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Eric A. Sobie

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentPharmacology and Systems Therapeutics
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     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lee P, Sobie EA, Peskin CS. Computer simulation of voltage sensitive calcium ion channels in a dendritic spine. J Theor Biol. 2013 Dec 7; 338:87-93.
      View in: PubMed
    2. Cummins MA, Devenyi RA, Sobie EA. Yoga for the sinoatrial node: sarcoplasmic reticulum calcium release confers flexibility. J Mol Cell Cardiol. 2013 Jul; 60:161-3.
      View in: PubMed
    3. Lee YS, Liu OZ, Hwang HS, Knollmann BC, Sobie EA. Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks. Biophys J. 2013 Mar 5; 104(5):1142-50.
      View in: PubMed
    4. Poláková E, Sobie EA. Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses. Cardiovasc Res. 2013 May 1; 98(2):233-9.
      View in: PubMed
    5. Lee YS, Liu OZ, Sobie EA. Decoding myocardial Ca²? signals across multiple spatial scales: a role for sensitivity analysis. J Mol Cell Cardiol. 2013 May; 58:92-9.
      View in: PubMed
    6. LaRocca TJ, Fabris F, Chen J, Benhayon D, Zhang S, McCollum L, Schecter AD, Cheung JY, Sobie EA, Hajjar RJ, Lebeche D. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-?B pathway. Am J Physiol Heart Circ Physiol. 2012 Aug 1; 303(3):H353-67.
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    7. Sarkar AX, Christini DJ, Sobie EA. Exploiting mathematical models to illuminate electrophysiological variability between individuals. J Physiol. 2012 Jun 1; 590(Pt 11):2555-67.
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    8. Liu OZ, Lederer WJ, Sobie EA. Does the Goldilocks Principle apply to calcium release restitution in heart cells? J Mol Cell Cardiol. 2012 Jan; 52(1):3-6.
      View in: PubMed
    9. Bao L, Kefaloyianni E, Lader J, Hong M, Morley G, Fishman GI, Sobie EA, Coetzee WA. Unique properties of the ATP-sensitive K? channel in the mouse ventricular cardiac conduction system. Circ Arrhythm Electrophysiol. 2011 Dec; 4(6):926-35.
      View in: PubMed
    10. Sobie EA. Computational modeling of the cell cycle. Sci Signal. 2011 Sep 27; 4(192):tr11.
      View in: PubMed
    11. Sobie EA. Bistability in biochemical signaling models. Sci Signal. 2011 Sep 27; 4(192):tr10.
      View in: PubMed
    12. Williams GS, Chikando AC, Tuan HT, Sobie EA, Lederer WJ, Jafri MS. Dynamics of calcium sparks and calcium leak in the heart. Biophys J. 2011 Sep 21; 101(6):1287-96.
      View in: PubMed
    13. Sobie EA. An introduction to dynamical systems. Sci Signal. 2011 Sep 20; 4(191):tr6.
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    14. Sobie EA. An introduction to MATLAB. Sci Signal. 2011 Sep 20; 4(191):tr7.
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    15. Sobie EA, Lee YS, Jenkins SL, Iyengar R. Systems biology--biomedical modeling. Sci Signal. 2011 Sep 13; 4(190):tr2.
      View in: PubMed
    16. Sobie EA, Lederer WJ. Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles. J Mol Cell Cardiol. 2012 Feb; 52(2):304-11.
      View in: PubMed
    17. Sarkar AX, Sobie EA. Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm. 2011 Nov; 8(11):1749-55.
      View in: PubMed
    18. Ramay HR, Liu OZ, Sobie EA. Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity. Cardiovasc Res. 2011 Sep 1; 91(4):598-605.
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    19. Liu J, Fackelmayer OJ, Hicks DB, Preiss L, Meier T, Sobie EA, Krulwich TA. Mutations in a helix-1 motif of the ATP synthase c-subunit of Bacillus pseudofirmus OF4 cause functional deficits and changes in the c-ring stability and mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry. 2011 Jun 21; 50(24):5497-506.
      View in: PubMed
    20. Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. J Mol Cell Cardiol. 2011 Jul; 51(1):4-15.
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    21. Sobie EA. Getting heart cells on the same wavelength: infrared triggering of Ca2+ transients in cardiac myocytes. J Physiol. 2011 Mar 15; 589(Pt 6):1243-4.
      View in: PubMed
    22. Lee YS, Dun W, Boyden PA, Sobie EA. Complex and rate-dependent beat-to-beat variations in Ca2+ transients of canine Purkinje cells. J Mol Cell Cardiol. 2011 Apr; 50(4):662-9.
      View in: PubMed
    23. Tuan HT, Williams GS, Chikando AC, Sobie EA, Lederer WJ, Jafri MS. Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4677-80.
      View in: PubMed
    24. Sobie EA, Sarkar AX. Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4657-60.
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    25. Chung CY, Bien H, Sobie EA, Dasari V, McKinnon D, Rosati B, Entcheva E. Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization. FASEB J. 2011 Mar; 25(3):851-62.
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    26. MacQuaide N, Ramay HR, Sobie EA, Smith GL. Differential sensitivity of Ca²+ wave and Ca²+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. J Physiol. 2010 Dec 1; 588(Pt 23):4731-42.
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    27. Hartman JM, Sobie EA, Smith GD. Spontaneous Ca2+ sparks and Ca2+ homeostasis in a minimal model of permeabilized ventricular myocytes. Am J Physiol Heart Circ Physiol. 2010 Dec; 299(6):H1996-2008.
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    28. Sarkar AX, Sobie EA. Regression analysis for constraining free parameters in electrophysiological models of cardiac cells. PLoS Comput Biol. 2010; 6(9):e1000914.
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    29. Sobie EA, Jenkins SL, Iyengar R, Krulwich TA. Training in systems pharmacology: predoctoral program in pharmacology and systems biology at Mount Sinai School of Medicine. Clin Pharmacol Ther. 2010 Jul; 88(1):19-22.
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    30. Ramay HR, Jafri MS, Lederer WJ, Sobie EA. Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes. Biophys J. 2010 Jun 2; 98(11):2515-23.
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    31. Josephson IR, Guia A, Sobie EA, Lederer WJ, Lakatta EG, Stern MD. Physiologic gating properties of unitary cardiac L-type Ca2+ channels. Biochem Biophys Res Commun. 2010 Jun 4; 396(3):763-6.
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    32. Williams GS, Smith GD, Sobie EA, Jafri MS. Models of cardiac excitation-contraction coupling in ventricular myocytes. Math Biosci. 2010 Jul; 226(1):1-15.
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    33. Trafford AW, Lederer WJ, Sobie EA. Keeping the beat: life without SERCA--is it possible? J Mol Cell Cardiol. 2009 Aug; 47(2):171-3.
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    34. Sobie EA. Parameter sensitivity analysis in electrophysiological models using multivariable regression. Biophys J. 2009 Feb 18; 96(4):1264-74.
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    35. Sobie EA, Ramay HR. Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model. J Physiol. 2009 Mar 15; 587(Pt 6):1293-9.
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    36. Bridge JH, Torres NS, Sobie EA. New insights into the structure and function of couplons. J Physiol. 2008 Aug 15; 586(16):3735.
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    37. Williams GS, Huertas MA, Sobie EA, Jafri MS, Smith GD. Moment closure for local control models of calcium-induced calcium release in cardiac myocytes. Biophys J. 2008 Aug; 95(4):1689-703.
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    38. Lipsky R, Potts EM, Tarzami ST, Puckerin AA, Stocks J, Schecter AD, Sobie EA, Akar FG, Diversé-Pierluissi MA. beta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathway. J Biol Chem. 2008 Jun 20; 283(25):17221-6.
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    39. Wang LJ, Sobie EA. Mathematical model of the neonatal mouse ventricular action potential. Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6):H2565-75.
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    40. Iyengar R, Diverse-Pierluissi MA, Jenkins SL, Chan AM, Devi LA, Sobie EA, Ting AT, Weinstein DC. Inquiry learning. Integrating content detail and critical reasoning by peer review. Science. 2008 Feb 29; 319(5867):1189-90.
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    41. Sobie EA, Cannell MB, Bridge JH. Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes. Biophys J. 2008 Apr 1; 94(7):L54-6.
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    42. Jenkins SL, Iyengar R, Diverse-Pierluissi MA, Chan AM, Devi LA, Sobie EA, Ting AT, Weinstein DC. Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment. Sci Signal. 2008; 1(9):tr2.
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    43. Ni J, Auston DA, Freilich DA, Muralidharan S, Sobie EA, Kao JP. Photochemical gating of intracellular Ca2+ release channels. J Am Chem Soc. 2007 May 2; 129(17):5316-7.
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    44. Sobie EA, Kao JP, Lederer WJ. Novel approach to real-time flash photolysis and confocal [Ca2+] imaging. Pflugers Arch. 2007 Jul; 454(4):663-73.
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    45. Williams GS, Huertas MA, Sobie EA, Jafri MS, Smith GD. A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes. Biophys J. 2007 Apr 1; 92(7):2311-28.
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    46. Collis LP, Meyers MB, Zhang J, Phoon CK, Sobie EA, Coetzee WA, Fishman GI. Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling. FASEB J. 2007 Feb; 21(2):475-87.
      View in: PubMed
    47. Sobie EA, Song LS, Lederer WJ. Restitution of Ca(2+) release and vulnerability to arrhythmias. J Cardiovasc Electrophysiol. 2006 May; 17 Suppl 1:S64-S70.
      View in: PubMed
    48. Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW, Cheng H. Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4305-10.
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    49. Sobie EA, Guatimosim S, Gómez-Viquez L, Song LS, Hartmann H, Saleet Jafri M, Lederer WJ. The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice. Prog Biophys Mol Biol. 2006 Jan-Apr; 90(1-3):172-85.
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    50. Song LS, Guatimosim S, Gómez-Viquez L, Sobie EA, Ziman A, Hartmann H, Lederer WJ. Calcium biology of the transverse tubules in heart. Ann N Y Acad Sci. 2005 Jun; 1047:99-111.
      View in: PubMed
    51. Sobie EA, Song LS, Lederer WJ. Local recovery of Ca2+ release in rat ventricular myocytes. J Physiol. 2005 Jun 1; 565(Pt 2):441-7.
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    52. Knot HJ, Laher I, Sobie EA, Guatimosim S, Gomez-Viquez L, Hartmann H, Song LS, Lederer WJ, Graier WF, Malli R, Frieden M, Petersen OH. Twenty years of calcium imaging: cell physiology to dye for. Mol Interv. 2005 Apr; 5(2):112-27.
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    53. Lederer JW, Gmosim S, Song LS, Sobie EA, Hartmann H, Lukyanenko V. Ca2+ sparks in heart muscle. J Muscle Res Cell Motil. 2004; 25(8):602-3.
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    54. Sobie EA, Guatimosim S, Song LS, Lederer WJ. The challenge of molecular medicine: complexity versus Occam's razor. J Clin Invest. 2003 Mar; 111(6):801-3.
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    55. Guatimosim S, Dilly K, Santana LF, Saleet Jafri M, Sobie EA, Lederer WJ. Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient. J Mol Cell Cardiol. 2002 Aug; 34(8):941-50.
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    56. Sobie EA, Dilly KW, dos Santos Cruz J, Lederer WJ, Jafri MS. Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release. Biophys J. 2002 Jul; 83(1):59-78.
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    57. Guatimosim S, Sobie EA, dos Santos Cruz J, Martin LA, Lederer WJ. Molecular identification of a TTX-sensitive Ca(2+) current. Am J Physiol Cell Physiol. 2001 May; 280(5):C1327-39.
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    58. Cheng DK, Tung L, Sobie EA. Nonuniform responses of transmembrane potential during electric field stimulation of single cardiac cells. Am J Physiol. 1999 Jul; 277(1 Pt 2):H351-62.
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    59. Susil RC, Sobie EA, Tung L. Separation between virtual sources modifies the response of cardiac tissue to field stimulation. J Cardiovasc Electrophysiol. 1999 May; 10(5):715-27.
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    60. Riemer TL, Sobie EA, Tung L. Stretch-induced changes in arrhythmogenesis and excitability in experimentally based heart cell models. Am J Physiol. 1998 Aug; 275(2 Pt 2):H431-42.
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    61. Sobie EA, Tung L. Postshock potential gradients and dispersion of repolarization in cells stimulated with monophasic and biphasic waveforms. J Cardiovasc Electrophysiol. 1998 Jul; 9(7):743-56.
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    62. Sobie EA, Susil RC, Tung L. A generalized activating function for predicting virtual electrodes in cardiac tissue. Biophys J. 1997 Sep; 73(3):1410-23.
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    63. Fishler MG, Sobie EA, Tung L, Thakor NV. Modeling the interaction between propagating cardiac waves and monophasic and biphasic field stimuli: the importance of the induced spatial excitatory response. J Cardiovasc Electrophysiol. 1996 Dec; 7(12):1183-96.
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    64. Fishler MG, Sobie EA, Thakor NV, Tung L. Mechanisms of cardiac cell excitation with premature monophasic and biphasic field stimuli: a model study. Biophys J. 1996 Mar; 70(3):1347-62.
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    65. Fishler MG, Sobie EA, Tung L, Thakor NV. Cardiac responses to premature monophasic and biphasic field stimuli. Results from cell and tissue modeling studies. J Electrocardiol. 1995; 28 Suppl:174-9.
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067