-5.
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    20. Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol. 2010 Aug; 68(2):220-30.
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    21. Kim SH, Fraser PE, Westaway D, St George-Hyslop PH, Ehrlich ME, Gandy S. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals. J Neurosci. 2010 Mar 17; 30(11):3870-5.
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    22. Kajiwara Y, Franciosi S, Takahashi N, Krug L, Schmeidler J, Taddei K, Haroutunian V, Fried U, Ehrlich M, Martins RN, Gandy S, Buxbaum JD. Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Mol Neurodegener. 2010; 5:1.
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    23. Lublin AL, Gandy S. Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease. Mt Sinai J Med. 2010 Jan-Feb; 77(1):43-9.
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    24. Dickstein DL, Walsh J, Brautigam H, Stockton SD, Gandy S, Hof PR. Role of vascular risk factors and vascular dysfunction in Alzheimer's disease. Mt Sinai J Med. 2010 Jan-Feb; 77(1):82-102.
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    25. Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PS, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Mol Neurodegener. 2009; 4:51.
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    26. Franciosi S, Gama Sosa MA, English DF, Oler E, Oung T, Janssen WG, De Gasperi R, Schmeidler J, Dickstein DL, Schmitz C, Gandy S, Hof PR, Buxbaum JD, Elder GA. Novel cerebrovascular pathology in mice fed a high cholesterol diet. Mol Neurodegener. 2009; 4:42.
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    27. Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S. Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Mol Neurodegener. 2009; 4:40.
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    28. Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol. 2009 Aug 21; 4(8):673-84.
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    29. Gandy S. An interview with Samuel Gandy, MD, PhD: Alzheimer's disease by Norman Sussman. CNS Spectr. 2009 May; 14(5):248-51.
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    30. Sohrabi HR, Bates KA, Rodrigues M, Taddei K, Laws SM, Lautenschlager NT, Dhaliwal SS, Johnston AN, Mackay-Sim A, Gandy S, Foster JK, Martins RN. Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. J Alzheimers Dis. 2009; 17(1):135-42.
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    31. Bates KA, Sohrabi HR, Rodrigues M, Beilby J, Dhaliwal SS, Taddei K, Criddle A, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster JK, Martins IJ, Lautenschlager NT, Mastaglia FL, Laws SM, Gandy SE, Martins RN. Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers. J Alzheimers Dis. 2009; 17(2):305-18.
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    32. Beeri MS, Schmeidler J, Silverman JM, Gandy S, Wysocki M, Hannigan CM, Purohit DP, Lesser G, Grossman HT, Haroutunian V. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology. 2008 Sep 2; 71(10):750-7.
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    33. Gnjec A, D'Costa KJ, Laws SM, Hedley R, Balakrishnan K, Taddei K, Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, Miklossy J, Hallmayer J, McGeer PL, Martins RN. Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. J Neuroinflammation. 2008; 5:36.
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    34. Qin W, Chachich M, Lane M, Roth G, Bryant M, de Cabo R, Ottinger MA, Mattison J, Ingram D, Gandy S, Pasinetti GM. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimers Dis. 2006 Dec; 10(4):417-22.
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    35. Greenberg SM, Rosand J, Schneider AT, Creed Pettigrew L, Gandy SE, Rovner B, Fitzsimmons BF, Smith EE, Edip Gurol M, Schwab K, Laurin J, Garceau D. A phase 2 study of tramiprosate for cerebral amyloid angiopathy. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):269-74.
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    36. Verdile G, Gandy SE, Martins RN. The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. Neurochem Res. 2007 Apr-May; 32(4-5):609-23.
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    37. Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 4; 281(31):21745-54.
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    38. Balakrishnan K, Verdile G, Mehta PD, Beilby J, Nolan D, Galvão DA, Newton R, Gandy SE, Martins RN. Plasma Abeta42 correlates positively with increased body fat in healthy individuals. J Alzheimers Dis. 2005 Dec; 8(3):269-82.
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    39. Verdile G, Fuller S, Atwood CS, Laws SM, Gandy SE, Martins RN. The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacol Res. 2004 Oct; 50(4):397-409.
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    40. Ghiso J, Shayo M, Calero M, Ng D, Tomidokoro Y, Gandy S, Rostagno A, Frangione B. Systemic catabolism of Alzheimer's Abeta40 and Abeta42. J Biol Chem. 2004 Oct 29; 279(44):45897-908.
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    41. Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. J Neurochem. 2004 Apr; 89(1):44-53.
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    42. Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. J Biol Chem. 2004 Jun 4; 279(23):23925-32.
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    43. Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, Gandy S, Santucci AC, Haroutunian V, Huntley GW, Buxbaum JD. Altered Abeta formation and long-term potentiation in a calsenilin knock-out. J Neurosci. 2003 Oct 8; 23(27):9097-106.
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    44. Dean B, Laws SM, Hone E, Taddei K, Scarr E, Thomas EA, Harper C, McClean C, Masters C, Lautenschlager N, Gandy SE, Martins RN. Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biol Psychiatry. 2003 Sep 15; 54(6):616-22.
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    45. Thomas EA, Laws SM, Sutcliffe JG, Harper C, Dean B, McClean C, Masters C, Lautenschlager N, Gandy SE, Martins RN. Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. Biol Psychiatry. 2003 Jul 15; 54(2):136-41.
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    46. Kwok JB, Halliday GM, Brooks WS, Dolios G, Laudon H, Murayama O, Hallupp M, Badenhop RF, Vickers J, Wang R, Naslund J, Takashima A, Gandy SE, Schofield PR. Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy. J Biol Chem. 2003 Feb 28; 278(9):6748-54.
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    47. Hedley R, Hallmayer J, Groth DM, Brooks WS, Gandy SE, Martins RN. Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia. Ann Neurol. 2002 Jun; 51(6):795-7.
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    48. Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, Fraser PE. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem. 2002 Aug 2; 277(31):28135-42.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067