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Last Name
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Ross L. Cagan

TitleASSOCIATE DEAN OF THE GRADUATE SCHOOL OF BIOLOGICAL SCIENCES
InstitutionMount Sinai
Address
    Other Positions
    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentDevelopmental and Regenerative Biology

    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentOncological Sciences

    TitlePROFESSOR
    InstitutionMount Sinai
    DepartmentOphthalmology


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Das TK, Dana D, Paroly SS, Perumal SK, Singh S, Jhun H, Pendse J, Cagan RL, Talele TT, Kumar S. Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis. Oncogenesis. 2013; 2:e69.
      View in: PubMed
    2. Hirabayashi S, Baranski TJ, Cagan RL. Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell. 2013 Aug 1; 154(3):664-75.
      View in: PubMed
    3. Cagan R. The San Francisco Declaration on Research Assessment. Dis Model Mech. 2013 Jul; 6(4):869-70.
      View in: PubMed
    4. Cagan RL, Justice MJ, Tidmarsh GF. Bridging the gap between basic and applied biology: towards preclinical translation. Dis Model Mech. 2013 May; 6(3):559-61.
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    5. Cagan R. Bench to bedside with fruit flies: an interview with Ross Cagan. Dis Model Mech. 2013 May; 6(3):567-9.
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    6. Pendse J, Ramachandran PV, Na J, Narisu N, Fink JL, Cagan RL, Collins FS, Baranski TJ. A Drosophila functional evaluation of candidates from human genome-wide association studies of type?2?diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. BMC Genomics. 2013; 14:136.
      View in: PubMed
    7. Na J, Cagan R. The Drosophila nephrocyte: back on stage. J Am Soc Nephrol. 2013 Feb; 24(2):161-3.
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    8. Rudrapatna VA, Bangi E, Cagan RL. Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion. EMBO Rep. 2013 Feb; 14(2):172-7.
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    9. Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R. A Drosophila model of high sugar diet-induced cardiomyopathy. PLoS Genet. 2013; 9(1):e1003175.
      View in: PubMed
    10. Das TK, Cagan RL. A Drosophila approach to thyroid cancer therapeutics. Drug Discov Today Technol. 2013; 10(1):e65-71.
      View in: PubMed
    11. Johnson RI, Bao S, Cagan RL. Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap/Cin85 ortholog. Dev Dyn. 2012 Dec; 241(12):1933-43.
      View in: PubMed
    12. Fu S, Yang Y, Das TK, Yen Y, Zhou BS, Zhou MM, Ohlmeyer M, Ko EC, Cagan R, Rosenstein BS, Chen SH, Kao J. Correction: ?-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers. PLoS One. 2012; 7(9).
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    13. Das TK, Sangodkar J, Negre N, Narla G, Cagan RL. Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors. Oncogene. 2013 Jun 27; 32(26):3184-97.
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    14. Fu S, Yang Y, Das TK, Tirtha D, Yen Y, Zhou BS, Zhou MM, Ohlmeyer M, Ko EC, Cagan R, Rosenstein BS, Chen SH, Kao J. ?-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers. PLoS One. 2012; 7(6):e38465.
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    15. Dar AC, Das TK, Shokat KM, Cagan RL. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 7; 486(7401):80-4.
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    16. Bangi E, Pitsouli C, Rahme LG, Cagan R, Apidianakis Y. Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. EMBO Rep. 2012 Jun; 13(6):569-76.
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    17. Cagan RL, Aguirre-Ghiso JA. A local view of cancer. Dev Cell. 2012 Mar 13; 22(3):472-4.
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    18. Heller E, Hurchla MA, Xiang J, Su X, Chen S, Schneider J, Joeng KS, Vidal M, Goldberg L, Deng H, Hornick MC, Prior JL, Piwnica-Worms D, Long F, Cagan R, Weilbaecher KN. Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. Cancer Res. 2012 Feb 15; 72(4):897-907.
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    19. Rudrapatna VA, Cagan RL, Das TK. Drosophila cancer models. Dev Dyn. 2012 Jan; 241(1):107-18.
      View in: PubMed
    20. Johnson RI, Sedgwick A, D'Souza-Schorey C, Cagan RL. Role for a Cindr-Arf6 axis in patterning emerging epithelia. Mol Biol Cell. 2011 Dec; 22(23):4513-26.
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    21. Cagan RL. The Drosophila nephrocyte. Curr Opin Nephrol Hypertens. 2011 Jul; 20(4):409-15.
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    22. Musselman LP, Fink JL, Narzinski K, Ramachandran PV, Hathiramani SS, Cagan RL, Baranski TJ. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis Model Mech. 2011 Nov; 4(6):842-9.
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    23. Larson DE, Johnson RI, Swat M, Cordero JB, Glazier JA, Cagan RL. Computer simulation of cellular patterning within the Drosophila pupal eye. PLoS Comput Biol. 2010; 6:e1000841.
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    24. Das T, Cagan R. Drosophila as a novel therapeutic discovery tool for thyroid cancer. Thyroid. 2010 Jul; 20(7):689-95.
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    25. Bao S, Fischbach KF, Corbin V, Cagan RL. Preferential adhesion maintains separation of ommatidia in the Drosophila eye. Dev Biol. 2010 Aug 15; 344(2):948-56.
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    26. Cordero JB, Macagno JP, Stefanatos RK, Strathdee KE, Cagan RL, Vidal M. Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev Cell. 2010 Jun 15; 18(6):999-1011.
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    27. Vidal M, Salavaggione L, Ylagan L, Wilkins M, Watson M, Weilbaecher K, Cagan R. A role for the epithelial microenvironment at tumor boundaries: evidence from Drosophila and human squamous cell carcinomas. Am J Pathol. 2010 Jun; 176(6):3007-14.
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    28. Cordero JB, Cagan RL. Canonical wingless signaling regulates cone cell specification in the Drosophila retina. Dev Dyn. 2010 Mar; 239(3):875-84.
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    29. Cagan RL, Reh TA. Preface. Aspects of eye development: advances over the past twenty years. Curr Top Dev Biol. 2010; 93:xi-xii.
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    30. Johnson RI, Cagan RL. A quantitative method to analyze Drosophila pupal eye patterning. PLoS One. 2009; 4(9):e7008.
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    31. Cagan R. Principles of Drosophila eye differentiation. Curr Top Dev Biol. 2009; 89:115-35.
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    32. Johnson RI, Seppa MJ, Cagan RL. The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning. J Cell Biol. 2008 Mar 24; 180(6):1191-204.
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    33. Seppa MJ, Johnson RI, Bao S, Cagan RL. Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina. Dev Biol. 2008 Jun 1; 318(1):1-16.
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    34. Larson DE, Liberman Z, Cagan RL. Cellular behavior in the developing Drosophila pupal retina. Mech Dev. 2008 Mar-Apr; 125(3-4):223-32.
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    35. Vidal M, Warner S, Read R, Cagan RL. Differing Src signaling levels have distinct outcomes in Drosophila. Cancer Res. 2007 Nov 1; 67(21):10278-85.
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    36. Bruinsma SP, Cagan RL, Baranski TJ. Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7098-103.
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    37. Cordero JB, Larson DE, Craig CR, Hays R, Cagan R. Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina. Development. 2007 May; 134(10):1861-71.
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    38. Bao S, Cagan R. Fast cloning inverted repeats for RNA interference. RNA. 2006 Nov; 12(11):2020-4.
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    39. Borghese L, Fletcher G, Mathieu J, Atzberger A, Eades WC, Cagan RL, Rørth P. Systematic analysis of the transcriptional switch inducing migration of border cells. Dev Cell. 2006 Apr; 10(4):497-508.
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    40. Vidal M, Larson DE, Cagan RL. Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev Cell. 2006 Jan; 10(1):33-44.
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    41. Vidal M, Cagan RL. Drosophila models for cancer research. Curr Opin Genet Dev. 2006 Feb; 16(1):10-6.
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    42. Read RD, Goodfellow PJ, Mardis ER, Novak N, Armstrong JR, Cagan RL. A Drosophila model of multiple endocrine neoplasia type 2. Genetics. 2005 Nov; 171(3):1057-81.
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    43. Bao S, Cagan R. Preferential adhesion mediated by Hibris and Roughest regulates morphogenesis and patterning in the Drosophila eye. Dev Cell. 2005 Jun; 8(6):925-35.
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    44. Vidal M, Wells S, Ryan A, Cagan R. ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Cancer Res. 2005 May 1; 65(9):3538-41.
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    45. Cordero J, Jassim O, Bao S, Cagan R. A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye. Mech Dev. 2004 Dec; 121(12):1523-30.
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    46. Craig CR, Fink JL, Yagi Y, Ip YT, Cagan RL. A Drosophila p38 orthologue is required for environmental stress responses. EMBO Rep. 2004 Nov; 5(11):1058-63.
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    47. Read RD, Bach EA, Cagan RL. Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol. 2004 Aug; 24(15):6676-89.
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    48. Rusconi JC, Fink JL, Cagan R. klumpfuss regulates cell death in the Drosophila retina. Mech Dev. 2004 Jun; 121(6):537-46.
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    49. Jassim OW, Fink JL, Cagan RL. Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response. EMBO J. 2003 Oct 15; 22(20):5622-32.
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    50. Cagan RL. Spermatogenesis: borrowing the apoptotic machinery. Curr Biol. 2003 Aug 5; 13(15):R600-2.
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    51. Spencer SA, Cagan RL. Echinoid is essential for regulation of Egfr signaling and R8 formation during Drosophila eye development. Development. 2003 Aug; 130(16):3725-33.
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    52. Brachmann CB, Cagan RL. Patterning the fly eye: the role of apoptosis. Trends Genet. 2003 Feb; 19(2):91-6.
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    53. Cagan R. The signals that drive kidney development: a view from the fly eye. Curr Opin Nephrol Hypertens. 2003 Jan; 12(1):11-7.
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    54. Hays R, Wickline L, Cagan R. Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1. Nat Cell Biol. 2002 Jun; 4(6):425-31.
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    55. Mills JC, Roth KA, Cagan RL, Gordon JI. DNA microarrays and beyond: completing the journey from tissue to cell. Nat Cell Biol. 2001 Aug; 3(8):E175-8.
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    56. Powell PA, Wesley C, Spencer S, Cagan RL. Scabrous complexes with Notch to mediate boundary formation. Nature. 2001 Feb 1; 409(6820):626-30.
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    57. Rusconi JC, Hays R, Cagan RL. Programmed cell death and patterning in Drosophila. Cell Death Differ. 2000 Nov; 7(11):1063-70.
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    58. Gorski SM, Brachmann CB, Tanenbaum SB, Cagan RL. Delta and notch promote correct localization of irreC-rst. Cell Death Differ. 2000 Oct; 7(10):1011-3.
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    59. Tanenbaum SB, Gorski SM, Rusconi JC, Cagan RL. A screen for dominant modifiers of the irreC-rst cell death phenotype in the developing Drosophila retina. Genetics. 2000 Sep; 156(1):205-17.
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    60. Brachmann CB, Jassim OW, Wachsmuth BD, Cagan RL. The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation. Curr Biol. 2000 May 4; 10(9):547-50.
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    61. Miller DT, Read R, Rusconi J, Cagan RL. The Drosophila primo locus encodes two low-molecular-weight tyrosine phosphatases. Gene. 2000 Feb 8; 243(1-2):1-9.
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    62. Nowotny P, Gorski SM, Han SW, Philips K, Ray WJ, Nowotny V, Jones CJ, Clark RF, Cagan RL, Goate AM. Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin. Mol Cell Neurosci. 2000 Jan; 15(1):88-98.
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    63. Spencer SA, Powell PA, Miller DT, Cagan RL. Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development. 1998 Dec; 125(23):4777-90.
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    64. Miller DT, Cagan RL. Local induction of patterning and programmed cell death in the developing Drosophila retina. Development. 1998 Jun; 125(12):2327-35.
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    65. Kopan R, Cagan R. Notch on the cutting edge. Trends Genet. 1997 Dec; 13(12):465-7.
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    66. Dokucu ME, Zipursky SL, Cagan RL. Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina. Development. 1996 Dec; 122(12):4139-47.
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    67. Krämer H, Cagan RL. Determination of photoreceptor cell fate in the Drosophila retina. Curr Opin Neurobiol. 1994 Feb; 4(1):14-20.
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    68. Reh TA, Cagan RL. Intrinsic and extrinsic signals in the developing vertebrate and fly eyes: viewing vertebrate and invertebrate eyes in the same light. Perspect Dev Neurobiol. 1994; 2(2):183-90.
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    69. Cagan R. Cell fate specification in the developing Drosophila retina. Dev Suppl. 1993; 19-28.
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    70. Rogge R, Cagan R, Majumdar A, Dulaney T, Banerjee U. Neuronal development in the Drosophila retina: the sextra gene defines an inhibitory component in the developmental pathway of R7 photoreceptor cells. Proc Natl Acad Sci U S A. 1992 Jun 15; 89(12):5271-5.
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    71. Cagan RL, Krämer H, Hart AC, Zipursky SL. The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand. Cell. 1992 May 1; 69(3):393-9.
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    72. Zipursky SL, Krämer H, Cagan R, Hart A, Vactor DV. Induction of the R7 neuron in the Drosophila compound eye: the bride of sevenless and sevenless interaction. Cold Spring Harb Symp Quant Biol. 1992; 57:381-9.
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    73. Van Vactor DL, Cagan RL, Krämer H, Zipursky SL. Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell. Cell. 1991 Dec 20; 67(6):1145-55.
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    74. Krämer H, Cagan RL, Zipursky SL. Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. Nature. 1991 Jul 18; 352(6332):207-12.
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    75. Cagan RL, Ready DF. The emergence of order in the Drosophila pupal retina. Dev Biol. 1989 Dec; 136(2):346-62.
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    76. Cagan RL, Ready DF. Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev. 1989 Aug; 3(8):1099-112.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067