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Last Name
Institution

Gareth R. John

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentNeurology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Brück W, Pförtner R, Pham T, Zhang J, Hayardeny L, Piryatinsky V, Hanisch UK, Regen T, van Rossum D, Brakelmann L, Hagemeier K, Kuhlmann T, Stadelmann C, John GR, Kramann N, Wegner C. Reduced astrocytic NF-?B activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol. 2012 Sep; 124(3):411-24.
      View in: PubMed
    2. Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012 Jul 2; 122(7):2454-68.
      View in: PubMed
    3. John GR. Investigation of astrocyte - oligodendrocyte interactions in human cultures. Methods Mol Biol. 2012; 814:401-14.
      View in: PubMed
    4. Gaupp S, Arezzo J, Dutta DJ, John GR, Raine CS. On the occurrence of hypomyelination in a transgenic mouse model: a consequence of the myelin basic protein promoter? J Neuropathol Exp Neurol. 2011 Dec; 70(12):1138-50.
      View in: PubMed
    5. Zhang J, Kramer EG, Asp L, Dutta DJ, Navrazhina K, Pham T, Mariani JN, Argaw AT, Melendez-Vasquez CV, John GR. Promoting myelin repair and return of function in multiple sclerosis. FEBS Lett. 2011 Dec 1; 585(23):3813-20.
      View in: PubMed
    6. Zhang J, Zhang Y, Dutta DJ, Argaw AT, Bonnamain V, Seto J, Braun DA, Zameer A, Hayot F, Lòpez CB, Raine CS, John GR. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. J Immunol. 2011 Aug 1; 187(3):1129-41.
      View in: PubMed
    7. Zhang J, Kramer EG, Mahase S, Dutta DJ, Bonnamain V, Argaw AT, John GR. Targeting oligodendrocyte protection and remyelination in multiple sclerosis. Mt Sinai J Med. 2011 Mar-Apr; 78(2):244-57.
      View in: PubMed
    8. Zhang Y, Jalili F, Ouamara N, Zameer A, Cosentino G, Mayne M, Hayardeny L, Antel JP, Bar-Or A, John GR. Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2. J Neuroimmunol. 2010 Oct 8; 227(1-2):71-9.
      View in: PubMed
    9. Zhang Y, Zhang J, Navrazhina K, Argaw AT, Zameer A, Gurfein BT, Brosnan CF, John GR. TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation. Glia. 2010 Jun; 58(8):964-74.
      View in: PubMed
    10. Zhang Y, Argaw AT, Gurfein BT, Zameer A, Snyder BJ, Ge C, Lu QR, Rowitch DH, Raine CS, Brosnan CF, John GR. Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19162-7.
      View in: PubMed
    11. Gurfein BT, Zhang Y, López CB, Argaw AT, Zameer A, Moran TM, John GR. IL-11 regulates autoimmune demyelination. J Immunol. 2009 Oct 1; 183(7):4229-40.
      View in: PubMed
    12. Argaw AT, Gurfein BT, Zhang Y, Zameer A, John GR. VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1977-82.
      View in: PubMed
    13. Brosnan CF, John GR. Revisiting Notch in remyelination of multiple sclerosis lesions. J Clin Invest. 2009 Jan; 119(1):10-3.
      View in: PubMed
    14. Zhang Y, Taveggia C, Melendez-Vasquez C, Einheber S, Raine CS, Salzer JL, Brosnan CF, John GR. Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J Neurosci. 2006 Nov 22; 26(47):12174-85.
      View in: PubMed
    15. Argaw AT, Zhang Y, Snyder BJ, Zhao ML, Kopp N, Lee SC, Raine CS, Brosnan CF, John GR. IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol. 2006 Oct 15; 177(8):5574-84.
      View in: PubMed
    16. Omari KM, John G, Lango R, Raine CS. Role for CXCR2 and CXCL1 on glia in multiple sclerosis. Glia. 2006 Jan 1; 53(1):24-31.
      View in: PubMed
    17. Omari KM, John GR, Sealfon SC, Raine CS. CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. Brain. 2005 May; 128(Pt 5):1003-15.
      View in: PubMed
    18. Rivieccio MA, John GR, Song X, Suh HS, Zhao Y, Lee SC, Brosnan CF. The cytokine IL-1beta activates IFN response factor 3 in human fetal astrocytes in culture. J Immunol. 2005 Mar 15; 174(6):3719-26.
      View in: PubMed
    19. John GR, Lee SC, Song X, Rivieccio M, Brosnan CF. IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia. 2005 Jan 15; 49(2):161-76.
      View in: PubMed
    20. John GR, Chen L, Rivieccio MA, Melendez-Vasquez CV, Hartley A, Brosnan CF. Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis. J Neurosci. 2004 Mar 17; 24(11):2837-45.
      View in: PubMed
    21. John GR, Lee SC, Brosnan CF. Cytokines: powerful regulators of glial cell activation. Neuroscientist. 2003 Feb; 9(1):10-22.
      View in: PubMed
    22. John GR, Shankar SL, Shafit-Zagardo B, Massimi A, Lee SC, Raine CS, Brosnan CF. Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nat Med. 2002 Oct; 8(10):1115-21.
      View in: PubMed
    23. John GR, Simpson JE, Woodroofe MN, Lee SC, Brosnan CF. Extracellular nucleotides differentially regulate interleukin-1beta signaling in primary human astrocytes: implications for inflammatory gene expression. J Neurosci. 2001 Jun 15; 21(12):4134-42.
      View in: PubMed
    24. Duffy HS, John GR, Lee SC, Brosnan CF, Spray DC. Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J Neurosci. 2000 Dec 1; 20(23):RC114.
      View in: PubMed
    25. Liu JS, John GR, Sikora A, Lee SC, Brosnan CF. Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. J Neurosci. 2000 Jul 15; 20(14):5292-9.
      View in: PubMed
    26. Smith KJ, Felts PA, John GR. Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension. Brain. 2000 Jan; 123 ( Pt 1):171-84.
      View in: PubMed
    27. John GR, Scemes E, Suadicani SO, Liu JS, Charles PC, Lee SC, Spray DC, Brosnan CF. IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11613-8.
      View in: PubMed
    28. Littleton JM, Grieve SJ, Griffiths PJ, John GR. Ethanol-induced alteration in membrane phospholipid composition : possible relationship to development of cellular tolerance to ethanol. Adv Exp Med Biol. 1980; 126:7-19.
      View in: PubMed
    29. Littleton JM, John GR, Grieve SJ. Alterations in phospholipid composition in ethanol tolerance and dependence. Alcohol Clin Exp Res. 1979 Jan; 3(1):50-6.
      View in: PubMed
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    Mount Sinai Profiles is managed by Conduits - The Institutes for Translational Sciences at Icahn School of Medicine, supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1TR000067