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Domenico Tortorella

TitleASSOCIATE PROFESSOR
InstitutionMount Sinai
DepartmentMicrobiology
Address

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Redmann V, Gardner T, Lau Z, Morohashi K, Felsenfeld D, Tortorella D. Novel Class of Potential Therapeutics that Target Ricin Retrograde Translocation. Toxins (Basel). 2013; 6(1):33-53.
      View in: PubMed
    2. Miller MS, Gardner TJ, Krammer F, Aguado LC, Tortorella D, Basler CF, Palese P. Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis. Sci Transl Med. 2013 Aug 14; 5(198):198ra107.
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    3. Gardner TJ, Bolovan-Fritts C, Teng MW, Redmann V, Kraus TA, Sperling R, Moran T, Britt W, Weinberger LS, Tortorella D. Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies. Clin Vaccine Immunol. 2013 Apr; 20(4):540-50.
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    4. Noriega V, Redmann V, Gardner T, Tortorella D. Diverse immune evasion strategies by human cytomegalovirus. Immunol Res. 2012 Dec; 54(1-3):140-51.
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    5. Noriega VM, Hesse J, Gardner TJ, Besold K, Plachter B, Tortorella D. Human cytomegalovirus US3 modulates destruction of MHC class I molecules. Mol Immunol. 2012 Jun; 51(2):245-53.
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    6. Redmann V, Oresic K, Tortorella LL, Cook JP, Lord M, Tortorella D. Dislocation of ricin toxin A chains in human cells utilizes selective cellular factors. J Biol Chem. 2011 Jun 17; 286(24):21231-8.
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    7. Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, Barker N, Marchesi F, Thirunarayanan N, Vischer HF, Qin L, Mayer L, Harpaz N, Leurs R, Furtado GC, Clevers H, Tortorella D, Smit MJ, Lira SA. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. J Clin Invest. 2010 Nov; 120(11):3969-78.
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    8. Ng CL, Oresic K, Tortorella D. TRAM1 is involved in disposal of ER membrane degradation substrates. Exp Cell Res. 2010 Aug 1; 316(13):2113-22.
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    9. Oresic K, Mueller B, Tortorella D. Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Biosci Rep. 2009 Jun; 29(3):173-81.
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    10. Oresic K, Ng CL, Tortorella D. TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. J Biol Chem. 2009 Feb 27; 284(9):5905-14.
      View in: PubMed
    11. Noriega VM, Tortorella D. Human cytomegalovirus-encoded immune modulators partner to downregulate major histocompatibility complex class I molecules. J Virol. 2009 Feb; 83(3):1359-67.
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    12. Oresic K, Tortorella D. Endoplasmic reticulum chaperones participate in human cytomegalovirus US2-mediated degradation of class I major histocompatibility complex molecules. J Gen Virol. 2008 May; 89(Pt 5):1122-30.
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    13. Atchison F, Blau B, Bodek K, van den Brandt B, Brys T, Daum M, Fierlinger P, Frei A, Geltenbort P, Hautle P, Henneck R, Heule S, Holley A, Kasprzak M, Kirch K, Knecht A, Konter JA, Kuzniak M, Liu CY, Morris CL, Pichlmaier A, Plonka C, Pokotilovski Y, Saunders A, Shin Y, Tortorella D, Wohlmuther M, Young AR, Zejma J, Zsigmond G. Cold neutron energy dependent production of ultracold neutrons in solid deuterium. Phys Rev Lett. 2007 Dec 31; 99(26):262502.
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    14. Noriega VM, Tortorella D. A bipartite trigger for dislocation directs the proteasomal degradation of an endoplasmic reticulum membrane glycoprotein. J Biol Chem. 2008 Feb 15; 283(7):4031-43.
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    15. Baker BM, Tortorella D. Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides. J Biol Chem. 2007 Sep 14; 282(37):26845-56.
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    16. Loureiro J, Lilley BN, Spooner E, Noriega V, Tortorella D, Ploegh HL. Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature. 2006 Jun 15; 441(7095):894-7.
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    17. Oresic K, Noriega V, Andrews L, Tortorella D. A structural determinant of human cytomegalovirus US2 dictates the down-regulation of class I major histocompatibility molecules. J Biol Chem. 2006 Jul 14; 281(28):19395-406.
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    18. Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. J Exp Med. 2005 Jan 17; 201(2):267-77.
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    19. Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, Tortorella D. Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell. 2004 Apr; 15(4):1635-46.
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    20. Blom D, Hirsch C, Stern P, Tortorella D, Ploegh HL. A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. EMBO J. 2004 Feb 11; 23(3):650-8.
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    21. Furman MH, Loureiro J, Ploegh HL, Tortorella D. Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. J Biol Chem. 2003 Sep 12; 278(37):34804-11.
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    22. Lilley BN, Tortorella D, Ploegh HL. Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer. Mol Biol Cell. 2003 Sep; 14(9):3690-8.
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    23. Tirosh B, Furman MH, Tortorella D, Ploegh HL. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J Biol Chem. 2003 Feb 28; 278(9):6664-72.
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    24. Furman MH, Dey N, Tortorella D, Ploegh HL. The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. J Virol. 2002 Nov; 76(22):11753-6.
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    25. Rehm A, Engelsberg A, Tortorella D, Körner IJ, Lehmann I, Ploegh HL, Höpken UE. Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells. J Virol. 2002 May; 76(10):5043-50.
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    26. Fiebiger E, Story C, Ploegh HL, Tortorella D. Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J. 2002 Mar 1; 21(5):1041-53.
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    27. Gewurz BE, Ploegh HL, Tortorella D. US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide. J Biol Chem. 2002 Mar 29; 277(13):11306-13.
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    28. Furman MH, Ploegh HL, Tortorella D. Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. J Biol Chem. 2002 Feb 1; 277(5):3258-67.
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    29. Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem Biol. 2001 Sep; 8(9):913-29.
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    30. Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL. Virus subversion of immunity: a structural perspective. Curr Opin Immunol. 2001 Aug; 13(4):442-50.
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    31. Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL, Wiley DC. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proc Natl Acad Sci U S A. 2001 Jun 5; 98(12):6794-9.
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    32. Gewurz BE, Wang EW, Tortorella D, Schust DJ, Ploegh HL. Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner. J Virol. 2001 Jun; 75(11):5197-204.
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    33. Rehm A, Stern P, Ploegh HL, Tortorella D. Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor. EMBO J. 2001 Apr 2; 20(7):1573-82.
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    34. Tortorella D, Gewurz B, Schust D, Furman M, Ploegh H. Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology. Immunol Invest. 2000 May; 29(2):97-100.
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    35. Tortorella D, Gewurz BE, Furman MH, Schust DJ, Ploegh HL. Viral subversion of the immune system. Annu Rev Immunol. 2000; 18:861-926.
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    36. Schust DJ, Tortorella D, Ploegh HL. Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens. J Reprod Immunol. 1999 Jul; 43(2):243-51.
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    37. Schust DJ, Tortorella D, Ploegh HL. HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. Semin Cancer Biol. 1999 Feb; 9(1):37-46.
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    38. Schust DJ, Tortorella D, Seebach J, Phan C, Ploegh HL. Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. J Exp Med. 1998 Aug 3; 188(3):497-503.
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    39. Tortorella D, Story CM, Huppa JB, Wiertz EJ, Jones TR, Bacik I, Bennink JR, Yewdell JW, Ploegh HL. Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol. 1998 Jul 27; 142(2):365-76.
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    40. Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H. Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6629-34.
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    41. Wiertz E, Hill A, Tortorella D, Ploegh H. Cytomegaloviruses use multiple mechanisms to elude the host immune response. Immunol Lett. 1997 Jun 1; 57(1-3):213-6.
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    42. Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature. 1996 Dec 5; 384(6608):432-8.
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    43. Tortorella D, Sesardic D, Dawes CS, London E. Immunochemical analysis shows all three domains of diphtheria toxin penetrate across model membranes. J Biol Chem. 1995 Nov 17; 270(46):27446-52.
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    44. Tortorella D, Sesardic D, Dawes CS, London E. Immunochemical analysis of the structure of diphtheria toxin shows all three domains undergo structural changes at low pH. J Biol Chem. 1995 Nov 17; 270(46):27439-45.
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    45. Tortorella D, London E. Method for efficient pelleting of small unilamellar model membrane vesicles. Anal Biochem. 1994 Mar; 217(2):176-80.
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    46. Tortorella D, Ulbrandt ND, London E. Simple centrifugation method for efficient pelleting of both small and large unilamellar vesicles that allows convenient measurement of protein binding. Biochemistry. 1993 Sep 7; 32(35):9181-8.
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    47. London E, Ulbrandt ND, Tortorella D, Jiang JX, Abrams FS. Insights into membrane protein folding and translocation from the behavior of bacterial toxins: models for membrane translocation. Soc Gen Physiol Ser. 1993; 48:45-61.
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