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Last Name
Institution

Fadi Akar

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentCardiology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Akar FG. Mitochondrial targets for arrhythmia suppression: is there a role for pharmacological intervention? J Interv Card Electrophysiol. 2013 Sep; 37(3):249-58.
      View in: PubMed
    2. Xie C, Biary N, Tocchetti CG, Aon MA, Paolocci N, Kauffman J, Akar FG. Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs. Am J Physiol Heart Circ Physiol. 2013 Apr 1; 304(7):H916-26.
      View in: PubMed
    3. Nederlof R, Xie C, Eerbeek O, Koeman A, Milstein DM, Hollmann MW, Mik EG, Warley A, Southworth R, Akar FG, Zuurbier CJ. Pathophysiological consequences of TAT-HKII peptide administration are independent of impaired vascular function and ensuing ischemia. Circ Res. 2013 Jan 18; 112(2):e8-13.
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    4. Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O'Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA. GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice. Diabetes. 2012 Dec; 61(12):3094-105.
      View in: PubMed
    5. Karam CS, Akar FG. Genetic silencing of pacemaker cells: local intervention with global implications. J Am Heart Assoc. 2012 Apr; 1(2):e001412.
      View in: PubMed
    6. Biary N, Xie C, Kauffman J, Akar FG. Biophysical properties and functional consequences of reactive oxygen species (ROS)-induced ROS release in intact myocardium. J Physiol. 2011 Nov 1; 589(Pt 21):5167-79.
      View in: PubMed
    7. Smeele KM, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O, Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ. Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis. Circ Res. 2011 May 13; 108(10):1165-9.
      View in: PubMed
    8. Akar FG, O'Rourke B. Mitochondria are sources of metabolic sink and arrhythmias. Pharmacol Ther. 2011 Sep; 131(3):287-94.
      View in: PubMed
    9. Xie C, Akar FG. Mitochondrial dysfunction: a new frontier in the search for elusive arrhythmia mechanisms. Front Physiol. 2010; 1:163.
      View in: PubMed
    10. Hajjar RJ, Akar FG. Regression of cardiac hypertrophy by cyclic guanosine monophosphate-dependent protein kinase signaling are myocytes active sources or mere beneficiaries? J Am Coll Cardiol. 2010 Dec 7; 56(24):2031-2.
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    11. Biary N, Akar FG. A brighter side of ROS revealed by selective activation of beta-adrenergic receptor subtypes. J Physiol. 2010 Aug 15; 588(Pt 16):2973-4.
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    12. Lyon AR, Joudrey PJ, Jin D, Nass RD, Aon MA, O'Rourke B, Akar FG. Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart. J Mol Cell Cardiol. 2010 Oct; 49(4):565-75.
      View in: PubMed
    13. Kong CW, Akar FG, Li RA. Translational potential of human embryonic and induced pluripotent stem cells for myocardial repair: insights from experimental models. Thromb Haemost. 2010 Jul; 104(1):30-8.
      View in: PubMed
    14. Jin H, Nass RD, Joudrey PJ, Lyon AR, Chemaly ER, Rapti K, Akar FG. Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart. Biophys J. 2010 May 19; 98(10):2063-71.
      View in: PubMed
    15. Akar FG. Left ventricular repolarization heterogeneity as an arrhythmic substrate in heart failure. Minerva Cardioangiol. 2010 Apr; 58(2):205-12.
      View in: PubMed
    16. Akar FG. Use-dependent modulation of myocardial conduction by a new class of HERG agonists: deal breaker or cherry on top? J Cardiovasc Electrophysiol. 2010 Aug 1; 21(8):930-2.
      View in: PubMed
    17. Hesketh GG, Shah MH, Halperin VL, Cooke CA, Akar FG, Yen TE, Kass DA, Machamer CE, Van Eyk JE, Tomaselli GF. Ultrastructure and regulation of lateralized connexin43 in the failing heart. Circ Res. 2010 Apr 2; 106(6):1153-63.
      View in: PubMed
    18. Jin H, Chemaly ER, Lee A, Kho C, Hadri L, Hajjar RJ, Akar FG. Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. FASEB J. 2010 Feb; 24(2):451-63.
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    19. Aiba T, Hesketh GG, Liu T, Carlisle R, Villa-Abrille MC, O'Rourke B, Akar FG, Tomaselli GF. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res. 2010 Feb 1; 85(3):454-63.
      View in: PubMed
    20. Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L, O'Rourke B. From mitochondrial dynamics to arrhythmias. Int J Biochem Cell Biol. 2009 Oct; 41(10):1940-8.
      View in: PubMed
    21. Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Chakir K, Dimaano VL, Abraham TP, O'Rourke B, Akar FG, Kass DA, Tomaselli GF. Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation. 2009 Mar 10; 119(9):1220-30.
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    22. Gao Z, Barth AS, DiSilvestre D, Akar FG, Tian Y, Tanskanen A, Kass DA, Winslow RL, Tomaselli GF. Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling. Physiol Genomics. 2008 Nov 12; 35(3):222-30.
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    23. Jin H, Lyon AR, Akar FG. Arrhythmia mechanisms in the failing heart. Pacing Clin Electrophysiol. 2008 Aug; 31(8):1048-56.
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    24. Soylemez S, Gurdal H, Sepici A, Akar F. The effect of long-term resveratrol treatment on relaxation to estrogen in aortae from male and female rats: role of nitric oxide and superoxide. Vascul Pharmacol. 2008 Aug-Sep; 49(2-3):97-105.
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    25. Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). FASEB J. 2008 Oct; 22(10):3648-60.
      View in: PubMed
    26. Lipsky R, Potts EM, Tarzami ST, Puckerin AA, Stocks J, Schecter AD, Sobie EA, Akar FG, Diversé-Pierluissi MA. beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway. J Biol Chem. 2008 Jun 20; 283(25):17221-6.
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    27. Seren M, Budak B, Turan N, Parlar AI, Akar F, Ulus AT. Collaborative therapy with nebivalol and L-NAME for spinal cord ischemia/reperfusion injury. Ann Vasc Surg. 2008 May-Jun; 22(3):425-31.
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    28. Nass RD, Aiba T, Tomaselli GF, Akar FG. Mechanisms of disease: ion channel remodeling in the failing ventricle. Nat Clin Pract Cardiovasc Med. 2008 Apr; 5(4):196-207.
      View in: PubMed
    29. Brown DA, Aon MA, Akar FG, Liu T, Sorarrain N, O'Rourke B. Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart. Cardiovasc Res. 2008 Jul 1; 79(1):141-9.
      View in: PubMed
    30. Akar FG. The perfect storm: defective calcium cycling in insulated fibers with reduced repolarization reserve. Circ Res. 2007 Nov 9; 101(10):968-70.
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    31. Akar JG, Akar FG. Regulation of ion channels and arrhythmias in the ischemic heart. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S37-41.
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    32. Akar FG, Nass RD, Hahn S, Cingolani E, Shah M, Hesketh GG, DiSilvestre D, Tunin RS, Kass DA, Tomaselli GF. Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 2007 Aug; 293(2):H1223-30.
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    33. O'Rourke B, Cortassa S, Akar F, Aon M. Mitochondrial ion channels in cardiac function and dysfunction. Novartis Found Symp. 2007; 287:140-51; discussion 152-6.
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    34. Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA. Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation. 2006 Sep 5; 114(10):1000-11.
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    35. Akar JG, Akar FG. Mapping arrhythmias in the failing heart: from Langendorff to patient. J Electrocardiol. 2006 Oct; 39(4 Suppl):S19-23.
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    36. Akar FG, Aon MA, Tomaselli GF, O'Rourke B. The mitochondrial origin of postischemic arrhythmias. J Clin Invest. 2005 Dec; 115(12):3527-35.
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    37. Shah M, Akar FG, Tomaselli GF. Molecular basis of arrhythmias. Circulation. 2005 Oct 18; 112(16):2517-29.
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    38. Akar FG, Tomaselli GF. Conduction abnormalities in nonischemic dilated cardiomyopathy: basic mechanisms and arrhythmic consequences. Trends Cardiovasc Med. 2005 Oct; 15(7):259-64.
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    39. Aon MA, Cortassa S, Akar FG, O'Rourke B. Mitochondrial criticality: a new concept at the turning point of life or death. Biochim Biophys Acta. 2006 Feb; 1762(2):232-40.
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    40. Spragg DD, Akar FG, Helm RH, Tunin RS, Tomaselli GF, Kass DA. Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovasc Res. 2005 Jul 1; 67(1):77-86.
      View in: PubMed
    41. Akar FG, Wu RC, Juang GJ, Tian Y, Burysek M, Disilvestre D, Xiong W, Armoundas AA, Tomaselli GF. Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2887-96.
      View in: PubMed
    42. Akar FG, Tomaselli GF. Ion channels as novel therapeutic targets in heart failure. Ann Med. 2005; 37(1):44-54.
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    43. Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation. 2005 Jan 4; 111(1):11-20.
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    44. Akar FG, Spragg DD, Tunin RS, Kass DA, Tomaselli GF. Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Circ Res. 2004 Oct 1; 95(7):717-25.
      View in: PubMed
    45. Poelzing S, Akar FG, Baron E, Rosenbaum DS. Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H2001-9.
      View in: PubMed
    46. Akar FG, Wu RC, Deschenes I, Armoundas AA, Piacentino V, Houser SR, Tomaselli GF. Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H602-9.
      View in: PubMed
    47. Akar FG, Rosenbaum DS. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ Res. 2003 Oct 3; 93(7):638-45.
      View in: PubMed
    48. Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation. 2002 Mar 12; 105(10):1247-53.
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    49. Akar FG, Roth BJ, Rosenbaum DS. Optical measurement of cell-to-cell coupling in intact heart using subthreshold electrical stimulation. Am J Physiol Heart Circ Physiol. 2001 Aug; 281(2):H533-42.
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    50. Akar F, Jiang G, Paul RJ, O'Neill WC. Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C579-84.
      View in: PubMed
    51. Akar F. Endothelial reactivity to the immediate hypersensitivity reaction of guinea pig pulmonary artery. Eur J Pharmacol. 2000 May 3; 395(3):225-8.
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    52. Akar FG, Laurita KR, Rosenbaum DS. Cellular basis for dispersion of repolarization underlying reentrant arrhythmias. J Electrocardiol. 2000; 33 Suppl:23-31.
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    53. Akar F, Skinner E, Klein JD, Jena M, Paul RJ, O'Neill WC. Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl- cotransporter in rat aorta. Am J Physiol. 1999 Jun; 276(6 Pt 1):C1383-90.
      View in: PubMed
    54. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation. 1999 Mar 16; 99(10):1385-94.
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    55. Laurita KR, Girouard SD, Akar FG, Rosenbaum DS. Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart. Circulation. 1998 Dec 15; 98(24):2774-80.
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    56. Uydes-Dogan BS, Akar F, Zengil H, Abacioglu N, Kanzik I. Effect of ovalbumin challenge on endothelial reactivity of pulmonary arteries from sensitized guinea-pigs. Pulm Pharmacol. 1995 Apr-Jun; 8(2-3):115-22.
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    57. Akar F, Ark M, Uydes BS, Soysal ME, Saraçoglu F, Abacioglu N, Van de Voorde J, Kanzik I. Nitric oxide production by human umbilical vessels in severe pre-eclampsia. J Hypertens. 1994 Nov; 12(11):1235-41.
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    58. Akar F, Uydes BS, Ayrancioglu K, Yener A, Aslamaci S, Arsan M, Törüner A, Kanzik I. Endothelial function of human gastroepiploic artery in comparison with saphenous vein. Cardiovasc Res. 1994 Apr; 28(4):500-4.
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    59. Türker RK, Ercan ZS, Zengil H, Akar F. Iloprost (ZK 36374) modulates the responses to beta-adrenoceptor agonists in guinea-pig airways and pulmonary vasculature. Arch Int Physiol Biochim. 1985 Nov; 93(4):263-9.
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    60. Metin M, Dörtlemez O, Dörtlemez H, Akar F, Ercan ZS, Türker RK. Prevention by a carbacyclin analogue (ZK 36 374) of digoxin-induced ventricular extrasystoles in guinea-pig myocardium. Eur J Pharmacol. 1984 Feb 10; 98(1):125-8.
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    61. Akar F, Ercan ZS, Türker RK. A marked H1-receptor-mediated vasodilator effect of histamine in the isolated perfused rat heart. Eur J Pharmacol. 1984 Jan 27; 97(3-4):265-9.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067