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Last Name
Institution

Djamel Lebeche

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentCardiology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chemaly ER, Kang S, Zhang S, McCollum L, Chen J, Bénard L, Purushothaman KR, Hajjar RJ, Lebeche D. Differential patterns of replacement and reactive fibrosis in pressure and volume overload are related to the propensity for ischaemia and involve resistin. J Physiol. 2013 Nov 1; 591(Pt 21):5337-55.
      View in: PubMed
    2. Karakikes I, Chaanine AH, Kang S, Mukete BN, Jeong D, Zhang S, Hajjar RJ, Lebeche D. Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling. J Am Heart Assoc. 2013 Apr; 2(2):e000078.
      View in: PubMed
    3. Balderman JA, Lee HY, Mahoney CE, Handy DE, White K, Annis S, Lebeche D, Hajjar RJ, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. J Am Heart Assoc. 2012 Dec; 1(6):e003905.
      View in: PubMed
    4. LaRocca TJ, Fabris F, Chen J, Benhayon D, Zhang S, McCollum L, Schecter AD, Cheung JY, Sobie EA, Hajjar RJ, Lebeche D. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-?B pathway. Am J Physiol Heart Circ Physiol. 2012 Aug 1; 303(3):H353-67.
      View in: PubMed
    5. Chemaly ER, Hadri L, Zhang S, Kim M, Kohlbrenner E, Sheng J, Liang L, Chen J, K-Raman P, Hajjar RJ, Lebeche D. Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats. J Mol Cell Cardiol. 2011 Aug; 51(2):144-55.
      View in: PubMed
    6. Kang S, Chemaly ER, Hajjar RJ, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011 May 27; 286(21):18465-73.
      View in: PubMed
    7. Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. J Mol Cell Cardiol. 2011 Jul; 51(1):4-15.
      View in: PubMed
    8. Hadri L, Bobe R, Kawase Y, Ladage D, Ishikawa K, Atassi F, Lebeche D, Kranias EG, Leopold JA, Lompré AM, Lipskaia L, Hajjar RJ. SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells. Mol Ther. 2010 Jul; 18(7):1284-92.
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    9. Dobrin JS, Lebeche D. Diabetic cardiomyopathy: signaling defects and therapeutic approaches. Expert Rev Cardiovasc Ther. 2010 Mar; 8(3):373-91.
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    10. Jin H, Hadri L, Palomeque J, Morel C, Karakikes I, Kaprielian R, Hajjar R, Lebeche D. KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling. J Mol Cell Cardiol. 2010 Jun; 48(6):1169-79.
      View in: PubMed
    11. Karakikes I, Kim M, Hadri L, Sakata S, Sun Y, Zhang W, Chemaly ER, Hajjar RJ, Lebeche D. Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. PLoS One. 2009; 4(7):e6474.
      View in: PubMed
    12. Suckau L, Fechner H, Chemaly E, Krohn S, Hadri L, Kockskämper J, Westermann D, Bisping E, Ly H, Wang X, Kawase Y, Chen J, Liang L, Sipo I, Vetter R, Weger S, Kurreck J, Erdmann V, Tschope C, Pieske B, Lebeche D, Schultheiss HP, Hajjar RJ, Poller WC. Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation. 2009 Mar 10; 119(9):1241-52.
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    13. Refaat M, Chemaly E, Lebeche D, Gwathmey JK, Hajjar RJ. Ventricular arrhythmias after left ventricular assist device implantation. Pacing Clin Electrophysiol. 2008 Oct; 31(10):1246-52.
      View in: PubMed
    14. Lebeche D, Davidoff AJ, Hajjar RJ. Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy. Nat Clin Pract Cardiovasc Med. 2008 Nov; 5(11):715-24.
      View in: PubMed
    15. Kim M, Oh JK, Sakata S, Liang I, Park W, Hajjar RJ, Lebeche D. Role of resistin in cardiac contractility and hypertrophy. J Mol Cell Cardiol. 2008 Aug; 45(2):270-80.
      View in: PubMed
    16. Misra P, Lebeche D, Ly H, Schwarzkopf M, Diaz G, Hajjar RJ, Schecter AD, Frangioni JV. Quantitation of CXCR4 expression in myocardial infarction using 99mTc-labeled SDF-1alpha. J Nucl Med. 2008 Jun; 49(6):963-9.
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    17. Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif JC, Tanguay JF, Hajjar RJ. Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. J Am Coll Cardiol. 2008 Mar 18; 51(11):1112-9.
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    18. Sakata S, Liang L, Sakata N, Sakata Y, Chemaly ER, Lebeche D, Takewa Y, Chen J, Park WJ, Kawase Y, Hajjar RJ. Preservation of mechanical and energetic function after adenoviral gene transfer in normal rat hearts. Clin Exp Pharmacol Physiol. 2007 Dec; 34(12):1300-6.
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    19. Kühn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med. 2007 Aug; 13(8):962-9.
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    20. Sakata S, Lebeche D, Sakata N, Sakata Y, Chemaly ER, Liang LF, Takewa Y, Jeong D, Park WJ, Kawase Y, Hajjar RJ. Targeted gene transfer increases contractility and decreases oxygen cost of contractility in normal rat hearts. Am J Physiol Heart Circ Physiol. 2007 May; 292(5):H2356-63.
      View in: PubMed
    21. Sakata S, Lebeche D, Sakata N, Sakata Y, Chemaly ER, Liang LF, Tsuji T, Takewa Y, del Monte F, Peluso R, Zsebo K, Jeong D, Park WJ, Kawase Y, Hajjar RJ. Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. J Mol Cell Cardiol. 2007 Apr; 42(4):852-61.
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    22. Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang L, Nakajima-Takenaka C, Tsuji T, Konishi N, del Monte F, Hajjar RJ, Takaki M. Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1204-7.
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    23. Lebeche D, Kaprielian R, Hajjar R. Modulation of action potential duration on myocyte hypertrophic pathways. J Mol Cell Cardiol. 2006 May; 40(5):725-35.
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    24. Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang LF, Padmanabhan P, Konishi N, Takaki M, del Monte F, Hajjar RJ. Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Mol Ther. 2006 May; 13(5):987-96.
      View in: PubMed
    25. Lebeche D, Dalal R, Jang M, del Monte F, Hajjar RJ. Transgenic models of heart failure: elucidation of the molecular mechanisms of heart disease. Heart Fail Clin. 2005 Jul; 1(2):219-36.
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    26. Schmidt U, Zhu X, Lebeche D, Huq F, Guerrero JL, Hajjar RJ. In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts. Cardiovasc Res. 2005 May 1; 66(2):318-23.
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    27. Lebeche D, Kaprielian R, del Monte F, Tomaselli G, Gwathmey JK, Schwartz A, Hajjar RJ. In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation. 2004 Nov 30; 110(22):3435-43.
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    28. Huq F, Lebeche D, Iyer V, Liao R, Hajjar RJ. Gene transfer of parvalbumin improves diastolic dysfunction in senescent myocytes. Circulation. 2004 Jun 8; 109(22):2780-5.
      View in: PubMed
    29. del Monte F, Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK, Hajjar RJ. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc Natl Acad Sci U S A. 2004 Apr 13; 101(15):5622-7.
      View in: PubMed
    30. Okafor CC, Perreault-Micale C, Hajjar RJ, Lebeche D, Skiroman K, Jabbour G, Doye AA, Lee MX, Laste N, Gwathmey JK. Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure. BMC Physiol. 2003 Jul 21; 3:6.
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    31. Communal C, Huq F, Lebeche D, Mestel C, Gwathmey JK, Hajjar RJ. Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes. Circulation. 2003 Mar 4; 107(8):1170-5.
      View in: PubMed
    32. del Monte F, Williams E, Lebeche D, Schmidt U, Rosenzweig A, Gwathmey JK, Lewandowski ED, Hajjar RJ. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure. Circulation. 2001 Sep 18; 104(12):1424-9.
      View in: PubMed
    33. Hajjar RJ, Schwinger RH, Schmidt U, Kim CS, Lebeche D, Doye AA, Gwathmey JK. Myofilament calcium regulation in human myocardium. Circulation. 2000 Apr 11; 101(14):1679-85.
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    34. Lebeche D, Malpel S, Cardoso WV. Fibroblast growth factor interactions in the developing lung. Mech Dev. 1999 Aug; 86(1-2):125-36.
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    35. Schmidt U, Hajjar RJ, Kim CS, Lebeche D, Doye AA, Gwathmey JK. Human heart failure: cAMP stimulation of SR Ca(2+)-ATPase activity and phosphorylation level of phospholamban. Am J Physiol. 1999 Aug; 277(2 Pt 2):H474-80.
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    36. Park WY, Miranda B, Lebeche D, Hashimoto G, Cardoso WV. FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev Biol. 1998 Sep 15; 201(2):125-34.
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    37. Lucero HA, Lebeche D, Kaminer B. ERcalcistorin/protein-disulfide isomerase acts as a calcium storage protein in the endoplasmic reticulum of a living cell. Comparison with calreticulin and calsequestrin. J Biol Chem. 1998 Apr 17; 273(16):9857-63.
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    38. Lucero HA, Lebeche D, Kaminer B. ERcalcistorin/protein disulfide isomerase (PDI). Sequence determination and expression of a cDNA clone encoding a calcium storage protein with PDI activity from endoplasmic reticulum of the sea urchin egg. J Biol Chem. 1994 Sep 16; 269(37):23112-9.
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    39. Lebeche D, Lucero HA, Kaminer B. Calcium binding properties of rabbit liver protein disulfide isomerase. Biochem Biophys Res Commun. 1994 Jul 15; 202(1):556-61.
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    40. Lebeche D, Kaminer B. Characterization of a calsequestrin-like protein from sea-urchin eggs. Biochem J. 1992 Nov 1; 287 ( Pt 3):741-7.
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    41. Henson JH, Begg DA, Beaulieu SM, Fishkind DJ, Bonder EM, Terasaki M, Lebeche D, Kaminer B. A calsequestrin-like protein in the endoplasmic reticulum of the sea urchin: localization and dynamics in the egg and first cell cycle embryo. J Cell Biol. 1989 Jul; 109(1):149-61.
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    42. Oberdorf JA, Lebeche D, Head JF, Kaminer B. Identification of a calsequestrin-like protein from sea urchin eggs. J Biol Chem. 1988 May 15; 263(14):6806-9.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067