Keywords
Last Name
Institution

Roger J. Hajjar

TitlePROFESSOR
InstitutionMount Sinai
DepartmentCardiology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pritchard TJ, Kawase Y, Haghighi K, Anjak A, Cai W, Jiang M, Nicolaou P, Pylar G, Karakikes I, Rapti K, Rubinstein J, Hajjar RJ, Kranias EG. Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts. PLoS One. 2013; 8(12):e80717.
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    2. Vandeput F, Szabo-Fresnais N, Ahmad F, Kho C, Lee A, Krall J, Dunlop A, Hazel MW, Wohlschlegel JA, Hajjar RJ, Houslay MD, Manganiello VC, Movsesian MA. Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms. Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49):19778-83.
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    3. Tilemann L, Lee A, Ishikawa K, Aguero J, Rapti K, Santos-Gallego C, Kohlbrenner E, Fish KM, Kho C, Hajjar RJ. SUMO-1 Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure. Sci Transl Med. 2013 Nov 13; 5(211):211ra159.
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    4. Gwathmey JK, Yerevanian A, Hajjar RJ. Targeting sarcoplasmic reticulum calcium ATPase by gene therapy. Hum Gene Ther. 2013 Nov; 24(11):937-47.
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    5. Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O, Giannarelli C, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R. Systems pharmacology of adverse event mitigation by drug combinations. Sci Transl Med. 2013 Oct 9; 5(206):206ra140.
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    6. Zsebo K, Yaroshinsky A, Rudy JJ, Wagner K, Greenberg B, Jessup M, Hajjar RJ. Long-Term Effects of AAV1/SERCA2a Gene Transfer in Patients With Severe Heart Failure: Analysis of Recurrent Cardiovascular Events and Mortality. Circ Res. 2014 Jan 3; 114(1):101-8.
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    7. Beaudoin J, Levine RA, Guerrero JL, Yosefy C, Sullivan S, Abedat S, Handschumacher MD, Szymanski C, Gilon D, Palmeri NO, Vlahakes GJ, Hajjar RJ, Beeri R. Late repair of ischemic mitral regurgitation does not prevent left ventricular remodeling: importance of timing for beneficial repair. Circulation. 2013 Sep 10; 128(11 Suppl 1):S248-52.
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    8. Chemaly ER, Kang S, Zhang S, McCollum L, Chen J, Bénard L, Purushothaman KR, Hajjar RJ, Lebeche D. Differential patterns of replacement and reactive fibrosis in pressure and volume overload are related to the propensity for ischaemia and involve resistin. J Physiol. 2013 Nov 1; 591(Pt 21):5337-55.
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    9. Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 2013 Nov; 34(35):8878-86.
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    10. Lipskaia L, Hadri L, Lopez JJ, Hajjar RJ, Bobe R. Benefit of SERCA2a gene transfer to vascular endothelial and smooth muscle cells: a new aspect in therapy of cardiovascular diseases. Curr Vasc Pharmacol. 2013 Jul; 11(4):465-79.
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    11. Hadri L, Kratlian RG, Benard L, Maron BA, Dorfmüller P, Ladage D, Guignabert C, Ishikawa K, Aguero J, Ibanez B, Turnbull IC, Kohlbrenner E, Liang L, Zsebo K, Humbert M, Hulot JS, Kawase Y, Hajjar RJ, Leopold JA. Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension. Circulation. 2013 Jul 30; 128(5):512-23.
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    12. Fargnoli AS, Katz MG, Yarnall C, Isidro A, Petrov M, Steuerwald N, Ghosh S, Richardville KC, Hillesheim R, Williams RD, Kohlbrenner E, Stedman HH, Hajjar RJ, Bridges CR. Cardiac surgical delivery of the sarcoplasmic reticulum calcium ATPase rescues myocytes in ischemic heart failure. Ann Thorac Surg. 2013 Aug; 96(2):586-95.
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    13. Ishikawa K, Aguero J, Naim C, Fish K, Hajjar RJ. Percutaneous approaches for efficient cardiac gene delivery. J Cardiovasc Transl Res. 2013 Aug; 6(4):649-59.
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    14. Arias T, Chen J, Fayad ZA, Fuster V, Hajjar RJ, Chemaly ER. Comparison of echocardiographic measurements of left ventricular volumes to full volume magnetic resonance imaging in normal and diseased rats. J Am Soc Echocardiogr. 2013 Aug; 26(8):910-8.
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    15. Ladage D, Yaniz-Galende E, Rapti K, Ishikawa K, Tilemann L, Shapiro S, Takewa Y, Muller-Ehmsen J, Schwarz M, Garcia MJ, Sanz J, Hajjar RJ, Kawase Y. Stimulating myocardial regeneration with periostin Peptide in large mammals improves function post-myocardial infarction but increases myocardial fibrosis. PLoS One. 2013; 8(5):e59656.
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    16. Karakikes I, Chaanine AH, Kang S, Mukete BN, Jeong D, Zhang S, Hajjar RJ, Lebeche D. Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling. J Am Heart Assoc. 2013 Apr; 2(2):e000078.
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    17. Louis Jeune V, Joergensen JA, Hajjar RJ, Weber T. Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy. Hum Gene Ther Methods. 2013 Apr; 24(2):59-67.
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    18. Lompré AM, Hadri L, Merlet E, Keuylian Z, Mougenot N, Karakikes I, Chen J, Atassi F, Marchand A, Blaise R, Limon I, McPhee SW, Samulski RJ, Hajjar RJ, Lipskaia L. Efficient transduction of vascular smooth muscle cells with a translational AAV2.5 vector: a new perspective for in-stent restenosis gene therapy. Gene Ther. 2013 Sep; 20(9):901-12.
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    19. Chaanine AH, Gordon RE, Kohlbrenner E, Benard L, Jeong D, Hajjar RJ. Potential role of BNIP3 in cardiac remodeling, myocardial stiffness, and endoplasmic reticulum: mitochondrial calcium homeostasis in diastolic and systolic heart failure. Circ Heart Fail. 2013 May; 6(3):572-83.
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    20. Hajjar RJ, Hulot JS. Myocardial delivery of stromal cell-derived factor 1 in patients with ischemic heart disease: safe and promising. Circ Res. 2013 Mar 1; 112(5):746-7.
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    21. Naim C, Yerevanian A, Hajjar RJ. Gene therapy for heart failure: where do we stand? Curr Cardiol Rep. 2013 Feb; 15(2):333.
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    22. Chemaly ER, Hajjar RJ, Lipskaia L. Molecular targets of current and prospective heart failure therapies. Heart. 2013 Jul; 99(14):992-1003.
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    23. Hajjar RJ. Potential of gene therapy as a treatment for heart failure. J Clin Invest. 2013 Jan 2; 123(1):53-61.
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    24. Chen J, Petrov A, Yaniz-Galende E, Liang L, de Haas HJ, Narula J, Hajjar RJ. The impact of pressure overload on coronary vascular changes following myocardial infarction in rats. Am J Physiol Heart Circ Physiol. 2013 Mar 1; 304(5):H719-28.
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    25. Fish KM, Ladage D, Kawase Y, Karakikes I, Jeong D, Ly H, Ishikawa K, Hadri L, Tilemann L, Muller-Ehmsen J, Samulski RJ, Kranias EG, Hajjar RJ. AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling. Circ Heart Fail. 2013 Mar; 6(2):310-7.
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    26. Oh JG, Kim J, Jang SP, Nguen M, Yang DK, Jeong D, Park ZY, Park SG, Hajjar RJ, Park WJ. Decoy peptides targeted to protein phosphatase 1 inhibit dephosphorylation of phospholamban in cardiomyocytes. J Mol Cell Cardiol. 2013 Mar; 56:63-71.
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    27. Balderman JA, Lee HY, Mahoney CE, Handy DE, White K, Annis S, Lebeche D, Hajjar RJ, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. J Am Heart Assoc. 2012 Dec; 1(6):e003905.
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    28. Kho C, Lee A, Hajjar RJ. Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy. Nat Rev Cardiol. 2012 Dec; 9(12):717-33.
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    29. Hajjar RJ, Leri A, Wang Y. BCVS scientific conference 2012 meeting report. Circ Res. 2012 Oct 12; 111(9):1121-4.
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    30. Cutler MJ, Wan X, Plummer BN, Liu H, Deschenes I, Laurita KR, Hajjar RJ, Rosenbaum DS. Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart. Circulation. 2012 Oct 23; 126(17):2095-104.
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    31. Yaniz-Galende E, Chen J, Chemaly E, Liang L, Hulot JS, McCollum L, Arias T, Fuster V, Zsebo KM, Hajjar RJ. Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells. Circ Res. 2012 Nov 9; 111(11):1434-45.
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    32. Park CS, Cha H, Kwon EJ, Jeong D, Hajjar RJ, Kranias EG, Cho C, Park WJ, Kim do H. AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure. PLoS One. 2012; 7(8):e43282.
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    33. Chemaly ER, Chaanine AH, Sakata S, Hajjar RJ. Stroke volume-to-wall stress ratio as a load-adjusted and stiffness-adjusted indicator of ventricular systolic performance in chronic loading. J Appl Physiol (1985). 2012 Oct 15; 113(8):1267-84.
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    34. Kohlbrenner E, Henckaerts E, Rapti K, Gordon RE, Linden RM, Hajjar RJ, Weber T. Quantification of AAV particle titers by infrared fluorescence scanning of coomassie-stained sodium dodecyl sulfate-polyacrylamide gels. Hum Gene Ther Methods. 2012 Jun; 23(3):198-203.
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    35. Lipskaia L, Hadri L, Le Prince P, Esposito B, Atassi F, Liang L, Glorian M, Limon I, Lompre AM, Lehoux S, Hajjar RJ. SERCA2a gene transfer prevents intimal proliferation in an organ culture of human internal mammary artery. Gene Ther. 2013 Apr; 20(4):396-406.
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    36. Serrao GW, Turnbull IC, Ancukiewicz D, Kim do E, Kao E, Cashman TJ, Hadri L, Hajjar RJ, Costa KD. Myocyte-depleted engineered cardiac tissues support therapeutic potential of mesenchymal stem cells. Tissue Eng Part A. 2012 Jul; 18(13-14):1322-33.
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    37. Kranias EG, Hajjar RJ. Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circ Res. 2012 Jun 8; 110(12):1646-60.
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    38. Shimada YJ, Ishikawa K, Kawase Y, Ladage D, Tilemann L, Shiota T, Hajjar RJ. Comparison of left ventricular stroke volume assessment by two- and three-dimensional echocardiography in a swine model of acute myocardial infarction validated by thermodilution method. Echocardiography. 2012 Oct; 29(9):1091-5.
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    39. Larocca TJ, Jeong D, Kohlbrenner E, Lee A, Chen J, Hajjar RJ, Tarzami ST. CXCR4 gene transfer prevents pressure overload induced heart failure. J Mol Cell Cardiol. 2012 Aug; 53(2):223-32.
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    40. LaRocca TJ, Fabris F, Chen J, Benhayon D, Zhang S, McCollum L, Schecter AD, Cheung JY, Sobie EA, Hajjar RJ, Lebeche D. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-?B pathway. Am J Physiol Heart Circ Physiol. 2012 Aug 1; 303(3):H353-67.
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    41. Hulot JS, Senyei G, Hajjar RJ. Sarcoplasmic reticulum and calcium cycling targeting by gene therapy. Gene Ther. 2012 Jun; 19(6):596-9.
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    42. Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med. 2012 Apr 18; 4(130):130ra47.
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    43. Kairouz V, Lipskaia L, Hajjar RJ, Chemaly ER. Molecular targets in heart failure gene therapy: current controversies and translational perspectives. Ann N Y Acad Sci. 2012 Apr; 1254:42-50.
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    44. Merlet E, Lipskaia L, Marchand A, Hadri L, Mougenot N, Atassi F, Liang L, Hatem SN, Hajjar RJ, Lompré AM. A calcium-sensitive promoter construct for gene therapy. Gene Ther. 2013 Mar; 20(3):248-54.
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    45. Lyon AR, Nikolaev VO, Miragoli M, Sikkel MB, Paur H, Benard L, Hulot JS, Kohlbrenner E, Hajjar RJ, Peters NS, Korchev YE, Macleod KT, Harding SE, Gorelik J. Plasticity of surface structures and ß(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ Heart Fail. 2012 May 1; 5(3):357-65.
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    46. Oh JG, Jeong D, Cha H, Kim JM, Lifirsu E, Kim J, Yang DK, Park CS, Kho C, Park S, Yoo YJ, Kim do H, Kim J, Hajjar RJ, Park WJ. PICOT increases cardiac contractility by inhibiting PKC? activity. J Mol Cell Cardiol. 2012 Jul; 53(1):53-63.
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    47. Tilemann L, Ishikawa K, Weber T, Hajjar RJ. Gene therapy for heart failure. Circ Res. 2012 Mar 2; 110(5):777-93.
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    48. Kratlian RG, Hajjar RJ. Cardiac gene therapy: from concept to reality. Curr Heart Fail Rep. 2012 Mar; 9(1):33-9.
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    49. Karam EG, Salamoun MM, Mneimneh ZN, Fayyad JA, Karam AN, Hajjar R, Dimassi H, Nock MK, Kessler RC. War and first onset of suicidality: the role of mental disorders. Psychol Med. 2012 Oct; 42(10):2109-18.
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    50. Kumarswamy R, Lyon AR, Volkmann I, Mills AM, Bretthauer J, Pahuja A, Geers-Knörr C, Kraft T, Hajjar RJ, Macleod KT, Harding SE, Thum T. SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway. Eur Heart J. 2012 May; 33(9):1067-75.
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    51. Ishikawa K, Chemaly ER, Tilemann L, Fish K, Ladage D, Aguero J, Vahl T, Santos-Gallego C, Kawase Y, Hajjar RJ. Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dt(max) complementary or redundant? Am J Physiol Heart Circ Physiol. 2012 Apr 1; 302(7):H1423-8.
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    52. Chaanine AH, Jeong D, Liang L, Chemaly ER, Fish K, Gordon RE, Hajjar RJ. JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure. Cell Death Dis. 2012; 3:265.
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    53. Ishikawa K, Kawase Y, Ladage D, Chemaly ER, Tilemann L, Fish K, Sanz J, Garcia MJ, Hajjar RJ. Temporal changes of strain parameters in the progress of chronic ischemia: with comparison to transmural infarction. Int J Cardiovasc Imaging. 2012 Oct; 28(7):1671-81.
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    54. Karakikes I, Hadri L, Rapti K, Ladage D, Ishikawa K, Tilemann L, Yi GH, Morel C, Gwathmey JK, Zsebo K, Weber T, Kawase Y, Hajjar RJ. Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer in porcine hearts. Mol Ther. 2012 Mar; 20(3):565-71.
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    55. Hajjar RJ, Cormode DP. Tracking cell therapy: bioluminescence lighting the way. JACC Cardiovasc Imaging. 2012 Jan; 5(1):56-8.
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    56. Lee SH, Kim J, Ryu JY, Lee S, Yang DK, Jeong D, Kim J, Lee SH, Kim JM, Hajjar RJ, Park WJ. Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. J Mol Cell Cardiol. 2012 Mar; 52(3):718-26.
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    57. Fu JD, Rushing SN, Lieu DK, Chan CW, Kong CW, Geng L, Wilson KD, Chiamvimonvat N, Boheler KR, Wu JC, Keller G, Hajjar RJ, Li RA. Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS One. 2011; 6(11):e27417.
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    58. Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M. Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Adv Mater. 2011 Dec 22; 23(48):5785-91.
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    59. Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ. Inhibition of PKCa/ß with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. Circ Res. 2011 Dec 9; 109(12):1396-400.
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    60. Ishikawa K, Tilemann L, Fish K, Hajjar RJ. Gene delivery methods in cardiac gene therapy. J Gene Med. 2011 Oct; 13(10):566-72.
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    61. Hulot JS, Hajjar R, Montalescot G. Clopidogrel and CYP2C19 testing: ready for clinical prime time? Clin Chem. 2012 Jan; 58(1):154-7.
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    62. Rapti K, Louis-Jeune V, Kohlbrenner E, Ishikawa K, Ladage D, Zolotukhin S, Hajjar RJ, Weber T. Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models. Mol Ther. 2012 Jan; 20(1):73-83.
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    63. Kho C, Lee A, Jeong D, Oh JG, Chaanine AH, Kizana E, Park WJ, Hajjar RJ. SUMO1-dependent modulation of SERCA2a in heart failure. Nature. 2011 Sep 29; 477(7366):601-5.
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    64. Shin JH, Bostick B, Yue Y, Hajjar R, Duan D. SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice. J Transl Med. 2011; 9:132.
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    65. Hadri L, Hajjar RJ. Calcium cycling proteins and their association with heart failure. Clin Pharmacol Ther. 2011 Oct; 90(4):620-4.
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    66. Hulot JS, Fauconnier J, Ramanujam D, Chaanine A, Aubart F, Sassi Y, Merkle S, Cazorla O, Ouillé A, Dupuis M, Hadri L, Jeong D, Mühlstedt S, Schmitt J, Braun A, Bénard L, Saliba Y, Laggerbauer B, Nieswandt B, Lacampagne A, Hajjar RJ, Lompré AM, Engelhardt S. Critical role for stromal interaction molecule 1 in cardiac hypertrophy. Circulation. 2011 Aug 16; 124(7):796-805.
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    67. Turnbull IC, Hadri L, Rapti K, Sadek M, Liang L, Shin HJ, Costa KD, Marin ML, Hajjar RJ, Faries PL. Aortic implantation of mesenchymal stem cells after aneurysm injury in a porcine model. J Surg Res. 2011 Sep; 170(1):e179-88.
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    68. Chaanine AH, Hajjar RJ. AKT signalling in the failing heart. Eur J Heart Fail. 2011 Aug; 13(8):825-9.
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    69. Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H, Hajjar RJ. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation. 2011 Jul 19; 124(3):304-13.
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    70. Chen J, Chemaly ER, Liang LF, LaRocca TJ, Yaniz-Galende E, Hajjar RJ. A new model of congestive heart failure in rats. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H994-1003.
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    71. Ishikawa K, Ladage D, Tilemann L, Fish K, Kawase Y, Hajjar RJ. Gene transfer for ischemic heart failure in a preclinical model. J Vis Exp. 2011; (51).
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    72. Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ, Kawase Y. Development of a preclinical model of ischemic cardiomyopathy in swine. Am J Physiol Heart Circ Physiol. 2011 Aug; 301(2):H530-7.
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    73. Rapti K, Chaanine AH, Hajjar RJ. Targeted gene therapy for the treatment of heart failure. Can J Cardiol. 2011 May-Jun; 27(3):265-83.
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    74. Chemaly ER, Hadri L, Zhang S, Kim M, Kohlbrenner E, Sheng J, Liang L, Chen J, K-Raman P, Hajjar RJ, Lebeche D. Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats. J Mol Cell Cardiol. 2011 Aug; 51(2):144-55.
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    75. Borah JC, Mujtaba S, Karakikes I, Zeng L, Muller M, Patel J, Moshkina N, Morohashi K, Zhang W, Gerona-Navarro G, Hajjar RJ, Zhou MM. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22; 18(4):531-41.
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    76. Ladage D, Turnbull IC, Ishikawa K, Takewa Y, Rapti K, Morel C, Karakikes I, Hadri L, Müller-Ehmsen J, Costa KD, Hajjar RJ, Kawase Y. Delivery of gelfoam-enabled cells and vectors into the pericardial space using a percutaneous approach in a porcine model. Gene Ther. 2011 Oct; 18(10):979-85.
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    77. Chen J, Lee SK, Abd-Elgaliel WR, Liang L, Galende EY, Hajjar RJ, Tung CH. Assessment of cardiovascular fibrosis using novel fluorescent probes. PLoS One. 2011; 6(4):e19097.
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    78. Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. J Mol Cell Cardiol. 2011 Jul; 51(1):4-15.
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    79. Kang S, Chemaly ER, Hajjar RJ, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011 May 27; 286(21):18465-73.
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    80. Ishikawa K, Ladage D, Tilemann L, Kawase Y, Hajjar RJ. Sterile abscess in the myocardium after direct intramyocardial injection related to gene therapy in a Swine model. ISRN Cardiol. 2011; 2011:319453.
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    81. Lyon AR, Bannister ML, Collins T, Pearce E, Sepehripour AH, Dubb SS, Garcia E, O'Gara P, Liang L, Kohlbrenner E, Hajjar RJ, Peters NS, Poole-Wilson PA, Macleod KT, Harding SE. SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circ Arrhythm Electrophysiol. 2011 Jun; 4(3):362-72.
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    82. Kawase Y, Ladage D, Hajjar RJ. Rescuing the failing heart by targeted gene transfer. J Am Coll Cardiol. 2011 Mar 8; 57(10):1169-80.
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    83. Cimmino G, Giannarelli C, Chen W, Alique M, Santos-Gallego CG, Fuster V, Hajjar RJ, Walsh CE, Badimon JJ. Adeno-associated virus serotype 8 ApoA-I gene transfer reduces progression of atherosclerosis in ApoE-KO mice: comparison of intramuscular and intravenous administration. J Cardiovasc Pharmacol. 2011 Mar; 57(3):325-33.
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    84. Goonasekera SA, Lam CK, Millay DP, Sargent MA, Hajjar RJ, Kranias EG, Molkentin JD. Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. J Clin Invest. 2011 Mar; 121(3):1044-52.
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    85. Kawase Y, Ladage D, Hajjar RJ. Method of gene delivery in large animal models of cardiovascular diseases. Methods Mol Biol. 2011; 709:355-67.
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    86. Bobe R, Hadri L, Lopez JJ, Sassi Y, Atassi F, Karakikes I, Liang L, Limon I, Lompré AM, Hatem SN, Hajjar RJ, Lipskaia L. SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells. J Mol Cell Cardiol. 2011 Apr; 50(4):621-33.
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    87. Gwathmey JK, Yerevanian AI, Hajjar RJ. Cardiac gene therapy with SERCA2a: from bench to bedside. J Mol Cell Cardiol. 2011 May; 50(5):803-12.
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    88. LaRocca TJ, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, Alvin Z, Champion HC, Haddad G, Hajjar RJ, Devi LA, Schecter AD, Tarzami ST. ß2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4. J Cardiovasc Pharmacol. 2010 Nov; 56(5):548-59.
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    89. Hajjar RJ, Akar FG. Regression of cardiac hypertrophy by cyclic guanosine monophosphate-dependent protein kinase signaling are myocytes active sources or mere beneficiaries? J Am Coll Cardiol. 2010 Dec 7; 56(24):2031-2.
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    90. Ishikawa K, Ladage D, Rapti K, Fernandez-Friera L, Maria Garcia-Lopez A, Sanz J, Hajjar RJ, Kawase Y, Garcia MJ. Multimodality imaging of chronic ischemia. Cardiol Res Pract. 2010; 2011:739702.
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    91. Peña JR, Szkudlarek AC, Warren CM, Heinrich LS, Gaffin RD, Jagatheesan G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM. Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2010 Dec; 49(6):993-1002.
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    92. Beeri R, Chaput M, Guerrero JL, Kawase Y, Yosefy C, Abedat S, Karakikes I, Morel C, Tisosky A, Sullivan S, Handschumacher MD, Gilon D, Vlahakes GJ, Hajjar RJ, Levine RA. Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation. Circ Heart Fail. 2010 Sep; 3(5):627-34.
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    93. Njeim MT, Hajjar RJ. Gene therapy for heart failure. Arch Cardiovasc Dis. 2010 Aug-Sep; 103(8-9):477-85.
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    189. Harding SE, del Monte F, Hajjar RJ. Antisense strategies for treatment of heart failure. Methods Mol Med. 2005; 106:69-82.
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    190. Antoun JG, Hajjar RJ. Gene and cell therapy in heart failure. J Med Liban. 2005 Jan-Mar; 53(1):28-38.
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    191. Bukhari F, MacGillivray T, del Monte F, Hajjar RJ. Genetic maneuvers to ameliorate ventricular function in heart failure: therapeutic potential and future implications. Expert Rev Cardiovasc Ther. 2005 Jan; 3(1):85-97.
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    192. Grazette LP, Boecker W, Matsui T, Semigran M, Force TL, Hajjar RJ, Rosenzweig A. Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. J Am Coll Cardiol. 2004 Dec 7; 44(11):2231-8.
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    193. Frangioni JV, Hajjar RJ. In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation. 2004 Nov 23; 110(21):3378-83.
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    194. Lebeche D, Kaprielian R, del Monte F, Tomaselli G, Gwathmey JK, Schwartz A, Hajjar RJ. In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation. 2004 Nov 30; 110(22):3435-43.
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    195. Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, del Monte F, Hajjar RJ, Linke WA. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res. 2004 Oct 1; 95(7):708-16.
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    196. del Monte F, Kizana E, Tabchy A, Hajjar RJ. Targeted gene transfer in heart failure: implications for novel gene identification. Curr Opin Mol Ther. 2004 Aug; 6(4):381-94.
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    197. Del Monte F, Dalal R, Tabchy A, Couget J, Bloch KD, Peterson R, Hajjar RJ. Transcriptional changes following restoration of SERCA2a levels in failing rat hearts. FASEB J. 2004 Sep; 18(12):1474-6.
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    198. Huq F, Lebeche D, Iyer V, Liao R, Hajjar RJ. Gene transfer of parvalbumin improves diastolic dysfunction in senescent myocytes. Circulation. 2004 Jun 8; 109(22):2780-5.
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    199. Boecker W, Bernecker OY, Wu JC, Zhu X, Sawa T, Grazette L, Rosenzweig A, del Monte F, Schmidt U, Hajjar RJ. Cardiac-specific gene expression facilitated by an enhanced myosin light chain promoter. Mol Imaging. 2004 Apr; 3(2):69-75.
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    200. del Monte F, Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK, Hajjar RJ. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc Natl Acad Sci U S A. 2004 Apr 13; 101(15):5622-7.
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    201. Chaudhri BB, del Monte F, Harding SE, Hajjar RJ. Gene transfer in cardiac myocytes. Surg Clin North Am. 2004 Feb; 84(1):141-59, ix-x.
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    202. Opitz CA, Kulke M, Leake MC, Neagoe C, Hinssen H, Hajjar RJ, Linke WA. Damped elastic recoil of the titin spring in myofibrils of human myocardium. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12688-93.
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    203. Chaudhri B, del Monte F, Hajjar RJ, Harding SE. Contractile effects of adenovirally-mediated increases in SERCA2a activity: a comparison between adult rat and rabbit ventricular myocytes. Mol Cell Biochem. 2003 Sep; 251(1-2):103-9.
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    204. Okafor CC, Perreault-Micale C, Hajjar RJ, Lebeche D, Skiroman K, Jabbour G, Doye AA, Lee MX, Laste N, Gwathmey JK. Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure. BMC Physiol. 2003 Jul 21; 3:6.
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    205. Bernecker OY, del Monte F, Hajjar RJ. Gene therapy for the treatment of heart failure--calcium signaling. Semin Thorac Cardiovasc Surg. 2003 Jul; 15(3):268-76.
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    206. Heist EK, Huq F, Hajjar R. Telomerase and the aging heart. Sci Aging Knowledge Environ. 2003 May 14; 2003(19):PE11.
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    207. MacNeill BD, Hayase M, Hajjar RJ. Targeting signaling pathways in heart failure by gene transfer. Curr Atheroscler Rep. 2003 May; 5(3):178-85.
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    208. Communal C, Huq F, Lebeche D, Mestel C, Gwathmey JK, Hajjar RJ. Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes. Circulation. 2003 Mar 4; 107(8):1170-5.
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    209. Hajjar RJ, Huq F, Matsui T, Rosenzweig A. Genetic editing of dysfunctional myocardium. Med Clin North Am. 2003 Mar; 87(2):553-67.
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    210. Okafor CC, Saunders L, Li X, Ito T, Dixon M, Stepenek A, Hajjar RJ, Wood JR, Doye AA, Gwathmey JK. Myofibrillar responsiveness to cAMP, PKA, and caffeine in an animal model of heart failure. Biochem Biophys Res Commun. 2003 Jan 10; 300(2):592-9.
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    211. del Monte F, Hajjar RJ. Efficient viral gene transfer to rodent hearts in vivo. Methods Mol Biol. 2003; 219:179-93.
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    212. del Monte F, Hajjar RJ. Targeting calcium cycling proteins in heart failure through gene transfer. J Physiol. 2003 Jan 1; 546(Pt 1):49-61.
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    213. Bernecker OY, Huq F, Heist EK, Podesser BK, Hajjar RJ. Apoptosis in heart failure and the senescent heart. Cardiovasc Toxicol. 2003; 3(3):183-90.
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    214. Huq F, Heist EK, Hajjar RJ. Titin--springing back to youth? Sci Aging Knowledge Environ. 2002 Dec 11; 2002(49):pe20.
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    215. Huq F, Del Monte F, Hajjar RJ. Modulating signaling pathways in hypertrophy and heart failure by gene transfer. J Card Fail. 2002 Dec; 8(6 Suppl):S389-400.
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    216. Hajjar RJ, MacRae CA. Adrenergic-receptor polymorphisms and heart failure. N Engl J Med. 2002 Oct 10; 347(15):1196-9.
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    217. Beeri R, Guerrero JL, Supple G, Sullivan S, Levine RA, Hajjar RJ. New efficient catheter-based system for myocardial gene delivery. Circulation. 2002 Oct 1; 106(14):1756-9.
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    218. Nakayama A, del Monte F, Hajjar RJ, Frangioni JV. Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy. Mol Imaging. 2002 Oct; 1(4):365-77.
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    219. Neagoe C, Kulke M, del Monte F, Gwathmey JK, de Tombe PP, Hajjar RJ, Linke WA. Titin isoform switch in ischemic human heart disease. Circulation. 2002 Sep 10; 106(11):1333-41.
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    220. Chaudhri B, Del Monte F, Hajjar RJ, Harding SE. Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2450-7.
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    221. Terracciano CM, Hajjar RJ, Harding SE. Overexpression of SERCA2a accelerates repolarisation in rabbit ventricular myocytes. Cell Calcium. 2002 Jun; 31(6):299-305.
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    222. Carr AN, Schmidt AG, Suzuki Y, del Monte F, Sato Y, Lanner C, Breeden K, Jing SL, Allen PB, Greengard P, Yatani A, Hoit BD, Grupp IL, Hajjar RJ, DePaoli-Roach AA, Kranias EG. Type 1 phosphatase, a negative regulator of cardiac function. Mol Cell Biol. 2002 Jun; 22(12):4124-35.
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    223. Hajjar RJ, Kradin RL. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17-2002. A 55-year-old man with second-degree atrioventricular block and chest pain. N Engl J Med. 2002 May 30; 346(22):1732-8.
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    224. Communal C, Sumandea M, de Tombe P, Narula J, Solaro RJ, Hajjar RJ. Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6252-6.
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    225. Ranu HK, Terracciano CM, Davia K, Bernobich E, Chaudhri B, Robinson SE, Bin Kang Z, Hajjar RJ, MacLeod KT, Harding SE. Effects of Na(+)/Ca(2+)-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes. J Mol Cell Cardiol. 2002 Apr; 34(4):389-400.
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    226. Kassiri Z, Hajjar R, Backx PH. Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes. J Mol Med (Berl). 2002 Jun; 80(6):351-8.
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    227. del Monte F, Harding SE, Dec GW, Gwathmey JK, Hajjar RJ. Targeting phospholamban by gene transfer in human heart failure. Circulation. 2002 Feb 26; 105(8):904-7.
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    228. Kaprielian R, del Monte F, Hajjar RJ. Targeting Ca2+ cycling proteins and the action potential in heart failure by gene transfer. Basic Res Cardiol. 2002; 97 Suppl 1:I136-45.
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    229. Del Monte F, Butler K, Boecker W, Gwathmey JK, Hajjar RJ. Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure. Physiol Genomics. 2002; 9(1):49-56.
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    230. Washington B, Butler K, Doye AA, Jang M, Hajjar RJ, Gwathmey JK. Heart function challenged with beta-receptor agonism or antagonism in a heart failure model. Cardiovasc Drugs Ther. 2001 Nov; 15(6):479-86.
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    231. del Monte F, Williams E, Lebeche D, Schmidt U, Rosenzweig A, Gwathmey JK, Lewandowski ED, Hajjar RJ. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure. Circulation. 2001 Sep 18; 104(12):1424-9.
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    232. Kuhlencordt PJ, Gyurko R, Han F, Scherrer-Crosbie M, Aretz TH, Hajjar R, Picard MH, Huang PL. Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation. 2001 Jul 24; 104(4):448-54.
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    233. Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, Force TL, Franke TF, Hajjar RJ, Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 2001 Jul 17; 104(3):330-5.
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    234. del Monte F, Hajjar RJ, Harding SE. Overwhelming evidence of the beneficial effects of SERCA gene transfer in heart failure. Circ Res. 2001 Jun 8; 88(11):E66-7.
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    235. Davia K, Bernobich E, Ranu HK, del Monte F, Terracciano CM, MacLeod KT, Adamson DL, Chaudhri B, Hajjar RJ, Harding SE. SERCA2A overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes. J Mol Cell Cardiol. 2001 May; 33(5):1005-15.
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    236. De Windt LJ, Lim HW, Bueno OF, Liang Q, Delling U, Braz JC, Glascock BJ, Kimball TF, del Monte F, Hajjar RJ, Molkentin JD. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3322-7.
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    237. Haq S, Choukroun G, Lim H, Tymitz KM, del Monte F, Gwathmey J, Grazette L, Michael A, Hajjar R, Force T, Molkentin JD. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation. 2001 Feb 6; 103(5):670-7.
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    238. Griffin JL, O'Donnell JM, White LT, Hajjar RJ, Lewandowski ED. Postnatal expression and activity of the mitochondrial 2-oxoglutarate-malate carrier in intact hearts. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1704-9.
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    239. Haq S, Choukroun G, Kang ZB, Ranu H, Matsui T, Rosenzweig A, Molkentin JD, Alessandrini A, Woodgett J, Hajjar R, Michael A, Force T. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol. 2000 Oct 2; 151(1):117-30.
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    240. Choukroun GJ, Marshansky V, Gustafson CE, McKee M, Hajjar RJ, Rosenzweig A, Brown D, Bonventre JV. Cytosolic phospholipase A(2) regulates golgi structure and modulates intracellular trafficking of membrane proteins. J Clin Invest. 2000 Oct; 106(8):983-93.
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    241. Hajjar RJ, Schwinger RH, Schmidt U, Kim CS, Lebeche D, Doye AA, Gwathmey JK. Myofilament calcium regulation in human myocardium. Circulation. 2000 Apr 11; 101(14):1679-85.
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    242. Pereira N, Parisi A, Dec GW, Choo J, Hajjar R, Gordon PC. Myocardial stunning in hyperthyroidism. Clin Cardiol. 2000 Apr; 23(4):298-300.
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    243. Hajjar RJ, del Monte F, Matsui T, Rosenzweig A. Prospects for gene therapy for heart failure. Circ Res. 2000 Mar 31; 86(6):616-21.
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    244. Hajjar RJ. The promise of gene therapy as a therapeutic modality in heart failure. J Med Liban. 2000 Mar-Apr; 48(2):86-8.
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    245. Schmidt U, del Monte F, Miyamoto MI, Matsui T, Gwathmey JK, Rosenzweig A, Hajjar RJ. Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase. Circulation. 2000 Feb 22; 101(7):790-6.
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    246. Miyamoto MI, del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T, Guerrero JL, Gwathmey JK, Rosenzweig A, Hajjar RJ. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):793-8.
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    247. Lee KH, Hajjar RJ, Matsui T, Choukroun G, Force TL, Rosenzweig A. Cardiac signal transduction. J Nucl Cardiol. 2000 Jan-Feb; 7(1):63-71.
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    248. Matsui T, Li L. Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 1999 Dec 7; 100(23):2373-9.
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    249. Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation. 1999 Dec 7; 100(23):2308-11.
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    250. Morris N, Kim CS, Doye AA, Hajjar RJ, Laste N, Gwathmey JK. A pilot study of a new chicken model of alcohol-induced cardiomyopathy. Alcohol Clin Exp Res. 1999 Oct; 23(10):1668-72.
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    251. Davia K, Hajjar RJ, Terracciano CM, Kent NS, Ranu HK, O'Gara P, Rosenzweig A, Harding SE. Functional alterations in adult rat myocytes after overexpression of phospholamban with use of adenovirus. Physiol Genomics. 1999 Aug 31; 1(2):41-50.
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    252. Choukroun G, Hajjar R, Fry S, del Monte F, Haq S, Guerrero JL, Picard M, Rosenzweig A, Force T. Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases. J Clin Invest. 1999 Aug; 104(4):391-8.
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    253. Schmidt U, Hajjar RJ, Kim CS, Lebeche D, Doye AA, Gwathmey JK. Human heart failure: cAMP stimulation of SR Ca(2+)-ATPase activity and phosphorylation level of phospholamban. Am J Physiol. 1999 Aug; 277(2 Pt 2):H474-80.
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    254. Miyamoto MI, Kim CS, Guerrero JL, Rosenzweig A, Gwathmey JK, Hajjar RJ. Ventricular pressure and dimension measurements in mice. Lab Anim Sci. 1999 Jun; 49(3):305-7.
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    255. Gwathmey JK, Kim CS, Hajjar RJ, Khan F, DiSalvo TG, Matsumori A, Bristow MR. Cellular and molecular remodeling in a heart failure model treated with the beta-blocker carteolol. Am J Physiol. 1999 May; 276(5 Pt 2):H1678-90.
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    256. Force T, Rosenzweig A, Choukroun G, Hajjar R. Calcineurin inhibitors and cardiac hypertrophy. Lancet. 1999 Apr 17; 353(9161):1290-2.
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    257. Force T, Hajjar R, Del Monte F, Rosenzweig A, Choukroun G. Signaling pathways mediating the response to hypertrophic stress in the heart. Gene Expr. 1999; 7(4-6):337-48.
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    258. Narula J, Hajjar RJ, Dec GW. Apoptosis in the failing heart. Cardiol Clin. 1998 Nov; 16(4):691-710, ix.
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    259. Perry HM, Bernard M, Horowitz M, Miller DK, Fleming S, Baker MZ, Flaherty J, Purushothaman R, Hajjar R, Kaiser FE, Patrick P, Morley JE. The effect of aging on bone mineral metabolism and bone mass in Native American women. J Am Geriatr Soc. 1998 Nov; 46(11):1418-22.
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    260. Meadows KN, Hajjar RJ, Gwathmey JK. Effects of pH and temperature on myocardial calcium-activation in Pterygoplichthys (catfish). J Comp Physiol B. 1998 Oct; 168(7):526-32.
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    261. Schmidt U, Hajjar RJ, Helm PA, Kim CS, Doye AA, Gwathmey JK. Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure. J Mol Cell Cardiol. 1998 Oct; 30(10):1929-37.
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    262. Hajjar RJ, Müller FU, Schmitz W, Schnabel P, Böhm M. Molecular aspects of adrenergic signal transduction in cardiac failure. J Mol Med (Berl). 1998 Oct; 76(11):747-55.
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    263. Choukroun G, Hajjar R, Kyriakis JM, Bonventre JV, Rosenzweig A, Force T. Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy. J Clin Invest. 1998 Oct 1; 102(7):1311-20.
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    264. Hajjar RJ, Schmidt U, Matsui T, Guerrero JL, Lee KH, Gwathmey JK, Dec GW, Semigran MJ, Rosenzweig A. Modulation of ventricular function through gene transfer in vivo. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5251-6.
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    265. Morley JE, Kaiser FE, Sih R, Hajjar R, Perry HM. Testosterone and frailty. Clin Geriatr Med. 1997 Nov; 13(4):685-95.
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    266. Hajjar RJ, DiSalvo TG, Schmidt U, Thaiyananthan G, Semigran MJ, Dec GW, Gwathmey JK. Clinical correlates of the myocardial force-frequency relationship in patients with end-stage heart failure. J Heart Lung Transplant. 1997 Nov; 16(11):1157-67.
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    267. Hajjar RJ, Schmidt U, Kang JX, Matsui T, Rosenzweig A. Adenoviral gene transfer of phospholamban in isolated rat cardiomyocytes. Rescue effects by concomitant gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase. Circ Res. 1997 Aug; 81(2):145-53.
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    268. Hajjar RJ, Kang JX, Gwathmey JK, Rosenzweig A. Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes. Circulation. 1997 Jan 21; 95(2):423-9.
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    269. Hajjar RJ, Schmidt U, Helm P, Gwathmey JK. Ca++ sensitizers impair cardiac relaxation in failing human myocardium. J Pharmacol Exp Ther. 1997 Jan; 280(1):247-54.
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    270. Kagaya Y, Hajjar RJ, Gwathmey JK, Barry WH, Lorell BH. Long-term angiotensin-converting enzyme inhibition with fosinopril improves depressed responsiveness to Ca2+ in myocytes from aortic-banded rats. Circulation. 1996 Dec 1; 94(11):2915-22.
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    271. Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec GW, Khaw BA. Apoptosis in myocytes in end-stage heart failure. N Engl J Med. 1996 Oct 17; 335(16):1182-9.
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    272. Paige JA, Liao R, Hajjar RJ, Foisy RL, Cory CR, O'Brien PJ, Gwathmey JK. Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss. Cardiovasc Res. 1996 Feb; 31(2):249-62.
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    273. Hajjar RJ, Rose GA, Madsen JC, Levine RA, DeSanctis RW. Extrapericardial cardiac tamponade after blunt chest trauma. Am Heart J. 1995 Sep; 130(3 Pt 1):620-1.
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    274. Schmidt U, Hajjar RJ, Gwathmey JK. The force-interval relationship in human myocardium. J Card Fail. 1995 Sep; 1(4):311-21.
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    275. Gwathmey JK, Liao R, Helm PA, Thaiyananthan G, Hajjar RJ. Is contractility depressed in the failing human heart? Cardiovasc Drugs Ther. 1995 Aug; 9(4):581-7.
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    276. Liao R, Helm PA, Hajjar RJ, Saha C, Gwathmey JK. [Ca2+]i in human heart failure: a review and discussion of current areas of controversy. Yale J Biol Med. 1994 Sep-Dec; 67(5-6):247-64.
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    277. Hajjar RJ, Ingwall JS, Gwathmey JK. Mechanism of action of 2,3-butanedione monoxime on contracture during metabolic inhibition. Am J Physiol. 1994 Jul; 267(1 Pt 2):H100-8.
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    278. Hajjar RJ, Liao R, Young JB, Fuleihan F, Glass MG, Gwathmey JK. Pathophysiological and biochemical characterisation of an avian model of dilated cardiomyopathy: comparison to findings in human dilated cardiomyopathy. Cardiovasc Res. 1993 Dec; 27(12):2212-21.
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    279. Glass MG, Fuleihan F, Liao R, Lincoff AM, Chapados R, Hamlin R, Apstein CS, Allen PD, Ingwall JS, Hajjar RJ, et al. Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force. Circ Res. 1993 Dec; 73(6):1077-89.
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    280. Gwathmey JK, Hajjar RJ. Calcium-activated force in a turkey model of spontaneous dilated cardiomyopathy: adaptive changes in thin myofilament Ca2+ regulation with resultant implications on contractile performance. J Mol Cell Cardiol. 1992 Dec; 24(12):1459-70.
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    281. Hajjar RJ, Gwathmey JK. Cross-bridge dynamics in human ventricular myocardium. Regulation of contractility in the failing heart. Circulation. 1992 Dec; 86(6):1819-26.
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    282. Hajjar RJ, Grossman W, Gwathmey JK. Responsiveness of the myofilaments to Ca2+ in human heart failure: implications for Ca2+ and force regulation. Basic Res Cardiol. 1992; 87 Suppl 1:143-59.
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    283. Hajjar RJ, Gwathmey JK. Calcium-sensitizing inotropic agents in the treatment of heart failure: a critical view. Cardiovasc Drugs Ther. 1991 Dec; 5(6):961-5.
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    284. Hajjar RJ, Bonventre JV. Oscillations of intracellular calcium induced by vasopressin in individual fura-2-loaded mesangial cells. Frequency dependence on basal calcium concentration, agonist concentration, and temperature. J Biol Chem. 1991 Nov 15; 266(32):21589-94.
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    285. Gwathmey JK, Hajjar RJ, Solaro RJ. Contractile deactivation and uncoupling of crossbridges. Effects of 2,3-butanedione monoxime on mammalian myocardium. Circ Res. 1991 Nov; 69(5):1280-92.
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    286. Force T, Hyman G, Hajjar R, Sellmayer A, Bonventre JV. Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. J Biol Chem. 1991 Mar 5; 266(7):4295-302.
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    287. Hajjar RJ, Gwathmey JK. Modulation of calcium-activation in control and pressure--overload hypertrophied ferret hearts: effect of DPI 201-106 on myofilament calcium responsiveness. J Mol Cell Cardiol. 1991 Jan; 23(1):65-75.
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    288. Gwathmey JK, Hajjar RJ. Protein kinase C activation in human ventricular myocardium. Biorheology. 1991; 28(3-4):151-60.
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    289. Gwathmey JK, Hajjar RJ. Relation between steady-state force and intracellular [Ca2+] in intact human myocardium. Index of myofibrillar responsiveness to Ca2+. Circulation. 1990 Oct; 82(4):1266-78.
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    290. Hajjar RJ, Gwathmey JK. Direct evidence of changes in myofilament responsiveness to Ca2+ during hypoxia and reoxygenation in myocardium. Am J Physiol. 1990 Sep; 259(3 Pt 2):H784-95.
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    291. Gwathmey JK, Hajjar RJ. Intracellular calcium related to force development in twitch contraction of mammalian myocardium. Cell Calcium. 1990 Sep; 11(8):531-8.
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    292. Gwathmey JK, Hajjar RJ. Effect of protein kinase C activation on sarcoplasmic reticulum function and apparent myofibrillar Ca2+ sensitivity in intact and skinned muscles from normal and diseased human myocardium. Circ Res. 1990 Sep; 67(3):744-52.
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    293. Gwathmey JK, Slawsky MT, Hajjar RJ, Briggs GM, Morgan JP. Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium. J Clin Invest. 1990 May; 85(5):1599-613.
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    294. Hajjar RJ, Gwathmey JK, Briggs GM, Morgan JP. Differential effect of DPI 201-106 on the sensitivity of the myofilaments to Ca2+ in intact and skinned trabeculae from control and myopathic human hearts. J Clin Invest. 1988 Nov; 82(5):1578-84.
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    295. Lormeau JC, Hajjar R. [A method of assay of the anti-factor Xa activity of CY 216]. Pathol Biol (Paris). 1988 Apr; 36(4):335-7.
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    296. Bienvenu P, Hajjar R, Fontanges R. [About proteinic impurities checking in a meningococcal vaccine. Mannitol interference in the Lowry protein determination (author's transl)]. Ann Pharm Fr. 1978; 36(5-6):263-8.
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    297. Diamant-Berger F, Haas C, Kieffer JP, Abry B, Hajjar R, Desnot F, Piwnica A, Dubost C. [Hemodynamic aspect of post ECC cardiac failures. Study of 193 cases]. Ann Anesthesiol Fr. 1977; 18(1):81-93.
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    298. Hajjar R. Diabetic ketoacidosis and influenza. Br Med J. 1971 Apr 3; 2(5752):46.
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    299. Hajjar R, Sattler F, Anderson BG, Gwinup G. Definition of the stimulus to secretion of the nasal salt gland of the sea gull. Horm Metab Res. 1970 Jan; 2(1):35-7.
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    Hajjar's Networks
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