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Last Name
Institution

Christopher Cardozo

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentPulmonary, Critical Care and Sleep Medicine
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    Other Positions
    TitleASSOCIATE PROFESSOR
    InstitutionMount Sinai
    DepartmentRehabilitation Medicine

    TitleASSOCIATE PROFESSOR
    InstitutionMount Sinai
    DepartmentPharmacology and Systems Therapeutics


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cea LA, Cisterna BA, Puebla C, Frank M, Figueroa XF, Cardozo C, Willecke K, Latorre R, Sáez JC. De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy. Proc Natl Acad Sci U S A. 2013 Oct 1; 110(40):16229-34.
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    2. Wu Y, Ruggiero CL, Bauman WA, Cardozo C. Ankrd1 is a transcriptional repressor for the androgen receptor that is downregulated by testosterone. Biochem Biophys Res Commun. 2013 Aug 2; 437(3):355-60.
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    3. Liu XH, Wu Y, Yao S, Levine AC, Kirschenbaum A, Collier L, Bauman WA, Cardozo CP. Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/ß-catenin signaling to T cell factor elements in the Numb promoter. J Biol Chem. 2013 Jun 21; 288(25):17990-8.
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    4. Qin W, Sun L, Cao J, Peng Y, Collier L, Wu Y, Creasey G, Li J, Qin Y, Jarvis J, Bauman WA, Zaidi M, Cardozo C. The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures. J Biol Chem. 2013 May 10; 288(19):13511-21.
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    5. Zhan H, Cardozo C, Raza A. MicroRNAs in myeloproliferative neoplasms. Br J Haematol. 2013 May; 161(4):471-83.
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    6. Sun L, Pan J, Peng Y, Wu Y, Li J, Liu X, Qin Y, Bauman WA, Cardozo C, Zaidi M, Qin W. Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling. J Spinal Cord Med. 2013 Nov; 36(6):616-22.
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    7. Zhan H, Cardozo C, Yu W, Wang A, Moliterno AR, Dang CV, Spivak JL. MicroRNA deregulation in polycythemia vera and essential thrombocythemia patients. Blood Cells Mol Dis. 2013 Mar; 50(3):190-5.
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    8. Liu XH, Yao S, Levine AC, Kirschenbaum A, Pan J, Wu Y, Qin W, Collier L, Bauman WA, Cardozo CP. Nandrolone, an anabolic steroid, stabilizes Numb protein through inhibition of mdm2 in C2C12 myoblasts. J Androl. 2012 Nov-Dec; 33(6):1216-23.
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    9. Wu Y, Zhao J, Zhao W, Pan J, Bauman WA, Cardozo CP. Nandrolone normalizes determinants of muscle mass and fiber type after spinal cord injury. J Neurotrauma. 2012 May 20; 29(8):1663-75.
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    10. Navarrett S, Collier L, Cardozo C, Dracheva S. Alterations of serotonin 2C and 2A receptors in response to T10 spinal cord transection in rats. Neurosci Lett. 2012 Jan 6; 506(1):74-8.
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    11. Wu Y, Collier L, Pan J, Qin W, Bauman WA, Cardozo CP. Testosterone reduced methylprednisolone-induced muscle atrophy in spinal cord-injured rats. Spinal Cord. 2012 Jan; 50(1):57-62.
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    12. Liu XH, Yao S, Qiao RF, Levine AC, Kirschenbaum A, Pan J, Wu Y, Qin W, Bauman WA, Cardozo CP. Nandrolone reduces activation of Notch signaling in denervated muscle associated with increased Numb expression. Biochem Biophys Res Commun. 2011 Oct 14; 414(1):165-9.
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    13. Wu Y, Hou J, Collier L, Pan J, Hou L, Qin W, Bauman WA, Cardozo CP. The administration of high-dose methylprednisolone for 24 h reduced muscle size and increased atrophy-related gene expression in spinal cord-injured rats. Spinal Cord. 2011 Aug; 49(8):867-73.
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    14. Qin W, Bauman WA, Cardozo CP. Evolving concepts in neurogenic osteoporosis. Curr Osteoporos Rep. 2010 Dec; 8(4):212-8.
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    15. Qin W, Pan J, Wu Y, Bauman WA, Cardozo C. Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1a. Biochem Biophys Res Commun. 2010 Dec 17; 403(3-4):473-8.
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    16. Qin W, Bauman WA, Cardozo C. Bone and muscle loss after spinal cord injury: organ interactions. Ann N Y Acad Sci. 2010 Nov; 1211:66-84.
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    17. Qin W, Pan J, Bauman WA, Cardozo CP. Differential alterations in gene expression profiles contribute to time-dependent effects of nandrolone to prevent denervation atrophy. BMC Genomics. 2010; 11:596.
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    18. Wu Y, Bauman WA, Blitzer RD, Cardozo C. Testosterone-induced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR. Biochem Biophys Res Commun. 2010 Oct 1; 400(4):679-83.
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    19. Cardozo CP, Qin W, Peng Y, Liu X, Wu Y, Pan J, Bauman WA, Zaidi M, Sun L. Nandrolone slows hindlimb bone loss in a rat model of bone loss due to denervation. Ann N Y Acad Sci. 2010 Mar; 1192:303-6.
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    20. Wu Y, Zhao W, Zhao J, Zhang Y, Qin W, Pan J, Bauman WA, Blitzer RD, Cardozo C. REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss. Endocrinology. 2010 Mar; 151(3):1050-9.
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    21. Jegede AB, Rosado-Rivera D, Bauman WA, Cardozo CP, Sano M, Moyer JM, Brooks M, Wecht JM. Cognitive performance in hypotensive persons with spinal cord injury. Clin Auton Res. 2010 Feb; 20(1):3-9.
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    22. Zeman RJ, Bauman WA, Wen X, Ouyang N, Etlinger JD, Cardozo CP. Improved functional recovery with oxandrolone after spinal cord injury in rats. Neuroreport. 2009 Jun 17; 20(9):864-8.
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    23. Qin W, Haroutunian V, Katsel P, Cardozo CP, Ho L, Buxbaum JD, Pasinetti GM. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Arch Neurol. 2009 Mar; 66(3):352-61.
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    24. Zeman RJ, Zhao J, Zhang Y, Zhao W, Wen X, Wu Y, Pan J, Bauman WA, Cardozo C. Differential skeletal muscle gene expression after upper or lower motor neuron transection. Pflugers Arch. 2009 Jul; 458(3):525-35.
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    25. La Fountaine MF, Radulovic M, Cardozo CP, Spungen AM, DeMeersman RE, Bauman WA. Effects of acute nitric oxide synthase inhibition on lower leg vascular function in chronic tetraplegia. J Spinal Cord Med. 2009; 32(5):538-44.
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    26. Zhao W, Qin W, Pan J, Wu Y, Bauman WA, Cardozo C. Dependence of dexamethasone-induced Akt/FOXO1 signaling, upregulation of MAFbx, and protein catabolism upon the glucocorticoid receptor. Biochem Biophys Res Commun. 2009 Jan 16; 378(3):668-72.
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    27. Zhao W, Pan J, Wang X, Wu Y, Bauman WA, Cardozo CP. Expression of the muscle atrophy factor muscle atrophy F-box is suppressed by testosterone. Endocrinology. 2008 Nov; 149(11):5449-60.
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    28. Zhao W, Pan J, Zhao Z, Wu Y, Bauman WA, Cardozo CP. Testosterone protects against dexamethasone-induced muscle atrophy, protein degradation and MAFbx upregulation. J Steroid Biochem Mol Biol. 2008 May; 110(1-2):125-9.
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    29. Zhao J, Zhang Y, Zhao W, Wu Y, Pan J, Bauman WA, Cardozo C. Effects of nandrolone on denervation atrophy depend upon time after nerve transection. Muscle Nerve. 2008 Jan; 37(1):42-9.
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    30. Wu Y, Zhao W, Zhao J, Pan J, Wu Q, Zhang Y, Bauman WA, Cardozo CP. Identification of androgen response elements in the insulin-like growth factor I upstream promoter. Endocrinology. 2007 Jun; 148(6):2984-93.
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    31. Zhao J, Wecht JM, Zhang Y, Wen X, Zeman R, Bauman WA, Cardozo C. iNOS expression in rat aorta is increased after spinal cord transection: a possible cause of orthostatic hypotension in man. Neurosci Lett. 2007 Mar 30; 415(3):210-4.
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    32. Cardozo CP. Respiratory complications of spinal cord injury. J Spinal Cord Med. 2007; 30(4):307-8.
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    33. Zhao W, Wu Y, Zhao J, Guo S, Bauman WA, Cardozo CP. Structure and function of the upstream promotor of the human Mafbx gene: the proximal upstream promotor modulates tissue-specificity. J Cell Biochem. 2005 Sep 1; 96(1):209-19.
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    34. Shabbir A, DiStasio S, Zhao J, Cardozo CP, Wolff MS, Caplan AJ. Differential effects of the organochlorine pesticide DDT and its metabolite p,p'-DDE on p-glycoprotein activity and expression. Toxicol Appl Pharmacol. 2005 Mar 1; 203(2):91-8.
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    35. Zhao J, Bauman WA, Huang R, Caplan AJ, Cardozo C. Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent manner. Steroids. 2004 May; 69(5):357-66.
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    36. Lee P, Shabbir A, Cardozo C, Caplan AJ. Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase. Mol Biol Cell. 2004 Apr; 15(4):1785-92.
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    37. Cardozo CP, Michaud C, Ost MC, Fliss AE, Yang E, Patterson C, Hall SJ, Caplan AJ. C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. Arch Biochem Biophys. 2003 Feb 1; 410(1):134-40.
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    38. Cardozo C, Michaud C. Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathway. Arch Biochem Biophys. 2002 Dec 1; 408(1):103-10.
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    39. Cardozo C, Wu X, Pan M, Wang H, Fisher EA. The inhibition of microsomal triglyceride transfer protein activity in rat hepatoma cells promotes proteasomal and nonproteasomal degradation of apoprotein b100. Biochemistry. 2002 Aug 6; 41(31):10105-14.
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    40. Rao J, Lee P, Benzeno S, Cardozo C, Albertus J, Robins DM, Caplan AJ. Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. J Biol Chem. 2001 Feb 23; 276(8):5814-20.
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    41. Loukissa A, Cardozo C, Altschuller-Felberg C, Nelson JE. Control of LMP7 expression in human endothelial cells by cytokines regulating cellular and humoral immunity. Cytokine. 2000 Sep; 12(9):1326-30.
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    42. Cherpillod P, Tipold A, Griot-Wenk M, Cardozo C, Schmid I, Fatzer R, Schobesberger M, Zurbriggen R, Bruckner L, Roch F, Vandevelde M, Wittek R, Zurbriggen A. DNA vaccine encoding nucleocapsid and surface proteins of wild type canine distemper virus protects its natural host against distemper. Vaccine. 2000 Jul 1; 18(26):2927-36.
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    43. Nelson JE, Loukissa A, Altschuller-Felberg C, Monaco JJ, Fallon JT, Cardozo C. Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats. J Lab Clin Med. 2000 Apr; 135(4):324-31.
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    44. Farout L, Lamare MC, Cardozo C, Harrisson M, Briand Y, Briand M. Distribution of proteasomes and of the five proteolytic activities in rat tissues. Arch Biochem Biophys. 2000 Feb 15; 374(2):207-12.
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    45. Nelson JE, Altschuller-Felberg C, Loukissa A, Cardozo C. Proteasome from cytokine-treated human cells shows stimulated BrAAP activity and depressed PGPH activity. Biochem Cell Biol. 2000; 78(2):115-8.
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    46. Wang R, Chait BT, Wolf I, Kohanski RA, Cardozo C. Lysozyme degradation by the bovine multicatalytic proteinase complex (proteasome): evidence for a nonprocessive mode of degradation. Biochemistry. 1999 Nov 2; 38(44):14573-81.
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    47. Cardozo C, Michaud C, Orlowski M. Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues. Biochemistry. 1999 Jul 27; 38(30):9768-77.
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    48. Cardozo C, Kohanski RA. Altered properties of the branched chain amino acid-preferring activity contribute to increased cleavages after branched chain residues by the "immunoproteasome". J Biol Chem. 1998 Jul 3; 273(27):16764-70.
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    49. Novaes G, de Queiroz AC, das Neves MM, Cardozo C, Ribeiro-Filho L, de Carvalho MH, Ponte G, Chaves A. Induction of acute and chronic pancreatitis with the use of the toxin of the scorpion Tityus serrulatus: experimental model in rats. Arq Gastroenterol. 1998 Jul-Sep; 35(3):216-22.
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    50. Orlowski M, Cardozo C, Eleuteri AM, Kohanski R, Kam CM, Powers JC. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 1997 Nov 11; 36(45):13946-53.
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    51. Eleuteri AM, Kohanski RA, Cardozo C, Orlowski M. Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity. J Biol Chem. 1997 May 2; 272(18):11824-31.
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    52. Cardozo C, Chen WE, Wilk S. Cleavage of Pro-X and Glu-X bonds catalyzed by the branched chain amino acid preferring activity of the bovine pituitary multicatalytic proteinase complex (20S proteasome). Arch Biochem Biophys. 1996 Oct 1; 334(1):113-20.
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    53. Schilero GJ, Almenoff P, Lesser M, Cardozo C. Peptidase inhibitors potentiate lysylbradykinin-induced bronchoconstriction in the rat. Regul Pept. 1996 Apr 9; 62(1):41-5.
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    54. Lesser M, Fung K, Almenoff PL, Rosenbaum C, Cardozo C. Hydrolysis of N-formylmethionyl chemotactic peptides by endopeptidase 24.11 and endopeptidase 24.15. Peptides. 1996; 17(1):13-6.
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    55. Cardozo C, Eleuteri AM, Orlowski M. Differences in catalytic activities and subunit pattern of multicatalytic proteinase complexes (proteasomes) isolated from bovine pituitary, lung, and liver. Changes in LMP7 and the component necessary for expression of the chymotrypsin-like activity. J Biol Chem. 1995 Sep 22; 270(38):22645-51.
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    56. Rosenbaum C, Cardozo C, Lesser M. Degradation of lysylbradykinin by endopeptidase 24.11 and endopeptidase 24.15. Peptides. 1995; 16(3):523-5.
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    57. Vinitsky A, Cardozo C, Sepp-Lorenzino L, Michaud C, Orlowski M. Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes. J Biol Chem. 1994 Nov 25; 269(47):29860-6.
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    58. Cardozo C, Vinitsky A, Michaud C, Orlowski M. Evidence that the nature of amino acid residues in the P3 position directs substrates to distinct catalytic sites of the pituitary multicatalytic proteinase complex (proteasome). Biochemistry. 1994 May 31; 33(21):6483-9.
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    59. Casale L, Cardozo C, Kalb T, Lesser M. Quantitation of endopeptidase 24.11 and endopeptidase 24.15 in human blood leukocytes. Enzyme Protein. 1994-1995; 48(3):143-8.
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    60. Klitzman D, Almenoff PL, Cardozo C, Lesser M. Bradykinin-induced airway microvascular leakage is potentiated by enalaprilat but not by phosphoramidon. Enzyme Protein. 1994-1995; 48(4):191-6.
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    61. Schilero GJ, Almenoff P, Cardozo C, Lesser M. Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat. Peptides. 1994; 15(8):1445-9.
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    62. Cardozo C, Orlowski M. Evidence that enzymatic conversion of N-[1(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate, a specific inhibitor of endopeptidase 24.15, to N-[1(R,S)-carboxy-3-phenylpropyl]-Ala-Ala is necessary for inhibition of angiotensin converting enzyme. Peptides. 1993 Nov-Dec; 14(6):1259-62.
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    63. Orlowski M, Cardozo C, Michaud C. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. Biochemistry. 1993 Feb 16; 32(6):1563-72.
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    64. Cardozo C. Catalytic components of the bovine pituitary multicatalytic proteinase complex (proteasome). Enzyme Protein. 1993; 47(4-6):296-305.
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    65. Lesser M, Fung K, Choi HS, Yoo OH, Cardozo C. Identification of two zinc metalloendopeptidases in alveolar macrophages of rats, guinea pigs, and human beings. J Lab Clin Med. 1992 Oct; 120(4):597-603.
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    66. Cardozo C, Vinitsky A, Hidalgo MC, Michaud C, Orlowski M. A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex. Biochemistry. 1992 Aug 18; 31(32):7373-80.
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    67. Cardozo C, Edelman J, Lesser M. Lipopolysaccharide-induced stimulation of alveolar macrophage opsonin-independent phagocytosis. J Surg Res. 1992 Aug; 53(2):170-4.
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    68. Lesser M, Padilla ML, Cardozo C. Induction of emphysema in hamsters by intratracheal instillation of cathepsin B. Am Rev Respir Dis. 1992 Mar; 145(3):661-8.
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    69. Cardozo C, Padilla ML, Choi HS, Lesser M. Goblet cell hyperplasia in large intrapulmonary airways after intratracheal injection of cathepsin B into hamsters. Am Rev Respir Dis. 1992 Mar; 145(3):675-9.
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    70. Cardozo C, Kurtz C, Lesser M. Degradation of rat lung collagens by cathepsin B. J Lab Clin Med. 1992 Feb; 119(2):169-75.
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    71. Cardozo C, Edelman J, Jagirdar J, Lesser M. Lipopolysaccharide-induced pulmonary vascular sequestration of polymorphonuclear leukocytes is complement independent. Am Rev Respir Dis. 1991 Jul; 144(1):173-8.
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    72. Orlowski M, Cardozo C, Hidalgo MC, Michaud C. Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex. Biochemistry. 1991 Jun 18; 30(24):5999-6005.
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    73. Warfel AH, Cardozo C, Yoo OH, Zucker-Franklin D. Cystatin C and cathepsin B production by alveolar macrophages from smokers and nonsmokers. J Leukoc Biol. 1991 Jan; 49(1):41-7.
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    74. Choi HS, Lesser M, Cardozo C, Orlowski M. Immunohistochemical localization of endopeptidase 24.15 in rat trachea, lung tissue, and alveolar macrophages. Am J Respir Cell Mol Biol. 1990 Dec; 3(6):619-24.
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    75. Lesser M, Chang JC, Galicki NI, Edelman J, Cardozo C. Cathepsin B and D activity in alveolar macrophages from rats with pulmonary granulomatous inflammation or acute lung injury. Agents Actions. 1989 Nov; 28(3-4):264-71.
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    76. Lesser M, Galicki N, Cardozo C, Gariola CG. Cathepsin L activity in alveolar macrophages of rats: response to cigarette smoke. Am J Respir Cell Mol Biol. 1989 Nov; 1(5):371-6.
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    77. Gairola CG, Galicki NI, Cardozo C, Lai YL, Lesser M. Cigarette smoke stimulates cathepsin B activity in alveolar macrophages of rats. J Lab Clin Med. 1989 Oct; 114(4):419-25.
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    78. Edelman J, Cardozo C, Lesser M. Lipopolysaccharide stimulates alveolar macrophage adherence in vivo and in vitro. Agents Actions. 1989 Mar; 26(3-4):287-91.
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    79. Downs D, Cardozo C, Schneiderman N, Yehle AL, VanDercar DH, Zwilling G. Central effects of atropine upon aversive classical conditioning in rabbits. Psychopharmacologia. 1972; 23(4):319-33.
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